$ NAD^{+} $ metabolism as a target for metabolic health: have we found the silver bullet?
Abstract $ NAD^{+} $ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, $ NAD^{+} $ has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Connell, Niels J. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2019 |
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| Übergeordnetes Werk: |
Enthalten in: Diabetologia - Berlin : Springer, 1965, 62(2019), 6 vom: 16. Feb., Seite 888-899 |
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| Übergeordnetes Werk: |
volume:62 ; year:2019 ; number:6 ; day:16 ; month:02 ; pages:888-899 |
| Links: |
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| DOI / URN: |
10.1007/s00125-019-4831-3 |
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| Katalog-ID: |
SPR001016881 |
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| 100 | 1 | |a Connell, Niels J. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a $ NAD^{+} $ metabolism as a target for metabolic health: have we found the silver bullet? |
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| 520 | |a Abstract $ NAD^{+} $ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, $ NAD^{+} $ has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated through sirtuin (SIRT) enzymes. The beneficial metabolic effects of the $ NAD^{+} $/SIRT axis have triggered an increased interest in $ NAD^{+} $ as an enhancer of energy metabolism. As a result, a myriad of publications have focused on $ NAD^{+} $ metabolism, with the majority of the work having been performed using in vitro models, and in vivo work largely consisting of interventions in Caenorhabditis elegans and rodents. Human intervention trials, on the other hand, are scarce. The aim of this review is to provide an overview of the state-of-the-art on influencing $ NAD^{+} $ metabolism in humans and to set the stage for what the future of this exciting field may hold. | ||
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10.1007/s00125-019-4831-3 doi (DE-627)SPR001016881 (SPR)s00125-019-4831-3-e DE-627 ger DE-627 rakwb eng Connell, Niels J. verfasserin aut $ NAD^{+} $ metabolism as a target for metabolic health: have we found the silver bullet? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract $ NAD^{+} $ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, $ NAD^{+} $ has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated through sirtuin (SIRT) enzymes. The beneficial metabolic effects of the $ NAD^{+} $/SIRT axis have triggered an increased interest in $ NAD^{+} $ as an enhancer of energy metabolism. As a result, a myriad of publications have focused on $ NAD^{+} $ metabolism, with the majority of the work having been performed using in vitro models, and in vivo work largely consisting of interventions in Caenorhabditis elegans and rodents. Human intervention trials, on the other hand, are scarce. The aim of this review is to provide an overview of the state-of-the-art on influencing $ NAD^{+} $ metabolism in humans and to set the stage for what the future of this exciting field may hold. Diabetes (dpeaa)DE-He213 Energy metabolism (dpeaa)DE-He213 Human (dpeaa)DE-He213 Metabolic disease (dpeaa)DE-He213 NAD (dpeaa)DE-He213 Review (dpeaa)DE-He213 Houtkooper, Riekelt H. aut Schrauwen, Patrick (orcid)0000-0002-0973-847X aut Enthalten in Diabetologia Berlin : Springer, 1965 62(2019), 6 vom: 16. Feb., Seite 888-899 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:62 year:2019 number:6 day:16 month:02 pages:888-899 https://dx.doi.org/10.1007/s00125-019-4831-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 62 2019 6 16 02 888-899 |
| spelling |
10.1007/s00125-019-4831-3 doi (DE-627)SPR001016881 (SPR)s00125-019-4831-3-e DE-627 ger DE-627 rakwb eng Connell, Niels J. verfasserin aut $ NAD^{+} $ metabolism as a target for metabolic health: have we found the silver bullet? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract $ NAD^{+} $ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, $ NAD^{+} $ has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated through sirtuin (SIRT) enzymes. The beneficial metabolic effects of the $ NAD^{+} $/SIRT axis have triggered an increased interest in $ NAD^{+} $ as an enhancer of energy metabolism. As a result, a myriad of publications have focused on $ NAD^{+} $ metabolism, with the majority of the work having been performed using in vitro models, and in vivo work largely consisting of interventions in Caenorhabditis elegans and rodents. Human intervention trials, on the other hand, are scarce. The aim of this review is to provide an overview of the state-of-the-art on influencing $ NAD^{+} $ metabolism in humans and to set the stage for what the future of this exciting field may hold. Diabetes (dpeaa)DE-He213 Energy metabolism (dpeaa)DE-He213 Human (dpeaa)DE-He213 Metabolic disease (dpeaa)DE-He213 NAD (dpeaa)DE-He213 Review (dpeaa)DE-He213 Houtkooper, Riekelt H. aut Schrauwen, Patrick (orcid)0000-0002-0973-847X aut Enthalten in Diabetologia Berlin : Springer, 1965 62(2019), 6 vom: 16. Feb., Seite 888-899 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:62 year:2019 number:6 day:16 month:02 pages:888-899 https://dx.doi.org/10.1007/s00125-019-4831-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 62 2019 6 16 02 888-899 |
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10.1007/s00125-019-4831-3 doi (DE-627)SPR001016881 (SPR)s00125-019-4831-3-e DE-627 ger DE-627 rakwb eng Connell, Niels J. verfasserin aut $ NAD^{+} $ metabolism as a target for metabolic health: have we found the silver bullet? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract $ NAD^{+} $ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, $ NAD^{+} $ has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated through sirtuin (SIRT) enzymes. The beneficial metabolic effects of the $ NAD^{+} $/SIRT axis have triggered an increased interest in $ NAD^{+} $ as an enhancer of energy metabolism. As a result, a myriad of publications have focused on $ NAD^{+} $ metabolism, with the majority of the work having been performed using in vitro models, and in vivo work largely consisting of interventions in Caenorhabditis elegans and rodents. Human intervention trials, on the other hand, are scarce. The aim of this review is to provide an overview of the state-of-the-art on influencing $ NAD^{+} $ metabolism in humans and to set the stage for what the future of this exciting field may hold. Diabetes (dpeaa)DE-He213 Energy metabolism (dpeaa)DE-He213 Human (dpeaa)DE-He213 Metabolic disease (dpeaa)DE-He213 NAD (dpeaa)DE-He213 Review (dpeaa)DE-He213 Houtkooper, Riekelt H. aut Schrauwen, Patrick (orcid)0000-0002-0973-847X aut Enthalten in Diabetologia Berlin : Springer, 1965 62(2019), 6 vom: 16. Feb., Seite 888-899 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:62 year:2019 number:6 day:16 month:02 pages:888-899 https://dx.doi.org/10.1007/s00125-019-4831-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 62 2019 6 16 02 888-899 |
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10.1007/s00125-019-4831-3 doi (DE-627)SPR001016881 (SPR)s00125-019-4831-3-e DE-627 ger DE-627 rakwb eng Connell, Niels J. verfasserin aut $ NAD^{+} $ metabolism as a target for metabolic health: have we found the silver bullet? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract $ NAD^{+} $ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, $ NAD^{+} $ has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated through sirtuin (SIRT) enzymes. The beneficial metabolic effects of the $ NAD^{+} $/SIRT axis have triggered an increased interest in $ NAD^{+} $ as an enhancer of energy metabolism. As a result, a myriad of publications have focused on $ NAD^{+} $ metabolism, with the majority of the work having been performed using in vitro models, and in vivo work largely consisting of interventions in Caenorhabditis elegans and rodents. Human intervention trials, on the other hand, are scarce. The aim of this review is to provide an overview of the state-of-the-art on influencing $ NAD^{+} $ metabolism in humans and to set the stage for what the future of this exciting field may hold. Diabetes (dpeaa)DE-He213 Energy metabolism (dpeaa)DE-He213 Human (dpeaa)DE-He213 Metabolic disease (dpeaa)DE-He213 NAD (dpeaa)DE-He213 Review (dpeaa)DE-He213 Houtkooper, Riekelt H. aut Schrauwen, Patrick (orcid)0000-0002-0973-847X aut Enthalten in Diabetologia Berlin : Springer, 1965 62(2019), 6 vom: 16. Feb., Seite 888-899 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:62 year:2019 number:6 day:16 month:02 pages:888-899 https://dx.doi.org/10.1007/s00125-019-4831-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 62 2019 6 16 02 888-899 |
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10.1007/s00125-019-4831-3 doi (DE-627)SPR001016881 (SPR)s00125-019-4831-3-e DE-627 ger DE-627 rakwb eng Connell, Niels J. verfasserin aut $ NAD^{+} $ metabolism as a target for metabolic health: have we found the silver bullet? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract $ NAD^{+} $ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, $ NAD^{+} $ has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated through sirtuin (SIRT) enzymes. The beneficial metabolic effects of the $ NAD^{+} $/SIRT axis have triggered an increased interest in $ NAD^{+} $ as an enhancer of energy metabolism. As a result, a myriad of publications have focused on $ NAD^{+} $ metabolism, with the majority of the work having been performed using in vitro models, and in vivo work largely consisting of interventions in Caenorhabditis elegans and rodents. Human intervention trials, on the other hand, are scarce. The aim of this review is to provide an overview of the state-of-the-art on influencing $ NAD^{+} $ metabolism in humans and to set the stage for what the future of this exciting field may hold. Diabetes (dpeaa)DE-He213 Energy metabolism (dpeaa)DE-He213 Human (dpeaa)DE-He213 Metabolic disease (dpeaa)DE-He213 NAD (dpeaa)DE-He213 Review (dpeaa)DE-He213 Houtkooper, Riekelt H. aut Schrauwen, Patrick (orcid)0000-0002-0973-847X aut Enthalten in Diabetologia Berlin : Springer, 1965 62(2019), 6 vom: 16. Feb., Seite 888-899 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:62 year:2019 number:6 day:16 month:02 pages:888-899 https://dx.doi.org/10.1007/s00125-019-4831-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 62 2019 6 16 02 888-899 |
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Connell, Niels J. @@aut@@ Houtkooper, Riekelt H. @@aut@@ Schrauwen, Patrick @@aut@@ |
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Connell, Niels J. |
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Connell, Niels J. misc Diabetes misc Energy metabolism misc Human misc Metabolic disease misc NAD misc Review $ NAD^{+} $ metabolism as a target for metabolic health: have we found the silver bullet? |
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$ NAD^{+} $ metabolism as a target for metabolic health: have we found the silver bullet? Diabetes (dpeaa)DE-He213 Energy metabolism (dpeaa)DE-He213 Human (dpeaa)DE-He213 Metabolic disease (dpeaa)DE-He213 NAD (dpeaa)DE-He213 Review (dpeaa)DE-He213 |
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$ nad^{+} $ metabolism as a target for metabolic health: have we found the silver bullet? |
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$ NAD^{+} $ metabolism as a target for metabolic health: have we found the silver bullet? |
| abstract |
Abstract $ NAD^{+} $ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, $ NAD^{+} $ has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated through sirtuin (SIRT) enzymes. The beneficial metabolic effects of the $ NAD^{+} $/SIRT axis have triggered an increased interest in $ NAD^{+} $ as an enhancer of energy metabolism. As a result, a myriad of publications have focused on $ NAD^{+} $ metabolism, with the majority of the work having been performed using in vitro models, and in vivo work largely consisting of interventions in Caenorhabditis elegans and rodents. Human intervention trials, on the other hand, are scarce. The aim of this review is to provide an overview of the state-of-the-art on influencing $ NAD^{+} $ metabolism in humans and to set the stage for what the future of this exciting field may hold. © The Author(s) 2019 |
| abstractGer |
Abstract $ NAD^{+} $ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, $ NAD^{+} $ has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated through sirtuin (SIRT) enzymes. The beneficial metabolic effects of the $ NAD^{+} $/SIRT axis have triggered an increased interest in $ NAD^{+} $ as an enhancer of energy metabolism. As a result, a myriad of publications have focused on $ NAD^{+} $ metabolism, with the majority of the work having been performed using in vitro models, and in vivo work largely consisting of interventions in Caenorhabditis elegans and rodents. Human intervention trials, on the other hand, are scarce. The aim of this review is to provide an overview of the state-of-the-art on influencing $ NAD^{+} $ metabolism in humans and to set the stage for what the future of this exciting field may hold. © The Author(s) 2019 |
| abstract_unstemmed |
Abstract $ NAD^{+} $ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, $ NAD^{+} $ has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated through sirtuin (SIRT) enzymes. The beneficial metabolic effects of the $ NAD^{+} $/SIRT axis have triggered an increased interest in $ NAD^{+} $ as an enhancer of energy metabolism. As a result, a myriad of publications have focused on $ NAD^{+} $ metabolism, with the majority of the work having been performed using in vitro models, and in vivo work largely consisting of interventions in Caenorhabditis elegans and rodents. Human intervention trials, on the other hand, are scarce. The aim of this review is to provide an overview of the state-of-the-art on influencing $ NAD^{+} $ metabolism in humans and to set the stage for what the future of this exciting field may hold. © The Author(s) 2019 |
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$ NAD^{+} $ metabolism as a target for metabolic health: have we found the silver bullet? |
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https://dx.doi.org/10.1007/s00125-019-4831-3 |
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Houtkooper, Riekelt H. Schrauwen, Patrick |
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| doi_str |
10.1007/s00125-019-4831-3 |
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2024-07-03T19:45:33.400Z |
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| score |
7.3975754 |