Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes
Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role o...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ekman, Ilse [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2019 |
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| Übergeordnetes Werk: |
Enthalten in: Diabetologia - Berlin : Springer, 1965, 62(2019), 9 vom: 03. Juli, Seite 1681-1688 |
|---|---|
| Übergeordnetes Werk: |
volume:62 ; year:2019 ; number:9 ; day:03 ; month:07 ; pages:1681-1688 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00125-019-4936-8 |
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| Katalog-ID: |
SPR001017888 |
|---|
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| 024 | 7 | |a 10.1007/s00125-019-4936-8 |2 doi | |
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| 100 | 1 | |a Ekman, Ilse |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes |
| 264 | 1 | |c 2019 | |
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| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 500 | |a © The Author(s) 2019 | ||
| 520 | |a Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role of a recently described subset, C-X-C motif chemokine receptor type 5-negative, programmed cell death protein 1-positive ($ CXCR5^{−} $PD-$ 1^{hi} $) peripheral T helper (Tph) cells, in human type 1 diabetes. Methods The phenotype of blood $ CXCR5^{−} $PD-$ 1^{hi} $ $ CD4^{+} $ T cells was analysed by multicolour flow cytometry. The frequencies of circulating $ CXCR5^{−} $PD-$ 1^{hi} $ T cells were analysed in a cohort of 44 children with newly diagnosed type 1 diabetes, 40 autoantibody-positive ($ AAb^{+} $) at-risk children and 84 autoantibody-negative healthy control children, and the findings were replicated in a separate cohort of 15 children with newly diagnosed type 1 diabetes and 15 healthy control children. Results Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells share several features associated with B cell helper function with circulating $ CXCR5^{+} $PD-$ 1^{hi} $ follicular T helper (Tfh) cells. Moreover, the frequency of circulating Tph cells was increased in children with newly diagnosed type 1 diabetes, especially in those who are positive for multiple autoantibodies. Importantly, circulating Tph cells were also increased in autoantibody-positive at-risk children who later progressed to type 1 diabetes. Conclusions/interpretation Our results demonstrate that circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells are associated with progression to clinical type 1 diabetes. Consequently, Tph cells could have potential both as a biomarker of disease progression and as a target for immunotherapy in type 1 diabetes. | ||
| 650 | 4 | |a Autoimmunity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a B cells |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Follicular T helper cell |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Human |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immunophenotyping |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Peripheral T helper cell |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a T cells |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Type 1 diabetes |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ihantola, Emmi-Leena |4 aut | |
| 700 | 1 | |a Viisanen, Tyyne |4 aut | |
| 700 | 1 | |a Rao, Deepak A. |4 aut | |
| 700 | 1 | |a Näntö-Salonen, Kirsti |4 aut | |
| 700 | 1 | |a Knip, Mikael |4 aut | |
| 700 | 1 | |a Veijola, Riitta |4 aut | |
| 700 | 1 | |a Toppari, Jorma |4 aut | |
| 700 | 1 | |a Ilonen, Jorma |4 aut | |
| 700 | 1 | |a Kinnunen, Tuure |0 (orcid)0000-0003-1595-5371 |4 aut | |
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10.1007/s00125-019-4936-8 doi (DE-627)SPR001017888 (SPR)s00125-019-4936-8-e DE-627 ger DE-627 rakwb eng Ekman, Ilse verfasserin aut Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role of a recently described subset, C-X-C motif chemokine receptor type 5-negative, programmed cell death protein 1-positive ($ CXCR5^{−} $PD-$ 1^{hi} $) peripheral T helper (Tph) cells, in human type 1 diabetes. Methods The phenotype of blood $ CXCR5^{−} $PD-$ 1^{hi} $ $ CD4^{+} $ T cells was analysed by multicolour flow cytometry. The frequencies of circulating $ CXCR5^{−} $PD-$ 1^{hi} $ T cells were analysed in a cohort of 44 children with newly diagnosed type 1 diabetes, 40 autoantibody-positive ($ AAb^{+} $) at-risk children and 84 autoantibody-negative healthy control children, and the findings were replicated in a separate cohort of 15 children with newly diagnosed type 1 diabetes and 15 healthy control children. Results Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells share several features associated with B cell helper function with circulating $ CXCR5^{+} $PD-$ 1^{hi} $ follicular T helper (Tfh) cells. Moreover, the frequency of circulating Tph cells was increased in children with newly diagnosed type 1 diabetes, especially in those who are positive for multiple autoantibodies. Importantly, circulating Tph cells were also increased in autoantibody-positive at-risk children who later progressed to type 1 diabetes. Conclusions/interpretation Our results demonstrate that circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells are associated with progression to clinical type 1 diabetes. Consequently, Tph cells could have potential both as a biomarker of disease progression and as a target for immunotherapy in type 1 diabetes. Autoimmunity (dpeaa)DE-He213 B cells (dpeaa)DE-He213 Follicular T helper cell (dpeaa)DE-He213 Human (dpeaa)DE-He213 Immunophenotyping (dpeaa)DE-He213 Peripheral T helper cell (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Type 1 diabetes (dpeaa)DE-He213 Ihantola, Emmi-Leena aut Viisanen, Tyyne aut Rao, Deepak A. aut Näntö-Salonen, Kirsti aut Knip, Mikael aut Veijola, Riitta aut Toppari, Jorma aut Ilonen, Jorma aut Kinnunen, Tuure (orcid)0000-0003-1595-5371 aut Enthalten in Diabetologia Berlin : Springer, 1965 62(2019), 9 vom: 03. Juli, Seite 1681-1688 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:62 year:2019 number:9 day:03 month:07 pages:1681-1688 https://dx.doi.org/10.1007/s00125-019-4936-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 62 2019 9 03 07 1681-1688 |
| spelling |
10.1007/s00125-019-4936-8 doi (DE-627)SPR001017888 (SPR)s00125-019-4936-8-e DE-627 ger DE-627 rakwb eng Ekman, Ilse verfasserin aut Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role of a recently described subset, C-X-C motif chemokine receptor type 5-negative, programmed cell death protein 1-positive ($ CXCR5^{−} $PD-$ 1^{hi} $) peripheral T helper (Tph) cells, in human type 1 diabetes. Methods The phenotype of blood $ CXCR5^{−} $PD-$ 1^{hi} $ $ CD4^{+} $ T cells was analysed by multicolour flow cytometry. The frequencies of circulating $ CXCR5^{−} $PD-$ 1^{hi} $ T cells were analysed in a cohort of 44 children with newly diagnosed type 1 diabetes, 40 autoantibody-positive ($ AAb^{+} $) at-risk children and 84 autoantibody-negative healthy control children, and the findings were replicated in a separate cohort of 15 children with newly diagnosed type 1 diabetes and 15 healthy control children. Results Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells share several features associated with B cell helper function with circulating $ CXCR5^{+} $PD-$ 1^{hi} $ follicular T helper (Tfh) cells. Moreover, the frequency of circulating Tph cells was increased in children with newly diagnosed type 1 diabetes, especially in those who are positive for multiple autoantibodies. Importantly, circulating Tph cells were also increased in autoantibody-positive at-risk children who later progressed to type 1 diabetes. Conclusions/interpretation Our results demonstrate that circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells are associated with progression to clinical type 1 diabetes. Consequently, Tph cells could have potential both as a biomarker of disease progression and as a target for immunotherapy in type 1 diabetes. Autoimmunity (dpeaa)DE-He213 B cells (dpeaa)DE-He213 Follicular T helper cell (dpeaa)DE-He213 Human (dpeaa)DE-He213 Immunophenotyping (dpeaa)DE-He213 Peripheral T helper cell (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Type 1 diabetes (dpeaa)DE-He213 Ihantola, Emmi-Leena aut Viisanen, Tyyne aut Rao, Deepak A. aut Näntö-Salonen, Kirsti aut Knip, Mikael aut Veijola, Riitta aut Toppari, Jorma aut Ilonen, Jorma aut Kinnunen, Tuure (orcid)0000-0003-1595-5371 aut Enthalten in Diabetologia Berlin : Springer, 1965 62(2019), 9 vom: 03. Juli, Seite 1681-1688 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:62 year:2019 number:9 day:03 month:07 pages:1681-1688 https://dx.doi.org/10.1007/s00125-019-4936-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 62 2019 9 03 07 1681-1688 |
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10.1007/s00125-019-4936-8 doi (DE-627)SPR001017888 (SPR)s00125-019-4936-8-e DE-627 ger DE-627 rakwb eng Ekman, Ilse verfasserin aut Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role of a recently described subset, C-X-C motif chemokine receptor type 5-negative, programmed cell death protein 1-positive ($ CXCR5^{−} $PD-$ 1^{hi} $) peripheral T helper (Tph) cells, in human type 1 diabetes. Methods The phenotype of blood $ CXCR5^{−} $PD-$ 1^{hi} $ $ CD4^{+} $ T cells was analysed by multicolour flow cytometry. The frequencies of circulating $ CXCR5^{−} $PD-$ 1^{hi} $ T cells were analysed in a cohort of 44 children with newly diagnosed type 1 diabetes, 40 autoantibody-positive ($ AAb^{+} $) at-risk children and 84 autoantibody-negative healthy control children, and the findings were replicated in a separate cohort of 15 children with newly diagnosed type 1 diabetes and 15 healthy control children. Results Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells share several features associated with B cell helper function with circulating $ CXCR5^{+} $PD-$ 1^{hi} $ follicular T helper (Tfh) cells. Moreover, the frequency of circulating Tph cells was increased in children with newly diagnosed type 1 diabetes, especially in those who are positive for multiple autoantibodies. Importantly, circulating Tph cells were also increased in autoantibody-positive at-risk children who later progressed to type 1 diabetes. Conclusions/interpretation Our results demonstrate that circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells are associated with progression to clinical type 1 diabetes. Consequently, Tph cells could have potential both as a biomarker of disease progression and as a target for immunotherapy in type 1 diabetes. Autoimmunity (dpeaa)DE-He213 B cells (dpeaa)DE-He213 Follicular T helper cell (dpeaa)DE-He213 Human (dpeaa)DE-He213 Immunophenotyping (dpeaa)DE-He213 Peripheral T helper cell (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Type 1 diabetes (dpeaa)DE-He213 Ihantola, Emmi-Leena aut Viisanen, Tyyne aut Rao, Deepak A. aut Näntö-Salonen, Kirsti aut Knip, Mikael aut Veijola, Riitta aut Toppari, Jorma aut Ilonen, Jorma aut Kinnunen, Tuure (orcid)0000-0003-1595-5371 aut Enthalten in Diabetologia Berlin : Springer, 1965 62(2019), 9 vom: 03. Juli, Seite 1681-1688 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:62 year:2019 number:9 day:03 month:07 pages:1681-1688 https://dx.doi.org/10.1007/s00125-019-4936-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 62 2019 9 03 07 1681-1688 |
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10.1007/s00125-019-4936-8 doi (DE-627)SPR001017888 (SPR)s00125-019-4936-8-e DE-627 ger DE-627 rakwb eng Ekman, Ilse verfasserin aut Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role of a recently described subset, C-X-C motif chemokine receptor type 5-negative, programmed cell death protein 1-positive ($ CXCR5^{−} $PD-$ 1^{hi} $) peripheral T helper (Tph) cells, in human type 1 diabetes. Methods The phenotype of blood $ CXCR5^{−} $PD-$ 1^{hi} $ $ CD4^{+} $ T cells was analysed by multicolour flow cytometry. The frequencies of circulating $ CXCR5^{−} $PD-$ 1^{hi} $ T cells were analysed in a cohort of 44 children with newly diagnosed type 1 diabetes, 40 autoantibody-positive ($ AAb^{+} $) at-risk children and 84 autoantibody-negative healthy control children, and the findings were replicated in a separate cohort of 15 children with newly diagnosed type 1 diabetes and 15 healthy control children. Results Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells share several features associated with B cell helper function with circulating $ CXCR5^{+} $PD-$ 1^{hi} $ follicular T helper (Tfh) cells. Moreover, the frequency of circulating Tph cells was increased in children with newly diagnosed type 1 diabetes, especially in those who are positive for multiple autoantibodies. Importantly, circulating Tph cells were also increased in autoantibody-positive at-risk children who later progressed to type 1 diabetes. Conclusions/interpretation Our results demonstrate that circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells are associated with progression to clinical type 1 diabetes. Consequently, Tph cells could have potential both as a biomarker of disease progression and as a target for immunotherapy in type 1 diabetes. Autoimmunity (dpeaa)DE-He213 B cells (dpeaa)DE-He213 Follicular T helper cell (dpeaa)DE-He213 Human (dpeaa)DE-He213 Immunophenotyping (dpeaa)DE-He213 Peripheral T helper cell (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Type 1 diabetes (dpeaa)DE-He213 Ihantola, Emmi-Leena aut Viisanen, Tyyne aut Rao, Deepak A. aut Näntö-Salonen, Kirsti aut Knip, Mikael aut Veijola, Riitta aut Toppari, Jorma aut Ilonen, Jorma aut Kinnunen, Tuure (orcid)0000-0003-1595-5371 aut Enthalten in Diabetologia Berlin : Springer, 1965 62(2019), 9 vom: 03. Juli, Seite 1681-1688 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:62 year:2019 number:9 day:03 month:07 pages:1681-1688 https://dx.doi.org/10.1007/s00125-019-4936-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 62 2019 9 03 07 1681-1688 |
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10.1007/s00125-019-4936-8 doi (DE-627)SPR001017888 (SPR)s00125-019-4936-8-e DE-627 ger DE-627 rakwb eng Ekman, Ilse verfasserin aut Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role of a recently described subset, C-X-C motif chemokine receptor type 5-negative, programmed cell death protein 1-positive ($ CXCR5^{−} $PD-$ 1^{hi} $) peripheral T helper (Tph) cells, in human type 1 diabetes. Methods The phenotype of blood $ CXCR5^{−} $PD-$ 1^{hi} $ $ CD4^{+} $ T cells was analysed by multicolour flow cytometry. The frequencies of circulating $ CXCR5^{−} $PD-$ 1^{hi} $ T cells were analysed in a cohort of 44 children with newly diagnosed type 1 diabetes, 40 autoantibody-positive ($ AAb^{+} $) at-risk children and 84 autoantibody-negative healthy control children, and the findings were replicated in a separate cohort of 15 children with newly diagnosed type 1 diabetes and 15 healthy control children. Results Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells share several features associated with B cell helper function with circulating $ CXCR5^{+} $PD-$ 1^{hi} $ follicular T helper (Tfh) cells. Moreover, the frequency of circulating Tph cells was increased in children with newly diagnosed type 1 diabetes, especially in those who are positive for multiple autoantibodies. Importantly, circulating Tph cells were also increased in autoantibody-positive at-risk children who later progressed to type 1 diabetes. Conclusions/interpretation Our results demonstrate that circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells are associated with progression to clinical type 1 diabetes. Consequently, Tph cells could have potential both as a biomarker of disease progression and as a target for immunotherapy in type 1 diabetes. Autoimmunity (dpeaa)DE-He213 B cells (dpeaa)DE-He213 Follicular T helper cell (dpeaa)DE-He213 Human (dpeaa)DE-He213 Immunophenotyping (dpeaa)DE-He213 Peripheral T helper cell (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Type 1 diabetes (dpeaa)DE-He213 Ihantola, Emmi-Leena aut Viisanen, Tyyne aut Rao, Deepak A. aut Näntö-Salonen, Kirsti aut Knip, Mikael aut Veijola, Riitta aut Toppari, Jorma aut Ilonen, Jorma aut Kinnunen, Tuure (orcid)0000-0003-1595-5371 aut Enthalten in Diabetologia Berlin : Springer, 1965 62(2019), 9 vom: 03. Juli, Seite 1681-1688 (DE-627)253722209 (DE-600)1458993-X 1432-0428 nnns volume:62 year:2019 number:9 day:03 month:07 pages:1681-1688 https://dx.doi.org/10.1007/s00125-019-4936-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 62 2019 9 03 07 1681-1688 |
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Enthalten in Diabetologia 62(2019), 9 vom: 03. Juli, Seite 1681-1688 volume:62 year:2019 number:9 day:03 month:07 pages:1681-1688 |
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Autoimmunity B cells Follicular T helper cell Human Immunophenotyping Peripheral T helper cell T cells Type 1 diabetes |
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Ekman, Ilse @@aut@@ Ihantola, Emmi-Leena @@aut@@ Viisanen, Tyyne @@aut@@ Rao, Deepak A. @@aut@@ Näntö-Salonen, Kirsti @@aut@@ Knip, Mikael @@aut@@ Veijola, Riitta @@aut@@ Toppari, Jorma @@aut@@ Ilonen, Jorma @@aut@@ Kinnunen, Tuure @@aut@@ |
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Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role of a recently described subset, C-X-C motif chemokine receptor type 5-negative, programmed cell death protein 1-positive ($ CXCR5^{−} $PD-$ 1^{hi} $) peripheral T helper (Tph) cells, in human type 1 diabetes. Methods The phenotype of blood $ CXCR5^{−} $PD-$ 1^{hi} $ $ CD4^{+} $ T cells was analysed by multicolour flow cytometry. The frequencies of circulating $ CXCR5^{−} $PD-$ 1^{hi} $ T cells were analysed in a cohort of 44 children with newly diagnosed type 1 diabetes, 40 autoantibody-positive ($ AAb^{+} $) at-risk children and 84 autoantibody-negative healthy control children, and the findings were replicated in a separate cohort of 15 children with newly diagnosed type 1 diabetes and 15 healthy control children. Results Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells share several features associated with B cell helper function with circulating $ CXCR5^{+} $PD-$ 1^{hi} $ follicular T helper (Tfh) cells. Moreover, the frequency of circulating Tph cells was increased in children with newly diagnosed type 1 diabetes, especially in those who are positive for multiple autoantibodies. Importantly, circulating Tph cells were also increased in autoantibody-positive at-risk children who later progressed to type 1 diabetes. Conclusions/interpretation Our results demonstrate that circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells are associated with progression to clinical type 1 diabetes. 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|
| author |
Ekman, Ilse |
| spellingShingle |
Ekman, Ilse misc Autoimmunity misc B cells misc Follicular T helper cell misc Human misc Immunophenotyping misc Peripheral T helper cell misc T cells misc Type 1 diabetes Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes |
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Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes Autoimmunity (dpeaa)DE-He213 B cells (dpeaa)DE-He213 Follicular T helper cell (dpeaa)DE-He213 Human (dpeaa)DE-He213 Immunophenotyping (dpeaa)DE-He213 Peripheral T helper cell (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Type 1 diabetes (dpeaa)DE-He213 |
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misc Autoimmunity misc B cells misc Follicular T helper cell misc Human misc Immunophenotyping misc Peripheral T helper cell misc T cells misc Type 1 diabetes |
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misc Autoimmunity misc B cells misc Follicular T helper cell misc Human misc Immunophenotyping misc Peripheral T helper cell misc T cells misc Type 1 diabetes |
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misc Autoimmunity misc B cells misc Follicular T helper cell misc Human misc Immunophenotyping misc Peripheral T helper cell misc T cells misc Type 1 diabetes |
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Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes |
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Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes |
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Ekman, Ilse |
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Diabetologia |
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Ekman, Ilse Ihantola, Emmi-Leena Viisanen, Tyyne Rao, Deepak A. Näntö-Salonen, Kirsti Knip, Mikael Veijola, Riitta Toppari, Jorma Ilonen, Jorma Kinnunen, Tuure |
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Elektronische Aufsätze |
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Ekman, Ilse |
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10.1007/s00125-019-4936-8 |
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circulating $ cxcr5^{−} $pd-$ 1^{hi} $ peripheral t helper cells are associated with progression to type 1 diabetes |
| title_auth |
Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes |
| abstract |
Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role of a recently described subset, C-X-C motif chemokine receptor type 5-negative, programmed cell death protein 1-positive ($ CXCR5^{−} $PD-$ 1^{hi} $) peripheral T helper (Tph) cells, in human type 1 diabetes. Methods The phenotype of blood $ CXCR5^{−} $PD-$ 1^{hi} $ $ CD4^{+} $ T cells was analysed by multicolour flow cytometry. The frequencies of circulating $ CXCR5^{−} $PD-$ 1^{hi} $ T cells were analysed in a cohort of 44 children with newly diagnosed type 1 diabetes, 40 autoantibody-positive ($ AAb^{+} $) at-risk children and 84 autoantibody-negative healthy control children, and the findings were replicated in a separate cohort of 15 children with newly diagnosed type 1 diabetes and 15 healthy control children. Results Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells share several features associated with B cell helper function with circulating $ CXCR5^{+} $PD-$ 1^{hi} $ follicular T helper (Tfh) cells. Moreover, the frequency of circulating Tph cells was increased in children with newly diagnosed type 1 diabetes, especially in those who are positive for multiple autoantibodies. Importantly, circulating Tph cells were also increased in autoantibody-positive at-risk children who later progressed to type 1 diabetes. Conclusions/interpretation Our results demonstrate that circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells are associated with progression to clinical type 1 diabetes. Consequently, Tph cells could have potential both as a biomarker of disease progression and as a target for immunotherapy in type 1 diabetes. © The Author(s) 2019 |
| abstractGer |
Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role of a recently described subset, C-X-C motif chemokine receptor type 5-negative, programmed cell death protein 1-positive ($ CXCR5^{−} $PD-$ 1^{hi} $) peripheral T helper (Tph) cells, in human type 1 diabetes. Methods The phenotype of blood $ CXCR5^{−} $PD-$ 1^{hi} $ $ CD4^{+} $ T cells was analysed by multicolour flow cytometry. The frequencies of circulating $ CXCR5^{−} $PD-$ 1^{hi} $ T cells were analysed in a cohort of 44 children with newly diagnosed type 1 diabetes, 40 autoantibody-positive ($ AAb^{+} $) at-risk children and 84 autoantibody-negative healthy control children, and the findings were replicated in a separate cohort of 15 children with newly diagnosed type 1 diabetes and 15 healthy control children. Results Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells share several features associated with B cell helper function with circulating $ CXCR5^{+} $PD-$ 1^{hi} $ follicular T helper (Tfh) cells. Moreover, the frequency of circulating Tph cells was increased in children with newly diagnosed type 1 diabetes, especially in those who are positive for multiple autoantibodies. Importantly, circulating Tph cells were also increased in autoantibody-positive at-risk children who later progressed to type 1 diabetes. Conclusions/interpretation Our results demonstrate that circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells are associated with progression to clinical type 1 diabetes. Consequently, Tph cells could have potential both as a biomarker of disease progression and as a target for immunotherapy in type 1 diabetes. © The Author(s) 2019 |
| abstract_unstemmed |
Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role of a recently described subset, C-X-C motif chemokine receptor type 5-negative, programmed cell death protein 1-positive ($ CXCR5^{−} $PD-$ 1^{hi} $) peripheral T helper (Tph) cells, in human type 1 diabetes. Methods The phenotype of blood $ CXCR5^{−} $PD-$ 1^{hi} $ $ CD4^{+} $ T cells was analysed by multicolour flow cytometry. The frequencies of circulating $ CXCR5^{−} $PD-$ 1^{hi} $ T cells were analysed in a cohort of 44 children with newly diagnosed type 1 diabetes, 40 autoantibody-positive ($ AAb^{+} $) at-risk children and 84 autoantibody-negative healthy control children, and the findings were replicated in a separate cohort of 15 children with newly diagnosed type 1 diabetes and 15 healthy control children. Results Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells share several features associated with B cell helper function with circulating $ CXCR5^{+} $PD-$ 1^{hi} $ follicular T helper (Tfh) cells. Moreover, the frequency of circulating Tph cells was increased in children with newly diagnosed type 1 diabetes, especially in those who are positive for multiple autoantibodies. Importantly, circulating Tph cells were also increased in autoantibody-positive at-risk children who later progressed to type 1 diabetes. Conclusions/interpretation Our results demonstrate that circulating $ CXCR5^{−} $PD-$ 1^{hi} $ Tph cells are associated with progression to clinical type 1 diabetes. Consequently, Tph cells could have potential both as a biomarker of disease progression and as a target for immunotherapy in type 1 diabetes. © The Author(s) 2019 |
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Circulating $ CXCR5^{−} $PD-$ 1^{hi} $ peripheral T helper cells are associated with progression to type 1 diabetes |
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Ihantola, Emmi-Leena Viisanen, Tyyne Rao, Deepak A. Näntö-Salonen, Kirsti Knip, Mikael Veijola, Riitta Toppari, Jorma Ilonen, Jorma Kinnunen, Tuure |
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| score |
7.400943 |