Hydrogen sulfide: a gasotransmitter of clinical relevance
Abstract Though the existence of hydrogen sulfide ($ H_{2} $S) in biological tissues has been known for over 300 years, it is the most recently appreciated of the gasotransmitters as a physiologic messenger molecule. The enzymes cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) had long...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Vandiver, M. Scott [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2012 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of molecular medicine - Berlin : Springer, 1922, 90(2012), 3 vom: 08. Feb., Seite 255-263 |
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| Übergeordnetes Werk: |
volume:90 ; year:2012 ; number:3 ; day:08 ; month:02 ; pages:255-263 |
| Links: |
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| DOI / URN: |
10.1007/s00109-012-0873-4 |
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| Katalog-ID: |
SPR000763292 |
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| 100 | 1 | |a Vandiver, M. Scott |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hydrogen sulfide: a gasotransmitter of clinical relevance |
| 264 | 1 | |c 2012 | |
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| 500 | |a © Springer-Verlag 2012 | ||
| 520 | |a Abstract Though the existence of hydrogen sulfide ($ H_{2} $S) in biological tissues has been known for over 300 years, it is the most recently appreciated of the gasotransmitters as a physiologic messenger molecule. The enzymes cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) had long been speculated to generate $ H_{2} $S, and inhibitors of these enzymes had been employed to characterize influences of $ H_{2} $S in various organs. Definitive evidence that $ H_{2} $S is a physiologic regulator came with the development of mice with targeted deletion of CSE and CBS. Best characterized is the role of $ H_{2} $S, formed by CSE, as an endothelial derived relaxing factor that normally regulates blood pressure by acting through ATP-sensitive potassium channels. $ H_{2} $S participates in various phases of the inflammatory process, predominantly exerting anti-inflammatory actions. Currently, the most advanced efforts to develop therapeutic agents involve the combination of $ H_{2} $S donors with non-steroidal anti-inflammatory drugs (NSAIDs). The $ H_{2} $S releasing moiety provides cytoprotection to gastric mucosa normally adversely affected by NSAIDs while the combination of $ H_{2} $S and inhibition of prostaglandin synthesis may afford synergistic anti-inflammatory influences. | ||
| 650 | 4 | |a Sulfhydration |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cardio protection |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Inflammation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cystathionine γ-lyase |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cystathionine-β-synthase |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Snyder, Solomon H. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of molecular medicine |d Berlin : Springer, 1922 |g 90(2012), 3 vom: 08. Feb., Seite 255-263 |w (DE-627)254630804 |w (DE-600)1462132-0 |x 1432-1440 |7 nnns |
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| 912 | |a GBV_ILN_2027 | ||
| 912 | |a GBV_ILN_2031 | ||
| 912 | |a GBV_ILN_2034 | ||
| 912 | |a GBV_ILN_2037 | ||
| 912 | |a GBV_ILN_2038 | ||
| 912 | |a GBV_ILN_2039 | ||
| 912 | |a GBV_ILN_2044 | ||
| 912 | |a GBV_ILN_2048 | ||
| 912 | |a GBV_ILN_2049 | ||
| 912 | |a GBV_ILN_2050 | ||
| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2057 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2070 | ||
| 912 | |a GBV_ILN_2086 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2093 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2107 | ||
| 912 | |a GBV_ILN_2108 | ||
| 912 | |a GBV_ILN_2110 | ||
| 912 | |a GBV_ILN_2111 | ||
| 912 | |a GBV_ILN_2112 | ||
| 912 | |a GBV_ILN_2113 | ||
| 912 | |a GBV_ILN_2116 | ||
| 912 | |a GBV_ILN_2118 | ||
| 912 | |a GBV_ILN_2119 | ||
| 912 | |a GBV_ILN_2122 | ||
| 912 | |a GBV_ILN_2129 | ||
| 912 | |a GBV_ILN_2143 | ||
| 912 | |a GBV_ILN_2144 | ||
| 912 | |a GBV_ILN_2147 | ||
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| 912 | |a GBV_ILN_4125 | ||
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| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4251 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
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10.1007/s00109-012-0873-4 doi (DE-627)SPR000763292 (SPR)s00109-012-0873-4-e DE-627 ger DE-627 rakwb eng Vandiver, M. Scott verfasserin aut Hydrogen sulfide: a gasotransmitter of clinical relevance 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2012 Abstract Though the existence of hydrogen sulfide ($ H_{2} $S) in biological tissues has been known for over 300 years, it is the most recently appreciated of the gasotransmitters as a physiologic messenger molecule. The enzymes cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) had long been speculated to generate $ H_{2} $S, and inhibitors of these enzymes had been employed to characterize influences of $ H_{2} $S in various organs. Definitive evidence that $ H_{2} $S is a physiologic regulator came with the development of mice with targeted deletion of CSE and CBS. Best characterized is the role of $ H_{2} $S, formed by CSE, as an endothelial derived relaxing factor that normally regulates blood pressure by acting through ATP-sensitive potassium channels. $ H_{2} $S participates in various phases of the inflammatory process, predominantly exerting anti-inflammatory actions. Currently, the most advanced efforts to develop therapeutic agents involve the combination of $ H_{2} $S donors with non-steroidal anti-inflammatory drugs (NSAIDs). The $ H_{2} $S releasing moiety provides cytoprotection to gastric mucosa normally adversely affected by NSAIDs while the combination of $ H_{2} $S and inhibition of prostaglandin synthesis may afford synergistic anti-inflammatory influences. Sulfhydration (dpeaa)DE-He213 Cardio protection (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Cystathionine γ-lyase (dpeaa)DE-He213 Cystathionine-β-synthase (dpeaa)DE-He213 Snyder, Solomon H. aut Enthalten in Journal of molecular medicine Berlin : Springer, 1922 90(2012), 3 vom: 08. Feb., Seite 255-263 (DE-627)254630804 (DE-600)1462132-0 1432-1440 nnns volume:90 year:2012 number:3 day:08 month:02 pages:255-263 https://dx.doi.org/10.1007/s00109-012-0873-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 90 2012 3 08 02 255-263 |
| spelling |
10.1007/s00109-012-0873-4 doi (DE-627)SPR000763292 (SPR)s00109-012-0873-4-e DE-627 ger DE-627 rakwb eng Vandiver, M. Scott verfasserin aut Hydrogen sulfide: a gasotransmitter of clinical relevance 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2012 Abstract Though the existence of hydrogen sulfide ($ H_{2} $S) in biological tissues has been known for over 300 years, it is the most recently appreciated of the gasotransmitters as a physiologic messenger molecule. The enzymes cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) had long been speculated to generate $ H_{2} $S, and inhibitors of these enzymes had been employed to characterize influences of $ H_{2} $S in various organs. Definitive evidence that $ H_{2} $S is a physiologic regulator came with the development of mice with targeted deletion of CSE and CBS. Best characterized is the role of $ H_{2} $S, formed by CSE, as an endothelial derived relaxing factor that normally regulates blood pressure by acting through ATP-sensitive potassium channels. $ H_{2} $S participates in various phases of the inflammatory process, predominantly exerting anti-inflammatory actions. Currently, the most advanced efforts to develop therapeutic agents involve the combination of $ H_{2} $S donors with non-steroidal anti-inflammatory drugs (NSAIDs). The $ H_{2} $S releasing moiety provides cytoprotection to gastric mucosa normally adversely affected by NSAIDs while the combination of $ H_{2} $S and inhibition of prostaglandin synthesis may afford synergistic anti-inflammatory influences. Sulfhydration (dpeaa)DE-He213 Cardio protection (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Cystathionine γ-lyase (dpeaa)DE-He213 Cystathionine-β-synthase (dpeaa)DE-He213 Snyder, Solomon H. aut Enthalten in Journal of molecular medicine Berlin : Springer, 1922 90(2012), 3 vom: 08. Feb., Seite 255-263 (DE-627)254630804 (DE-600)1462132-0 1432-1440 nnns volume:90 year:2012 number:3 day:08 month:02 pages:255-263 https://dx.doi.org/10.1007/s00109-012-0873-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 90 2012 3 08 02 255-263 |
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10.1007/s00109-012-0873-4 doi (DE-627)SPR000763292 (SPR)s00109-012-0873-4-e DE-627 ger DE-627 rakwb eng Vandiver, M. Scott verfasserin aut Hydrogen sulfide: a gasotransmitter of clinical relevance 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2012 Abstract Though the existence of hydrogen sulfide ($ H_{2} $S) in biological tissues has been known for over 300 years, it is the most recently appreciated of the gasotransmitters as a physiologic messenger molecule. The enzymes cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) had long been speculated to generate $ H_{2} $S, and inhibitors of these enzymes had been employed to characterize influences of $ H_{2} $S in various organs. Definitive evidence that $ H_{2} $S is a physiologic regulator came with the development of mice with targeted deletion of CSE and CBS. Best characterized is the role of $ H_{2} $S, formed by CSE, as an endothelial derived relaxing factor that normally regulates blood pressure by acting through ATP-sensitive potassium channels. $ H_{2} $S participates in various phases of the inflammatory process, predominantly exerting anti-inflammatory actions. Currently, the most advanced efforts to develop therapeutic agents involve the combination of $ H_{2} $S donors with non-steroidal anti-inflammatory drugs (NSAIDs). The $ H_{2} $S releasing moiety provides cytoprotection to gastric mucosa normally adversely affected by NSAIDs while the combination of $ H_{2} $S and inhibition of prostaglandin synthesis may afford synergistic anti-inflammatory influences. Sulfhydration (dpeaa)DE-He213 Cardio protection (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Cystathionine γ-lyase (dpeaa)DE-He213 Cystathionine-β-synthase (dpeaa)DE-He213 Snyder, Solomon H. aut Enthalten in Journal of molecular medicine Berlin : Springer, 1922 90(2012), 3 vom: 08. Feb., Seite 255-263 (DE-627)254630804 (DE-600)1462132-0 1432-1440 nnns volume:90 year:2012 number:3 day:08 month:02 pages:255-263 https://dx.doi.org/10.1007/s00109-012-0873-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 90 2012 3 08 02 255-263 |
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10.1007/s00109-012-0873-4 doi (DE-627)SPR000763292 (SPR)s00109-012-0873-4-e DE-627 ger DE-627 rakwb eng Vandiver, M. Scott verfasserin aut Hydrogen sulfide: a gasotransmitter of clinical relevance 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2012 Abstract Though the existence of hydrogen sulfide ($ H_{2} $S) in biological tissues has been known for over 300 years, it is the most recently appreciated of the gasotransmitters as a physiologic messenger molecule. The enzymes cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) had long been speculated to generate $ H_{2} $S, and inhibitors of these enzymes had been employed to characterize influences of $ H_{2} $S in various organs. Definitive evidence that $ H_{2} $S is a physiologic regulator came with the development of mice with targeted deletion of CSE and CBS. Best characterized is the role of $ H_{2} $S, formed by CSE, as an endothelial derived relaxing factor that normally regulates blood pressure by acting through ATP-sensitive potassium channels. $ H_{2} $S participates in various phases of the inflammatory process, predominantly exerting anti-inflammatory actions. Currently, the most advanced efforts to develop therapeutic agents involve the combination of $ H_{2} $S donors with non-steroidal anti-inflammatory drugs (NSAIDs). The $ H_{2} $S releasing moiety provides cytoprotection to gastric mucosa normally adversely affected by NSAIDs while the combination of $ H_{2} $S and inhibition of prostaglandin synthesis may afford synergistic anti-inflammatory influences. Sulfhydration (dpeaa)DE-He213 Cardio protection (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Cystathionine γ-lyase (dpeaa)DE-He213 Cystathionine-β-synthase (dpeaa)DE-He213 Snyder, Solomon H. aut Enthalten in Journal of molecular medicine Berlin : Springer, 1922 90(2012), 3 vom: 08. Feb., Seite 255-263 (DE-627)254630804 (DE-600)1462132-0 1432-1440 nnns volume:90 year:2012 number:3 day:08 month:02 pages:255-263 https://dx.doi.org/10.1007/s00109-012-0873-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 90 2012 3 08 02 255-263 |
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10.1007/s00109-012-0873-4 doi (DE-627)SPR000763292 (SPR)s00109-012-0873-4-e DE-627 ger DE-627 rakwb eng Vandiver, M. Scott verfasserin aut Hydrogen sulfide: a gasotransmitter of clinical relevance 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2012 Abstract Though the existence of hydrogen sulfide ($ H_{2} $S) in biological tissues has been known for over 300 years, it is the most recently appreciated of the gasotransmitters as a physiologic messenger molecule. The enzymes cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) had long been speculated to generate $ H_{2} $S, and inhibitors of these enzymes had been employed to characterize influences of $ H_{2} $S in various organs. Definitive evidence that $ H_{2} $S is a physiologic regulator came with the development of mice with targeted deletion of CSE and CBS. Best characterized is the role of $ H_{2} $S, formed by CSE, as an endothelial derived relaxing factor that normally regulates blood pressure by acting through ATP-sensitive potassium channels. $ H_{2} $S participates in various phases of the inflammatory process, predominantly exerting anti-inflammatory actions. Currently, the most advanced efforts to develop therapeutic agents involve the combination of $ H_{2} $S donors with non-steroidal anti-inflammatory drugs (NSAIDs). The $ H_{2} $S releasing moiety provides cytoprotection to gastric mucosa normally adversely affected by NSAIDs while the combination of $ H_{2} $S and inhibition of prostaglandin synthesis may afford synergistic anti-inflammatory influences. Sulfhydration (dpeaa)DE-He213 Cardio protection (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Cystathionine γ-lyase (dpeaa)DE-He213 Cystathionine-β-synthase (dpeaa)DE-He213 Snyder, Solomon H. aut Enthalten in Journal of molecular medicine Berlin : Springer, 1922 90(2012), 3 vom: 08. Feb., Seite 255-263 (DE-627)254630804 (DE-600)1462132-0 1432-1440 nnns volume:90 year:2012 number:3 day:08 month:02 pages:255-263 https://dx.doi.org/10.1007/s00109-012-0873-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 90 2012 3 08 02 255-263 |
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Sulfhydration Cardio protection Inflammation Cystathionine γ-lyase Cystathionine-β-synthase |
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Vandiver, M. Scott @@aut@@ Snyder, Solomon H. @@aut@@ |
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The enzymes cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) had long been speculated to generate $ H_{2} $S, and inhibitors of these enzymes had been employed to characterize influences of $ H_{2} $S in various organs. Definitive evidence that $ H_{2} $S is a physiologic regulator came with the development of mice with targeted deletion of CSE and CBS. Best characterized is the role of $ H_{2} $S, formed by CSE, as an endothelial derived relaxing factor that normally regulates blood pressure by acting through ATP-sensitive potassium channels. $ H_{2} $S participates in various phases of the inflammatory process, predominantly exerting anti-inflammatory actions. Currently, the most advanced efforts to develop therapeutic agents involve the combination of $ H_{2} $S donors with non-steroidal anti-inflammatory drugs (NSAIDs). 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Vandiver, M. Scott |
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Vandiver, M. Scott misc Sulfhydration misc Cardio protection misc Inflammation misc Cystathionine γ-lyase misc Cystathionine-β-synthase Hydrogen sulfide: a gasotransmitter of clinical relevance |
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Hydrogen sulfide: a gasotransmitter of clinical relevance Sulfhydration (dpeaa)DE-He213 Cardio protection (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Cystathionine γ-lyase (dpeaa)DE-He213 Cystathionine-β-synthase (dpeaa)DE-He213 |
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hydrogen sulfide: a gasotransmitter of clinical relevance |
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Hydrogen sulfide: a gasotransmitter of clinical relevance |
| abstract |
Abstract Though the existence of hydrogen sulfide ($ H_{2} $S) in biological tissues has been known for over 300 years, it is the most recently appreciated of the gasotransmitters as a physiologic messenger molecule. The enzymes cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) had long been speculated to generate $ H_{2} $S, and inhibitors of these enzymes had been employed to characterize influences of $ H_{2} $S in various organs. Definitive evidence that $ H_{2} $S is a physiologic regulator came with the development of mice with targeted deletion of CSE and CBS. Best characterized is the role of $ H_{2} $S, formed by CSE, as an endothelial derived relaxing factor that normally regulates blood pressure by acting through ATP-sensitive potassium channels. $ H_{2} $S participates in various phases of the inflammatory process, predominantly exerting anti-inflammatory actions. Currently, the most advanced efforts to develop therapeutic agents involve the combination of $ H_{2} $S donors with non-steroidal anti-inflammatory drugs (NSAIDs). The $ H_{2} $S releasing moiety provides cytoprotection to gastric mucosa normally adversely affected by NSAIDs while the combination of $ H_{2} $S and inhibition of prostaglandin synthesis may afford synergistic anti-inflammatory influences. © Springer-Verlag 2012 |
| abstractGer |
Abstract Though the existence of hydrogen sulfide ($ H_{2} $S) in biological tissues has been known for over 300 years, it is the most recently appreciated of the gasotransmitters as a physiologic messenger molecule. The enzymes cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) had long been speculated to generate $ H_{2} $S, and inhibitors of these enzymes had been employed to characterize influences of $ H_{2} $S in various organs. Definitive evidence that $ H_{2} $S is a physiologic regulator came with the development of mice with targeted deletion of CSE and CBS. Best characterized is the role of $ H_{2} $S, formed by CSE, as an endothelial derived relaxing factor that normally regulates blood pressure by acting through ATP-sensitive potassium channels. $ H_{2} $S participates in various phases of the inflammatory process, predominantly exerting anti-inflammatory actions. Currently, the most advanced efforts to develop therapeutic agents involve the combination of $ H_{2} $S donors with non-steroidal anti-inflammatory drugs (NSAIDs). The $ H_{2} $S releasing moiety provides cytoprotection to gastric mucosa normally adversely affected by NSAIDs while the combination of $ H_{2} $S and inhibition of prostaglandin synthesis may afford synergistic anti-inflammatory influences. © Springer-Verlag 2012 |
| abstract_unstemmed |
Abstract Though the existence of hydrogen sulfide ($ H_{2} $S) in biological tissues has been known for over 300 years, it is the most recently appreciated of the gasotransmitters as a physiologic messenger molecule. The enzymes cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) had long been speculated to generate $ H_{2} $S, and inhibitors of these enzymes had been employed to characterize influences of $ H_{2} $S in various organs. Definitive evidence that $ H_{2} $S is a physiologic regulator came with the development of mice with targeted deletion of CSE and CBS. Best characterized is the role of $ H_{2} $S, formed by CSE, as an endothelial derived relaxing factor that normally regulates blood pressure by acting through ATP-sensitive potassium channels. $ H_{2} $S participates in various phases of the inflammatory process, predominantly exerting anti-inflammatory actions. Currently, the most advanced efforts to develop therapeutic agents involve the combination of $ H_{2} $S donors with non-steroidal anti-inflammatory drugs (NSAIDs). The $ H_{2} $S releasing moiety provides cytoprotection to gastric mucosa normally adversely affected by NSAIDs while the combination of $ H_{2} $S and inhibition of prostaglandin synthesis may afford synergistic anti-inflammatory influences. © Springer-Verlag 2012 |
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Hydrogen sulfide: a gasotransmitter of clinical relevance |
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Snyder, Solomon H. |
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| score |
7.3988447 |