Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus

Aims/hypotheses Chronic hyperglycaemia increases dipeptidyl peptidase IV (DPP-IV) activity in endothelial cells in vitro. The present study was designed to assess the effect of high glucose on circulating DPP-IV activity in patients with type 1 and type 2 diabetes. Methods Plasma DPP-IV activity was...
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Autor*in:	Mannucci, E. [verfasserIn] Pala, L. Ciani, S. Bardini, G. Pezzatini, A. Sposato, I. Cremasco, F. Ognibene, A. Rotella, C. M.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2005

Schlagwörter:	Diabetes mellitus Dipeptidyl peptidase IV

Anmerkung:	© Springer-Verlag 2005

Übergeordnetes Werk:	Enthalten in: Diabetologia - Berlin : Springer, 1965, 48(2005), 6 vom: 29. Apr., Seite 1168-1172
Übergeordnetes Werk:	volume:48 ; year:2005 ; number:6 ; day:29 ; month:04 ; pages:1168-1172

Links:	Volltext

DOI / URN:	10.1007/s00125-005-1749-8

Katalog-ID:	SPR000961876

Internformat


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245	1	0	\|a Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus
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520			\|a Aims/hypotheses Chronic hyperglycaemia increases dipeptidyl peptidase IV (DPP-IV) activity in endothelial cells in vitro. The present study was designed to assess the effect of high glucose on circulating DPP-IV activity in patients with type 1 and type 2 diabetes. Methods Plasma DPP-IV activity was measured in 29 patients with type 1 diabetes and 29 age-, sex- and BMI-matched control subjects. We also assessed DPP-IV activity in 31 type 2 diabetic patients with $ HbA_{1} $c >8.5% and in plasma from matched groups of 31 newly diagnosed diabetic subjects with $ HbA_{1} $c <7.5%, 31 subjects with IGT and 62 subjects with NGT. In a further sample of 66 type 2 diabetic patients, a longitudinal study was also performed to evaluate variations in DPP-IV activity and $ HbA_{1} $c over 3 months. Results DPP-IV activity in type 1 diabetic patients was not significantly different from that in control subjects; however, a significant correlation between DPP-IV and $ HbA_{1} $c was observed in diabetic subjects (r=0.47; p<0.01). Type 2 diabetic patients with $ HbA_{1} $c >8.5% showed significantly (p<0.05) higher DPP-IV activity (mean±SD 27.7±7.1 U/l) than newly diagnosed diabetic patients and subjects with IGT (22.1±6.0 and 18.8±8.8 U/l, respectively). Variations in DPP-IV activity over 3 months in type 2 diabetic patients showed a significant positive correlation with variations in $ HbA_{1} $c (r=0.26; p<0.05). Conclusions/interpretation Chronic hyperglycaemia induces a significant increase in DPP-IV activity in type 1 and type 2 diabetes. This phenomenon could contribute to the reduction in circulating active glucagon-like peptide-1 and to the consequent postprandial hyperglycaemia in type 2 diabetic patients with poor metabolic control.
650		4	\|a Diabetes mellitus \|7 (dpeaa)DE-He213
650		4	\|a Dipeptidyl peptidase IV \|7 (dpeaa)DE-He213
700	1		\|a Pala, L. \|4 aut
700	1		\|a Ciani, S. \|4 aut
700	1		\|a Bardini, G. \|4 aut
700	1		\|a Pezzatini, A. \|4 aut
700	1		\|a Sposato, I. \|4 aut
700	1		\|a Cremasco, F. \|4 aut
700	1		\|a Ognibene, A. \|4 aut
700	1		\|a Rotella, C. M. \|4 aut
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856	4	0	\|u https://dx.doi.org/10.1007/s00125-005-1749-8 \|z lizenzpflichtig \|3 Volltext
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912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_702
912			\|a GBV_ILN_711
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
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912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
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912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2472
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_2548
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
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912			\|a GBV_ILN_4328
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
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Indexfelder

author_variant	e m em l p lp s c sc g b gb a p ap i s is f c fc a o ao c m r cm cmr
matchkey_str	article:14320428:2005----::yegyamanraedppiyppiaevcii
hierarchy_sort_str	2005
publishDate	2005
allfields	10.1007/s00125-005-1749-8 doi (DE-627)SPR000961876 (SPR)s00125-005-1749-8-e DE-627 ger DE-627 rakwb eng Mannucci, E. verfasserin aut Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Aims/hypotheses Chronic hyperglycaemia increases dipeptidyl peptidase IV (DPP-IV) activity in endothelial cells in vitro. The present study was designed to assess the effect of high glucose on circulating DPP-IV activity in patients with type 1 and type 2 diabetes. Methods Plasma DPP-IV activity was measured in 29 patients with type 1 diabetes and 29 age-, sex- and BMI-matched control subjects. We also assessed DPP-IV activity in 31 type 2 diabetic patients with $ HbA_{1} $c >8.5% and in plasma from matched groups of 31 newly diagnosed diabetic subjects with $ HbA_{1} $c <7.5%, 31 subjects with IGT and 62 subjects with NGT. In a further sample of 66 type 2 diabetic patients, a longitudinal study was also performed to evaluate variations in DPP-IV activity and $ HbA_{1} $c over 3 months. Results DPP-IV activity in type 1 diabetic patients was not significantly different from that in control subjects; however, a significant correlation between DPP-IV and $ HbA_{1} $c was observed in diabetic subjects (r=0.47; p<0.01). Type 2 diabetic patients with $ HbA_{1} $c >8.5% showed significantly (p<0.05) higher DPP-IV activity (mean±SD 27.7±7.1 U/l) than newly diagnosed diabetic patients and subjects with IGT (22.1±6.0 and 18.8±8.8 U/l, respectively). Variations in DPP-IV activity over 3 months in type 2 diabetic patients showed a significant positive correlation with variations in $ HbA_{1} $c (r=0.26; p<0.05). Conclusions/interpretation Chronic hyperglycaemia induces a significant increase in DPP-IV activity in type 1 and type 2 diabetes. This phenomenon could contribute to the reduction in circulating active glucagon-like peptide-1 and to the consequent postprandial hyperglycaemia in type 2 diabetic patients with poor metabolic control. Diabetes mellitus (dpeaa)DE-He213 Dipeptidyl peptidase IV (dpeaa)DE-He213 Pala, L. aut Ciani, S. aut Bardini, G. aut Pezzatini, A. aut Sposato, I. aut Cremasco, F. aut Ognibene, A. aut Rotella, C. M. aut Enthalten in Diabetologia Berlin : Springer, 1965 48(2005), 6 vom: 29. Apr., Seite 1168-1172 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:48 year:2005 number:6 day:29 month:04 pages:1168-1172 https://dx.doi.org/10.1007/s00125-005-1749-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 48 2005 6 29 04 1168-1172
spelling	10.1007/s00125-005-1749-8 doi (DE-627)SPR000961876 (SPR)s00125-005-1749-8-e DE-627 ger DE-627 rakwb eng Mannucci, E. verfasserin aut Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Aims/hypotheses Chronic hyperglycaemia increases dipeptidyl peptidase IV (DPP-IV) activity in endothelial cells in vitro. The present study was designed to assess the effect of high glucose on circulating DPP-IV activity in patients with type 1 and type 2 diabetes. Methods Plasma DPP-IV activity was measured in 29 patients with type 1 diabetes and 29 age-, sex- and BMI-matched control subjects. We also assessed DPP-IV activity in 31 type 2 diabetic patients with $ HbA_{1} $c >8.5% and in plasma from matched groups of 31 newly diagnosed diabetic subjects with $ HbA_{1} $c <7.5%, 31 subjects with IGT and 62 subjects with NGT. In a further sample of 66 type 2 diabetic patients, a longitudinal study was also performed to evaluate variations in DPP-IV activity and $ HbA_{1} $c over 3 months. Results DPP-IV activity in type 1 diabetic patients was not significantly different from that in control subjects; however, a significant correlation between DPP-IV and $ HbA_{1} $c was observed in diabetic subjects (r=0.47; p<0.01). Type 2 diabetic patients with $ HbA_{1} $c >8.5% showed significantly (p<0.05) higher DPP-IV activity (mean±SD 27.7±7.1 U/l) than newly diagnosed diabetic patients and subjects with IGT (22.1±6.0 and 18.8±8.8 U/l, respectively). Variations in DPP-IV activity over 3 months in type 2 diabetic patients showed a significant positive correlation with variations in $ HbA_{1} $c (r=0.26; p<0.05). Conclusions/interpretation Chronic hyperglycaemia induces a significant increase in DPP-IV activity in type 1 and type 2 diabetes. This phenomenon could contribute to the reduction in circulating active glucagon-like peptide-1 and to the consequent postprandial hyperglycaemia in type 2 diabetic patients with poor metabolic control. Diabetes mellitus (dpeaa)DE-He213 Dipeptidyl peptidase IV (dpeaa)DE-He213 Pala, L. aut Ciani, S. aut Bardini, G. aut Pezzatini, A. aut Sposato, I. aut Cremasco, F. aut Ognibene, A. aut Rotella, C. M. aut Enthalten in Diabetologia Berlin : Springer, 1965 48(2005), 6 vom: 29. Apr., Seite 1168-1172 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:48 year:2005 number:6 day:29 month:04 pages:1168-1172 https://dx.doi.org/10.1007/s00125-005-1749-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 48 2005 6 29 04 1168-1172
allfields_unstemmed	10.1007/s00125-005-1749-8 doi (DE-627)SPR000961876 (SPR)s00125-005-1749-8-e DE-627 ger DE-627 rakwb eng Mannucci, E. verfasserin aut Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Aims/hypotheses Chronic hyperglycaemia increases dipeptidyl peptidase IV (DPP-IV) activity in endothelial cells in vitro. The present study was designed to assess the effect of high glucose on circulating DPP-IV activity in patients with type 1 and type 2 diabetes. Methods Plasma DPP-IV activity was measured in 29 patients with type 1 diabetes and 29 age-, sex- and BMI-matched control subjects. We also assessed DPP-IV activity in 31 type 2 diabetic patients with $ HbA_{1} $c >8.5% and in plasma from matched groups of 31 newly diagnosed diabetic subjects with $ HbA_{1} $c <7.5%, 31 subjects with IGT and 62 subjects with NGT. In a further sample of 66 type 2 diabetic patients, a longitudinal study was also performed to evaluate variations in DPP-IV activity and $ HbA_{1} $c over 3 months. Results DPP-IV activity in type 1 diabetic patients was not significantly different from that in control subjects; however, a significant correlation between DPP-IV and $ HbA_{1} $c was observed in diabetic subjects (r=0.47; p<0.01). Type 2 diabetic patients with $ HbA_{1} $c >8.5% showed significantly (p<0.05) higher DPP-IV activity (mean±SD 27.7±7.1 U/l) than newly diagnosed diabetic patients and subjects with IGT (22.1±6.0 and 18.8±8.8 U/l, respectively). Variations in DPP-IV activity over 3 months in type 2 diabetic patients showed a significant positive correlation with variations in $ HbA_{1} $c (r=0.26; p<0.05). Conclusions/interpretation Chronic hyperglycaemia induces a significant increase in DPP-IV activity in type 1 and type 2 diabetes. This phenomenon could contribute to the reduction in circulating active glucagon-like peptide-1 and to the consequent postprandial hyperglycaemia in type 2 diabetic patients with poor metabolic control. Diabetes mellitus (dpeaa)DE-He213 Dipeptidyl peptidase IV (dpeaa)DE-He213 Pala, L. aut Ciani, S. aut Bardini, G. aut Pezzatini, A. aut Sposato, I. aut Cremasco, F. aut Ognibene, A. aut Rotella, C. M. aut Enthalten in Diabetologia Berlin : Springer, 1965 48(2005), 6 vom: 29. Apr., Seite 1168-1172 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:48 year:2005 number:6 day:29 month:04 pages:1168-1172 https://dx.doi.org/10.1007/s00125-005-1749-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 48 2005 6 29 04 1168-1172
allfieldsGer	10.1007/s00125-005-1749-8 doi (DE-627)SPR000961876 (SPR)s00125-005-1749-8-e DE-627 ger DE-627 rakwb eng Mannucci, E. verfasserin aut Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Aims/hypotheses Chronic hyperglycaemia increases dipeptidyl peptidase IV (DPP-IV) activity in endothelial cells in vitro. The present study was designed to assess the effect of high glucose on circulating DPP-IV activity in patients with type 1 and type 2 diabetes. Methods Plasma DPP-IV activity was measured in 29 patients with type 1 diabetes and 29 age-, sex- and BMI-matched control subjects. We also assessed DPP-IV activity in 31 type 2 diabetic patients with $ HbA_{1} $c >8.5% and in plasma from matched groups of 31 newly diagnosed diabetic subjects with $ HbA_{1} $c <7.5%, 31 subjects with IGT and 62 subjects with NGT. In a further sample of 66 type 2 diabetic patients, a longitudinal study was also performed to evaluate variations in DPP-IV activity and $ HbA_{1} $c over 3 months. Results DPP-IV activity in type 1 diabetic patients was not significantly different from that in control subjects; however, a significant correlation between DPP-IV and $ HbA_{1} $c was observed in diabetic subjects (r=0.47; p<0.01). Type 2 diabetic patients with $ HbA_{1} $c >8.5% showed significantly (p<0.05) higher DPP-IV activity (mean±SD 27.7±7.1 U/l) than newly diagnosed diabetic patients and subjects with IGT (22.1±6.0 and 18.8±8.8 U/l, respectively). Variations in DPP-IV activity over 3 months in type 2 diabetic patients showed a significant positive correlation with variations in $ HbA_{1} $c (r=0.26; p<0.05). Conclusions/interpretation Chronic hyperglycaemia induces a significant increase in DPP-IV activity in type 1 and type 2 diabetes. This phenomenon could contribute to the reduction in circulating active glucagon-like peptide-1 and to the consequent postprandial hyperglycaemia in type 2 diabetic patients with poor metabolic control. Diabetes mellitus (dpeaa)DE-He213 Dipeptidyl peptidase IV (dpeaa)DE-He213 Pala, L. aut Ciani, S. aut Bardini, G. aut Pezzatini, A. aut Sposato, I. aut Cremasco, F. aut Ognibene, A. aut Rotella, C. M. aut Enthalten in Diabetologia Berlin : Springer, 1965 48(2005), 6 vom: 29. Apr., Seite 1168-1172 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:48 year:2005 number:6 day:29 month:04 pages:1168-1172 https://dx.doi.org/10.1007/s00125-005-1749-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 48 2005 6 29 04 1168-1172
allfieldsSound	10.1007/s00125-005-1749-8 doi (DE-627)SPR000961876 (SPR)s00125-005-1749-8-e DE-627 ger DE-627 rakwb eng Mannucci, E. verfasserin aut Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Aims/hypotheses Chronic hyperglycaemia increases dipeptidyl peptidase IV (DPP-IV) activity in endothelial cells in vitro. The present study was designed to assess the effect of high glucose on circulating DPP-IV activity in patients with type 1 and type 2 diabetes. Methods Plasma DPP-IV activity was measured in 29 patients with type 1 diabetes and 29 age-, sex- and BMI-matched control subjects. We also assessed DPP-IV activity in 31 type 2 diabetic patients with $ HbA_{1} $c >8.5% and in plasma from matched groups of 31 newly diagnosed diabetic subjects with $ HbA_{1} $c <7.5%, 31 subjects with IGT and 62 subjects with NGT. In a further sample of 66 type 2 diabetic patients, a longitudinal study was also performed to evaluate variations in DPP-IV activity and $ HbA_{1} $c over 3 months. Results DPP-IV activity in type 1 diabetic patients was not significantly different from that in control subjects; however, a significant correlation between DPP-IV and $ HbA_{1} $c was observed in diabetic subjects (r=0.47; p<0.01). Type 2 diabetic patients with $ HbA_{1} $c >8.5% showed significantly (p<0.05) higher DPP-IV activity (mean±SD 27.7±7.1 U/l) than newly diagnosed diabetic patients and subjects with IGT (22.1±6.0 and 18.8±8.8 U/l, respectively). Variations in DPP-IV activity over 3 months in type 2 diabetic patients showed a significant positive correlation with variations in $ HbA_{1} $c (r=0.26; p<0.05). Conclusions/interpretation Chronic hyperglycaemia induces a significant increase in DPP-IV activity in type 1 and type 2 diabetes. This phenomenon could contribute to the reduction in circulating active glucagon-like peptide-1 and to the consequent postprandial hyperglycaemia in type 2 diabetic patients with poor metabolic control. Diabetes mellitus (dpeaa)DE-He213 Dipeptidyl peptidase IV (dpeaa)DE-He213 Pala, L. aut Ciani, S. aut Bardini, G. aut Pezzatini, A. aut Sposato, I. aut Cremasco, F. aut Ognibene, A. aut Rotella, C. M. aut Enthalten in Diabetologia Berlin : Springer, 1965 48(2005), 6 vom: 29. Apr., Seite 1168-1172 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:48 year:2005 number:6 day:29 month:04 pages:1168-1172 https://dx.doi.org/10.1007/s00125-005-1749-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 48 2005 6 29 04 1168-1172
language	English
source	Enthalten in Diabetologia 48(2005), 6 vom: 29. Apr., Seite 1168-1172 volume:48 year:2005 number:6 day:29 month:04 pages:1168-1172
sourceStr	Enthalten in Diabetologia 48(2005), 6 vom: 29. Apr., Seite 1168-1172 volume:48 year:2005 number:6 day:29 month:04 pages:1168-1172
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Diabetes mellitus Dipeptidyl peptidase IV
isfreeaccess_bool	false
container_title	Diabetologia
authorswithroles_txt_mv	Mannucci, E. @@aut@@ Pala, L. @@aut@@ Ciani, S. @@aut@@ Bardini, G. @@aut@@ Pezzatini, A. @@aut@@ Sposato, I. @@aut@@ Cremasco, F. @@aut@@ Ognibene, A. @@aut@@ Rotella, C. M. @@aut@@
publishDateDaySort_date	2005-04-29T00:00:00Z
hierarchy_top_id	253722209
id	SPR000961876
language_de	englisch
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The present study was designed to assess the effect of high glucose on circulating DPP-IV activity in patients with type 1 and type 2 diabetes. Methods Plasma DPP-IV activity was measured in 29 patients with type 1 diabetes and 29 age-, sex- and BMI-matched control subjects. We also assessed DPP-IV activity in 31 type 2 diabetic patients with $ HbA_{1} $c >8.5% and in plasma from matched groups of 31 newly diagnosed diabetic subjects with $ HbA_{1} $c <7.5%, 31 subjects with IGT and 62 subjects with NGT. In a further sample of 66 type 2 diabetic patients, a longitudinal study was also performed to evaluate variations in DPP-IV activity and $ HbA_{1} $c over 3 months. Results DPP-IV activity in type 1 diabetic patients was not significantly different from that in control subjects; however, a significant correlation between DPP-IV and $ HbA_{1} $c was observed in diabetic subjects (r=0.47; p<0.01). Type 2 diabetic patients with $ HbA_{1} $c >8.5% showed significantly (p<0.05) higher DPP-IV activity (mean±SD 27.7±7.1 U/l) than newly diagnosed diabetic patients and subjects with IGT (22.1±6.0 and 18.8±8.8 U/l, respectively). Variations in DPP-IV activity over 3 months in type 2 diabetic patients showed a significant positive correlation with variations in $ HbA_{1} $c (r=0.26; p<0.05). Conclusions/interpretation Chronic hyperglycaemia induces a significant increase in DPP-IV activity in type 1 and type 2 diabetes. 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author	Mannucci, E.
spellingShingle	Mannucci, E. misc Diabetes mellitus misc Dipeptidyl peptidase IV Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus
authorStr	Mannucci, E.
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topic_title	Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus Diabetes mellitus (dpeaa)DE-He213 Dipeptidyl peptidase IV (dpeaa)DE-He213
topic	misc Diabetes mellitus misc Dipeptidyl peptidase IV
topic_unstemmed	misc Diabetes mellitus misc Dipeptidyl peptidase IV
topic_browse	misc Diabetes mellitus misc Dipeptidyl peptidase IV
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title	Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus
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title_full	Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus
author_sort	Mannucci, E.
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author_browse	Mannucci, E. Pala, L. Ciani, S. Bardini, G. Pezzatini, A. Sposato, I. Cremasco, F. Ognibene, A. Rotella, C. M.
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doi_str_mv	10.1007/s00125-005-1749-8
title_sort	hyperglycaemia increases dipeptidyl peptidase iv activity in diabetes mellitus
title_auth	Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus
abstract	Aims/hypotheses Chronic hyperglycaemia increases dipeptidyl peptidase IV (DPP-IV) activity in endothelial cells in vitro. The present study was designed to assess the effect of high glucose on circulating DPP-IV activity in patients with type 1 and type 2 diabetes. Methods Plasma DPP-IV activity was measured in 29 patients with type 1 diabetes and 29 age-, sex- and BMI-matched control subjects. We also assessed DPP-IV activity in 31 type 2 diabetic patients with $ HbA_{1} $c >8.5% and in plasma from matched groups of 31 newly diagnosed diabetic subjects with $ HbA_{1} $c <7.5%, 31 subjects with IGT and 62 subjects with NGT. In a further sample of 66 type 2 diabetic patients, a longitudinal study was also performed to evaluate variations in DPP-IV activity and $ HbA_{1} $c over 3 months. Results DPP-IV activity in type 1 diabetic patients was not significantly different from that in control subjects; however, a significant correlation between DPP-IV and $ HbA_{1} $c was observed in diabetic subjects (r=0.47; p<0.01). Type 2 diabetic patients with $ HbA_{1} $c >8.5% showed significantly (p<0.05) higher DPP-IV activity (mean±SD 27.7±7.1 U/l) than newly diagnosed diabetic patients and subjects with IGT (22.1±6.0 and 18.8±8.8 U/l, respectively). Variations in DPP-IV activity over 3 months in type 2 diabetic patients showed a significant positive correlation with variations in $ HbA_{1} $c (r=0.26; p<0.05). Conclusions/interpretation Chronic hyperglycaemia induces a significant increase in DPP-IV activity in type 1 and type 2 diabetes. This phenomenon could contribute to the reduction in circulating active glucagon-like peptide-1 and to the consequent postprandial hyperglycaemia in type 2 diabetic patients with poor metabolic control. © Springer-Verlag 2005
abstractGer	Aims/hypotheses Chronic hyperglycaemia increases dipeptidyl peptidase IV (DPP-IV) activity in endothelial cells in vitro. The present study was designed to assess the effect of high glucose on circulating DPP-IV activity in patients with type 1 and type 2 diabetes. Methods Plasma DPP-IV activity was measured in 29 patients with type 1 diabetes and 29 age-, sex- and BMI-matched control subjects. We also assessed DPP-IV activity in 31 type 2 diabetic patients with $ HbA_{1} $c >8.5% and in plasma from matched groups of 31 newly diagnosed diabetic subjects with $ HbA_{1} $c <7.5%, 31 subjects with IGT and 62 subjects with NGT. In a further sample of 66 type 2 diabetic patients, a longitudinal study was also performed to evaluate variations in DPP-IV activity and $ HbA_{1} $c over 3 months. Results DPP-IV activity in type 1 diabetic patients was not significantly different from that in control subjects; however, a significant correlation between DPP-IV and $ HbA_{1} $c was observed in diabetic subjects (r=0.47; p<0.01). Type 2 diabetic patients with $ HbA_{1} $c >8.5% showed significantly (p<0.05) higher DPP-IV activity (mean±SD 27.7±7.1 U/l) than newly diagnosed diabetic patients and subjects with IGT (22.1±6.0 and 18.8±8.8 U/l, respectively). Variations in DPP-IV activity over 3 months in type 2 diabetic patients showed a significant positive correlation with variations in $ HbA_{1} $c (r=0.26; p<0.05). Conclusions/interpretation Chronic hyperglycaemia induces a significant increase in DPP-IV activity in type 1 and type 2 diabetes. This phenomenon could contribute to the reduction in circulating active glucagon-like peptide-1 and to the consequent postprandial hyperglycaemia in type 2 diabetic patients with poor metabolic control. © Springer-Verlag 2005
abstract_unstemmed	Aims/hypotheses Chronic hyperglycaemia increases dipeptidyl peptidase IV (DPP-IV) activity in endothelial cells in vitro. The present study was designed to assess the effect of high glucose on circulating DPP-IV activity in patients with type 1 and type 2 diabetes. Methods Plasma DPP-IV activity was measured in 29 patients with type 1 diabetes and 29 age-, sex- and BMI-matched control subjects. We also assessed DPP-IV activity in 31 type 2 diabetic patients with $ HbA_{1} $c >8.5% and in plasma from matched groups of 31 newly diagnosed diabetic subjects with $ HbA_{1} $c <7.5%, 31 subjects with IGT and 62 subjects with NGT. In a further sample of 66 type 2 diabetic patients, a longitudinal study was also performed to evaluate variations in DPP-IV activity and $ HbA_{1} $c over 3 months. Results DPP-IV activity in type 1 diabetic patients was not significantly different from that in control subjects; however, a significant correlation between DPP-IV and $ HbA_{1} $c was observed in diabetic subjects (r=0.47; p<0.01). Type 2 diabetic patients with $ HbA_{1} $c >8.5% showed significantly (p<0.05) higher DPP-IV activity (mean±SD 27.7±7.1 U/l) than newly diagnosed diabetic patients and subjects with IGT (22.1±6.0 and 18.8±8.8 U/l, respectively). Variations in DPP-IV activity over 3 months in type 2 diabetic patients showed a significant positive correlation with variations in $ HbA_{1} $c (r=0.26; p<0.05). Conclusions/interpretation Chronic hyperglycaemia induces a significant increase in DPP-IV activity in type 1 and type 2 diabetes. This phenomenon could contribute to the reduction in circulating active glucagon-like peptide-1 and to the consequent postprandial hyperglycaemia in type 2 diabetic patients with poor metabolic control. © Springer-Verlag 2005
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container_issue	6
title_short	Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus
url	https://dx.doi.org/10.1007/s00125-005-1749-8
remote_bool	true
author2	Pala, L. Ciani, S. Bardini, G. Pezzatini, A. Sposato, I. Cremasco, F. Ognibene, A. Rotella, C. M.
author2Str	Pala, L. Ciani, S. Bardini, G. Pezzatini, A. Sposato, I. Cremasco, F. Ognibene, A. Rotella, C. M.
ppnlink	253722209
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isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s00125-005-1749-8
up_date	2024-07-03T19:18:37.408Z
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The present study was designed to assess the effect of high glucose on circulating DPP-IV activity in patients with type 1 and type 2 diabetes. Methods Plasma DPP-IV activity was measured in 29 patients with type 1 diabetes and 29 age-, sex- and BMI-matched control subjects. We also assessed DPP-IV activity in 31 type 2 diabetic patients with $ HbA_{1} $c >8.5% and in plasma from matched groups of 31 newly diagnosed diabetic subjects with $ HbA_{1} $c <7.5%, 31 subjects with IGT and 62 subjects with NGT. In a further sample of 66 type 2 diabetic patients, a longitudinal study was also performed to evaluate variations in DPP-IV activity and $ HbA_{1} $c over 3 months. Results DPP-IV activity in type 1 diabetic patients was not significantly different from that in control subjects; however, a significant correlation between DPP-IV and $ HbA_{1} $c was observed in diabetic subjects (r=0.47; p<0.01). Type 2 diabetic patients with $ HbA_{1} $c >8.5% showed significantly (p<0.05) higher DPP-IV activity (mean±SD 27.7±7.1 U/l) than newly diagnosed diabetic patients and subjects with IGT (22.1±6.0 and 18.8±8.8 U/l, respectively). Variations in DPP-IV activity over 3 months in type 2 diabetic patients showed a significant positive correlation with variations in $ HbA_{1} $c (r=0.26; p<0.05). Conclusions/interpretation Chronic hyperglycaemia induces a significant increase in DPP-IV activity in type 1 and type 2 diabetes. 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Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus

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