Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population
Aims/hypothesis Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects o...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kuo, Jane Z. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2013 |
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| Übergeordnetes Werk: |
Enthalten in: Diabetologia - Berlin : Springer, 1965, 56(2013), 12 vom: 08. Sept., Seite 2619-2628 |
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| Übergeordnetes Werk: |
volume:56 ; year:2013 ; number:12 ; day:08 ; month:09 ; pages:2619-2628 |
| Links: |
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| DOI / URN: |
10.1007/s00125-013-3047-1 |
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| Katalog-ID: |
SPR000994138 |
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| 100 | 1 | |a Kuo, Jane Z. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population |
| 264 | 1 | |c 2013 | |
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| 520 | |a Aims/hypothesis Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects of these loci in an East Asian population. Methods A total of 9,335 unrelated Chinese Han individuals, including 4,535 with type 2 diabetes and 4,800 non-diabetic ethnically matched controls, were genotyped using the Illumina 200K Metabochip. We tested 50 established loci for type 2 diabetes and related traits (fasting glucose, fasting insulin, 2 h glucose). Disease association with the additive model of inheritance was analysed with logistic regression. Results We found that 14 loci significantly transferred to the Chinese population, with two loci (p = 5.7 × $ 10^{−12} $ for KCNQ1; p = 5.0 × $ 10^{−8} $ for CDKN2A/B-CDKN2BAS) reaching independent genome-wide statistical significance. Five of these 14 loci had similar lead single-nucleotide polymorphisms (SNPs) as were found in the European studies while the other nine were different. Further stepwise conditional analysis identified a total of seven secondary signals and an independent novel locus at the 3′ end of CDKAL1. Conclusions/interpretation These results suggest that many loci associated with type 2 diabetes are commonly shared between European and Chinese populations. Identification of population-specific SNPs may increase our understanding of the genetic architecture underlying type 2 diabetes in different ethnic populations. | ||
| 650 | 4 | |a Ethnic difference |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Genetic association |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Type 2 diabetes |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Sheu, Wayne Huey-Herng |4 aut | |
| 700 | 1 | |a Assimes, Themistocles L. |4 aut | |
| 700 | 1 | |a Hung, Yi-Jen |4 aut | |
| 700 | 1 | |a Absher, Devin |4 aut | |
| 700 | 1 | |a Chiu, Yen-Feng |4 aut | |
| 700 | 1 | |a Mak, Jordan |4 aut | |
| 700 | 1 | |a Wang, Jun-Sing |4 aut | |
| 700 | 1 | |a Kwon, Soonil |4 aut | |
| 700 | 1 | |a Hsu, Chih-Cheng |4 aut | |
| 700 | 1 | |a Goodarzi, Mark O. |4 aut | |
| 700 | 1 | |a Lee, I-Te |4 aut | |
| 700 | 1 | |a Knowles, Joshua W. |4 aut | |
| 700 | 1 | |a Miller, Brittany E. |4 aut | |
| 700 | 1 | |a Lee, Wen-Jane |4 aut | |
| 700 | 1 | |a Juang, Jyh-Ming J. |4 aut | |
| 700 | 1 | |a Wang, Tzung-Dau |4 aut | |
| 700 | 1 | |a Guo, Xiuqing |4 aut | |
| 700 | 1 | |a Taylor, Kent D. |4 aut | |
| 700 | 1 | |a Chuang, Lee-Ming |4 aut | |
| 700 | 1 | |a Hsiung, Chao A. |4 aut | |
| 700 | 1 | |a Quertermous, Thomas |4 aut | |
| 700 | 1 | |a Rotter, Jerome I. |4 aut | |
| 700 | 1 | |a Chen, Yii-Der I. |4 aut | |
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10.1007/s00125-013-3047-1 doi (DE-627)SPR000994138 (SPR)s00125-013-3047-1-e DE-627 ger DE-627 rakwb eng Kuo, Jane Z. verfasserin aut Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Aims/hypothesis Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects of these loci in an East Asian population. Methods A total of 9,335 unrelated Chinese Han individuals, including 4,535 with type 2 diabetes and 4,800 non-diabetic ethnically matched controls, were genotyped using the Illumina 200K Metabochip. We tested 50 established loci for type 2 diabetes and related traits (fasting glucose, fasting insulin, 2 h glucose). Disease association with the additive model of inheritance was analysed with logistic regression. Results We found that 14 loci significantly transferred to the Chinese population, with two loci (p = 5.7 × $ 10^{−12} $ for KCNQ1; p = 5.0 × $ 10^{−8} $ for CDKN2A/B-CDKN2BAS) reaching independent genome-wide statistical significance. Five of these 14 loci had similar lead single-nucleotide polymorphisms (SNPs) as were found in the European studies while the other nine were different. Further stepwise conditional analysis identified a total of seven secondary signals and an independent novel locus at the 3′ end of CDKAL1. Conclusions/interpretation These results suggest that many loci associated with type 2 diabetes are commonly shared between European and Chinese populations. Identification of population-specific SNPs may increase our understanding of the genetic architecture underlying type 2 diabetes in different ethnic populations. Ethnic difference (dpeaa)DE-He213 Genetic association (dpeaa)DE-He213 Type 2 diabetes (dpeaa)DE-He213 Sheu, Wayne Huey-Herng aut Assimes, Themistocles L. aut Hung, Yi-Jen aut Absher, Devin aut Chiu, Yen-Feng aut Mak, Jordan aut Wang, Jun-Sing aut Kwon, Soonil aut Hsu, Chih-Cheng aut Goodarzi, Mark O. aut Lee, I-Te aut Knowles, Joshua W. aut Miller, Brittany E. aut Lee, Wen-Jane aut Juang, Jyh-Ming J. aut Wang, Tzung-Dau aut Guo, Xiuqing aut Taylor, Kent D. aut Chuang, Lee-Ming aut Hsiung, Chao A. aut Quertermous, Thomas aut Rotter, Jerome I. aut Chen, Yii-Der I. aut Enthalten in Diabetologia Berlin : Springer, 1965 56(2013), 12 vom: 08. Sept., Seite 2619-2628 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:56 year:2013 number:12 day:08 month:09 pages:2619-2628 https://dx.doi.org/10.1007/s00125-013-3047-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 56 2013 12 08 09 2619-2628 |
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10.1007/s00125-013-3047-1 doi (DE-627)SPR000994138 (SPR)s00125-013-3047-1-e DE-627 ger DE-627 rakwb eng Kuo, Jane Z. verfasserin aut Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Aims/hypothesis Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects of these loci in an East Asian population. Methods A total of 9,335 unrelated Chinese Han individuals, including 4,535 with type 2 diabetes and 4,800 non-diabetic ethnically matched controls, were genotyped using the Illumina 200K Metabochip. We tested 50 established loci for type 2 diabetes and related traits (fasting glucose, fasting insulin, 2 h glucose). Disease association with the additive model of inheritance was analysed with logistic regression. Results We found that 14 loci significantly transferred to the Chinese population, with two loci (p = 5.7 × $ 10^{−12} $ for KCNQ1; p = 5.0 × $ 10^{−8} $ for CDKN2A/B-CDKN2BAS) reaching independent genome-wide statistical significance. Five of these 14 loci had similar lead single-nucleotide polymorphisms (SNPs) as were found in the European studies while the other nine were different. Further stepwise conditional analysis identified a total of seven secondary signals and an independent novel locus at the 3′ end of CDKAL1. Conclusions/interpretation These results suggest that many loci associated with type 2 diabetes are commonly shared between European and Chinese populations. Identification of population-specific SNPs may increase our understanding of the genetic architecture underlying type 2 diabetes in different ethnic populations. Ethnic difference (dpeaa)DE-He213 Genetic association (dpeaa)DE-He213 Type 2 diabetes (dpeaa)DE-He213 Sheu, Wayne Huey-Herng aut Assimes, Themistocles L. aut Hung, Yi-Jen aut Absher, Devin aut Chiu, Yen-Feng aut Mak, Jordan aut Wang, Jun-Sing aut Kwon, Soonil aut Hsu, Chih-Cheng aut Goodarzi, Mark O. aut Lee, I-Te aut Knowles, Joshua W. aut Miller, Brittany E. aut Lee, Wen-Jane aut Juang, Jyh-Ming J. aut Wang, Tzung-Dau aut Guo, Xiuqing aut Taylor, Kent D. aut Chuang, Lee-Ming aut Hsiung, Chao A. aut Quertermous, Thomas aut Rotter, Jerome I. aut Chen, Yii-Der I. aut Enthalten in Diabetologia Berlin : Springer, 1965 56(2013), 12 vom: 08. Sept., Seite 2619-2628 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:56 year:2013 number:12 day:08 month:09 pages:2619-2628 https://dx.doi.org/10.1007/s00125-013-3047-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 56 2013 12 08 09 2619-2628 |
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10.1007/s00125-013-3047-1 doi (DE-627)SPR000994138 (SPR)s00125-013-3047-1-e DE-627 ger DE-627 rakwb eng Kuo, Jane Z. verfasserin aut Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Aims/hypothesis Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects of these loci in an East Asian population. Methods A total of 9,335 unrelated Chinese Han individuals, including 4,535 with type 2 diabetes and 4,800 non-diabetic ethnically matched controls, were genotyped using the Illumina 200K Metabochip. We tested 50 established loci for type 2 diabetes and related traits (fasting glucose, fasting insulin, 2 h glucose). Disease association with the additive model of inheritance was analysed with logistic regression. Results We found that 14 loci significantly transferred to the Chinese population, with two loci (p = 5.7 × $ 10^{−12} $ for KCNQ1; p = 5.0 × $ 10^{−8} $ for CDKN2A/B-CDKN2BAS) reaching independent genome-wide statistical significance. Five of these 14 loci had similar lead single-nucleotide polymorphisms (SNPs) as were found in the European studies while the other nine were different. Further stepwise conditional analysis identified a total of seven secondary signals and an independent novel locus at the 3′ end of CDKAL1. Conclusions/interpretation These results suggest that many loci associated with type 2 diabetes are commonly shared between European and Chinese populations. Identification of population-specific SNPs may increase our understanding of the genetic architecture underlying type 2 diabetes in different ethnic populations. Ethnic difference (dpeaa)DE-He213 Genetic association (dpeaa)DE-He213 Type 2 diabetes (dpeaa)DE-He213 Sheu, Wayne Huey-Herng aut Assimes, Themistocles L. aut Hung, Yi-Jen aut Absher, Devin aut Chiu, Yen-Feng aut Mak, Jordan aut Wang, Jun-Sing aut Kwon, Soonil aut Hsu, Chih-Cheng aut Goodarzi, Mark O. aut Lee, I-Te aut Knowles, Joshua W. aut Miller, Brittany E. aut Lee, Wen-Jane aut Juang, Jyh-Ming J. aut Wang, Tzung-Dau aut Guo, Xiuqing aut Taylor, Kent D. aut Chuang, Lee-Ming aut Hsiung, Chao A. aut Quertermous, Thomas aut Rotter, Jerome I. aut Chen, Yii-Der I. aut Enthalten in Diabetologia Berlin : Springer, 1965 56(2013), 12 vom: 08. Sept., Seite 2619-2628 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:56 year:2013 number:12 day:08 month:09 pages:2619-2628 https://dx.doi.org/10.1007/s00125-013-3047-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 56 2013 12 08 09 2619-2628 |
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10.1007/s00125-013-3047-1 doi (DE-627)SPR000994138 (SPR)s00125-013-3047-1-e DE-627 ger DE-627 rakwb eng Kuo, Jane Z. verfasserin aut Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Aims/hypothesis Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects of these loci in an East Asian population. Methods A total of 9,335 unrelated Chinese Han individuals, including 4,535 with type 2 diabetes and 4,800 non-diabetic ethnically matched controls, were genotyped using the Illumina 200K Metabochip. We tested 50 established loci for type 2 diabetes and related traits (fasting glucose, fasting insulin, 2 h glucose). Disease association with the additive model of inheritance was analysed with logistic regression. Results We found that 14 loci significantly transferred to the Chinese population, with two loci (p = 5.7 × $ 10^{−12} $ for KCNQ1; p = 5.0 × $ 10^{−8} $ for CDKN2A/B-CDKN2BAS) reaching independent genome-wide statistical significance. Five of these 14 loci had similar lead single-nucleotide polymorphisms (SNPs) as were found in the European studies while the other nine were different. Further stepwise conditional analysis identified a total of seven secondary signals and an independent novel locus at the 3′ end of CDKAL1. Conclusions/interpretation These results suggest that many loci associated with type 2 diabetes are commonly shared between European and Chinese populations. Identification of population-specific SNPs may increase our understanding of the genetic architecture underlying type 2 diabetes in different ethnic populations. Ethnic difference (dpeaa)DE-He213 Genetic association (dpeaa)DE-He213 Type 2 diabetes (dpeaa)DE-He213 Sheu, Wayne Huey-Herng aut Assimes, Themistocles L. aut Hung, Yi-Jen aut Absher, Devin aut Chiu, Yen-Feng aut Mak, Jordan aut Wang, Jun-Sing aut Kwon, Soonil aut Hsu, Chih-Cheng aut Goodarzi, Mark O. aut Lee, I-Te aut Knowles, Joshua W. aut Miller, Brittany E. aut Lee, Wen-Jane aut Juang, Jyh-Ming J. aut Wang, Tzung-Dau aut Guo, Xiuqing aut Taylor, Kent D. aut Chuang, Lee-Ming aut Hsiung, Chao A. aut Quertermous, Thomas aut Rotter, Jerome I. aut Chen, Yii-Der I. aut Enthalten in Diabetologia Berlin : Springer, 1965 56(2013), 12 vom: 08. Sept., Seite 2619-2628 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:56 year:2013 number:12 day:08 month:09 pages:2619-2628 https://dx.doi.org/10.1007/s00125-013-3047-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 56 2013 12 08 09 2619-2628 |
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10.1007/s00125-013-3047-1 doi (DE-627)SPR000994138 (SPR)s00125-013-3047-1-e DE-627 ger DE-627 rakwb eng Kuo, Jane Z. verfasserin aut Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Aims/hypothesis Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects of these loci in an East Asian population. Methods A total of 9,335 unrelated Chinese Han individuals, including 4,535 with type 2 diabetes and 4,800 non-diabetic ethnically matched controls, were genotyped using the Illumina 200K Metabochip. We tested 50 established loci for type 2 diabetes and related traits (fasting glucose, fasting insulin, 2 h glucose). Disease association with the additive model of inheritance was analysed with logistic regression. Results We found that 14 loci significantly transferred to the Chinese population, with two loci (p = 5.7 × $ 10^{−12} $ for KCNQ1; p = 5.0 × $ 10^{−8} $ for CDKN2A/B-CDKN2BAS) reaching independent genome-wide statistical significance. Five of these 14 loci had similar lead single-nucleotide polymorphisms (SNPs) as were found in the European studies while the other nine were different. Further stepwise conditional analysis identified a total of seven secondary signals and an independent novel locus at the 3′ end of CDKAL1. Conclusions/interpretation These results suggest that many loci associated with type 2 diabetes are commonly shared between European and Chinese populations. Identification of population-specific SNPs may increase our understanding of the genetic architecture underlying type 2 diabetes in different ethnic populations. Ethnic difference (dpeaa)DE-He213 Genetic association (dpeaa)DE-He213 Type 2 diabetes (dpeaa)DE-He213 Sheu, Wayne Huey-Herng aut Assimes, Themistocles L. aut Hung, Yi-Jen aut Absher, Devin aut Chiu, Yen-Feng aut Mak, Jordan aut Wang, Jun-Sing aut Kwon, Soonil aut Hsu, Chih-Cheng aut Goodarzi, Mark O. aut Lee, I-Te aut Knowles, Joshua W. aut Miller, Brittany E. aut Lee, Wen-Jane aut Juang, Jyh-Ming J. aut Wang, Tzung-Dau aut Guo, Xiuqing aut Taylor, Kent D. aut Chuang, Lee-Ming aut Hsiung, Chao A. aut Quertermous, Thomas aut Rotter, Jerome I. aut Chen, Yii-Der I. aut Enthalten in Diabetologia Berlin : Springer, 1965 56(2013), 12 vom: 08. Sept., Seite 2619-2628 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:56 year:2013 number:12 day:08 month:09 pages:2619-2628 https://dx.doi.org/10.1007/s00125-013-3047-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 56 2013 12 08 09 2619-2628 |
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Kuo, Jane Z. @@aut@@ Sheu, Wayne Huey-Herng @@aut@@ Assimes, Themistocles L. @@aut@@ Hung, Yi-Jen @@aut@@ Absher, Devin @@aut@@ Chiu, Yen-Feng @@aut@@ Mak, Jordan @@aut@@ Wang, Jun-Sing @@aut@@ Kwon, Soonil @@aut@@ Hsu, Chih-Cheng @@aut@@ Goodarzi, Mark O. @@aut@@ Lee, I-Te @@aut@@ Knowles, Joshua W. @@aut@@ Miller, Brittany E. @@aut@@ Lee, Wen-Jane @@aut@@ Juang, Jyh-Ming J. @@aut@@ Wang, Tzung-Dau @@aut@@ Guo, Xiuqing @@aut@@ Taylor, Kent D. @@aut@@ Chuang, Lee-Ming @@aut@@ Hsiung, Chao A. @@aut@@ Quertermous, Thomas @@aut@@ Rotter, Jerome I. @@aut@@ Chen, Yii-Der I. @@aut@@ |
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Kuo, Jane Z. |
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Kuo, Jane Z. misc Ethnic difference misc Genetic association misc Type 2 diabetes Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population |
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Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population Ethnic difference (dpeaa)DE-He213 Genetic association (dpeaa)DE-He213 Type 2 diabetes (dpeaa)DE-He213 |
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misc Ethnic difference misc Genetic association misc Type 2 diabetes |
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misc Ethnic difference misc Genetic association misc Type 2 diabetes |
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misc Ethnic difference misc Genetic association misc Type 2 diabetes |
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Diabetologia |
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Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population |
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(DE-627)SPR000994138 (SPR)s00125-013-3047-1-e |
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Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population |
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Kuo, Jane Z. |
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Diabetologia |
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Kuo, Jane Z. Sheu, Wayne Huey-Herng Assimes, Themistocles L. Hung, Yi-Jen Absher, Devin Chiu, Yen-Feng Mak, Jordan Wang, Jun-Sing Kwon, Soonil Hsu, Chih-Cheng Goodarzi, Mark O. Lee, I-Te Knowles, Joshua W. Miller, Brittany E. Lee, Wen-Jane Juang, Jyh-Ming J. Wang, Tzung-Dau Guo, Xiuqing Taylor, Kent D. Chuang, Lee-Ming Hsiung, Chao A. Quertermous, Thomas Rotter, Jerome I. Chen, Yii-Der I. |
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Elektronische Aufsätze |
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Kuo, Jane Z. |
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10.1007/s00125-013-3047-1 |
| title_sort |
trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of cdkal1 and novel variants of several susceptibility loci for type 2 diabetes in a han chinese population |
| title_auth |
Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population |
| abstract |
Aims/hypothesis Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects of these loci in an East Asian population. Methods A total of 9,335 unrelated Chinese Han individuals, including 4,535 with type 2 diabetes and 4,800 non-diabetic ethnically matched controls, were genotyped using the Illumina 200K Metabochip. We tested 50 established loci for type 2 diabetes and related traits (fasting glucose, fasting insulin, 2 h glucose). Disease association with the additive model of inheritance was analysed with logistic regression. Results We found that 14 loci significantly transferred to the Chinese population, with two loci (p = 5.7 × $ 10^{−12} $ for KCNQ1; p = 5.0 × $ 10^{−8} $ for CDKN2A/B-CDKN2BAS) reaching independent genome-wide statistical significance. Five of these 14 loci had similar lead single-nucleotide polymorphisms (SNPs) as were found in the European studies while the other nine were different. Further stepwise conditional analysis identified a total of seven secondary signals and an independent novel locus at the 3′ end of CDKAL1. Conclusions/interpretation These results suggest that many loci associated with type 2 diabetes are commonly shared between European and Chinese populations. Identification of population-specific SNPs may increase our understanding of the genetic architecture underlying type 2 diabetes in different ethnic populations. © The Author(s) 2013 |
| abstractGer |
Aims/hypothesis Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects of these loci in an East Asian population. Methods A total of 9,335 unrelated Chinese Han individuals, including 4,535 with type 2 diabetes and 4,800 non-diabetic ethnically matched controls, were genotyped using the Illumina 200K Metabochip. We tested 50 established loci for type 2 diabetes and related traits (fasting glucose, fasting insulin, 2 h glucose). Disease association with the additive model of inheritance was analysed with logistic regression. Results We found that 14 loci significantly transferred to the Chinese population, with two loci (p = 5.7 × $ 10^{−12} $ for KCNQ1; p = 5.0 × $ 10^{−8} $ for CDKN2A/B-CDKN2BAS) reaching independent genome-wide statistical significance. Five of these 14 loci had similar lead single-nucleotide polymorphisms (SNPs) as were found in the European studies while the other nine were different. Further stepwise conditional analysis identified a total of seven secondary signals and an independent novel locus at the 3′ end of CDKAL1. Conclusions/interpretation These results suggest that many loci associated with type 2 diabetes are commonly shared between European and Chinese populations. Identification of population-specific SNPs may increase our understanding of the genetic architecture underlying type 2 diabetes in different ethnic populations. © The Author(s) 2013 |
| abstract_unstemmed |
Aims/hypothesis Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects of these loci in an East Asian population. Methods A total of 9,335 unrelated Chinese Han individuals, including 4,535 with type 2 diabetes and 4,800 non-diabetic ethnically matched controls, were genotyped using the Illumina 200K Metabochip. We tested 50 established loci for type 2 diabetes and related traits (fasting glucose, fasting insulin, 2 h glucose). Disease association with the additive model of inheritance was analysed with logistic regression. Results We found that 14 loci significantly transferred to the Chinese population, with two loci (p = 5.7 × $ 10^{−12} $ for KCNQ1; p = 5.0 × $ 10^{−8} $ for CDKN2A/B-CDKN2BAS) reaching independent genome-wide statistical significance. Five of these 14 loci had similar lead single-nucleotide polymorphisms (SNPs) as were found in the European studies while the other nine were different. Further stepwise conditional analysis identified a total of seven secondary signals and an independent novel locus at the 3′ end of CDKAL1. Conclusions/interpretation These results suggest that many loci associated with type 2 diabetes are commonly shared between European and Chinese populations. Identification of population-specific SNPs may increase our understanding of the genetic architecture underlying type 2 diabetes in different ethnic populations. © The Author(s) 2013 |
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| title_short |
Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population |
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https://dx.doi.org/10.1007/s00125-013-3047-1 |
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Sheu, Wayne Huey-Herng Assimes, Themistocles L. Hung, Yi-Jen Absher, Devin Chiu, Yen-Feng Mak, Jordan Wang, Jun-Sing Kwon, Soonil Hsu, Chih-Cheng Goodarzi, Mark O. Lee, I-Te Knowles, Joshua W. Miller, Brittany E. Lee, Wen-Jane Juang, Jyh-Ming J. Wang, Tzung-Dau Guo, Xiuqing Taylor, Kent D. Chuang, Lee-Ming Hsiung, Chao A. Quertermous, Thomas Rotter, Jerome I. Chen, Yii-Der I. |
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Sheu, Wayne Huey-Herng Assimes, Themistocles L. Hung, Yi-Jen Absher, Devin Chiu, Yen-Feng Mak, Jordan Wang, Jun-Sing Kwon, Soonil Hsu, Chih-Cheng Goodarzi, Mark O. Lee, I-Te Knowles, Joshua W. Miller, Brittany E. Lee, Wen-Jane Juang, Jyh-Ming J. Wang, Tzung-Dau Guo, Xiuqing Taylor, Kent D. Chuang, Lee-Ming Hsiung, Chao A. Quertermous, Thomas Rotter, Jerome I. Chen, Yii-Der I. |
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10.1007/s00125-013-3047-1 |
| up_date |
2024-07-03T19:34:10.302Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR000994138</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519120215.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2013 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00125-013-3047-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR000994138</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00125-013-3047-1-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kuo, Jane Z.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2013</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2013</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Aims/hypothesis Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects of these loci in an East Asian population. Methods A total of 9,335 unrelated Chinese Han individuals, including 4,535 with type 2 diabetes and 4,800 non-diabetic ethnically matched controls, were genotyped using the Illumina 200K Metabochip. We tested 50 established loci for type 2 diabetes and related traits (fasting glucose, fasting insulin, 2 h glucose). Disease association with the additive model of inheritance was analysed with logistic regression. Results We found that 14 loci significantly transferred to the Chinese population, with two loci (p = 5.7 × $ 10^{−12} $ for KCNQ1; p = 5.0 × $ 10^{−8} $ for CDKN2A/B-CDKN2BAS) reaching independent genome-wide statistical significance. Five of these 14 loci had similar lead single-nucleotide polymorphisms (SNPs) as were found in the European studies while the other nine were different. Further stepwise conditional analysis identified a total of seven secondary signals and an independent novel locus at the 3′ end of CDKAL1. Conclusions/interpretation These results suggest that many loci associated with type 2 diabetes are commonly shared between European and Chinese populations. 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| score |
7.4001675 |