Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy
Background This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed. Patients and methods The study com...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sefa Okten, M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
Cardiomyopathy, familial idiopathic |
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| Anmerkung: |
© Springer Medizin Verlag 2016 |
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| Übergeordnetes Werk: |
Enthalten in: Herz - München : Urban & Vogel, 1997, 42(2016), 7 vom: 10. Nov., Seite 669-676 |
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| Übergeordnetes Werk: |
volume:42 ; year:2016 ; number:7 ; day:10 ; month:11 ; pages:669-676 |
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| DOI / URN: |
10.1007/s00059-016-4498-1 |
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| Katalog-ID: |
SPR000462322 |
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| 100 | 1 | |a Sefa Okten, M. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy |
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| 520 | |a Background This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed. Patients and methods The study comprised 77 subjects aged 16–63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). Results No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p < 0.001) and FS values (39.4 ± 6.6 vs. 41.45 ± 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (−17.34 ± 2.19% vs. −19.21 ± 2.16%, p < 0.001) and strain rate (0.94 ± 0.14 $ s^{−1} $ vs. 1.03 ± 0.14 $ s^{−1} $, p < 0.001), radial strain (34.47 ± 9.14% vs 42.79 ± 11.91%, p < 0.001) and strain rate (1.6 ± 0.38 $ s^{−1} $ vs. 1.75 ± 0.29 $ s^{−1} $, p = 0.006), circumferential strain (−6.07 ± 2.83% vs. −18.29 ± 3.39%, p < 0.001) and strain rate (1.09 ± 0.24 $ s^{−1} $ vs. 1.2 ± 0.25 $ s^{−1} $, p = 0.004), and torsion (10.07 ± 5.$ 18^{o} $/cm vs. 12.42 ± 5.$ 78^{o} $/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls. Conclusion LV deformation parameters are impaired in first-degree relatives of patients with IDCM. Screening of this population using standard 2D echocardiography and strain imaging may provide early detection of those with subclinical myocardial dysfunction. | ||
| 650 | 4 | |a Cardiomyopathy, familial idiopathic |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dilated cardiomyopathy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cardiomyopathy, idiopathic dilated |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Echocardiography |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Tuluce, K. |4 aut | |
| 700 | 1 | |a Yakar Tuluce, S. |4 aut | |
| 700 | 1 | |a Kilic, S. |4 aut | |
| 700 | 1 | |a Soner Kemal, H. |4 aut | |
| 700 | 1 | |a Sayin, A. |4 aut | |
| 700 | 1 | |a Vuran, O. |4 aut | |
| 700 | 1 | |a Yagmur, B. |4 aut | |
| 700 | 1 | |a Mutlu, I. |4 aut | |
| 700 | 1 | |a Simsek, E. |4 aut | |
| 700 | 1 | |a Soydas Cinar, C. |4 aut | |
| 700 | 1 | |a Gurgun, C. |4 aut | |
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10.1007/s00059-016-4498-1 doi (DE-627)SPR000462322 (SPR)s00059-016-4498-1-e DE-627 ger DE-627 rakwb eng Sefa Okten, M. verfasserin aut Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Medizin Verlag 2016 Background This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed. Patients and methods The study comprised 77 subjects aged 16–63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). Results No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p < 0.001) and FS values (39.4 ± 6.6 vs. 41.45 ± 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (−17.34 ± 2.19% vs. −19.21 ± 2.16%, p < 0.001) and strain rate (0.94 ± 0.14 $ s^{−1} $ vs. 1.03 ± 0.14 $ s^{−1} $, p < 0.001), radial strain (34.47 ± 9.14% vs 42.79 ± 11.91%, p < 0.001) and strain rate (1.6 ± 0.38 $ s^{−1} $ vs. 1.75 ± 0.29 $ s^{−1} $, p = 0.006), circumferential strain (−6.07 ± 2.83% vs. −18.29 ± 3.39%, p < 0.001) and strain rate (1.09 ± 0.24 $ s^{−1} $ vs. 1.2 ± 0.25 $ s^{−1} $, p = 0.004), and torsion (10.07 ± 5.$ 18^{o} $/cm vs. 12.42 ± 5.$ 78^{o} $/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls. Conclusion LV deformation parameters are impaired in first-degree relatives of patients with IDCM. Screening of this population using standard 2D echocardiography and strain imaging may provide early detection of those with subclinical myocardial dysfunction. Cardiomyopathy, familial idiopathic (dpeaa)DE-He213 Dilated cardiomyopathy (dpeaa)DE-He213 Cardiomyopathy, idiopathic dilated (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Tuluce, K. aut Yakar Tuluce, S. aut Kilic, S. aut Soner Kemal, H. aut Sayin, A. aut Vuran, O. aut Yagmur, B. aut Mutlu, I. aut Simsek, E. aut Soydas Cinar, C. aut Gurgun, C. aut Enthalten in Herz München : Urban & Vogel, 1997 42(2016), 7 vom: 10. Nov., Seite 669-676 (DE-627)320568296 (DE-600)2016203-0 1615-6692 nnns volume:42 year:2016 number:7 day:10 month:11 pages:669-676 https://dx.doi.org/10.1007/s00059-016-4498-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 42 2016 7 10 11 669-676 |
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10.1007/s00059-016-4498-1 doi (DE-627)SPR000462322 (SPR)s00059-016-4498-1-e DE-627 ger DE-627 rakwb eng Sefa Okten, M. verfasserin aut Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Medizin Verlag 2016 Background This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed. Patients and methods The study comprised 77 subjects aged 16–63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). Results No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p < 0.001) and FS values (39.4 ± 6.6 vs. 41.45 ± 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (−17.34 ± 2.19% vs. −19.21 ± 2.16%, p < 0.001) and strain rate (0.94 ± 0.14 $ s^{−1} $ vs. 1.03 ± 0.14 $ s^{−1} $, p < 0.001), radial strain (34.47 ± 9.14% vs 42.79 ± 11.91%, p < 0.001) and strain rate (1.6 ± 0.38 $ s^{−1} $ vs. 1.75 ± 0.29 $ s^{−1} $, p = 0.006), circumferential strain (−6.07 ± 2.83% vs. −18.29 ± 3.39%, p < 0.001) and strain rate (1.09 ± 0.24 $ s^{−1} $ vs. 1.2 ± 0.25 $ s^{−1} $, p = 0.004), and torsion (10.07 ± 5.$ 18^{o} $/cm vs. 12.42 ± 5.$ 78^{o} $/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls. Conclusion LV deformation parameters are impaired in first-degree relatives of patients with IDCM. Screening of this population using standard 2D echocardiography and strain imaging may provide early detection of those with subclinical myocardial dysfunction. Cardiomyopathy, familial idiopathic (dpeaa)DE-He213 Dilated cardiomyopathy (dpeaa)DE-He213 Cardiomyopathy, idiopathic dilated (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Tuluce, K. aut Yakar Tuluce, S. aut Kilic, S. aut Soner Kemal, H. aut Sayin, A. aut Vuran, O. aut Yagmur, B. aut Mutlu, I. aut Simsek, E. aut Soydas Cinar, C. aut Gurgun, C. aut Enthalten in Herz München : Urban & Vogel, 1997 42(2016), 7 vom: 10. Nov., Seite 669-676 (DE-627)320568296 (DE-600)2016203-0 1615-6692 nnns volume:42 year:2016 number:7 day:10 month:11 pages:669-676 https://dx.doi.org/10.1007/s00059-016-4498-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 42 2016 7 10 11 669-676 |
| allfields_unstemmed |
10.1007/s00059-016-4498-1 doi (DE-627)SPR000462322 (SPR)s00059-016-4498-1-e DE-627 ger DE-627 rakwb eng Sefa Okten, M. verfasserin aut Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Medizin Verlag 2016 Background This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed. Patients and methods The study comprised 77 subjects aged 16–63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). Results No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p < 0.001) and FS values (39.4 ± 6.6 vs. 41.45 ± 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (−17.34 ± 2.19% vs. −19.21 ± 2.16%, p < 0.001) and strain rate (0.94 ± 0.14 $ s^{−1} $ vs. 1.03 ± 0.14 $ s^{−1} $, p < 0.001), radial strain (34.47 ± 9.14% vs 42.79 ± 11.91%, p < 0.001) and strain rate (1.6 ± 0.38 $ s^{−1} $ vs. 1.75 ± 0.29 $ s^{−1} $, p = 0.006), circumferential strain (−6.07 ± 2.83% vs. −18.29 ± 3.39%, p < 0.001) and strain rate (1.09 ± 0.24 $ s^{−1} $ vs. 1.2 ± 0.25 $ s^{−1} $, p = 0.004), and torsion (10.07 ± 5.$ 18^{o} $/cm vs. 12.42 ± 5.$ 78^{o} $/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls. Conclusion LV deformation parameters are impaired in first-degree relatives of patients with IDCM. Screening of this population using standard 2D echocardiography and strain imaging may provide early detection of those with subclinical myocardial dysfunction. Cardiomyopathy, familial idiopathic (dpeaa)DE-He213 Dilated cardiomyopathy (dpeaa)DE-He213 Cardiomyopathy, idiopathic dilated (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Tuluce, K. aut Yakar Tuluce, S. aut Kilic, S. aut Soner Kemal, H. aut Sayin, A. aut Vuran, O. aut Yagmur, B. aut Mutlu, I. aut Simsek, E. aut Soydas Cinar, C. aut Gurgun, C. aut Enthalten in Herz München : Urban & Vogel, 1997 42(2016), 7 vom: 10. Nov., Seite 669-676 (DE-627)320568296 (DE-600)2016203-0 1615-6692 nnns volume:42 year:2016 number:7 day:10 month:11 pages:669-676 https://dx.doi.org/10.1007/s00059-016-4498-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 42 2016 7 10 11 669-676 |
| allfieldsGer |
10.1007/s00059-016-4498-1 doi (DE-627)SPR000462322 (SPR)s00059-016-4498-1-e DE-627 ger DE-627 rakwb eng Sefa Okten, M. verfasserin aut Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Medizin Verlag 2016 Background This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed. Patients and methods The study comprised 77 subjects aged 16–63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). Results No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p < 0.001) and FS values (39.4 ± 6.6 vs. 41.45 ± 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (−17.34 ± 2.19% vs. −19.21 ± 2.16%, p < 0.001) and strain rate (0.94 ± 0.14 $ s^{−1} $ vs. 1.03 ± 0.14 $ s^{−1} $, p < 0.001), radial strain (34.47 ± 9.14% vs 42.79 ± 11.91%, p < 0.001) and strain rate (1.6 ± 0.38 $ s^{−1} $ vs. 1.75 ± 0.29 $ s^{−1} $, p = 0.006), circumferential strain (−6.07 ± 2.83% vs. −18.29 ± 3.39%, p < 0.001) and strain rate (1.09 ± 0.24 $ s^{−1} $ vs. 1.2 ± 0.25 $ s^{−1} $, p = 0.004), and torsion (10.07 ± 5.$ 18^{o} $/cm vs. 12.42 ± 5.$ 78^{o} $/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls. Conclusion LV deformation parameters are impaired in first-degree relatives of patients with IDCM. Screening of this population using standard 2D echocardiography and strain imaging may provide early detection of those with subclinical myocardial dysfunction. Cardiomyopathy, familial idiopathic (dpeaa)DE-He213 Dilated cardiomyopathy (dpeaa)DE-He213 Cardiomyopathy, idiopathic dilated (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Tuluce, K. aut Yakar Tuluce, S. aut Kilic, S. aut Soner Kemal, H. aut Sayin, A. aut Vuran, O. aut Yagmur, B. aut Mutlu, I. aut Simsek, E. aut Soydas Cinar, C. aut Gurgun, C. aut Enthalten in Herz München : Urban & Vogel, 1997 42(2016), 7 vom: 10. Nov., Seite 669-676 (DE-627)320568296 (DE-600)2016203-0 1615-6692 nnns volume:42 year:2016 number:7 day:10 month:11 pages:669-676 https://dx.doi.org/10.1007/s00059-016-4498-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 42 2016 7 10 11 669-676 |
| allfieldsSound |
10.1007/s00059-016-4498-1 doi (DE-627)SPR000462322 (SPR)s00059-016-4498-1-e DE-627 ger DE-627 rakwb eng Sefa Okten, M. verfasserin aut Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Medizin Verlag 2016 Background This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed. Patients and methods The study comprised 77 subjects aged 16–63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). Results No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p < 0.001) and FS values (39.4 ± 6.6 vs. 41.45 ± 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (−17.34 ± 2.19% vs. −19.21 ± 2.16%, p < 0.001) and strain rate (0.94 ± 0.14 $ s^{−1} $ vs. 1.03 ± 0.14 $ s^{−1} $, p < 0.001), radial strain (34.47 ± 9.14% vs 42.79 ± 11.91%, p < 0.001) and strain rate (1.6 ± 0.38 $ s^{−1} $ vs. 1.75 ± 0.29 $ s^{−1} $, p = 0.006), circumferential strain (−6.07 ± 2.83% vs. −18.29 ± 3.39%, p < 0.001) and strain rate (1.09 ± 0.24 $ s^{−1} $ vs. 1.2 ± 0.25 $ s^{−1} $, p = 0.004), and torsion (10.07 ± 5.$ 18^{o} $/cm vs. 12.42 ± 5.$ 78^{o} $/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls. Conclusion LV deformation parameters are impaired in first-degree relatives of patients with IDCM. Screening of this population using standard 2D echocardiography and strain imaging may provide early detection of those with subclinical myocardial dysfunction. Cardiomyopathy, familial idiopathic (dpeaa)DE-He213 Dilated cardiomyopathy (dpeaa)DE-He213 Cardiomyopathy, idiopathic dilated (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Tuluce, K. aut Yakar Tuluce, S. aut Kilic, S. aut Soner Kemal, H. aut Sayin, A. aut Vuran, O. aut Yagmur, B. aut Mutlu, I. aut Simsek, E. aut Soydas Cinar, C. aut Gurgun, C. aut Enthalten in Herz München : Urban & Vogel, 1997 42(2016), 7 vom: 10. Nov., Seite 669-676 (DE-627)320568296 (DE-600)2016203-0 1615-6692 nnns volume:42 year:2016 number:7 day:10 month:11 pages:669-676 https://dx.doi.org/10.1007/s00059-016-4498-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 42 2016 7 10 11 669-676 |
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Enthalten in Herz 42(2016), 7 vom: 10. Nov., Seite 669-676 volume:42 year:2016 number:7 day:10 month:11 pages:669-676 |
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Enthalten in Herz 42(2016), 7 vom: 10. Nov., Seite 669-676 volume:42 year:2016 number:7 day:10 month:11 pages:669-676 |
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Cardiomyopathy, familial idiopathic Dilated cardiomyopathy Cardiomyopathy, idiopathic dilated Echocardiography |
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Sefa Okten, M. @@aut@@ Tuluce, K. @@aut@@ Yakar Tuluce, S. @@aut@@ Kilic, S. @@aut@@ Soner Kemal, H. @@aut@@ Sayin, A. @@aut@@ Vuran, O. @@aut@@ Yagmur, B. @@aut@@ Mutlu, I. @@aut@@ Simsek, E. @@aut@@ Soydas Cinar, C. @@aut@@ Gurgun, C. @@aut@@ |
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Patients and methods The study comprised 77 subjects aged 16–63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). Results No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p < 0.001) and FS values (39.4 ± 6.6 vs. 41.45 ± 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (−17.34 ± 2.19% vs. −19.21 ± 2.16%, p < 0.001) and strain rate (0.94 ± 0.14 $ s^{−1} $ vs. 1.03 ± 0.14 $ s^{−1} $, p < 0.001), radial strain (34.47 ± 9.14% vs 42.79 ± 11.91%, p < 0.001) and strain rate (1.6 ± 0.38 $ s^{−1} $ vs. 1.75 ± 0.29 $ s^{−1} $, p = 0.006), circumferential strain (−6.07 ± 2.83% vs. −18.29 ± 3.39%, p < 0.001) and strain rate (1.09 ± 0.24 $ s^{−1} $ vs. 1.2 ± 0.25 $ s^{−1} $, p = 0.004), and torsion (10.07 ± 5.$ 18^{o} $/cm vs. 12.42 ± 5.$ 78^{o} $/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls. Conclusion LV deformation parameters are impaired in first-degree relatives of patients with IDCM. 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|
| author |
Sefa Okten, M. |
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Sefa Okten, M. misc Cardiomyopathy, familial idiopathic misc Dilated cardiomyopathy misc Cardiomyopathy, idiopathic dilated misc Echocardiography Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy |
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1615-6692 |
| topic_title |
Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy Cardiomyopathy, familial idiopathic (dpeaa)DE-He213 Dilated cardiomyopathy (dpeaa)DE-He213 Cardiomyopathy, idiopathic dilated (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 |
| topic |
misc Cardiomyopathy, familial idiopathic misc Dilated cardiomyopathy misc Cardiomyopathy, idiopathic dilated misc Echocardiography |
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misc Cardiomyopathy, familial idiopathic misc Dilated cardiomyopathy misc Cardiomyopathy, idiopathic dilated misc Echocardiography |
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misc Cardiomyopathy, familial idiopathic misc Dilated cardiomyopathy misc Cardiomyopathy, idiopathic dilated misc Echocardiography |
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Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy |
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Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy |
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Sefa Okten, M. |
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Sefa Okten, M. Tuluce, K. Yakar Tuluce, S. Kilic, S. Soner Kemal, H. Sayin, A. Vuran, O. Yagmur, B. Mutlu, I. Simsek, E. Soydas Cinar, C. Gurgun, C. |
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Elektronische Aufsätze |
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Sefa Okten, M. |
| doi_str_mv |
10.1007/s00059-016-4498-1 |
| title_sort |
screening first-degree relatives of patients with idiopathic dilated cardiomyopathy |
| title_auth |
Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy |
| abstract |
Background This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed. Patients and methods The study comprised 77 subjects aged 16–63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). Results No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p < 0.001) and FS values (39.4 ± 6.6 vs. 41.45 ± 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (−17.34 ± 2.19% vs. −19.21 ± 2.16%, p < 0.001) and strain rate (0.94 ± 0.14 $ s^{−1} $ vs. 1.03 ± 0.14 $ s^{−1} $, p < 0.001), radial strain (34.47 ± 9.14% vs 42.79 ± 11.91%, p < 0.001) and strain rate (1.6 ± 0.38 $ s^{−1} $ vs. 1.75 ± 0.29 $ s^{−1} $, p = 0.006), circumferential strain (−6.07 ± 2.83% vs. −18.29 ± 3.39%, p < 0.001) and strain rate (1.09 ± 0.24 $ s^{−1} $ vs. 1.2 ± 0.25 $ s^{−1} $, p = 0.004), and torsion (10.07 ± 5.$ 18^{o} $/cm vs. 12.42 ± 5.$ 78^{o} $/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls. Conclusion LV deformation parameters are impaired in first-degree relatives of patients with IDCM. Screening of this population using standard 2D echocardiography and strain imaging may provide early detection of those with subclinical myocardial dysfunction. © Springer Medizin Verlag 2016 |
| abstractGer |
Background This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed. Patients and methods The study comprised 77 subjects aged 16–63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). Results No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p < 0.001) and FS values (39.4 ± 6.6 vs. 41.45 ± 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (−17.34 ± 2.19% vs. −19.21 ± 2.16%, p < 0.001) and strain rate (0.94 ± 0.14 $ s^{−1} $ vs. 1.03 ± 0.14 $ s^{−1} $, p < 0.001), radial strain (34.47 ± 9.14% vs 42.79 ± 11.91%, p < 0.001) and strain rate (1.6 ± 0.38 $ s^{−1} $ vs. 1.75 ± 0.29 $ s^{−1} $, p = 0.006), circumferential strain (−6.07 ± 2.83% vs. −18.29 ± 3.39%, p < 0.001) and strain rate (1.09 ± 0.24 $ s^{−1} $ vs. 1.2 ± 0.25 $ s^{−1} $, p = 0.004), and torsion (10.07 ± 5.$ 18^{o} $/cm vs. 12.42 ± 5.$ 78^{o} $/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls. Conclusion LV deformation parameters are impaired in first-degree relatives of patients with IDCM. Screening of this population using standard 2D echocardiography and strain imaging may provide early detection of those with subclinical myocardial dysfunction. © Springer Medizin Verlag 2016 |
| abstract_unstemmed |
Background This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed. Patients and methods The study comprised 77 subjects aged 16–63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). Results No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p < 0.001) and FS values (39.4 ± 6.6 vs. 41.45 ± 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (−17.34 ± 2.19% vs. −19.21 ± 2.16%, p < 0.001) and strain rate (0.94 ± 0.14 $ s^{−1} $ vs. 1.03 ± 0.14 $ s^{−1} $, p < 0.001), radial strain (34.47 ± 9.14% vs 42.79 ± 11.91%, p < 0.001) and strain rate (1.6 ± 0.38 $ s^{−1} $ vs. 1.75 ± 0.29 $ s^{−1} $, p = 0.006), circumferential strain (−6.07 ± 2.83% vs. −18.29 ± 3.39%, p < 0.001) and strain rate (1.09 ± 0.24 $ s^{−1} $ vs. 1.2 ± 0.25 $ s^{−1} $, p = 0.004), and torsion (10.07 ± 5.$ 18^{o} $/cm vs. 12.42 ± 5.$ 78^{o} $/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls. Conclusion LV deformation parameters are impaired in first-degree relatives of patients with IDCM. Screening of this population using standard 2D echocardiography and strain imaging may provide early detection of those with subclinical myocardial dysfunction. © Springer Medizin Verlag 2016 |
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Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy |
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https://dx.doi.org/10.1007/s00059-016-4498-1 |
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Tuluce, K. Yakar Tuluce, S. Kilic, S. Soner Kemal, H. Sayin, A. Vuran, O. Yagmur, B. Mutlu, I. Simsek, E. Soydas Cinar, C. Gurgun, C. |
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Tuluce, K. Yakar Tuluce, S. Kilic, S. Soner Kemal, H. Sayin, A. Vuran, O. Yagmur, B. Mutlu, I. Simsek, E. Soydas Cinar, C. Gurgun, C. |
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10.1007/s00059-016-4498-1 |
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2024-07-03T16:14:33.252Z |
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Patients and methods The study comprised 77 subjects aged 16–63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). Results No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p < 0.001) and FS values (39.4 ± 6.6 vs. 41.45 ± 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (−17.34 ± 2.19% vs. −19.21 ± 2.16%, p < 0.001) and strain rate (0.94 ± 0.14 $ s^{−1} $ vs. 1.03 ± 0.14 $ s^{−1} $, p < 0.001), radial strain (34.47 ± 9.14% vs 42.79 ± 11.91%, p < 0.001) and strain rate (1.6 ± 0.38 $ s^{−1} $ vs. 1.75 ± 0.29 $ s^{−1} $, p = 0.006), circumferential strain (−6.07 ± 2.83% vs. −18.29 ± 3.39%, p < 0.001) and strain rate (1.09 ± 0.24 $ s^{−1} $ vs. 1.2 ± 0.25 $ s^{−1} $, p = 0.004), and torsion (10.07 ± 5.$ 18^{o} $/cm vs. 12.42 ± 5.$ 78^{o} $/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls. Conclusion LV deformation parameters are impaired in first-degree relatives of patients with IDCM. 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| score |
7.400528 |