Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer

Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in dee...
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Gespeichert in:

Autor*in:	Hepp, Rodrigo [verfasserIn] Ammerpohl, Mark Morgenstern, Christina Nielinger, Lisa Erichsen, Patricia Abdallah, Abdallah Galalae, Razvan

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Radiotherapy Breast cancer Cardiac dose Deep inspiration breath-hold Surface scanner

Anmerkung:	© Springer-Verlag Berlin Heidelberg 2015

Übergeordnetes Werk:	Enthalten in: Strahlentherapie und Onkologie - Berlin : Springer Medizin, 1997, 191(2015), 9 vom: 18. Apr., Seite 710-716
Übergeordnetes Werk:	volume:191 ; year:2015 ; number:9 ; day:18 ; month:04 ; pages:710-716

Links:	Volltext

DOI / URN:	10.1007/s00066-015-0838-y

Katalog-ID:	SPR000513296

Internformat


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100	1		\|a Hepp, Rodrigo \|e verfasserin \|4 aut
245	1	0	\|a Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer
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520			\|a Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL.
650		4	\|a Radiotherapy \|7 (dpeaa)DE-He213
650		4	\|a Breast cancer \|7 (dpeaa)DE-He213
650		4	\|a Cardiac dose \|7 (dpeaa)DE-He213
650		4	\|a Deep inspiration breath-hold \|7 (dpeaa)DE-He213
650		4	\|a Surface scanner \|7 (dpeaa)DE-He213
700	1		\|a Ammerpohl, Mark \|4 aut
700	1		\|a Morgenstern, Christina \|4 aut
700	1		\|a Nielinger, Lisa \|4 aut
700	1		\|a Erichsen, Patricia \|4 aut
700	1		\|a Abdallah, Abdallah \|4 aut
700	1		\|a Galalae, Razvan \|4 aut
773	0	8	\|i Enthalten in \|t Strahlentherapie und Onkologie \|d Berlin : Springer Medizin, 1997 \|g 191(2015), 9 vom: 18. Apr., Seite 710-716 \|w (DE-627)312407866 \|w (DE-600)2003907-4 \|x 1439-099X \|7 nnns
773	1	8	\|g volume:191 \|g year:2015 \|g number:9 \|g day:18 \|g month:04 \|g pages:710-716
856	4	0	\|u https://dx.doi.org/10.1007/s00066-015-0838-y \|z lizenzpflichtig \|3 Volltext
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912			\|a GBV_ILN_110
912			\|a GBV_ILN_120
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_267
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_702
912			\|a GBV_ILN_711
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
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912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2472
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_2548
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
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912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4277
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
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951			\|a AR
952			\|d 191 \|j 2015 \|e 9 \|b 18 \|c 04 \|h 710-716

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author_variant	r h rh m a ma c m cm l n ln p e pe a a aa r g rg
matchkey_str	article:1439099X:2015----::epnprtobethldbrdohrpilfs
hierarchy_sort_str	2015
publishDate	2015
allfields	10.1007/s00066-015-0838-y doi (DE-627)SPR000513296 (SPR)s00066-015-0838-y-e DE-627 ger DE-627 rakwb eng Hepp, Rodrigo verfasserin aut Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. Radiotherapy (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Cardiac dose (dpeaa)DE-He213 Deep inspiration breath-hold (dpeaa)DE-He213 Surface scanner (dpeaa)DE-He213 Ammerpohl, Mark aut Morgenstern, Christina aut Nielinger, Lisa aut Erichsen, Patricia aut Abdallah, Abdallah aut Galalae, Razvan aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 191(2015), 9 vom: 18. Apr., Seite 710-716 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:191 year:2015 number:9 day:18 month:04 pages:710-716 https://dx.doi.org/10.1007/s00066-015-0838-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 191 2015 9 18 04 710-716
spelling	10.1007/s00066-015-0838-y doi (DE-627)SPR000513296 (SPR)s00066-015-0838-y-e DE-627 ger DE-627 rakwb eng Hepp, Rodrigo verfasserin aut Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. Radiotherapy (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Cardiac dose (dpeaa)DE-He213 Deep inspiration breath-hold (dpeaa)DE-He213 Surface scanner (dpeaa)DE-He213 Ammerpohl, Mark aut Morgenstern, Christina aut Nielinger, Lisa aut Erichsen, Patricia aut Abdallah, Abdallah aut Galalae, Razvan aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 191(2015), 9 vom: 18. Apr., Seite 710-716 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:191 year:2015 number:9 day:18 month:04 pages:710-716 https://dx.doi.org/10.1007/s00066-015-0838-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 191 2015 9 18 04 710-716
allfields_unstemmed	10.1007/s00066-015-0838-y doi (DE-627)SPR000513296 (SPR)s00066-015-0838-y-e DE-627 ger DE-627 rakwb eng Hepp, Rodrigo verfasserin aut Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. Radiotherapy (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Cardiac dose (dpeaa)DE-He213 Deep inspiration breath-hold (dpeaa)DE-He213 Surface scanner (dpeaa)DE-He213 Ammerpohl, Mark aut Morgenstern, Christina aut Nielinger, Lisa aut Erichsen, Patricia aut Abdallah, Abdallah aut Galalae, Razvan aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 191(2015), 9 vom: 18. Apr., Seite 710-716 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:191 year:2015 number:9 day:18 month:04 pages:710-716 https://dx.doi.org/10.1007/s00066-015-0838-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 191 2015 9 18 04 710-716
allfieldsGer	10.1007/s00066-015-0838-y doi (DE-627)SPR000513296 (SPR)s00066-015-0838-y-e DE-627 ger DE-627 rakwb eng Hepp, Rodrigo verfasserin aut Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. Radiotherapy (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Cardiac dose (dpeaa)DE-He213 Deep inspiration breath-hold (dpeaa)DE-He213 Surface scanner (dpeaa)DE-He213 Ammerpohl, Mark aut Morgenstern, Christina aut Nielinger, Lisa aut Erichsen, Patricia aut Abdallah, Abdallah aut Galalae, Razvan aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 191(2015), 9 vom: 18. Apr., Seite 710-716 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:191 year:2015 number:9 day:18 month:04 pages:710-716 https://dx.doi.org/10.1007/s00066-015-0838-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 191 2015 9 18 04 710-716
allfieldsSound	10.1007/s00066-015-0838-y doi (DE-627)SPR000513296 (SPR)s00066-015-0838-y-e DE-627 ger DE-627 rakwb eng Hepp, Rodrigo verfasserin aut Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. Radiotherapy (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Cardiac dose (dpeaa)DE-He213 Deep inspiration breath-hold (dpeaa)DE-He213 Surface scanner (dpeaa)DE-He213 Ammerpohl, Mark aut Morgenstern, Christina aut Nielinger, Lisa aut Erichsen, Patricia aut Abdallah, Abdallah aut Galalae, Razvan aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 191(2015), 9 vom: 18. Apr., Seite 710-716 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:191 year:2015 number:9 day:18 month:04 pages:710-716 https://dx.doi.org/10.1007/s00066-015-0838-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 191 2015 9 18 04 710-716
language	English
source	Enthalten in Strahlentherapie und Onkologie 191(2015), 9 vom: 18. Apr., Seite 710-716 volume:191 year:2015 number:9 day:18 month:04 pages:710-716
sourceStr	Enthalten in Strahlentherapie und Onkologie 191(2015), 9 vom: 18. Apr., Seite 710-716 volume:191 year:2015 number:9 day:18 month:04 pages:710-716
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Radiotherapy Breast cancer Cardiac dose Deep inspiration breath-hold Surface scanner
isfreeaccess_bool	false
container_title	Strahlentherapie und Onkologie
authorswithroles_txt_mv	Hepp, Rodrigo @@aut@@ Ammerpohl, Mark @@aut@@ Morgenstern, Christina @@aut@@ Nielinger, Lisa @@aut@@ Erichsen, Patricia @@aut@@ Abdallah, Abdallah @@aut@@ Galalae, Razvan @@aut@@
publishDateDaySort_date	2015-04-18T00:00:00Z
hierarchy_top_id	312407866
id	SPR000513296
language_de	englisch
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The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Radiotherapy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Breast cancer</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cardiac dose</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Deep inspiration breath-hold</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Surface scanner</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ammerpohl, Mark</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Morgenstern, Christina</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nielinger, Lisa</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Erichsen, Patricia</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Abdallah, Abdallah</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Galalae, Razvan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Strahlentherapie und Onkologie</subfield><subfield code="d">Berlin : Springer Medizin, 1997</subfield><subfield code="g">191(2015), 9 vom: 18. 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author	Hepp, Rodrigo
spellingShingle	Hepp, Rodrigo misc Radiotherapy misc Breast cancer misc Cardiac dose misc Deep inspiration breath-hold misc Surface scanner Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer
authorStr	Hepp, Rodrigo
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topic_title	Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer Radiotherapy (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Cardiac dose (dpeaa)DE-He213 Deep inspiration breath-hold (dpeaa)DE-He213 Surface scanner (dpeaa)DE-He213
topic	misc Radiotherapy misc Breast cancer misc Cardiac dose misc Deep inspiration breath-hold misc Surface scanner
topic_unstemmed	misc Radiotherapy misc Breast cancer misc Cardiac dose misc Deep inspiration breath-hold misc Surface scanner
topic_browse	misc Radiotherapy misc Breast cancer misc Cardiac dose misc Deep inspiration breath-hold misc Surface scanner
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title	Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer
ctrlnum	(DE-627)SPR000513296 (SPR)s00066-015-0838-y-e
title_full	Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer
author_sort	Hepp, Rodrigo
journal	Strahlentherapie und Onkologie
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author_browse	Hepp, Rodrigo Ammerpohl, Mark Morgenstern, Christina Nielinger, Lisa Erichsen, Patricia Abdallah, Abdallah Galalae, Razvan
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author-letter	Hepp, Rodrigo
doi_str_mv	10.1007/s00066-015-0838-y
title_sort	deep inspiration breath-hold (dibh) radiotherapy in left-sided breast cancer
title_auth	Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer
abstract	Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. © Springer-Verlag Berlin Heidelberg 2015
abstractGer	Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. © Springer-Verlag Berlin Heidelberg 2015
abstract_unstemmed	Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. © Springer-Verlag Berlin Heidelberg 2015
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container_issue	9
title_short	Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer
url	https://dx.doi.org/10.1007/s00066-015-0838-y
remote_bool	true
author2	Ammerpohl, Mark Morgenstern, Christina Nielinger, Lisa Erichsen, Patricia Abdallah, Abdallah Galalae, Razvan
author2Str	Ammerpohl, Mark Morgenstern, Christina Nielinger, Lisa Erichsen, Patricia Abdallah, Abdallah Galalae, Razvan
ppnlink	312407866
mediatype_str_mv	c
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s00066-015-0838-y
up_date	2024-07-03T16:35:26.721Z
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The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. 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Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer

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