Effect of tidal volume in children with acute hypoxemic respiratory failure

Objectives To determine if tidal volume (VT) between 6 and 10 ml/kg body weight using pressure control ventilation affects outcome for children with acute hypoxemic respiratory failure (AHRF) or acute lung injury (ALI). To validate lung injury severity markers such as oxygenation index (OI), $ PaO_{...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Khemani, Robinder G. [verfasserIn] Conti, David Alonzo, Todd A. Bart, Robert D. Newth, Christopher J. L.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Pediatrics Positive pressure respiration Lung volume measurements

Anmerkung:	© Springer-Verlag 2009

Übergeordnetes Werk:	Enthalten in: Intensive care medicine - Berlin : Springer, 1975, 35(2009), 8 vom: 17. Juni, Seite 1428-1437
Übergeordnetes Werk:	volume:35 ; year:2009 ; number:8 ; day:17 ; month:06 ; pages:1428-1437

Links:	Volltext

DOI / URN:	10.1007/s00134-009-1527-z

Katalog-ID:	SPR001206486

Internformat


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100	1		\|a Khemani, Robinder G. \|e verfasserin \|4 aut
245	1	0	\|a Effect of tidal volume in children with acute hypoxemic respiratory failure
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520			\|a Objectives To determine if tidal volume (VT) between 6 and 10 ml/kg body weight using pressure control ventilation affects outcome for children with acute hypoxemic respiratory failure (AHRF) or acute lung injury (ALI). To validate lung injury severity markers such as oxygenation index (OI), $ PaO_{2} $/$ FiO_{2} $ (PF) ratio, and lung injury score (LIS). Design Retrospective, January 2000–July 2007. Setting Tertiary care, 20-bed PICU. Patients Three hundred and ninety-eight endotracheally intubated and mechanically ventilated children with PF ratio <300. Outcomes were mortality and 28-day ventilator free days. Measurements and main results Three hundred and ninety-eight children met study criteria, with 20% mortality. 192 children had ALI. Using >90% pressure control ventilation, 85% of patients achieved VT less than 10 ml/kg. Median VT was not significantly different between survivors and non-survivors during the first 3 days of mechanical ventilation. After controlling for diagnostic category, age, delta P (PIP-PEEP), PEEP, and severity of lung disease, VT was not associated with mortality (P > 0.1), but higher VT at baseline and on day 1 of mechanical ventilation was associated with more ventilator free days (P < 0.05). This was particularly seen in patients with better respiratory system compliance [Crs > 0.5 ml/$ cmH_{2} $0/kg, OR = 0.70 (0.52, 0.95)]. OI, PF ratio, and LIS were all associated with mortality (P < 0.05). Conclusions When ventilating children using lung protective strategies with pressure control ventilation, observed VT is between 6 and 10 ml/kg and is not associated with increased mortality. Moreover, higher VT within this range is associated with more ventilator free days, particularly for patients with less severe disease.
650		4	\|a Pediatrics \|7 (dpeaa)DE-He213
650		4	\|a Positive pressure respiration \|7 (dpeaa)DE-He213
650		4	\|a Lung volume measurements \|7 (dpeaa)DE-He213
700	1		\|a Conti, David \|4 aut
700	1		\|a Alonzo, Todd A. \|4 aut
700	1		\|a Bart, Robert D. \|4 aut
700	1		\|a Newth, Christopher J. L. \|4 aut
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912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
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912			\|a GBV_ILN_250
912			\|a GBV_ILN_267
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
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912			\|a GBV_ILN_711
912			\|a GBV_ILN_2001
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912			\|a GBV_ILN_2004
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912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
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author_variant	r g k rg rgk d c dc t a a ta taa r d b rd rdb c j l n cjl cjln
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publishDate	2009
allfields	10.1007/s00134-009-1527-z doi (DE-627)SPR001206486 (SPR)s00134-009-1527-z-e DE-627 ger DE-627 rakwb eng Khemani, Robinder G. verfasserin aut Effect of tidal volume in children with acute hypoxemic respiratory failure 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Objectives To determine if tidal volume (VT) between 6 and 10 ml/kg body weight using pressure control ventilation affects outcome for children with acute hypoxemic respiratory failure (AHRF) or acute lung injury (ALI). To validate lung injury severity markers such as oxygenation index (OI), $ PaO_{2} $/$ FiO_{2} $ (PF) ratio, and lung injury score (LIS). Design Retrospective, January 2000–July 2007. Setting Tertiary care, 20-bed PICU. Patients Three hundred and ninety-eight endotracheally intubated and mechanically ventilated children with PF ratio <300. Outcomes were mortality and 28-day ventilator free days. Measurements and main results Three hundred and ninety-eight children met study criteria, with 20% mortality. 192 children had ALI. Using >90% pressure control ventilation, 85% of patients achieved VT less than 10 ml/kg. Median VT was not significantly different between survivors and non-survivors during the first 3 days of mechanical ventilation. After controlling for diagnostic category, age, delta P (PIP-PEEP), PEEP, and severity of lung disease, VT was not associated with mortality (P > 0.1), but higher VT at baseline and on day 1 of mechanical ventilation was associated with more ventilator free days (P < 0.05). This was particularly seen in patients with better respiratory system compliance [Crs > 0.5 ml/$ cmH_{2} $0/kg, OR = 0.70 (0.52, 0.95)]. OI, PF ratio, and LIS were all associated with mortality (P < 0.05). Conclusions When ventilating children using lung protective strategies with pressure control ventilation, observed VT is between 6 and 10 ml/kg and is not associated with increased mortality. Moreover, higher VT within this range is associated with more ventilator free days, particularly for patients with less severe disease. Pediatrics (dpeaa)DE-He213 Positive pressure respiration (dpeaa)DE-He213 Lung volume measurements (dpeaa)DE-He213 Conti, David aut Alonzo, Todd A. aut Bart, Robert D. aut Newth, Christopher J. L. aut Enthalten in Intensive care medicine Berlin : Springer, 1975 35(2009), 8 vom: 17. Juni, Seite 1428-1437 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:35 year:2009 number:8 day:17 month:06 pages:1428-1437 https://dx.doi.org/10.1007/s00134-009-1527-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2009 8 17 06 1428-1437
spelling	10.1007/s00134-009-1527-z doi (DE-627)SPR001206486 (SPR)s00134-009-1527-z-e DE-627 ger DE-627 rakwb eng Khemani, Robinder G. verfasserin aut Effect of tidal volume in children with acute hypoxemic respiratory failure 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Objectives To determine if tidal volume (VT) between 6 and 10 ml/kg body weight using pressure control ventilation affects outcome for children with acute hypoxemic respiratory failure (AHRF) or acute lung injury (ALI). To validate lung injury severity markers such as oxygenation index (OI), $ PaO_{2} $/$ FiO_{2} $ (PF) ratio, and lung injury score (LIS). Design Retrospective, January 2000–July 2007. Setting Tertiary care, 20-bed PICU. Patients Three hundred and ninety-eight endotracheally intubated and mechanically ventilated children with PF ratio <300. Outcomes were mortality and 28-day ventilator free days. Measurements and main results Three hundred and ninety-eight children met study criteria, with 20% mortality. 192 children had ALI. Using >90% pressure control ventilation, 85% of patients achieved VT less than 10 ml/kg. Median VT was not significantly different between survivors and non-survivors during the first 3 days of mechanical ventilation. After controlling for diagnostic category, age, delta P (PIP-PEEP), PEEP, and severity of lung disease, VT was not associated with mortality (P > 0.1), but higher VT at baseline and on day 1 of mechanical ventilation was associated with more ventilator free days (P < 0.05). This was particularly seen in patients with better respiratory system compliance [Crs > 0.5 ml/$ cmH_{2} $0/kg, OR = 0.70 (0.52, 0.95)]. OI, PF ratio, and LIS were all associated with mortality (P < 0.05). Conclusions When ventilating children using lung protective strategies with pressure control ventilation, observed VT is between 6 and 10 ml/kg and is not associated with increased mortality. Moreover, higher VT within this range is associated with more ventilator free days, particularly for patients with less severe disease. Pediatrics (dpeaa)DE-He213 Positive pressure respiration (dpeaa)DE-He213 Lung volume measurements (dpeaa)DE-He213 Conti, David aut Alonzo, Todd A. aut Bart, Robert D. aut Newth, Christopher J. L. aut Enthalten in Intensive care medicine Berlin : Springer, 1975 35(2009), 8 vom: 17. Juni, Seite 1428-1437 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:35 year:2009 number:8 day:17 month:06 pages:1428-1437 https://dx.doi.org/10.1007/s00134-009-1527-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2009 8 17 06 1428-1437
allfields_unstemmed	10.1007/s00134-009-1527-z doi (DE-627)SPR001206486 (SPR)s00134-009-1527-z-e DE-627 ger DE-627 rakwb eng Khemani, Robinder G. verfasserin aut Effect of tidal volume in children with acute hypoxemic respiratory failure 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Objectives To determine if tidal volume (VT) between 6 and 10 ml/kg body weight using pressure control ventilation affects outcome for children with acute hypoxemic respiratory failure (AHRF) or acute lung injury (ALI). To validate lung injury severity markers such as oxygenation index (OI), $ PaO_{2} $/$ FiO_{2} $ (PF) ratio, and lung injury score (LIS). Design Retrospective, January 2000–July 2007. Setting Tertiary care, 20-bed PICU. Patients Three hundred and ninety-eight endotracheally intubated and mechanically ventilated children with PF ratio <300. Outcomes were mortality and 28-day ventilator free days. Measurements and main results Three hundred and ninety-eight children met study criteria, with 20% mortality. 192 children had ALI. Using >90% pressure control ventilation, 85% of patients achieved VT less than 10 ml/kg. Median VT was not significantly different between survivors and non-survivors during the first 3 days of mechanical ventilation. After controlling for diagnostic category, age, delta P (PIP-PEEP), PEEP, and severity of lung disease, VT was not associated with mortality (P > 0.1), but higher VT at baseline and on day 1 of mechanical ventilation was associated with more ventilator free days (P < 0.05). This was particularly seen in patients with better respiratory system compliance [Crs > 0.5 ml/$ cmH_{2} $0/kg, OR = 0.70 (0.52, 0.95)]. OI, PF ratio, and LIS were all associated with mortality (P < 0.05). Conclusions When ventilating children using lung protective strategies with pressure control ventilation, observed VT is between 6 and 10 ml/kg and is not associated with increased mortality. Moreover, higher VT within this range is associated with more ventilator free days, particularly for patients with less severe disease. Pediatrics (dpeaa)DE-He213 Positive pressure respiration (dpeaa)DE-He213 Lung volume measurements (dpeaa)DE-He213 Conti, David aut Alonzo, Todd A. aut Bart, Robert D. aut Newth, Christopher J. L. aut Enthalten in Intensive care medicine Berlin : Springer, 1975 35(2009), 8 vom: 17. Juni, Seite 1428-1437 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:35 year:2009 number:8 day:17 month:06 pages:1428-1437 https://dx.doi.org/10.1007/s00134-009-1527-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2009 8 17 06 1428-1437
allfieldsGer	10.1007/s00134-009-1527-z doi (DE-627)SPR001206486 (SPR)s00134-009-1527-z-e DE-627 ger DE-627 rakwb eng Khemani, Robinder G. verfasserin aut Effect of tidal volume in children with acute hypoxemic respiratory failure 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Objectives To determine if tidal volume (VT) between 6 and 10 ml/kg body weight using pressure control ventilation affects outcome for children with acute hypoxemic respiratory failure (AHRF) or acute lung injury (ALI). To validate lung injury severity markers such as oxygenation index (OI), $ PaO_{2} $/$ FiO_{2} $ (PF) ratio, and lung injury score (LIS). Design Retrospective, January 2000–July 2007. Setting Tertiary care, 20-bed PICU. Patients Three hundred and ninety-eight endotracheally intubated and mechanically ventilated children with PF ratio <300. Outcomes were mortality and 28-day ventilator free days. Measurements and main results Three hundred and ninety-eight children met study criteria, with 20% mortality. 192 children had ALI. Using >90% pressure control ventilation, 85% of patients achieved VT less than 10 ml/kg. Median VT was not significantly different between survivors and non-survivors during the first 3 days of mechanical ventilation. After controlling for diagnostic category, age, delta P (PIP-PEEP), PEEP, and severity of lung disease, VT was not associated with mortality (P > 0.1), but higher VT at baseline and on day 1 of mechanical ventilation was associated with more ventilator free days (P < 0.05). This was particularly seen in patients with better respiratory system compliance [Crs > 0.5 ml/$ cmH_{2} $0/kg, OR = 0.70 (0.52, 0.95)]. OI, PF ratio, and LIS were all associated with mortality (P < 0.05). Conclusions When ventilating children using lung protective strategies with pressure control ventilation, observed VT is between 6 and 10 ml/kg and is not associated with increased mortality. Moreover, higher VT within this range is associated with more ventilator free days, particularly for patients with less severe disease. Pediatrics (dpeaa)DE-He213 Positive pressure respiration (dpeaa)DE-He213 Lung volume measurements (dpeaa)DE-He213 Conti, David aut Alonzo, Todd A. aut Bart, Robert D. aut Newth, Christopher J. L. aut Enthalten in Intensive care medicine Berlin : Springer, 1975 35(2009), 8 vom: 17. Juni, Seite 1428-1437 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:35 year:2009 number:8 day:17 month:06 pages:1428-1437 https://dx.doi.org/10.1007/s00134-009-1527-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2009 8 17 06 1428-1437
allfieldsSound	10.1007/s00134-009-1527-z doi (DE-627)SPR001206486 (SPR)s00134-009-1527-z-e DE-627 ger DE-627 rakwb eng Khemani, Robinder G. verfasserin aut Effect of tidal volume in children with acute hypoxemic respiratory failure 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Objectives To determine if tidal volume (VT) between 6 and 10 ml/kg body weight using pressure control ventilation affects outcome for children with acute hypoxemic respiratory failure (AHRF) or acute lung injury (ALI). To validate lung injury severity markers such as oxygenation index (OI), $ PaO_{2} $/$ FiO_{2} $ (PF) ratio, and lung injury score (LIS). Design Retrospective, January 2000–July 2007. Setting Tertiary care, 20-bed PICU. Patients Three hundred and ninety-eight endotracheally intubated and mechanically ventilated children with PF ratio <300. Outcomes were mortality and 28-day ventilator free days. Measurements and main results Three hundred and ninety-eight children met study criteria, with 20% mortality. 192 children had ALI. Using >90% pressure control ventilation, 85% of patients achieved VT less than 10 ml/kg. Median VT was not significantly different between survivors and non-survivors during the first 3 days of mechanical ventilation. After controlling for diagnostic category, age, delta P (PIP-PEEP), PEEP, and severity of lung disease, VT was not associated with mortality (P > 0.1), but higher VT at baseline and on day 1 of mechanical ventilation was associated with more ventilator free days (P < 0.05). This was particularly seen in patients with better respiratory system compliance [Crs > 0.5 ml/$ cmH_{2} $0/kg, OR = 0.70 (0.52, 0.95)]. OI, PF ratio, and LIS were all associated with mortality (P < 0.05). Conclusions When ventilating children using lung protective strategies with pressure control ventilation, observed VT is between 6 and 10 ml/kg and is not associated with increased mortality. Moreover, higher VT within this range is associated with more ventilator free days, particularly for patients with less severe disease. Pediatrics (dpeaa)DE-He213 Positive pressure respiration (dpeaa)DE-He213 Lung volume measurements (dpeaa)DE-He213 Conti, David aut Alonzo, Todd A. aut Bart, Robert D. aut Newth, Christopher J. L. aut Enthalten in Intensive care medicine Berlin : Springer, 1975 35(2009), 8 vom: 17. Juni, Seite 1428-1437 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:35 year:2009 number:8 day:17 month:06 pages:1428-1437 https://dx.doi.org/10.1007/s00134-009-1527-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2009 8 17 06 1428-1437
language	English
source	Enthalten in Intensive care medicine 35(2009), 8 vom: 17. Juni, Seite 1428-1437 volume:35 year:2009 number:8 day:17 month:06 pages:1428-1437
sourceStr	Enthalten in Intensive care medicine 35(2009), 8 vom: 17. Juni, Seite 1428-1437 volume:35 year:2009 number:8 day:17 month:06 pages:1428-1437
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pediatrics Positive pressure respiration Lung volume measurements
isfreeaccess_bool	false
container_title	Intensive care medicine
authorswithroles_txt_mv	Khemani, Robinder G. @@aut@@ Conti, David @@aut@@ Alonzo, Todd A. @@aut@@ Bart, Robert D. @@aut@@ Newth, Christopher J. L. @@aut@@
publishDateDaySort_date	2009-06-17T00:00:00Z
hierarchy_top_id	253724104
id	SPR001206486
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR001206486</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520011636.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2009 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00134-009-1527-z</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR001206486</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00134-009-1527-z-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Khemani, Robinder G.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Effect of tidal volume in children with acute hypoxemic respiratory failure</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2009</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer-Verlag 2009</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objectives To determine if tidal volume (VT) between 6 and 10 ml/kg body weight using pressure control ventilation affects outcome for children with acute hypoxemic respiratory failure (AHRF) or acute lung injury (ALI). To validate lung injury severity markers such as oxygenation index (OI), $ PaO_{2} $/$ FiO_{2} $ (PF) ratio, and lung injury score (LIS). Design Retrospective, January 2000–July 2007. Setting Tertiary care, 20-bed PICU. Patients Three hundred and ninety-eight endotracheally intubated and mechanically ventilated children with PF ratio <300. Outcomes were mortality and 28-day ventilator free days. Measurements and main results Three hundred and ninety-eight children met study criteria, with 20% mortality. 192 children had ALI. Using >90% pressure control ventilation, 85% of patients achieved VT less than 10 ml/kg. Median VT was not significantly different between survivors and non-survivors during the first 3 days of mechanical ventilation. After controlling for diagnostic category, age, delta P (PIP-PEEP), PEEP, and severity of lung disease, VT was not associated with mortality (P > 0.1), but higher VT at baseline and on day 1 of mechanical ventilation was associated with more ventilator free days (P < 0.05). This was particularly seen in patients with better respiratory system compliance [Crs > 0.5 ml/$ cmH_{2} $0/kg, OR = 0.70 (0.52, 0.95)]. OI, PF ratio, and LIS were all associated with mortality (P < 0.05). Conclusions When ventilating children using lung protective strategies with pressure control ventilation, observed VT is between 6 and 10 ml/kg and is not associated with increased mortality. 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author	Khemani, Robinder G.
spellingShingle	Khemani, Robinder G. misc Pediatrics misc Positive pressure respiration misc Lung volume measurements Effect of tidal volume in children with acute hypoxemic respiratory failure
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topic_title	Effect of tidal volume in children with acute hypoxemic respiratory failure Pediatrics (dpeaa)DE-He213 Positive pressure respiration (dpeaa)DE-He213 Lung volume measurements (dpeaa)DE-He213
topic	misc Pediatrics misc Positive pressure respiration misc Lung volume measurements
topic_unstemmed	misc Pediatrics misc Positive pressure respiration misc Lung volume measurements
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title	Effect of tidal volume in children with acute hypoxemic respiratory failure
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title_full	Effect of tidal volume in children with acute hypoxemic respiratory failure
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author_browse	Khemani, Robinder G. Conti, David Alonzo, Todd A. Bart, Robert D. Newth, Christopher J. L.
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format_se	Elektronische Aufsätze
author-letter	Khemani, Robinder G.
doi_str_mv	10.1007/s00134-009-1527-z
title_sort	effect of tidal volume in children with acute hypoxemic respiratory failure
title_auth	Effect of tidal volume in children with acute hypoxemic respiratory failure
abstract	Objectives To determine if tidal volume (VT) between 6 and 10 ml/kg body weight using pressure control ventilation affects outcome for children with acute hypoxemic respiratory failure (AHRF) or acute lung injury (ALI). To validate lung injury severity markers such as oxygenation index (OI), $ PaO_{2} $/$ FiO_{2} $ (PF) ratio, and lung injury score (LIS). Design Retrospective, January 2000–July 2007. Setting Tertiary care, 20-bed PICU. Patients Three hundred and ninety-eight endotracheally intubated and mechanically ventilated children with PF ratio <300. Outcomes were mortality and 28-day ventilator free days. Measurements and main results Three hundred and ninety-eight children met study criteria, with 20% mortality. 192 children had ALI. Using >90% pressure control ventilation, 85% of patients achieved VT less than 10 ml/kg. Median VT was not significantly different between survivors and non-survivors during the first 3 days of mechanical ventilation. After controlling for diagnostic category, age, delta P (PIP-PEEP), PEEP, and severity of lung disease, VT was not associated with mortality (P > 0.1), but higher VT at baseline and on day 1 of mechanical ventilation was associated with more ventilator free days (P < 0.05). This was particularly seen in patients with better respiratory system compliance [Crs > 0.5 ml/$ cmH_{2} $0/kg, OR = 0.70 (0.52, 0.95)]. OI, PF ratio, and LIS were all associated with mortality (P < 0.05). Conclusions When ventilating children using lung protective strategies with pressure control ventilation, observed VT is between 6 and 10 ml/kg and is not associated with increased mortality. Moreover, higher VT within this range is associated with more ventilator free days, particularly for patients with less severe disease. © Springer-Verlag 2009
abstractGer	Objectives To determine if tidal volume (VT) between 6 and 10 ml/kg body weight using pressure control ventilation affects outcome for children with acute hypoxemic respiratory failure (AHRF) or acute lung injury (ALI). To validate lung injury severity markers such as oxygenation index (OI), $ PaO_{2} $/$ FiO_{2} $ (PF) ratio, and lung injury score (LIS). Design Retrospective, January 2000–July 2007. Setting Tertiary care, 20-bed PICU. Patients Three hundred and ninety-eight endotracheally intubated and mechanically ventilated children with PF ratio <300. Outcomes were mortality and 28-day ventilator free days. Measurements and main results Three hundred and ninety-eight children met study criteria, with 20% mortality. 192 children had ALI. Using >90% pressure control ventilation, 85% of patients achieved VT less than 10 ml/kg. Median VT was not significantly different between survivors and non-survivors during the first 3 days of mechanical ventilation. After controlling for diagnostic category, age, delta P (PIP-PEEP), PEEP, and severity of lung disease, VT was not associated with mortality (P > 0.1), but higher VT at baseline and on day 1 of mechanical ventilation was associated with more ventilator free days (P < 0.05). This was particularly seen in patients with better respiratory system compliance [Crs > 0.5 ml/$ cmH_{2} $0/kg, OR = 0.70 (0.52, 0.95)]. OI, PF ratio, and LIS were all associated with mortality (P < 0.05). Conclusions When ventilating children using lung protective strategies with pressure control ventilation, observed VT is between 6 and 10 ml/kg and is not associated with increased mortality. Moreover, higher VT within this range is associated with more ventilator free days, particularly for patients with less severe disease. © Springer-Verlag 2009
abstract_unstemmed	Objectives To determine if tidal volume (VT) between 6 and 10 ml/kg body weight using pressure control ventilation affects outcome for children with acute hypoxemic respiratory failure (AHRF) or acute lung injury (ALI). To validate lung injury severity markers such as oxygenation index (OI), $ PaO_{2} $/$ FiO_{2} $ (PF) ratio, and lung injury score (LIS). Design Retrospective, January 2000–July 2007. Setting Tertiary care, 20-bed PICU. Patients Three hundred and ninety-eight endotracheally intubated and mechanically ventilated children with PF ratio <300. Outcomes were mortality and 28-day ventilator free days. Measurements and main results Three hundred and ninety-eight children met study criteria, with 20% mortality. 192 children had ALI. Using >90% pressure control ventilation, 85% of patients achieved VT less than 10 ml/kg. Median VT was not significantly different between survivors and non-survivors during the first 3 days of mechanical ventilation. After controlling for diagnostic category, age, delta P (PIP-PEEP), PEEP, and severity of lung disease, VT was not associated with mortality (P > 0.1), but higher VT at baseline and on day 1 of mechanical ventilation was associated with more ventilator free days (P < 0.05). This was particularly seen in patients with better respiratory system compliance [Crs > 0.5 ml/$ cmH_{2} $0/kg, OR = 0.70 (0.52, 0.95)]. OI, PF ratio, and LIS were all associated with mortality (P < 0.05). Conclusions When ventilating children using lung protective strategies with pressure control ventilation, observed VT is between 6 and 10 ml/kg and is not associated with increased mortality. Moreover, higher VT within this range is associated with more ventilator free days, particularly for patients with less severe disease. © Springer-Verlag 2009
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container_issue	8
title_short	Effect of tidal volume in children with acute hypoxemic respiratory failure
url	https://dx.doi.org/10.1007/s00134-009-1527-z
remote_bool	true
author2	Conti, David Alonzo, Todd A. Bart, Robert D. Newth, Christopher J. L.
author2Str	Conti, David Alonzo, Todd A. Bart, Robert D. Newth, Christopher J. L.
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doi_str	10.1007/s00134-009-1527-z
up_date	2024-07-03T21:01:22.775Z
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To validate lung injury severity markers such as oxygenation index (OI), $ PaO_{2} $/$ FiO_{2} $ (PF) ratio, and lung injury score (LIS). Design Retrospective, January 2000–July 2007. Setting Tertiary care, 20-bed PICU. Patients Three hundred and ninety-eight endotracheally intubated and mechanically ventilated children with PF ratio <300. Outcomes were mortality and 28-day ventilator free days. Measurements and main results Three hundred and ninety-eight children met study criteria, with 20% mortality. 192 children had ALI. Using >90% pressure control ventilation, 85% of patients achieved VT less than 10 ml/kg. Median VT was not significantly different between survivors and non-survivors during the first 3 days of mechanical ventilation. After controlling for diagnostic category, age, delta P (PIP-PEEP), PEEP, and severity of lung disease, VT was not associated with mortality (P > 0.1), but higher VT at baseline and on day 1 of mechanical ventilation was associated with more ventilator free days (P < 0.05). This was particularly seen in patients with better respiratory system compliance [Crs > 0.5 ml/$ cmH_{2} $0/kg, OR = 0.70 (0.52, 0.95)]. OI, PF ratio, and LIS were all associated with mortality (P < 0.05). Conclusions When ventilating children using lung protective strategies with pressure control ventilation, observed VT is between 6 and 10 ml/kg and is not associated with increased mortality. 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Effect of tidal volume in children with acute hypoxemic respiratory failure

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