Synthesis, structure elucidation, and anti-inflammatory/anti-cancer/anti-bacterial activities of novel (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones
Abstract A series of hitherto unreported (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones (4a–j) were prepared from formylated/acetylated active proton compounds (2a–j) and 1-adamantanamine (3) under microwave irradiation in good to excellent yields. The structures of 4a–j have been unequivocally establi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kalita, Utpalparna [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science+Business Media New York 2014 |
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| Übergeordnetes Werk: |
Enthalten in: Medicinal chemistry research - Cambridge, Mass. [u.a.] : Birkhäuser Boston, 1991, 24(2014), 1 vom: 03. Juli, Seite 32-50 |
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| Übergeordnetes Werk: |
volume:24 ; year:2014 ; number:1 ; day:03 ; month:07 ; pages:32-50 |
| Links: |
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| DOI / URN: |
10.1007/s00044-014-1086-x |
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| Katalog-ID: |
SPR000404713 |
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| 100 | 1 | |a Kalita, Utpalparna |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Synthesis, structure elucidation, and anti-inflammatory/anti-cancer/anti-bacterial activities of novel (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones |
| 264 | 1 | |c 2014 | |
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| 500 | |a © Springer Science+Business Media New York 2014 | ||
| 520 | |a Abstract A series of hitherto unreported (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones (4a–j) were prepared from formylated/acetylated active proton compounds (2a–j) and 1-adamantanamine (3) under microwave irradiation in good to excellent yields. The structures of 4a–j have been unequivocally established with the help of spectral and analytical data. All the products were found to exist in Z form which was also supported by X-ray crystallographic studies. Compounds 4a–j were assessed for their biological activities by testing their anti-inflammatory, anti-cancer, and anti-bacterial properties. The compounds 4h and 4i showed highest anti-inflammatory properties, while the compounds 4a and 4g were found to be the most cytotoxic and may have anti-cancer properties. However, none of the compounds exhibited anti-bacterial activity. | ||
| 650 | 4 | |a Enaminone |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Adamantane |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anti-inflammatory activity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anti-cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anti-bacterial |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kaping, Shunan |4 aut | |
| 700 | 1 | |a Nongkynrih, Revinus |4 aut | |
| 700 | 1 | |a Sunn, Melboureen |4 aut | |
| 700 | 1 | |a Boiss, Ivee |4 aut | |
| 700 | 1 | |a Singha, Laishram Indira |4 aut | |
| 700 | 1 | |a Vishwakarma, Jai Narain |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Medicinal chemistry research |d Cambridge, Mass. [u.a.] : Birkhäuser Boston, 1991 |g 24(2014), 1 vom: 03. Juli, Seite 32-50 |w (DE-627)490223427 |w (DE-600)2191978-1 |x 1554-8120 |7 nnns |
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10.1007/s00044-014-1086-x doi (DE-627)SPR000404713 (SPR)s00044-014-1086-x-e DE-627 ger DE-627 rakwb eng Kalita, Utpalparna verfasserin aut Synthesis, structure elucidation, and anti-inflammatory/anti-cancer/anti-bacterial activities of novel (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media New York 2014 Abstract A series of hitherto unreported (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones (4a–j) were prepared from formylated/acetylated active proton compounds (2a–j) and 1-adamantanamine (3) under microwave irradiation in good to excellent yields. The structures of 4a–j have been unequivocally established with the help of spectral and analytical data. All the products were found to exist in Z form which was also supported by X-ray crystallographic studies. Compounds 4a–j were assessed for their biological activities by testing their anti-inflammatory, anti-cancer, and anti-bacterial properties. The compounds 4h and 4i showed highest anti-inflammatory properties, while the compounds 4a and 4g were found to be the most cytotoxic and may have anti-cancer properties. However, none of the compounds exhibited anti-bacterial activity. Enaminone (dpeaa)DE-He213 Adamantane (dpeaa)DE-He213 Anti-inflammatory activity (dpeaa)DE-He213 Anti-cancer (dpeaa)DE-He213 Anti-bacterial (dpeaa)DE-He213 Kaping, Shunan aut Nongkynrih, Revinus aut Sunn, Melboureen aut Boiss, Ivee aut Singha, Laishram Indira aut Vishwakarma, Jai Narain aut Enthalten in Medicinal chemistry research Cambridge, Mass. [u.a.] : Birkhäuser Boston, 1991 24(2014), 1 vom: 03. Juli, Seite 32-50 (DE-627)490223427 (DE-600)2191978-1 1554-8120 nnns volume:24 year:2014 number:1 day:03 month:07 pages:32-50 https://dx.doi.org/10.1007/s00044-014-1086-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2014 1 03 07 32-50 |
| spelling |
10.1007/s00044-014-1086-x doi (DE-627)SPR000404713 (SPR)s00044-014-1086-x-e DE-627 ger DE-627 rakwb eng Kalita, Utpalparna verfasserin aut Synthesis, structure elucidation, and anti-inflammatory/anti-cancer/anti-bacterial activities of novel (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media New York 2014 Abstract A series of hitherto unreported (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones (4a–j) were prepared from formylated/acetylated active proton compounds (2a–j) and 1-adamantanamine (3) under microwave irradiation in good to excellent yields. The structures of 4a–j have been unequivocally established with the help of spectral and analytical data. All the products were found to exist in Z form which was also supported by X-ray crystallographic studies. Compounds 4a–j were assessed for their biological activities by testing their anti-inflammatory, anti-cancer, and anti-bacterial properties. The compounds 4h and 4i showed highest anti-inflammatory properties, while the compounds 4a and 4g were found to be the most cytotoxic and may have anti-cancer properties. However, none of the compounds exhibited anti-bacterial activity. Enaminone (dpeaa)DE-He213 Adamantane (dpeaa)DE-He213 Anti-inflammatory activity (dpeaa)DE-He213 Anti-cancer (dpeaa)DE-He213 Anti-bacterial (dpeaa)DE-He213 Kaping, Shunan aut Nongkynrih, Revinus aut Sunn, Melboureen aut Boiss, Ivee aut Singha, Laishram Indira aut Vishwakarma, Jai Narain aut Enthalten in Medicinal chemistry research Cambridge, Mass. [u.a.] : Birkhäuser Boston, 1991 24(2014), 1 vom: 03. Juli, Seite 32-50 (DE-627)490223427 (DE-600)2191978-1 1554-8120 nnns volume:24 year:2014 number:1 day:03 month:07 pages:32-50 https://dx.doi.org/10.1007/s00044-014-1086-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2014 1 03 07 32-50 |
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Kalita, Utpalparna @@aut@@ Kaping, Shunan @@aut@@ Nongkynrih, Revinus @@aut@@ Sunn, Melboureen @@aut@@ Boiss, Ivee @@aut@@ Singha, Laishram Indira @@aut@@ Vishwakarma, Jai Narain @@aut@@ |
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Kalita, Utpalparna |
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Synthesis, structure elucidation, and anti-inflammatory/anti-cancer/anti-bacterial activities of novel (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones Enaminone (dpeaa)DE-He213 Adamantane (dpeaa)DE-He213 Anti-inflammatory activity (dpeaa)DE-He213 Anti-cancer (dpeaa)DE-He213 Anti-bacterial (dpeaa)DE-He213 |
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Synthesis, structure elucidation, and anti-inflammatory/anti-cancer/anti-bacterial activities of novel (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones |
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Synthesis, structure elucidation, and anti-inflammatory/anti-cancer/anti-bacterial activities of novel (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones |
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Kalita, Utpalparna Kaping, Shunan Nongkynrih, Revinus Sunn, Melboureen Boiss, Ivee Singha, Laishram Indira Vishwakarma, Jai Narain |
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synthesis, structure elucidation, and anti-inflammatory/anti-cancer/anti-bacterial activities of novel (z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones |
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Synthesis, structure elucidation, and anti-inflammatory/anti-cancer/anti-bacterial activities of novel (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones |
| abstract |
Abstract A series of hitherto unreported (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones (4a–j) were prepared from formylated/acetylated active proton compounds (2a–j) and 1-adamantanamine (3) under microwave irradiation in good to excellent yields. The structures of 4a–j have been unequivocally established with the help of spectral and analytical data. All the products were found to exist in Z form which was also supported by X-ray crystallographic studies. Compounds 4a–j were assessed for their biological activities by testing their anti-inflammatory, anti-cancer, and anti-bacterial properties. The compounds 4h and 4i showed highest anti-inflammatory properties, while the compounds 4a and 4g were found to be the most cytotoxic and may have anti-cancer properties. However, none of the compounds exhibited anti-bacterial activity. © Springer Science+Business Media New York 2014 |
| abstractGer |
Abstract A series of hitherto unreported (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones (4a–j) were prepared from formylated/acetylated active proton compounds (2a–j) and 1-adamantanamine (3) under microwave irradiation in good to excellent yields. The structures of 4a–j have been unequivocally established with the help of spectral and analytical data. All the products were found to exist in Z form which was also supported by X-ray crystallographic studies. Compounds 4a–j were assessed for their biological activities by testing their anti-inflammatory, anti-cancer, and anti-bacterial properties. The compounds 4h and 4i showed highest anti-inflammatory properties, while the compounds 4a and 4g were found to be the most cytotoxic and may have anti-cancer properties. However, none of the compounds exhibited anti-bacterial activity. © Springer Science+Business Media New York 2014 |
| abstract_unstemmed |
Abstract A series of hitherto unreported (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones (4a–j) were prepared from formylated/acetylated active proton compounds (2a–j) and 1-adamantanamine (3) under microwave irradiation in good to excellent yields. The structures of 4a–j have been unequivocally established with the help of spectral and analytical data. All the products were found to exist in Z form which was also supported by X-ray crystallographic studies. Compounds 4a–j were assessed for their biological activities by testing their anti-inflammatory, anti-cancer, and anti-bacterial properties. The compounds 4h and 4i showed highest anti-inflammatory properties, while the compounds 4a and 4g were found to be the most cytotoxic and may have anti-cancer properties. However, none of the compounds exhibited anti-bacterial activity. © Springer Science+Business Media New York 2014 |
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| title_short |
Synthesis, structure elucidation, and anti-inflammatory/anti-cancer/anti-bacterial activities of novel (Z)-3-adamantyl-1-aryl-prop/but-2-en-1-ones |
| url |
https://dx.doi.org/10.1007/s00044-014-1086-x |
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| author2 |
Kaping, Shunan Nongkynrih, Revinus Sunn, Melboureen Boiss, Ivee Singha, Laishram Indira Vishwakarma, Jai Narain |
| author2Str |
Kaping, Shunan Nongkynrih, Revinus Sunn, Melboureen Boiss, Ivee Singha, Laishram Indira Vishwakarma, Jai Narain |
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| doi_str |
10.1007/s00044-014-1086-x |
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2024-07-03T15:51:25.846Z |
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| score |
7.400426 |