Tubular proteinuria and enzymuria following open heart surgery
Objective We investigated the effect of cardiac surgery on a marker of tubular damage, an enzyme called neutral endopeptidase (NEP), and on a marker of tubular function, retinol binding protein (RBP). Markers of tubular damage or function are useful in the early detection of acute renal failure and...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Blaikley, John [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2003 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2003 |
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| Übergeordnetes Werk: |
Enthalten in: Intensive care medicine - Berlin : Springer, 1975, 29(2003), 8 vom: 10. Juli, Seite 1364-1367 |
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| Übergeordnetes Werk: |
volume:29 ; year:2003 ; number:8 ; day:10 ; month:07 ; pages:1364-1367 |
| Links: |
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| DOI / URN: |
10.1007/s00134-003-1876-y |
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SPR001181378 |
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| 100 | 1 | |a Blaikley, John |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Tubular proteinuria and enzymuria following open heart surgery |
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| 520 | |a Objective We investigated the effect of cardiac surgery on a marker of tubular damage, an enzyme called neutral endopeptidase (NEP), and on a marker of tubular function, retinol binding protein (RBP). Markers of tubular damage or function are useful in the early detection of acute renal failure and help identify the risk factors for this disease. We also examined if colloid interfered with NEP measurement. Design A controlled prospective cohort study. Setting A teaching cardio-thoracic unit in London, England. Patients and participants Thirty-four patients underwent cardiac surgery. Eight patients waiting for cardiac surgery acted as controls. Interventions Twenty-five patients had coronary artery bypass graft, four patients had valve replacements, one patient had a coronary artery bypass graft with a valve replacement and one patient had a left ventricular aneurysm repair. Measurements and Results Neutral endopeptidase was measured in all the patients and controls. In separate subgroups RBP (n=5) and Gelofusine use (n=12) were recorded. Urine samples were collected pre-operatively, 3 h, 1 and 4 days post-operatively. NEP rose significantly (p<0.05) after cardiac surgery compared with the control population. RBP also rose significantly (p<0.05) after cardiac surgery. NEP correlated with RBP 3 h post-operatively (p<0.05, r2=0.97). There was no correlation between the amount of Gelofusine given and NEP excretion. Conclusion Excretion of NEP and RBP were both increased after cardiac surgery. Colloid did not affect the excretion of NEP, although in other studies it has affected the excretion of RBP. This may make NEP excretion a better index of acute and impending renal damage following cardiac surgery. | ||
| 650 | 4 | |a Cardiopulmonary bypass |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neutral endopeptidase |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Acute renal failure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Proteinuria |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Sutton, Peter |4 aut | |
| 700 | 1 | |a Walter, Mary |4 aut | |
| 700 | 1 | |a Lapsley, Martha |4 aut | |
| 700 | 1 | |a Norden, Anthony |4 aut | |
| 700 | 1 | |a Pugsley, Wilf |4 aut | |
| 700 | 1 | |a Unwin, Robert |4 aut | |
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10.1007/s00134-003-1876-y doi (DE-627)SPR001181378 (SPR)s00134-003-1876-y-e DE-627 ger DE-627 rakwb eng Blaikley, John verfasserin aut Tubular proteinuria and enzymuria following open heart surgery 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Objective We investigated the effect of cardiac surgery on a marker of tubular damage, an enzyme called neutral endopeptidase (NEP), and on a marker of tubular function, retinol binding protein (RBP). Markers of tubular damage or function are useful in the early detection of acute renal failure and help identify the risk factors for this disease. We also examined if colloid interfered with NEP measurement. Design A controlled prospective cohort study. Setting A teaching cardio-thoracic unit in London, England. Patients and participants Thirty-four patients underwent cardiac surgery. Eight patients waiting for cardiac surgery acted as controls. Interventions Twenty-five patients had coronary artery bypass graft, four patients had valve replacements, one patient had a coronary artery bypass graft with a valve replacement and one patient had a left ventricular aneurysm repair. Measurements and Results Neutral endopeptidase was measured in all the patients and controls. In separate subgroups RBP (n=5) and Gelofusine use (n=12) were recorded. Urine samples were collected pre-operatively, 3 h, 1 and 4 days post-operatively. NEP rose significantly (p<0.05) after cardiac surgery compared with the control population. RBP also rose significantly (p<0.05) after cardiac surgery. NEP correlated with RBP 3 h post-operatively (p<0.05, r2=0.97). There was no correlation between the amount of Gelofusine given and NEP excretion. Conclusion Excretion of NEP and RBP were both increased after cardiac surgery. Colloid did not affect the excretion of NEP, although in other studies it has affected the excretion of RBP. This may make NEP excretion a better index of acute and impending renal damage following cardiac surgery. Cardiopulmonary bypass (dpeaa)DE-He213 Neutral endopeptidase (dpeaa)DE-He213 Acute renal failure (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Sutton, Peter aut Walter, Mary aut Lapsley, Martha aut Norden, Anthony aut Pugsley, Wilf aut Unwin, Robert aut Enthalten in Intensive care medicine Berlin : Springer, 1975 29(2003), 8 vom: 10. Juli, Seite 1364-1367 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:29 year:2003 number:8 day:10 month:07 pages:1364-1367 https://dx.doi.org/10.1007/s00134-003-1876-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2003 8 10 07 1364-1367 |
| spelling |
10.1007/s00134-003-1876-y doi (DE-627)SPR001181378 (SPR)s00134-003-1876-y-e DE-627 ger DE-627 rakwb eng Blaikley, John verfasserin aut Tubular proteinuria and enzymuria following open heart surgery 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Objective We investigated the effect of cardiac surgery on a marker of tubular damage, an enzyme called neutral endopeptidase (NEP), and on a marker of tubular function, retinol binding protein (RBP). Markers of tubular damage or function are useful in the early detection of acute renal failure and help identify the risk factors for this disease. We also examined if colloid interfered with NEP measurement. Design A controlled prospective cohort study. Setting A teaching cardio-thoracic unit in London, England. Patients and participants Thirty-four patients underwent cardiac surgery. Eight patients waiting for cardiac surgery acted as controls. Interventions Twenty-five patients had coronary artery bypass graft, four patients had valve replacements, one patient had a coronary artery bypass graft with a valve replacement and one patient had a left ventricular aneurysm repair. Measurements and Results Neutral endopeptidase was measured in all the patients and controls. In separate subgroups RBP (n=5) and Gelofusine use (n=12) were recorded. Urine samples were collected pre-operatively, 3 h, 1 and 4 days post-operatively. NEP rose significantly (p<0.05) after cardiac surgery compared with the control population. RBP also rose significantly (p<0.05) after cardiac surgery. NEP correlated with RBP 3 h post-operatively (p<0.05, r2=0.97). There was no correlation between the amount of Gelofusine given and NEP excretion. Conclusion Excretion of NEP and RBP were both increased after cardiac surgery. Colloid did not affect the excretion of NEP, although in other studies it has affected the excretion of RBP. This may make NEP excretion a better index of acute and impending renal damage following cardiac surgery. Cardiopulmonary bypass (dpeaa)DE-He213 Neutral endopeptidase (dpeaa)DE-He213 Acute renal failure (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Sutton, Peter aut Walter, Mary aut Lapsley, Martha aut Norden, Anthony aut Pugsley, Wilf aut Unwin, Robert aut Enthalten in Intensive care medicine Berlin : Springer, 1975 29(2003), 8 vom: 10. Juli, Seite 1364-1367 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:29 year:2003 number:8 day:10 month:07 pages:1364-1367 https://dx.doi.org/10.1007/s00134-003-1876-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2003 8 10 07 1364-1367 |
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10.1007/s00134-003-1876-y doi (DE-627)SPR001181378 (SPR)s00134-003-1876-y-e DE-627 ger DE-627 rakwb eng Blaikley, John verfasserin aut Tubular proteinuria and enzymuria following open heart surgery 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Objective We investigated the effect of cardiac surgery on a marker of tubular damage, an enzyme called neutral endopeptidase (NEP), and on a marker of tubular function, retinol binding protein (RBP). Markers of tubular damage or function are useful in the early detection of acute renal failure and help identify the risk factors for this disease. We also examined if colloid interfered with NEP measurement. Design A controlled prospective cohort study. Setting A teaching cardio-thoracic unit in London, England. Patients and participants Thirty-four patients underwent cardiac surgery. Eight patients waiting for cardiac surgery acted as controls. Interventions Twenty-five patients had coronary artery bypass graft, four patients had valve replacements, one patient had a coronary artery bypass graft with a valve replacement and one patient had a left ventricular aneurysm repair. Measurements and Results Neutral endopeptidase was measured in all the patients and controls. In separate subgroups RBP (n=5) and Gelofusine use (n=12) were recorded. Urine samples were collected pre-operatively, 3 h, 1 and 4 days post-operatively. NEP rose significantly (p<0.05) after cardiac surgery compared with the control population. RBP also rose significantly (p<0.05) after cardiac surgery. NEP correlated with RBP 3 h post-operatively (p<0.05, r2=0.97). There was no correlation between the amount of Gelofusine given and NEP excretion. Conclusion Excretion of NEP and RBP were both increased after cardiac surgery. Colloid did not affect the excretion of NEP, although in other studies it has affected the excretion of RBP. This may make NEP excretion a better index of acute and impending renal damage following cardiac surgery. Cardiopulmonary bypass (dpeaa)DE-He213 Neutral endopeptidase (dpeaa)DE-He213 Acute renal failure (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Sutton, Peter aut Walter, Mary aut Lapsley, Martha aut Norden, Anthony aut Pugsley, Wilf aut Unwin, Robert aut Enthalten in Intensive care medicine Berlin : Springer, 1975 29(2003), 8 vom: 10. Juli, Seite 1364-1367 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:29 year:2003 number:8 day:10 month:07 pages:1364-1367 https://dx.doi.org/10.1007/s00134-003-1876-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2003 8 10 07 1364-1367 |
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10.1007/s00134-003-1876-y doi (DE-627)SPR001181378 (SPR)s00134-003-1876-y-e DE-627 ger DE-627 rakwb eng Blaikley, John verfasserin aut Tubular proteinuria and enzymuria following open heart surgery 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Objective We investigated the effect of cardiac surgery on a marker of tubular damage, an enzyme called neutral endopeptidase (NEP), and on a marker of tubular function, retinol binding protein (RBP). Markers of tubular damage or function are useful in the early detection of acute renal failure and help identify the risk factors for this disease. We also examined if colloid interfered with NEP measurement. Design A controlled prospective cohort study. Setting A teaching cardio-thoracic unit in London, England. Patients and participants Thirty-four patients underwent cardiac surgery. Eight patients waiting for cardiac surgery acted as controls. Interventions Twenty-five patients had coronary artery bypass graft, four patients had valve replacements, one patient had a coronary artery bypass graft with a valve replacement and one patient had a left ventricular aneurysm repair. Measurements and Results Neutral endopeptidase was measured in all the patients and controls. In separate subgroups RBP (n=5) and Gelofusine use (n=12) were recorded. Urine samples were collected pre-operatively, 3 h, 1 and 4 days post-operatively. NEP rose significantly (p<0.05) after cardiac surgery compared with the control population. RBP also rose significantly (p<0.05) after cardiac surgery. NEP correlated with RBP 3 h post-operatively (p<0.05, r2=0.97). There was no correlation between the amount of Gelofusine given and NEP excretion. Conclusion Excretion of NEP and RBP were both increased after cardiac surgery. Colloid did not affect the excretion of NEP, although in other studies it has affected the excretion of RBP. This may make NEP excretion a better index of acute and impending renal damage following cardiac surgery. Cardiopulmonary bypass (dpeaa)DE-He213 Neutral endopeptidase (dpeaa)DE-He213 Acute renal failure (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Sutton, Peter aut Walter, Mary aut Lapsley, Martha aut Norden, Anthony aut Pugsley, Wilf aut Unwin, Robert aut Enthalten in Intensive care medicine Berlin : Springer, 1975 29(2003), 8 vom: 10. Juli, Seite 1364-1367 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:29 year:2003 number:8 day:10 month:07 pages:1364-1367 https://dx.doi.org/10.1007/s00134-003-1876-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2003 8 10 07 1364-1367 |
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10.1007/s00134-003-1876-y doi (DE-627)SPR001181378 (SPR)s00134-003-1876-y-e DE-627 ger DE-627 rakwb eng Blaikley, John verfasserin aut Tubular proteinuria and enzymuria following open heart surgery 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Objective We investigated the effect of cardiac surgery on a marker of tubular damage, an enzyme called neutral endopeptidase (NEP), and on a marker of tubular function, retinol binding protein (RBP). Markers of tubular damage or function are useful in the early detection of acute renal failure and help identify the risk factors for this disease. We also examined if colloid interfered with NEP measurement. Design A controlled prospective cohort study. Setting A teaching cardio-thoracic unit in London, England. Patients and participants Thirty-four patients underwent cardiac surgery. Eight patients waiting for cardiac surgery acted as controls. Interventions Twenty-five patients had coronary artery bypass graft, four patients had valve replacements, one patient had a coronary artery bypass graft with a valve replacement and one patient had a left ventricular aneurysm repair. Measurements and Results Neutral endopeptidase was measured in all the patients and controls. In separate subgroups RBP (n=5) and Gelofusine use (n=12) were recorded. Urine samples were collected pre-operatively, 3 h, 1 and 4 days post-operatively. NEP rose significantly (p<0.05) after cardiac surgery compared with the control population. RBP also rose significantly (p<0.05) after cardiac surgery. NEP correlated with RBP 3 h post-operatively (p<0.05, r2=0.97). There was no correlation between the amount of Gelofusine given and NEP excretion. Conclusion Excretion of NEP and RBP were both increased after cardiac surgery. Colloid did not affect the excretion of NEP, although in other studies it has affected the excretion of RBP. This may make NEP excretion a better index of acute and impending renal damage following cardiac surgery. Cardiopulmonary bypass (dpeaa)DE-He213 Neutral endopeptidase (dpeaa)DE-He213 Acute renal failure (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Sutton, Peter aut Walter, Mary aut Lapsley, Martha aut Norden, Anthony aut Pugsley, Wilf aut Unwin, Robert aut Enthalten in Intensive care medicine Berlin : Springer, 1975 29(2003), 8 vom: 10. Juli, Seite 1364-1367 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:29 year:2003 number:8 day:10 month:07 pages:1364-1367 https://dx.doi.org/10.1007/s00134-003-1876-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2003 8 10 07 1364-1367 |
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Enthalten in Intensive care medicine 29(2003), 8 vom: 10. Juli, Seite 1364-1367 volume:29 year:2003 number:8 day:10 month:07 pages:1364-1367 |
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Enthalten in Intensive care medicine 29(2003), 8 vom: 10. Juli, Seite 1364-1367 volume:29 year:2003 number:8 day:10 month:07 pages:1364-1367 |
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Cardiopulmonary bypass Neutral endopeptidase Acute renal failure Proteinuria |
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Blaikley, John @@aut@@ Sutton, Peter @@aut@@ Walter, Mary @@aut@@ Lapsley, Martha @@aut@@ Norden, Anthony @@aut@@ Pugsley, Wilf @@aut@@ Unwin, Robert @@aut@@ |
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Markers of tubular damage or function are useful in the early detection of acute renal failure and help identify the risk factors for this disease. We also examined if colloid interfered with NEP measurement. Design A controlled prospective cohort study. Setting A teaching cardio-thoracic unit in London, England. Patients and participants Thirty-four patients underwent cardiac surgery. Eight patients waiting for cardiac surgery acted as controls. Interventions Twenty-five patients had coronary artery bypass graft, four patients had valve replacements, one patient had a coronary artery bypass graft with a valve replacement and one patient had a left ventricular aneurysm repair. Measurements and Results Neutral endopeptidase was measured in all the patients and controls. In separate subgroups RBP (n=5) and Gelofusine use (n=12) were recorded. Urine samples were collected pre-operatively, 3 h, 1 and 4 days post-operatively. NEP rose significantly (p<0.05) after cardiac surgery compared with the control population. RBP also rose significantly (p<0.05) after cardiac surgery. NEP correlated with RBP 3 h post-operatively (p<0.05, r2=0.97). There was no correlation between the amount of Gelofusine given and NEP excretion. Conclusion Excretion of NEP and RBP were both increased after cardiac surgery. Colloid did not affect the excretion of NEP, although in other studies it has affected the excretion of RBP. 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Blaikley, John |
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Blaikley, John misc Cardiopulmonary bypass misc Neutral endopeptidase misc Acute renal failure misc Proteinuria Tubular proteinuria and enzymuria following open heart surgery |
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Tubular proteinuria and enzymuria following open heart surgery Cardiopulmonary bypass (dpeaa)DE-He213 Neutral endopeptidase (dpeaa)DE-He213 Acute renal failure (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 |
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misc Cardiopulmonary bypass misc Neutral endopeptidase misc Acute renal failure misc Proteinuria |
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misc Cardiopulmonary bypass misc Neutral endopeptidase misc Acute renal failure misc Proteinuria |
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Tubular proteinuria and enzymuria following open heart surgery |
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Tubular proteinuria and enzymuria following open heart surgery |
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Blaikley, John Sutton, Peter Walter, Mary Lapsley, Martha Norden, Anthony Pugsley, Wilf Unwin, Robert |
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tubular proteinuria and enzymuria following open heart surgery |
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Tubular proteinuria and enzymuria following open heart surgery |
| abstract |
Objective We investigated the effect of cardiac surgery on a marker of tubular damage, an enzyme called neutral endopeptidase (NEP), and on a marker of tubular function, retinol binding protein (RBP). Markers of tubular damage or function are useful in the early detection of acute renal failure and help identify the risk factors for this disease. We also examined if colloid interfered with NEP measurement. Design A controlled prospective cohort study. Setting A teaching cardio-thoracic unit in London, England. Patients and participants Thirty-four patients underwent cardiac surgery. Eight patients waiting for cardiac surgery acted as controls. Interventions Twenty-five patients had coronary artery bypass graft, four patients had valve replacements, one patient had a coronary artery bypass graft with a valve replacement and one patient had a left ventricular aneurysm repair. Measurements and Results Neutral endopeptidase was measured in all the patients and controls. In separate subgroups RBP (n=5) and Gelofusine use (n=12) were recorded. Urine samples were collected pre-operatively, 3 h, 1 and 4 days post-operatively. NEP rose significantly (p<0.05) after cardiac surgery compared with the control population. RBP also rose significantly (p<0.05) after cardiac surgery. NEP correlated with RBP 3 h post-operatively (p<0.05, r2=0.97). There was no correlation between the amount of Gelofusine given and NEP excretion. Conclusion Excretion of NEP and RBP were both increased after cardiac surgery. Colloid did not affect the excretion of NEP, although in other studies it has affected the excretion of RBP. This may make NEP excretion a better index of acute and impending renal damage following cardiac surgery. © Springer-Verlag 2003 |
| abstractGer |
Objective We investigated the effect of cardiac surgery on a marker of tubular damage, an enzyme called neutral endopeptidase (NEP), and on a marker of tubular function, retinol binding protein (RBP). Markers of tubular damage or function are useful in the early detection of acute renal failure and help identify the risk factors for this disease. We also examined if colloid interfered with NEP measurement. Design A controlled prospective cohort study. Setting A teaching cardio-thoracic unit in London, England. Patients and participants Thirty-four patients underwent cardiac surgery. Eight patients waiting for cardiac surgery acted as controls. Interventions Twenty-five patients had coronary artery bypass graft, four patients had valve replacements, one patient had a coronary artery bypass graft with a valve replacement and one patient had a left ventricular aneurysm repair. Measurements and Results Neutral endopeptidase was measured in all the patients and controls. In separate subgroups RBP (n=5) and Gelofusine use (n=12) were recorded. Urine samples were collected pre-operatively, 3 h, 1 and 4 days post-operatively. NEP rose significantly (p<0.05) after cardiac surgery compared with the control population. RBP also rose significantly (p<0.05) after cardiac surgery. NEP correlated with RBP 3 h post-operatively (p<0.05, r2=0.97). There was no correlation between the amount of Gelofusine given and NEP excretion. Conclusion Excretion of NEP and RBP were both increased after cardiac surgery. Colloid did not affect the excretion of NEP, although in other studies it has affected the excretion of RBP. This may make NEP excretion a better index of acute and impending renal damage following cardiac surgery. © Springer-Verlag 2003 |
| abstract_unstemmed |
Objective We investigated the effect of cardiac surgery on a marker of tubular damage, an enzyme called neutral endopeptidase (NEP), and on a marker of tubular function, retinol binding protein (RBP). Markers of tubular damage or function are useful in the early detection of acute renal failure and help identify the risk factors for this disease. We also examined if colloid interfered with NEP measurement. Design A controlled prospective cohort study. Setting A teaching cardio-thoracic unit in London, England. Patients and participants Thirty-four patients underwent cardiac surgery. Eight patients waiting for cardiac surgery acted as controls. Interventions Twenty-five patients had coronary artery bypass graft, four patients had valve replacements, one patient had a coronary artery bypass graft with a valve replacement and one patient had a left ventricular aneurysm repair. Measurements and Results Neutral endopeptidase was measured in all the patients and controls. In separate subgroups RBP (n=5) and Gelofusine use (n=12) were recorded. Urine samples were collected pre-operatively, 3 h, 1 and 4 days post-operatively. NEP rose significantly (p<0.05) after cardiac surgery compared with the control population. RBP also rose significantly (p<0.05) after cardiac surgery. NEP correlated with RBP 3 h post-operatively (p<0.05, r2=0.97). There was no correlation between the amount of Gelofusine given and NEP excretion. Conclusion Excretion of NEP and RBP were both increased after cardiac surgery. Colloid did not affect the excretion of NEP, although in other studies it has affected the excretion of RBP. This may make NEP excretion a better index of acute and impending renal damage following cardiac surgery. © Springer-Verlag 2003 |
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Tubular proteinuria and enzymuria following open heart surgery |
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Sutton, Peter Walter, Mary Lapsley, Martha Norden, Anthony Pugsley, Wilf Unwin, Robert |
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| score |
7.3984165 |