Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects

Abstract Androgen receptor (AR) reactivation was closely related with the recurrence of human prostate cancer. Currently, several limitations of AR inhibitors impede their application, such as the acquired drug resistance and the potential off-target binding. Recently, proteolysis targeting chimera...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Da, Yang [verfasserIn] Liu, Shaodong Lin, Pei Wang, Feng Yan, Renjie Shu, Yongzhi Lin, Jun

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Prostate cancer PROTAC Androgen receptor Targeted protein degradation

Anmerkung:	© Springer Science+Business Media, LLC, part of Springer Nature 2019

Übergeordnetes Werk:	Enthalten in: Medicinal chemistry research - Cambridge, Mass. [u.a.] : Birkhäuser Boston, 1991, 29(2019), 2 vom: 04. Dez., Seite 334-340
Übergeordnetes Werk:	volume:29 ; year:2019 ; number:2 ; day:04 ; month:12 ; pages:334-340

Links:	Volltext

DOI / URN:	10.1007/s00044-019-02485-4

Katalog-ID:	SPR00041977X

Internformat


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520			\|a Abstract Androgen receptor (AR) reactivation was closely related with the recurrence of human prostate cancer. Currently, several limitations of AR inhibitors impede their application, such as the acquired drug resistance and the potential off-target binding. Recently, proteolysis targeting chimera (PROTAC) has been used to treat various diseases by degrading target proteins, which has shown higher selectivity than the corresponding inhibitor. In this study, PAP508 was developed as a novel PROTAC degrader of AR proteins. The results suggested the effect of PAP508 on AR protein depended on the action of proteasome, furthermore, the degradation effect was concentration- and time-dependent manner in LNCaP and VCaP cells. PAP508 can inhibit the proliferation, migration, and invasion of prostate cancer cells. These data suggested that PAP508 is a potent and efficacious compound for the development of PROTAC targeted AR.
650		4	\|a Prostate cancer \|7 (dpeaa)DE-He213
650		4	\|a PROTAC \|7 (dpeaa)DE-He213
650		4	\|a Androgen receptor \|7 (dpeaa)DE-He213
650		4	\|a Targeted protein degradation \|7 (dpeaa)DE-He213
700	1		\|a Liu, Shaodong \|4 aut
700	1		\|a Lin, Pei \|4 aut
700	1		\|a Wang, Feng \|4 aut
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700	1		\|a Shu, Yongzhi \|4 aut
700	1		\|a Lin, Jun \|4 aut
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912			\|a GBV_ILN_32
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_120
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2116
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2119
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2188
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2472
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_2548
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
912			\|a GBV_ILN_4338
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Indexfelder

author_variant	y d yd s l sl p l pl f w fw r y ry y s ys j l jl
matchkey_str	article:15548120:2019----::einyteiadilgclvlainfmlmlclpoasopt
hierarchy_sort_str	2019
publishDate	2019
allfields	10.1007/s00044-019-02485-4 doi (DE-627)SPR00041977X (SPR)s00044-019-02485-4-e DE-627 ger DE-627 rakwb eng Da, Yang verfasserin aut Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2019 Abstract Androgen receptor (AR) reactivation was closely related with the recurrence of human prostate cancer. Currently, several limitations of AR inhibitors impede their application, such as the acquired drug resistance and the potential off-target binding. Recently, proteolysis targeting chimera (PROTAC) has been used to treat various diseases by degrading target proteins, which has shown higher selectivity than the corresponding inhibitor. In this study, PAP508 was developed as a novel PROTAC degrader of AR proteins. The results suggested the effect of PAP508 on AR protein depended on the action of proteasome, furthermore, the degradation effect was concentration- and time-dependent manner in LNCaP and VCaP cells. PAP508 can inhibit the proliferation, migration, and invasion of prostate cancer cells. These data suggested that PAP508 is a potent and efficacious compound for the development of PROTAC targeted AR. Prostate cancer (dpeaa)DE-He213 PROTAC (dpeaa)DE-He213 Androgen receptor (dpeaa)DE-He213 Targeted protein degradation (dpeaa)DE-He213 Liu, Shaodong aut Lin, Pei aut Wang, Feng aut Yan, Renjie aut Shu, Yongzhi aut Lin, Jun aut Enthalten in Medicinal chemistry research Cambridge, Mass. [u.a.] : Birkhäuser Boston, 1991 29(2019), 2 vom: 04. Dez., Seite 334-340 (DE-627)490223427 (DE-600)2191978-1 1554-8120 nnns volume:29 year:2019 number:2 day:04 month:12 pages:334-340 https://dx.doi.org/10.1007/s00044-019-02485-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 2 04 12 334-340
spelling	10.1007/s00044-019-02485-4 doi (DE-627)SPR00041977X (SPR)s00044-019-02485-4-e DE-627 ger DE-627 rakwb eng Da, Yang verfasserin aut Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2019 Abstract Androgen receptor (AR) reactivation was closely related with the recurrence of human prostate cancer. Currently, several limitations of AR inhibitors impede their application, such as the acquired drug resistance and the potential off-target binding. Recently, proteolysis targeting chimera (PROTAC) has been used to treat various diseases by degrading target proteins, which has shown higher selectivity than the corresponding inhibitor. In this study, PAP508 was developed as a novel PROTAC degrader of AR proteins. The results suggested the effect of PAP508 on AR protein depended on the action of proteasome, furthermore, the degradation effect was concentration- and time-dependent manner in LNCaP and VCaP cells. PAP508 can inhibit the proliferation, migration, and invasion of prostate cancer cells. These data suggested that PAP508 is a potent and efficacious compound for the development of PROTAC targeted AR. Prostate cancer (dpeaa)DE-He213 PROTAC (dpeaa)DE-He213 Androgen receptor (dpeaa)DE-He213 Targeted protein degradation (dpeaa)DE-He213 Liu, Shaodong aut Lin, Pei aut Wang, Feng aut Yan, Renjie aut Shu, Yongzhi aut Lin, Jun aut Enthalten in Medicinal chemistry research Cambridge, Mass. [u.a.] : Birkhäuser Boston, 1991 29(2019), 2 vom: 04. Dez., Seite 334-340 (DE-627)490223427 (DE-600)2191978-1 1554-8120 nnns volume:29 year:2019 number:2 day:04 month:12 pages:334-340 https://dx.doi.org/10.1007/s00044-019-02485-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 2 04 12 334-340
allfields_unstemmed	10.1007/s00044-019-02485-4 doi (DE-627)SPR00041977X (SPR)s00044-019-02485-4-e DE-627 ger DE-627 rakwb eng Da, Yang verfasserin aut Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2019 Abstract Androgen receptor (AR) reactivation was closely related with the recurrence of human prostate cancer. Currently, several limitations of AR inhibitors impede their application, such as the acquired drug resistance and the potential off-target binding. Recently, proteolysis targeting chimera (PROTAC) has been used to treat various diseases by degrading target proteins, which has shown higher selectivity than the corresponding inhibitor. In this study, PAP508 was developed as a novel PROTAC degrader of AR proteins. The results suggested the effect of PAP508 on AR protein depended on the action of proteasome, furthermore, the degradation effect was concentration- and time-dependent manner in LNCaP and VCaP cells. PAP508 can inhibit the proliferation, migration, and invasion of prostate cancer cells. These data suggested that PAP508 is a potent and efficacious compound for the development of PROTAC targeted AR. Prostate cancer (dpeaa)DE-He213 PROTAC (dpeaa)DE-He213 Androgen receptor (dpeaa)DE-He213 Targeted protein degradation (dpeaa)DE-He213 Liu, Shaodong aut Lin, Pei aut Wang, Feng aut Yan, Renjie aut Shu, Yongzhi aut Lin, Jun aut Enthalten in Medicinal chemistry research Cambridge, Mass. [u.a.] : Birkhäuser Boston, 1991 29(2019), 2 vom: 04. Dez., Seite 334-340 (DE-627)490223427 (DE-600)2191978-1 1554-8120 nnns volume:29 year:2019 number:2 day:04 month:12 pages:334-340 https://dx.doi.org/10.1007/s00044-019-02485-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 2 04 12 334-340
allfieldsGer	10.1007/s00044-019-02485-4 doi (DE-627)SPR00041977X (SPR)s00044-019-02485-4-e DE-627 ger DE-627 rakwb eng Da, Yang verfasserin aut Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2019 Abstract Androgen receptor (AR) reactivation was closely related with the recurrence of human prostate cancer. Currently, several limitations of AR inhibitors impede their application, such as the acquired drug resistance and the potential off-target binding. Recently, proteolysis targeting chimera (PROTAC) has been used to treat various diseases by degrading target proteins, which has shown higher selectivity than the corresponding inhibitor. In this study, PAP508 was developed as a novel PROTAC degrader of AR proteins. The results suggested the effect of PAP508 on AR protein depended on the action of proteasome, furthermore, the degradation effect was concentration- and time-dependent manner in LNCaP and VCaP cells. PAP508 can inhibit the proliferation, migration, and invasion of prostate cancer cells. These data suggested that PAP508 is a potent and efficacious compound for the development of PROTAC targeted AR. Prostate cancer (dpeaa)DE-He213 PROTAC (dpeaa)DE-He213 Androgen receptor (dpeaa)DE-He213 Targeted protein degradation (dpeaa)DE-He213 Liu, Shaodong aut Lin, Pei aut Wang, Feng aut Yan, Renjie aut Shu, Yongzhi aut Lin, Jun aut Enthalten in Medicinal chemistry research Cambridge, Mass. [u.a.] : Birkhäuser Boston, 1991 29(2019), 2 vom: 04. Dez., Seite 334-340 (DE-627)490223427 (DE-600)2191978-1 1554-8120 nnns volume:29 year:2019 number:2 day:04 month:12 pages:334-340 https://dx.doi.org/10.1007/s00044-019-02485-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 2 04 12 334-340
allfieldsSound	10.1007/s00044-019-02485-4 doi (DE-627)SPR00041977X (SPR)s00044-019-02485-4-e DE-627 ger DE-627 rakwb eng Da, Yang verfasserin aut Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2019 Abstract Androgen receptor (AR) reactivation was closely related with the recurrence of human prostate cancer. Currently, several limitations of AR inhibitors impede their application, such as the acquired drug resistance and the potential off-target binding. Recently, proteolysis targeting chimera (PROTAC) has been used to treat various diseases by degrading target proteins, which has shown higher selectivity than the corresponding inhibitor. In this study, PAP508 was developed as a novel PROTAC degrader of AR proteins. The results suggested the effect of PAP508 on AR protein depended on the action of proteasome, furthermore, the degradation effect was concentration- and time-dependent manner in LNCaP and VCaP cells. PAP508 can inhibit the proliferation, migration, and invasion of prostate cancer cells. These data suggested that PAP508 is a potent and efficacious compound for the development of PROTAC targeted AR. Prostate cancer (dpeaa)DE-He213 PROTAC (dpeaa)DE-He213 Androgen receptor (dpeaa)DE-He213 Targeted protein degradation (dpeaa)DE-He213 Liu, Shaodong aut Lin, Pei aut Wang, Feng aut Yan, Renjie aut Shu, Yongzhi aut Lin, Jun aut Enthalten in Medicinal chemistry research Cambridge, Mass. [u.a.] : Birkhäuser Boston, 1991 29(2019), 2 vom: 04. Dez., Seite 334-340 (DE-627)490223427 (DE-600)2191978-1 1554-8120 nnns volume:29 year:2019 number:2 day:04 month:12 pages:334-340 https://dx.doi.org/10.1007/s00044-019-02485-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 2 04 12 334-340
language	English
source	Enthalten in Medicinal chemistry research 29(2019), 2 vom: 04. Dez., Seite 334-340 volume:29 year:2019 number:2 day:04 month:12 pages:334-340
sourceStr	Enthalten in Medicinal chemistry research 29(2019), 2 vom: 04. Dez., Seite 334-340 volume:29 year:2019 number:2 day:04 month:12 pages:334-340
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Prostate cancer PROTAC Androgen receptor Targeted protein degradation
isfreeaccess_bool	false
container_title	Medicinal chemistry research
authorswithroles_txt_mv	Da, Yang @@aut@@ Liu, Shaodong @@aut@@ Lin, Pei @@aut@@ Wang, Feng @@aut@@ Yan, Renjie @@aut@@ Shu, Yongzhi @@aut@@ Lin, Jun @@aut@@
publishDateDaySort_date	2019-12-04T00:00:00Z
hierarchy_top_id	490223427
id	SPR00041977X
language_de	englisch
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author	Da, Yang
spellingShingle	Da, Yang misc Prostate cancer misc PROTAC misc Androgen receptor misc Targeted protein degradation Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects
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topic_title	Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects Prostate cancer (dpeaa)DE-He213 PROTAC (dpeaa)DE-He213 Androgen receptor (dpeaa)DE-He213 Targeted protein degradation (dpeaa)DE-He213
topic	misc Prostate cancer misc PROTAC misc Androgen receptor misc Targeted protein degradation
topic_unstemmed	misc Prostate cancer misc PROTAC misc Androgen receptor misc Targeted protein degradation
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title	Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects
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title_full	Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects
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author_browse	Da, Yang Liu, Shaodong Lin, Pei Wang, Feng Yan, Renjie Shu, Yongzhi Lin, Jun
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doi_str_mv	10.1007/s00044-019-02485-4
title_sort	design, synthesis, and biological evaluation of small molecule protacs for potential anticancer effects
title_auth	Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects
abstract	Abstract Androgen receptor (AR) reactivation was closely related with the recurrence of human prostate cancer. Currently, several limitations of AR inhibitors impede their application, such as the acquired drug resistance and the potential off-target binding. Recently, proteolysis targeting chimera (PROTAC) has been used to treat various diseases by degrading target proteins, which has shown higher selectivity than the corresponding inhibitor. In this study, PAP508 was developed as a novel PROTAC degrader of AR proteins. The results suggested the effect of PAP508 on AR protein depended on the action of proteasome, furthermore, the degradation effect was concentration- and time-dependent manner in LNCaP and VCaP cells. PAP508 can inhibit the proliferation, migration, and invasion of prostate cancer cells. These data suggested that PAP508 is a potent and efficacious compound for the development of PROTAC targeted AR. © Springer Science+Business Media, LLC, part of Springer Nature 2019
abstractGer	Abstract Androgen receptor (AR) reactivation was closely related with the recurrence of human prostate cancer. Currently, several limitations of AR inhibitors impede their application, such as the acquired drug resistance and the potential off-target binding. Recently, proteolysis targeting chimera (PROTAC) has been used to treat various diseases by degrading target proteins, which has shown higher selectivity than the corresponding inhibitor. In this study, PAP508 was developed as a novel PROTAC degrader of AR proteins. The results suggested the effect of PAP508 on AR protein depended on the action of proteasome, furthermore, the degradation effect was concentration- and time-dependent manner in LNCaP and VCaP cells. PAP508 can inhibit the proliferation, migration, and invasion of prostate cancer cells. These data suggested that PAP508 is a potent and efficacious compound for the development of PROTAC targeted AR. © Springer Science+Business Media, LLC, part of Springer Nature 2019
abstract_unstemmed	Abstract Androgen receptor (AR) reactivation was closely related with the recurrence of human prostate cancer. Currently, several limitations of AR inhibitors impede their application, such as the acquired drug resistance and the potential off-target binding. Recently, proteolysis targeting chimera (PROTAC) has been used to treat various diseases by degrading target proteins, which has shown higher selectivity than the corresponding inhibitor. In this study, PAP508 was developed as a novel PROTAC degrader of AR proteins. The results suggested the effect of PAP508 on AR protein depended on the action of proteasome, furthermore, the degradation effect was concentration- and time-dependent manner in LNCaP and VCaP cells. PAP508 can inhibit the proliferation, migration, and invasion of prostate cancer cells. These data suggested that PAP508 is a potent and efficacious compound for the development of PROTAC targeted AR. © Springer Science+Business Media, LLC, part of Springer Nature 2019
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container_issue	2
title_short	Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects
url	https://dx.doi.org/10.1007/s00044-019-02485-4
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author2	Liu, Shaodong Lin, Pei Wang, Feng Yan, Renjie Shu, Yongzhi Lin, Jun
author2Str	Liu, Shaodong Lin, Pei Wang, Feng Yan, Renjie Shu, Yongzhi Lin, Jun
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doi_str	10.1007/s00044-019-02485-4
up_date	2024-07-03T15:58:16.454Z
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Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects

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