Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer
Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in dee...
Ausführliche Beschreibung
Autor*in: |
Hepp, Rodrigo [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2015 |
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Schlagwörter: |
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Anmerkung: |
© Springer-Verlag Berlin Heidelberg 2015 |
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Übergeordnetes Werk: |
Enthalten in: Strahlentherapie und Onkologie - Berlin : Springer Medizin, 1997, 191(2015), 9 vom: 18. Apr., Seite 710-716 |
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Übergeordnetes Werk: |
volume:191 ; year:2015 ; number:9 ; day:18 ; month:04 ; pages:710-716 |
Links: |
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DOI / URN: |
10.1007/s00066-015-0838-y |
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Katalog-ID: |
SPR000513296 |
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520 | |a Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. | ||
650 | 4 | |a Radiotherapy |7 (dpeaa)DE-He213 | |
650 | 4 | |a Breast cancer |7 (dpeaa)DE-He213 | |
650 | 4 | |a Cardiac dose |7 (dpeaa)DE-He213 | |
650 | 4 | |a Deep inspiration breath-hold |7 (dpeaa)DE-He213 | |
650 | 4 | |a Surface scanner |7 (dpeaa)DE-He213 | |
700 | 1 | |a Ammerpohl, Mark |4 aut | |
700 | 1 | |a Morgenstern, Christina |4 aut | |
700 | 1 | |a Nielinger, Lisa |4 aut | |
700 | 1 | |a Erichsen, Patricia |4 aut | |
700 | 1 | |a Abdallah, Abdallah |4 aut | |
700 | 1 | |a Galalae, Razvan |4 aut | |
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10.1007/s00066-015-0838-y doi (DE-627)SPR000513296 (SPR)s00066-015-0838-y-e DE-627 ger DE-627 rakwb eng Hepp, Rodrigo verfasserin aut Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. Radiotherapy (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Cardiac dose (dpeaa)DE-He213 Deep inspiration breath-hold (dpeaa)DE-He213 Surface scanner (dpeaa)DE-He213 Ammerpohl, Mark aut Morgenstern, Christina aut Nielinger, Lisa aut Erichsen, Patricia aut Abdallah, Abdallah aut Galalae, Razvan aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 191(2015), 9 vom: 18. Apr., Seite 710-716 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:191 year:2015 number:9 day:18 month:04 pages:710-716 https://dx.doi.org/10.1007/s00066-015-0838-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 191 2015 9 18 04 710-716 |
spelling |
10.1007/s00066-015-0838-y doi (DE-627)SPR000513296 (SPR)s00066-015-0838-y-e DE-627 ger DE-627 rakwb eng Hepp, Rodrigo verfasserin aut Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. Radiotherapy (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Cardiac dose (dpeaa)DE-He213 Deep inspiration breath-hold (dpeaa)DE-He213 Surface scanner (dpeaa)DE-He213 Ammerpohl, Mark aut Morgenstern, Christina aut Nielinger, Lisa aut Erichsen, Patricia aut Abdallah, Abdallah aut Galalae, Razvan aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 191(2015), 9 vom: 18. Apr., Seite 710-716 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:191 year:2015 number:9 day:18 month:04 pages:710-716 https://dx.doi.org/10.1007/s00066-015-0838-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 191 2015 9 18 04 710-716 |
allfields_unstemmed |
10.1007/s00066-015-0838-y doi (DE-627)SPR000513296 (SPR)s00066-015-0838-y-e DE-627 ger DE-627 rakwb eng Hepp, Rodrigo verfasserin aut Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. Radiotherapy (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Cardiac dose (dpeaa)DE-He213 Deep inspiration breath-hold (dpeaa)DE-He213 Surface scanner (dpeaa)DE-He213 Ammerpohl, Mark aut Morgenstern, Christina aut Nielinger, Lisa aut Erichsen, Patricia aut Abdallah, Abdallah aut Galalae, Razvan aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 191(2015), 9 vom: 18. Apr., Seite 710-716 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:191 year:2015 number:9 day:18 month:04 pages:710-716 https://dx.doi.org/10.1007/s00066-015-0838-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 191 2015 9 18 04 710-716 |
allfieldsGer |
10.1007/s00066-015-0838-y doi (DE-627)SPR000513296 (SPR)s00066-015-0838-y-e DE-627 ger DE-627 rakwb eng Hepp, Rodrigo verfasserin aut Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. Radiotherapy (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Cardiac dose (dpeaa)DE-He213 Deep inspiration breath-hold (dpeaa)DE-He213 Surface scanner (dpeaa)DE-He213 Ammerpohl, Mark aut Morgenstern, Christina aut Nielinger, Lisa aut Erichsen, Patricia aut Abdallah, Abdallah aut Galalae, Razvan aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 191(2015), 9 vom: 18. Apr., Seite 710-716 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:191 year:2015 number:9 day:18 month:04 pages:710-716 https://dx.doi.org/10.1007/s00066-015-0838-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 191 2015 9 18 04 710-716 |
allfieldsSound |
10.1007/s00066-015-0838-y doi (DE-627)SPR000513296 (SPR)s00066-015-0838-y-e DE-627 ger DE-627 rakwb eng Hepp, Rodrigo verfasserin aut Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. Radiotherapy (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Cardiac dose (dpeaa)DE-He213 Deep inspiration breath-hold (dpeaa)DE-He213 Surface scanner (dpeaa)DE-He213 Ammerpohl, Mark aut Morgenstern, Christina aut Nielinger, Lisa aut Erichsen, Patricia aut Abdallah, Abdallah aut Galalae, Razvan aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 191(2015), 9 vom: 18. Apr., Seite 710-716 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:191 year:2015 number:9 day:18 month:04 pages:710-716 https://dx.doi.org/10.1007/s00066-015-0838-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 191 2015 9 18 04 710-716 |
language |
English |
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Enthalten in Strahlentherapie und Onkologie 191(2015), 9 vom: 18. Apr., Seite 710-716 volume:191 year:2015 number:9 day:18 month:04 pages:710-716 |
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Enthalten in Strahlentherapie und Onkologie 191(2015), 9 vom: 18. Apr., Seite 710-716 volume:191 year:2015 number:9 day:18 month:04 pages:710-716 |
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Article |
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Radiotherapy Breast cancer Cardiac dose Deep inspiration breath-hold Surface scanner |
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Strahlentherapie und Onkologie |
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Hepp, Rodrigo @@aut@@ Ammerpohl, Mark @@aut@@ Morgenstern, Christina @@aut@@ Nielinger, Lisa @@aut@@ Erichsen, Patricia @@aut@@ Abdallah, Abdallah @@aut@@ Galalae, Razvan @@aut@@ |
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2015-04-18T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR000513296</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519155136.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2015 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00066-015-0838-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR000513296</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00066-015-0838-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hepp, Rodrigo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer-Verlag Berlin Heidelberg 2015</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. 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author |
Hepp, Rodrigo |
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Hepp, Rodrigo misc Radiotherapy misc Breast cancer misc Cardiac dose misc Deep inspiration breath-hold misc Surface scanner Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer |
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Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer Radiotherapy (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Cardiac dose (dpeaa)DE-He213 Deep inspiration breath-hold (dpeaa)DE-He213 Surface scanner (dpeaa)DE-He213 |
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misc Radiotherapy misc Breast cancer misc Cardiac dose misc Deep inspiration breath-hold misc Surface scanner |
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misc Radiotherapy misc Breast cancer misc Cardiac dose misc Deep inspiration breath-hold misc Surface scanner |
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Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer |
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Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer |
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Hepp, Rodrigo |
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Strahlentherapie und Onkologie |
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Hepp, Rodrigo Ammerpohl, Mark Morgenstern, Christina Nielinger, Lisa Erichsen, Patricia Abdallah, Abdallah Galalae, Razvan |
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deep inspiration breath-hold (dibh) radiotherapy in left-sided breast cancer |
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Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer |
abstract |
Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. © Springer-Verlag Berlin Heidelberg 2015 |
abstractGer |
Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. © Springer-Verlag Berlin Heidelberg 2015 |
abstract_unstemmed |
Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart $ D_{2 cm} $3 was less than 42 Gy in DIBH. In FB the heart $ D_{2 cm} $3 was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. © Springer-Verlag Berlin Heidelberg 2015 |
collection_details |
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container_issue |
9 |
title_short |
Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer |
url |
https://dx.doi.org/10.1007/s00066-015-0838-y |
remote_bool |
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author2 |
Ammerpohl, Mark Morgenstern, Christina Nielinger, Lisa Erichsen, Patricia Abdallah, Abdallah Galalae, Razvan |
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Ammerpohl, Mark Morgenstern, Christina Nielinger, Lisa Erichsen, Patricia Abdallah, Abdallah Galalae, Razvan |
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doi_str |
10.1007/s00066-015-0838-y |
up_date |
2024-07-03T16:35:26.721Z |
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The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients’ acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 $ cm^{3} $ ($ D_{2 cm} $3), volume receiving ≥ 5 Gy ($ V_{5} $), 10 Gy ($ V_{10} $), 15 Gy ($ V_{15} $) and 20 Gy ($ V_{20} $). 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|
score |
7.400591 |