Target lesion calcification and risk of adverse outcomes in patients with drug-eluting stents
Background Studies focusing on the relationship between calcified lesions and adverse outcomes in the drug-eluting stent (DES) era have presented inconsistent conclusions. The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Huang, Bao-Tao [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Anmerkung: |
© Urban & Vogel 2015 |
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| Übergeordnetes Werk: |
Enthalten in: Herz - München : Urban & Vogel, 1997, 40(2015), 8 vom: 27. Juni, Seite 1097-1106 |
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| Übergeordnetes Werk: |
volume:40 ; year:2015 ; number:8 ; day:27 ; month:06 ; pages:1097-1106 |
| Links: |
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| DOI / URN: |
10.1007/s00059-015-4324-1 |
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SPR00045981X |
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| 520 | |a Background Studies focusing on the relationship between calcified lesions and adverse outcomes in the drug-eluting stent (DES) era have presented inconsistent conclusions. The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergoing DES implantation. Methods A systematic search was conducted on Medline (Ovid SP, 1946 to 28 February 2014), Embase (Ovid SP, 1974 to 28 February 2014), and the Chinese Biomedical Literature Database (CBM, 1978 to 28 February 2014). Abstracts from the 2012 and 2013 scientific meetings of the American College of Cardiology and American Heart Association were manually searched. Hazard ratios (HRs) were pooled using a fixed or random effects model in the context of heterogeneity. Results A total of 13 studies comprising 66,361 patients were included. Target lesion calcification was associated with an increased risk of all-cause mortality (HR = 1.41; 95 % CI = 1.27–1.56), cardiac death (HR = 1.97; 95 % CI = 1.68–2.31), myocardial infarction (HR = 1.33; 95 % CI = 1.13–1.57), target lesion revascularization (TLR; HR 1.47, 95 % CI 1.18–1.83), stent thrombosis (HR 1.63, 95 % CI 1.36–1.96), and major cardiovascular events (HR 1.37, 95 % CI 1.19–1.58). The results proved robust in subgroup analyses for TLR and stent thrombosis. Conclusion Calcified target lesions are risk factors for adverse outcomes in the DES era. Further studies focusing on comprehensive therapy in patients with coronary calcification are urgently needed. | ||
| 650 | 4 | |a Coronary artery calcification |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Risk factor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Drug-eluting stent |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Percutaneous coronary intervention |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Outcome |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Zhao, Zhen-Gang |4 aut | |
| 700 | 1 | |a Huang, De-Jia |4 aut | |
| 700 | 1 | |a Chen, Mao |4 aut | |
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10.1007/s00059-015-4324-1 doi (DE-627)SPR00045981X (SPR)s00059-015-4324-1-e DE-627 ger DE-627 rakwb eng Huang, Bao-Tao verfasserin aut Target lesion calcification and risk of adverse outcomes in patients with drug-eluting stents 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Urban & Vogel 2015 Background Studies focusing on the relationship between calcified lesions and adverse outcomes in the drug-eluting stent (DES) era have presented inconsistent conclusions. The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergoing DES implantation. Methods A systematic search was conducted on Medline (Ovid SP, 1946 to 28 February 2014), Embase (Ovid SP, 1974 to 28 February 2014), and the Chinese Biomedical Literature Database (CBM, 1978 to 28 February 2014). Abstracts from the 2012 and 2013 scientific meetings of the American College of Cardiology and American Heart Association were manually searched. Hazard ratios (HRs) were pooled using a fixed or random effects model in the context of heterogeneity. Results A total of 13 studies comprising 66,361 patients were included. Target lesion calcification was associated with an increased risk of all-cause mortality (HR = 1.41; 95 % CI = 1.27–1.56), cardiac death (HR = 1.97; 95 % CI = 1.68–2.31), myocardial infarction (HR = 1.33; 95 % CI = 1.13–1.57), target lesion revascularization (TLR; HR 1.47, 95 % CI 1.18–1.83), stent thrombosis (HR 1.63, 95 % CI 1.36–1.96), and major cardiovascular events (HR 1.37, 95 % CI 1.19–1.58). The results proved robust in subgroup analyses for TLR and stent thrombosis. Conclusion Calcified target lesions are risk factors for adverse outcomes in the DES era. Further studies focusing on comprehensive therapy in patients with coronary calcification are urgently needed. Coronary artery calcification (dpeaa)DE-He213 Risk factor (dpeaa)DE-He213 Drug-eluting stent (dpeaa)DE-He213 Percutaneous coronary intervention (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Huang, Fang-Yang aut Zuo, Zhi-Liang aut Liu, Wei aut Huang, Kai-Sen aut Liao, Yan-Biao aut Wang, Peng-Ju aut Peng, Yong aut Zhang, Chen aut Zhao, Zhen-Gang aut Huang, De-Jia aut Chen, Mao aut Enthalten in Herz München : Urban & Vogel, 1997 40(2015), 8 vom: 27. Juni, Seite 1097-1106 (DE-627)320568296 (DE-600)2016203-0 1615-6692 nnns volume:40 year:2015 number:8 day:27 month:06 pages:1097-1106 https://dx.doi.org/10.1007/s00059-015-4324-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 40 2015 8 27 06 1097-1106 |
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10.1007/s00059-015-4324-1 doi (DE-627)SPR00045981X (SPR)s00059-015-4324-1-e DE-627 ger DE-627 rakwb eng Huang, Bao-Tao verfasserin aut Target lesion calcification and risk of adverse outcomes in patients with drug-eluting stents 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Urban & Vogel 2015 Background Studies focusing on the relationship between calcified lesions and adverse outcomes in the drug-eluting stent (DES) era have presented inconsistent conclusions. The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergoing DES implantation. Methods A systematic search was conducted on Medline (Ovid SP, 1946 to 28 February 2014), Embase (Ovid SP, 1974 to 28 February 2014), and the Chinese Biomedical Literature Database (CBM, 1978 to 28 February 2014). Abstracts from the 2012 and 2013 scientific meetings of the American College of Cardiology and American Heart Association were manually searched. Hazard ratios (HRs) were pooled using a fixed or random effects model in the context of heterogeneity. Results A total of 13 studies comprising 66,361 patients were included. Target lesion calcification was associated with an increased risk of all-cause mortality (HR = 1.41; 95 % CI = 1.27–1.56), cardiac death (HR = 1.97; 95 % CI = 1.68–2.31), myocardial infarction (HR = 1.33; 95 % CI = 1.13–1.57), target lesion revascularization (TLR; HR 1.47, 95 % CI 1.18–1.83), stent thrombosis (HR 1.63, 95 % CI 1.36–1.96), and major cardiovascular events (HR 1.37, 95 % CI 1.19–1.58). The results proved robust in subgroup analyses for TLR and stent thrombosis. Conclusion Calcified target lesions are risk factors for adverse outcomes in the DES era. Further studies focusing on comprehensive therapy in patients with coronary calcification are urgently needed. Coronary artery calcification (dpeaa)DE-He213 Risk factor (dpeaa)DE-He213 Drug-eluting stent (dpeaa)DE-He213 Percutaneous coronary intervention (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Huang, Fang-Yang aut Zuo, Zhi-Liang aut Liu, Wei aut Huang, Kai-Sen aut Liao, Yan-Biao aut Wang, Peng-Ju aut Peng, Yong aut Zhang, Chen aut Zhao, Zhen-Gang aut Huang, De-Jia aut Chen, Mao aut Enthalten in Herz München : Urban & Vogel, 1997 40(2015), 8 vom: 27. Juni, Seite 1097-1106 (DE-627)320568296 (DE-600)2016203-0 1615-6692 nnns volume:40 year:2015 number:8 day:27 month:06 pages:1097-1106 https://dx.doi.org/10.1007/s00059-015-4324-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 40 2015 8 27 06 1097-1106 |
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10.1007/s00059-015-4324-1 doi (DE-627)SPR00045981X (SPR)s00059-015-4324-1-e DE-627 ger DE-627 rakwb eng Huang, Bao-Tao verfasserin aut Target lesion calcification and risk of adverse outcomes in patients with drug-eluting stents 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Urban & Vogel 2015 Background Studies focusing on the relationship between calcified lesions and adverse outcomes in the drug-eluting stent (DES) era have presented inconsistent conclusions. The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergoing DES implantation. Methods A systematic search was conducted on Medline (Ovid SP, 1946 to 28 February 2014), Embase (Ovid SP, 1974 to 28 February 2014), and the Chinese Biomedical Literature Database (CBM, 1978 to 28 February 2014). Abstracts from the 2012 and 2013 scientific meetings of the American College of Cardiology and American Heart Association were manually searched. Hazard ratios (HRs) were pooled using a fixed or random effects model in the context of heterogeneity. Results A total of 13 studies comprising 66,361 patients were included. Target lesion calcification was associated with an increased risk of all-cause mortality (HR = 1.41; 95 % CI = 1.27–1.56), cardiac death (HR = 1.97; 95 % CI = 1.68–2.31), myocardial infarction (HR = 1.33; 95 % CI = 1.13–1.57), target lesion revascularization (TLR; HR 1.47, 95 % CI 1.18–1.83), stent thrombosis (HR 1.63, 95 % CI 1.36–1.96), and major cardiovascular events (HR 1.37, 95 % CI 1.19–1.58). The results proved robust in subgroup analyses for TLR and stent thrombosis. Conclusion Calcified target lesions are risk factors for adverse outcomes in the DES era. Further studies focusing on comprehensive therapy in patients with coronary calcification are urgently needed. Coronary artery calcification (dpeaa)DE-He213 Risk factor (dpeaa)DE-He213 Drug-eluting stent (dpeaa)DE-He213 Percutaneous coronary intervention (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Huang, Fang-Yang aut Zuo, Zhi-Liang aut Liu, Wei aut Huang, Kai-Sen aut Liao, Yan-Biao aut Wang, Peng-Ju aut Peng, Yong aut Zhang, Chen aut Zhao, Zhen-Gang aut Huang, De-Jia aut Chen, Mao aut Enthalten in Herz München : Urban & Vogel, 1997 40(2015), 8 vom: 27. Juni, Seite 1097-1106 (DE-627)320568296 (DE-600)2016203-0 1615-6692 nnns volume:40 year:2015 number:8 day:27 month:06 pages:1097-1106 https://dx.doi.org/10.1007/s00059-015-4324-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 40 2015 8 27 06 1097-1106 |
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10.1007/s00059-015-4324-1 doi (DE-627)SPR00045981X (SPR)s00059-015-4324-1-e DE-627 ger DE-627 rakwb eng Huang, Bao-Tao verfasserin aut Target lesion calcification and risk of adverse outcomes in patients with drug-eluting stents 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Urban & Vogel 2015 Background Studies focusing on the relationship between calcified lesions and adverse outcomes in the drug-eluting stent (DES) era have presented inconsistent conclusions. The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergoing DES implantation. Methods A systematic search was conducted on Medline (Ovid SP, 1946 to 28 February 2014), Embase (Ovid SP, 1974 to 28 February 2014), and the Chinese Biomedical Literature Database (CBM, 1978 to 28 February 2014). Abstracts from the 2012 and 2013 scientific meetings of the American College of Cardiology and American Heart Association were manually searched. Hazard ratios (HRs) were pooled using a fixed or random effects model in the context of heterogeneity. Results A total of 13 studies comprising 66,361 patients were included. Target lesion calcification was associated with an increased risk of all-cause mortality (HR = 1.41; 95 % CI = 1.27–1.56), cardiac death (HR = 1.97; 95 % CI = 1.68–2.31), myocardial infarction (HR = 1.33; 95 % CI = 1.13–1.57), target lesion revascularization (TLR; HR 1.47, 95 % CI 1.18–1.83), stent thrombosis (HR 1.63, 95 % CI 1.36–1.96), and major cardiovascular events (HR 1.37, 95 % CI 1.19–1.58). The results proved robust in subgroup analyses for TLR and stent thrombosis. Conclusion Calcified target lesions are risk factors for adverse outcomes in the DES era. Further studies focusing on comprehensive therapy in patients with coronary calcification are urgently needed. Coronary artery calcification (dpeaa)DE-He213 Risk factor (dpeaa)DE-He213 Drug-eluting stent (dpeaa)DE-He213 Percutaneous coronary intervention (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Huang, Fang-Yang aut Zuo, Zhi-Liang aut Liu, Wei aut Huang, Kai-Sen aut Liao, Yan-Biao aut Wang, Peng-Ju aut Peng, Yong aut Zhang, Chen aut Zhao, Zhen-Gang aut Huang, De-Jia aut Chen, Mao aut Enthalten in Herz München : Urban & Vogel, 1997 40(2015), 8 vom: 27. Juni, Seite 1097-1106 (DE-627)320568296 (DE-600)2016203-0 1615-6692 nnns volume:40 year:2015 number:8 day:27 month:06 pages:1097-1106 https://dx.doi.org/10.1007/s00059-015-4324-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 40 2015 8 27 06 1097-1106 |
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10.1007/s00059-015-4324-1 doi (DE-627)SPR00045981X (SPR)s00059-015-4324-1-e DE-627 ger DE-627 rakwb eng Huang, Bao-Tao verfasserin aut Target lesion calcification and risk of adverse outcomes in patients with drug-eluting stents 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Urban & Vogel 2015 Background Studies focusing on the relationship between calcified lesions and adverse outcomes in the drug-eluting stent (DES) era have presented inconsistent conclusions. The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergoing DES implantation. Methods A systematic search was conducted on Medline (Ovid SP, 1946 to 28 February 2014), Embase (Ovid SP, 1974 to 28 February 2014), and the Chinese Biomedical Literature Database (CBM, 1978 to 28 February 2014). Abstracts from the 2012 and 2013 scientific meetings of the American College of Cardiology and American Heart Association were manually searched. Hazard ratios (HRs) were pooled using a fixed or random effects model in the context of heterogeneity. Results A total of 13 studies comprising 66,361 patients were included. Target lesion calcification was associated with an increased risk of all-cause mortality (HR = 1.41; 95 % CI = 1.27–1.56), cardiac death (HR = 1.97; 95 % CI = 1.68–2.31), myocardial infarction (HR = 1.33; 95 % CI = 1.13–1.57), target lesion revascularization (TLR; HR 1.47, 95 % CI 1.18–1.83), stent thrombosis (HR 1.63, 95 % CI 1.36–1.96), and major cardiovascular events (HR 1.37, 95 % CI 1.19–1.58). The results proved robust in subgroup analyses for TLR and stent thrombosis. Conclusion Calcified target lesions are risk factors for adverse outcomes in the DES era. Further studies focusing on comprehensive therapy in patients with coronary calcification are urgently needed. Coronary artery calcification (dpeaa)DE-He213 Risk factor (dpeaa)DE-He213 Drug-eluting stent (dpeaa)DE-He213 Percutaneous coronary intervention (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Huang, Fang-Yang aut Zuo, Zhi-Liang aut Liu, Wei aut Huang, Kai-Sen aut Liao, Yan-Biao aut Wang, Peng-Ju aut Peng, Yong aut Zhang, Chen aut Zhao, Zhen-Gang aut Huang, De-Jia aut Chen, Mao aut Enthalten in Herz München : Urban & Vogel, 1997 40(2015), 8 vom: 27. Juni, Seite 1097-1106 (DE-627)320568296 (DE-600)2016203-0 1615-6692 nnns volume:40 year:2015 number:8 day:27 month:06 pages:1097-1106 https://dx.doi.org/10.1007/s00059-015-4324-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 40 2015 8 27 06 1097-1106 |
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Enthalten in Herz 40(2015), 8 vom: 27. Juni, Seite 1097-1106 volume:40 year:2015 number:8 day:27 month:06 pages:1097-1106 |
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Coronary artery calcification Risk factor Drug-eluting stent Percutaneous coronary intervention Outcome |
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Huang, Bao-Tao @@aut@@ Huang, Fang-Yang @@aut@@ Zuo, Zhi-Liang @@aut@@ Liu, Wei @@aut@@ Huang, Kai-Sen @@aut@@ Liao, Yan-Biao @@aut@@ Wang, Peng-Ju @@aut@@ Peng, Yong @@aut@@ Zhang, Chen @@aut@@ Zhao, Zhen-Gang @@aut@@ Huang, De-Jia @@aut@@ Chen, Mao @@aut@@ |
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The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergoing DES implantation. Methods A systematic search was conducted on Medline (Ovid SP, 1946 to 28 February 2014), Embase (Ovid SP, 1974 to 28 February 2014), and the Chinese Biomedical Literature Database (CBM, 1978 to 28 February 2014). Abstracts from the 2012 and 2013 scientific meetings of the American College of Cardiology and American Heart Association were manually searched. Hazard ratios (HRs) were pooled using a fixed or random effects model in the context of heterogeneity. Results A total of 13 studies comprising 66,361 patients were included. Target lesion calcification was associated with an increased risk of all-cause mortality (HR = 1.41; 95 % CI = 1.27–1.56), cardiac death (HR = 1.97; 95 % CI = 1.68–2.31), myocardial infarction (HR = 1.33; 95 % CI = 1.13–1.57), target lesion revascularization (TLR; HR 1.47, 95 % CI 1.18–1.83), stent thrombosis (HR 1.63, 95 % CI 1.36–1.96), and major cardiovascular events (HR 1.37, 95 % CI 1.19–1.58). The results proved robust in subgroup analyses for TLR and stent thrombosis. Conclusion Calcified target lesions are risk factors for adverse outcomes in the DES era. 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Huang, Bao-Tao Huang, Fang-Yang Zuo, Zhi-Liang Liu, Wei Huang, Kai-Sen Liao, Yan-Biao Wang, Peng-Ju Peng, Yong Zhang, Chen Zhao, Zhen-Gang Huang, De-Jia Chen, Mao |
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Elektronische Aufsätze |
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Huang, Bao-Tao |
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10.1007/s00059-015-4324-1 |
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target lesion calcification and risk of adverse outcomes in patients with drug-eluting stents |
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Target lesion calcification and risk of adverse outcomes in patients with drug-eluting stents |
| abstract |
Background Studies focusing on the relationship between calcified lesions and adverse outcomes in the drug-eluting stent (DES) era have presented inconsistent conclusions. The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergoing DES implantation. Methods A systematic search was conducted on Medline (Ovid SP, 1946 to 28 February 2014), Embase (Ovid SP, 1974 to 28 February 2014), and the Chinese Biomedical Literature Database (CBM, 1978 to 28 February 2014). Abstracts from the 2012 and 2013 scientific meetings of the American College of Cardiology and American Heart Association were manually searched. Hazard ratios (HRs) were pooled using a fixed or random effects model in the context of heterogeneity. Results A total of 13 studies comprising 66,361 patients were included. Target lesion calcification was associated with an increased risk of all-cause mortality (HR = 1.41; 95 % CI = 1.27–1.56), cardiac death (HR = 1.97; 95 % CI = 1.68–2.31), myocardial infarction (HR = 1.33; 95 % CI = 1.13–1.57), target lesion revascularization (TLR; HR 1.47, 95 % CI 1.18–1.83), stent thrombosis (HR 1.63, 95 % CI 1.36–1.96), and major cardiovascular events (HR 1.37, 95 % CI 1.19–1.58). The results proved robust in subgroup analyses for TLR and stent thrombosis. Conclusion Calcified target lesions are risk factors for adverse outcomes in the DES era. Further studies focusing on comprehensive therapy in patients with coronary calcification are urgently needed. © Urban & Vogel 2015 |
| abstractGer |
Background Studies focusing on the relationship between calcified lesions and adverse outcomes in the drug-eluting stent (DES) era have presented inconsistent conclusions. The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergoing DES implantation. Methods A systematic search was conducted on Medline (Ovid SP, 1946 to 28 February 2014), Embase (Ovid SP, 1974 to 28 February 2014), and the Chinese Biomedical Literature Database (CBM, 1978 to 28 February 2014). Abstracts from the 2012 and 2013 scientific meetings of the American College of Cardiology and American Heart Association were manually searched. Hazard ratios (HRs) were pooled using a fixed or random effects model in the context of heterogeneity. Results A total of 13 studies comprising 66,361 patients were included. Target lesion calcification was associated with an increased risk of all-cause mortality (HR = 1.41; 95 % CI = 1.27–1.56), cardiac death (HR = 1.97; 95 % CI = 1.68–2.31), myocardial infarction (HR = 1.33; 95 % CI = 1.13–1.57), target lesion revascularization (TLR; HR 1.47, 95 % CI 1.18–1.83), stent thrombosis (HR 1.63, 95 % CI 1.36–1.96), and major cardiovascular events (HR 1.37, 95 % CI 1.19–1.58). The results proved robust in subgroup analyses for TLR and stent thrombosis. Conclusion Calcified target lesions are risk factors for adverse outcomes in the DES era. Further studies focusing on comprehensive therapy in patients with coronary calcification are urgently needed. © Urban & Vogel 2015 |
| abstract_unstemmed |
Background Studies focusing on the relationship between calcified lesions and adverse outcomes in the drug-eluting stent (DES) era have presented inconsistent conclusions. The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergoing DES implantation. Methods A systematic search was conducted on Medline (Ovid SP, 1946 to 28 February 2014), Embase (Ovid SP, 1974 to 28 February 2014), and the Chinese Biomedical Literature Database (CBM, 1978 to 28 February 2014). Abstracts from the 2012 and 2013 scientific meetings of the American College of Cardiology and American Heart Association were manually searched. Hazard ratios (HRs) were pooled using a fixed or random effects model in the context of heterogeneity. Results A total of 13 studies comprising 66,361 patients were included. Target lesion calcification was associated with an increased risk of all-cause mortality (HR = 1.41; 95 % CI = 1.27–1.56), cardiac death (HR = 1.97; 95 % CI = 1.68–2.31), myocardial infarction (HR = 1.33; 95 % CI = 1.13–1.57), target lesion revascularization (TLR; HR 1.47, 95 % CI 1.18–1.83), stent thrombosis (HR 1.63, 95 % CI 1.36–1.96), and major cardiovascular events (HR 1.37, 95 % CI 1.19–1.58). The results proved robust in subgroup analyses for TLR and stent thrombosis. Conclusion Calcified target lesions are risk factors for adverse outcomes in the DES era. Further studies focusing on comprehensive therapy in patients with coronary calcification are urgently needed. © Urban & Vogel 2015 |
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| score |
7.399168 |