Cardiac function in Ghanaian children with severe malaria
Purpose The aim was to assess whether impaired cardiac function contributes to symptoms of severe malaria in general or to metabolic acidosis in particular in children living in endemic regions. Methods In a prospective observational investigation, 183 children with severe malaria were investigated...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Nguah, Samuel B. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Anmerkung: |
© © jointly held by Springer and ESICM 2012 |
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| Übergeordnetes Werk: |
Enthalten in: Intensive care medicine - Berlin : Springer, 1975, 38(2012), 12 vom: 14. Aug., Seite 2032-2041 |
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| Übergeordnetes Werk: |
volume:38 ; year:2012 ; number:12 ; day:14 ; month:08 ; pages:2032-2041 |
| Links: |
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| DOI / URN: |
10.1007/s00134-012-2676-z |
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| Katalog-ID: |
SPR001215418 |
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| 100 | 1 | |a Nguah, Samuel B. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cardiac function in Ghanaian children with severe malaria |
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| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 500 | |a © © jointly held by Springer and ESICM 2012 | ||
| 520 | |a Purpose The aim was to assess whether impaired cardiac function contributes to symptoms of severe malaria in general or to metabolic acidosis in particular in children living in endemic regions. Methods In a prospective observational investigation, 183 children with severe malaria were investigated for hemodynamic status and cardiac function upon admission (day 0) and after recovery (day 42). Cardiac function parameters were assessed by cardiac ultrasonography. Blood gas analyses and cardiac enzymes were measured at hospitalization and follow-up. Differences in subgroups with and without metabolic acidosis as well as other severe malaria-defining symptoms and conditions were assessed. Results Cardiac index (CI) was significantly increased on day 0 compared to day 42 (5.8 ml/$ m^{2} $, SD ± 1.8 ml/$ m^{2} $, versus 4.7 ml/$ m^{2} $, SD ± 1.4 ml/$ m^{2} $; P < 0.001). CI correlated negatively with hemoglobin levels but not with parameters indicating impaired tissue perfusion or metabolic acidosis. Parasite levels had a significant influence on metabolic acidosis but not on CI. Alterations related to cardiac function, hemoglobin levels and metabolic acidosis were most prominent in children younger than 2 years. Conclusion Increased CI reflecting high output status is associated with low hemoglobin levels while metabolic acidosis is linked to parasite levels. | ||
| 650 | 4 | |a Severe malaria |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cardiac function |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cardiac index |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Feldt, Torsten |4 aut | |
| 700 | 1 | |a Hoffmann, Steffi |4 aut | |
| 700 | 1 | |a Pelletier, Daniel |4 aut | |
| 700 | 1 | |a Ansong, Daniel |4 aut | |
| 700 | 1 | |a Sylverken, Justice |4 aut | |
| 700 | 1 | |a Mehrfar, Parisa |4 aut | |
| 700 | 1 | |a Herr, Johanna |4 aut | |
| 700 | 1 | |a Thiel, Christian |4 aut | |
| 700 | 1 | |a Ehrhardt, Stephan |4 aut | |
| 700 | 1 | |a Burchard, Gerd D. |4 aut | |
| 700 | 1 | |a Cramer, Jakob P. |4 aut | |
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10.1007/s00134-012-2676-z doi (DE-627)SPR001215418 (SPR)s00134-012-2676-z-e DE-627 ger DE-627 rakwb eng Nguah, Samuel B. verfasserin aut Cardiac function in Ghanaian children with severe malaria 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © jointly held by Springer and ESICM 2012 Purpose The aim was to assess whether impaired cardiac function contributes to symptoms of severe malaria in general or to metabolic acidosis in particular in children living in endemic regions. Methods In a prospective observational investigation, 183 children with severe malaria were investigated for hemodynamic status and cardiac function upon admission (day 0) and after recovery (day 42). Cardiac function parameters were assessed by cardiac ultrasonography. Blood gas analyses and cardiac enzymes were measured at hospitalization and follow-up. Differences in subgroups with and without metabolic acidosis as well as other severe malaria-defining symptoms and conditions were assessed. Results Cardiac index (CI) was significantly increased on day 0 compared to day 42 (5.8 ml/$ m^{2} $, SD ± 1.8 ml/$ m^{2} $, versus 4.7 ml/$ m^{2} $, SD ± 1.4 ml/$ m^{2} $; P < 0.001). CI correlated negatively with hemoglobin levels but not with parameters indicating impaired tissue perfusion or metabolic acidosis. Parasite levels had a significant influence on metabolic acidosis but not on CI. Alterations related to cardiac function, hemoglobin levels and metabolic acidosis were most prominent in children younger than 2 years. Conclusion Increased CI reflecting high output status is associated with low hemoglobin levels while metabolic acidosis is linked to parasite levels. Severe malaria (dpeaa)DE-He213 Cardiac function (dpeaa)DE-He213 Cardiac index (dpeaa)DE-He213 Feldt, Torsten aut Hoffmann, Steffi aut Pelletier, Daniel aut Ansong, Daniel aut Sylverken, Justice aut Mehrfar, Parisa aut Herr, Johanna aut Thiel, Christian aut Ehrhardt, Stephan aut Burchard, Gerd D. aut Cramer, Jakob P. aut Enthalten in Intensive care medicine Berlin : Springer, 1975 38(2012), 12 vom: 14. Aug., Seite 2032-2041 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:38 year:2012 number:12 day:14 month:08 pages:2032-2041 https://dx.doi.org/10.1007/s00134-012-2676-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 38 2012 12 14 08 2032-2041 |
| spelling |
10.1007/s00134-012-2676-z doi (DE-627)SPR001215418 (SPR)s00134-012-2676-z-e DE-627 ger DE-627 rakwb eng Nguah, Samuel B. verfasserin aut Cardiac function in Ghanaian children with severe malaria 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © jointly held by Springer and ESICM 2012 Purpose The aim was to assess whether impaired cardiac function contributes to symptoms of severe malaria in general or to metabolic acidosis in particular in children living in endemic regions. Methods In a prospective observational investigation, 183 children with severe malaria were investigated for hemodynamic status and cardiac function upon admission (day 0) and after recovery (day 42). Cardiac function parameters were assessed by cardiac ultrasonography. Blood gas analyses and cardiac enzymes were measured at hospitalization and follow-up. Differences in subgroups with and without metabolic acidosis as well as other severe malaria-defining symptoms and conditions were assessed. Results Cardiac index (CI) was significantly increased on day 0 compared to day 42 (5.8 ml/$ m^{2} $, SD ± 1.8 ml/$ m^{2} $, versus 4.7 ml/$ m^{2} $, SD ± 1.4 ml/$ m^{2} $; P < 0.001). CI correlated negatively with hemoglobin levels but not with parameters indicating impaired tissue perfusion or metabolic acidosis. Parasite levels had a significant influence on metabolic acidosis but not on CI. Alterations related to cardiac function, hemoglobin levels and metabolic acidosis were most prominent in children younger than 2 years. Conclusion Increased CI reflecting high output status is associated with low hemoglobin levels while metabolic acidosis is linked to parasite levels. Severe malaria (dpeaa)DE-He213 Cardiac function (dpeaa)DE-He213 Cardiac index (dpeaa)DE-He213 Feldt, Torsten aut Hoffmann, Steffi aut Pelletier, Daniel aut Ansong, Daniel aut Sylverken, Justice aut Mehrfar, Parisa aut Herr, Johanna aut Thiel, Christian aut Ehrhardt, Stephan aut Burchard, Gerd D. aut Cramer, Jakob P. aut Enthalten in Intensive care medicine Berlin : Springer, 1975 38(2012), 12 vom: 14. Aug., Seite 2032-2041 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:38 year:2012 number:12 day:14 month:08 pages:2032-2041 https://dx.doi.org/10.1007/s00134-012-2676-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 38 2012 12 14 08 2032-2041 |
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10.1007/s00134-012-2676-z doi (DE-627)SPR001215418 (SPR)s00134-012-2676-z-e DE-627 ger DE-627 rakwb eng Nguah, Samuel B. verfasserin aut Cardiac function in Ghanaian children with severe malaria 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © jointly held by Springer and ESICM 2012 Purpose The aim was to assess whether impaired cardiac function contributes to symptoms of severe malaria in general or to metabolic acidosis in particular in children living in endemic regions. Methods In a prospective observational investigation, 183 children with severe malaria were investigated for hemodynamic status and cardiac function upon admission (day 0) and after recovery (day 42). Cardiac function parameters were assessed by cardiac ultrasonography. Blood gas analyses and cardiac enzymes were measured at hospitalization and follow-up. Differences in subgroups with and without metabolic acidosis as well as other severe malaria-defining symptoms and conditions were assessed. Results Cardiac index (CI) was significantly increased on day 0 compared to day 42 (5.8 ml/$ m^{2} $, SD ± 1.8 ml/$ m^{2} $, versus 4.7 ml/$ m^{2} $, SD ± 1.4 ml/$ m^{2} $; P < 0.001). CI correlated negatively with hemoglobin levels but not with parameters indicating impaired tissue perfusion or metabolic acidosis. Parasite levels had a significant influence on metabolic acidosis but not on CI. Alterations related to cardiac function, hemoglobin levels and metabolic acidosis were most prominent in children younger than 2 years. Conclusion Increased CI reflecting high output status is associated with low hemoglobin levels while metabolic acidosis is linked to parasite levels. Severe malaria (dpeaa)DE-He213 Cardiac function (dpeaa)DE-He213 Cardiac index (dpeaa)DE-He213 Feldt, Torsten aut Hoffmann, Steffi aut Pelletier, Daniel aut Ansong, Daniel aut Sylverken, Justice aut Mehrfar, Parisa aut Herr, Johanna aut Thiel, Christian aut Ehrhardt, Stephan aut Burchard, Gerd D. aut Cramer, Jakob P. aut Enthalten in Intensive care medicine Berlin : Springer, 1975 38(2012), 12 vom: 14. Aug., Seite 2032-2041 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:38 year:2012 number:12 day:14 month:08 pages:2032-2041 https://dx.doi.org/10.1007/s00134-012-2676-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 38 2012 12 14 08 2032-2041 |
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10.1007/s00134-012-2676-z doi (DE-627)SPR001215418 (SPR)s00134-012-2676-z-e DE-627 ger DE-627 rakwb eng Nguah, Samuel B. verfasserin aut Cardiac function in Ghanaian children with severe malaria 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © jointly held by Springer and ESICM 2012 Purpose The aim was to assess whether impaired cardiac function contributes to symptoms of severe malaria in general or to metabolic acidosis in particular in children living in endemic regions. Methods In a prospective observational investigation, 183 children with severe malaria were investigated for hemodynamic status and cardiac function upon admission (day 0) and after recovery (day 42). Cardiac function parameters were assessed by cardiac ultrasonography. Blood gas analyses and cardiac enzymes were measured at hospitalization and follow-up. Differences in subgroups with and without metabolic acidosis as well as other severe malaria-defining symptoms and conditions were assessed. Results Cardiac index (CI) was significantly increased on day 0 compared to day 42 (5.8 ml/$ m^{2} $, SD ± 1.8 ml/$ m^{2} $, versus 4.7 ml/$ m^{2} $, SD ± 1.4 ml/$ m^{2} $; P < 0.001). CI correlated negatively with hemoglobin levels but not with parameters indicating impaired tissue perfusion or metabolic acidosis. Parasite levels had a significant influence on metabolic acidosis but not on CI. Alterations related to cardiac function, hemoglobin levels and metabolic acidosis were most prominent in children younger than 2 years. Conclusion Increased CI reflecting high output status is associated with low hemoglobin levels while metabolic acidosis is linked to parasite levels. Severe malaria (dpeaa)DE-He213 Cardiac function (dpeaa)DE-He213 Cardiac index (dpeaa)DE-He213 Feldt, Torsten aut Hoffmann, Steffi aut Pelletier, Daniel aut Ansong, Daniel aut Sylverken, Justice aut Mehrfar, Parisa aut Herr, Johanna aut Thiel, Christian aut Ehrhardt, Stephan aut Burchard, Gerd D. aut Cramer, Jakob P. aut Enthalten in Intensive care medicine Berlin : Springer, 1975 38(2012), 12 vom: 14. Aug., Seite 2032-2041 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:38 year:2012 number:12 day:14 month:08 pages:2032-2041 https://dx.doi.org/10.1007/s00134-012-2676-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 38 2012 12 14 08 2032-2041 |
| allfieldsSound |
10.1007/s00134-012-2676-z doi (DE-627)SPR001215418 (SPR)s00134-012-2676-z-e DE-627 ger DE-627 rakwb eng Nguah, Samuel B. verfasserin aut Cardiac function in Ghanaian children with severe malaria 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © jointly held by Springer and ESICM 2012 Purpose The aim was to assess whether impaired cardiac function contributes to symptoms of severe malaria in general or to metabolic acidosis in particular in children living in endemic regions. Methods In a prospective observational investigation, 183 children with severe malaria were investigated for hemodynamic status and cardiac function upon admission (day 0) and after recovery (day 42). Cardiac function parameters were assessed by cardiac ultrasonography. Blood gas analyses and cardiac enzymes were measured at hospitalization and follow-up. Differences in subgroups with and without metabolic acidosis as well as other severe malaria-defining symptoms and conditions were assessed. Results Cardiac index (CI) was significantly increased on day 0 compared to day 42 (5.8 ml/$ m^{2} $, SD ± 1.8 ml/$ m^{2} $, versus 4.7 ml/$ m^{2} $, SD ± 1.4 ml/$ m^{2} $; P < 0.001). CI correlated negatively with hemoglobin levels but not with parameters indicating impaired tissue perfusion or metabolic acidosis. Parasite levels had a significant influence on metabolic acidosis but not on CI. Alterations related to cardiac function, hemoglobin levels and metabolic acidosis were most prominent in children younger than 2 years. Conclusion Increased CI reflecting high output status is associated with low hemoglobin levels while metabolic acidosis is linked to parasite levels. Severe malaria (dpeaa)DE-He213 Cardiac function (dpeaa)DE-He213 Cardiac index (dpeaa)DE-He213 Feldt, Torsten aut Hoffmann, Steffi aut Pelletier, Daniel aut Ansong, Daniel aut Sylverken, Justice aut Mehrfar, Parisa aut Herr, Johanna aut Thiel, Christian aut Ehrhardt, Stephan aut Burchard, Gerd D. aut Cramer, Jakob P. aut Enthalten in Intensive care medicine Berlin : Springer, 1975 38(2012), 12 vom: 14. Aug., Seite 2032-2041 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:38 year:2012 number:12 day:14 month:08 pages:2032-2041 https://dx.doi.org/10.1007/s00134-012-2676-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 38 2012 12 14 08 2032-2041 |
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Nguah, Samuel B. @@aut@@ Feldt, Torsten @@aut@@ Hoffmann, Steffi @@aut@@ Pelletier, Daniel @@aut@@ Ansong, Daniel @@aut@@ Sylverken, Justice @@aut@@ Mehrfar, Parisa @@aut@@ Herr, Johanna @@aut@@ Thiel, Christian @@aut@@ Ehrhardt, Stephan @@aut@@ Burchard, Gerd D. @@aut@@ Cramer, Jakob P. @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR001215418</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519071001.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2012 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00134-012-2676-z</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR001215418</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00134-012-2676-z-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Nguah, Samuel B.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cardiac function in Ghanaian children with severe malaria</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2012</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© © jointly held by Springer and ESICM 2012</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose The aim was to assess whether impaired cardiac function contributes to symptoms of severe malaria in general or to metabolic acidosis in particular in children living in endemic regions. Methods In a prospective observational investigation, 183 children with severe malaria were investigated for hemodynamic status and cardiac function upon admission (day 0) and after recovery (day 42). Cardiac function parameters were assessed by cardiac ultrasonography. Blood gas analyses and cardiac enzymes were measured at hospitalization and follow-up. Differences in subgroups with and without metabolic acidosis as well as other severe malaria-defining symptoms and conditions were assessed. Results Cardiac index (CI) was significantly increased on day 0 compared to day 42 (5.8 ml/$ m^{2} $, SD ± 1.8 ml/$ m^{2} $, versus 4.7 ml/$ m^{2} $, SD ± 1.4 ml/$ m^{2} $; P < 0.001). CI correlated negatively with hemoglobin levels but not with parameters indicating impaired tissue perfusion or metabolic acidosis. Parasite levels had a significant influence on metabolic acidosis but not on CI. Alterations related to cardiac function, hemoglobin levels and metabolic acidosis were most prominent in children younger than 2 years. 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Nguah, Samuel B. |
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Nguah, Samuel B. misc Severe malaria misc Cardiac function misc Cardiac index Cardiac function in Ghanaian children with severe malaria |
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Cardiac function in Ghanaian children with severe malaria Severe malaria (dpeaa)DE-He213 Cardiac function (dpeaa)DE-He213 Cardiac index (dpeaa)DE-He213 |
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Cardiac function in Ghanaian children with severe malaria |
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Nguah, Samuel B. Feldt, Torsten Hoffmann, Steffi Pelletier, Daniel Ansong, Daniel Sylverken, Justice Mehrfar, Parisa Herr, Johanna Thiel, Christian Ehrhardt, Stephan Burchard, Gerd D. Cramer, Jakob P. |
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Nguah, Samuel B. |
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10.1007/s00134-012-2676-z |
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cardiac function in ghanaian children with severe malaria |
| title_auth |
Cardiac function in Ghanaian children with severe malaria |
| abstract |
Purpose The aim was to assess whether impaired cardiac function contributes to symptoms of severe malaria in general or to metabolic acidosis in particular in children living in endemic regions. Methods In a prospective observational investigation, 183 children with severe malaria were investigated for hemodynamic status and cardiac function upon admission (day 0) and after recovery (day 42). Cardiac function parameters were assessed by cardiac ultrasonography. Blood gas analyses and cardiac enzymes were measured at hospitalization and follow-up. Differences in subgroups with and without metabolic acidosis as well as other severe malaria-defining symptoms and conditions were assessed. Results Cardiac index (CI) was significantly increased on day 0 compared to day 42 (5.8 ml/$ m^{2} $, SD ± 1.8 ml/$ m^{2} $, versus 4.7 ml/$ m^{2} $, SD ± 1.4 ml/$ m^{2} $; P < 0.001). CI correlated negatively with hemoglobin levels but not with parameters indicating impaired tissue perfusion or metabolic acidosis. Parasite levels had a significant influence on metabolic acidosis but not on CI. Alterations related to cardiac function, hemoglobin levels and metabolic acidosis were most prominent in children younger than 2 years. Conclusion Increased CI reflecting high output status is associated with low hemoglobin levels while metabolic acidosis is linked to parasite levels. © © jointly held by Springer and ESICM 2012 |
| abstractGer |
Purpose The aim was to assess whether impaired cardiac function contributes to symptoms of severe malaria in general or to metabolic acidosis in particular in children living in endemic regions. Methods In a prospective observational investigation, 183 children with severe malaria were investigated for hemodynamic status and cardiac function upon admission (day 0) and after recovery (day 42). Cardiac function parameters were assessed by cardiac ultrasonography. Blood gas analyses and cardiac enzymes were measured at hospitalization and follow-up. Differences in subgroups with and without metabolic acidosis as well as other severe malaria-defining symptoms and conditions were assessed. Results Cardiac index (CI) was significantly increased on day 0 compared to day 42 (5.8 ml/$ m^{2} $, SD ± 1.8 ml/$ m^{2} $, versus 4.7 ml/$ m^{2} $, SD ± 1.4 ml/$ m^{2} $; P < 0.001). CI correlated negatively with hemoglobin levels but not with parameters indicating impaired tissue perfusion or metabolic acidosis. Parasite levels had a significant influence on metabolic acidosis but not on CI. Alterations related to cardiac function, hemoglobin levels and metabolic acidosis were most prominent in children younger than 2 years. Conclusion Increased CI reflecting high output status is associated with low hemoglobin levels while metabolic acidosis is linked to parasite levels. © © jointly held by Springer and ESICM 2012 |
| abstract_unstemmed |
Purpose The aim was to assess whether impaired cardiac function contributes to symptoms of severe malaria in general or to metabolic acidosis in particular in children living in endemic regions. Methods In a prospective observational investigation, 183 children with severe malaria were investigated for hemodynamic status and cardiac function upon admission (day 0) and after recovery (day 42). Cardiac function parameters were assessed by cardiac ultrasonography. Blood gas analyses and cardiac enzymes were measured at hospitalization and follow-up. Differences in subgroups with and without metabolic acidosis as well as other severe malaria-defining symptoms and conditions were assessed. Results Cardiac index (CI) was significantly increased on day 0 compared to day 42 (5.8 ml/$ m^{2} $, SD ± 1.8 ml/$ m^{2} $, versus 4.7 ml/$ m^{2} $, SD ± 1.4 ml/$ m^{2} $; P < 0.001). CI correlated negatively with hemoglobin levels but not with parameters indicating impaired tissue perfusion or metabolic acidosis. Parasite levels had a significant influence on metabolic acidosis but not on CI. Alterations related to cardiac function, hemoglobin levels and metabolic acidosis were most prominent in children younger than 2 years. Conclusion Increased CI reflecting high output status is associated with low hemoglobin levels while metabolic acidosis is linked to parasite levels. © © jointly held by Springer and ESICM 2012 |
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Cardiac function in Ghanaian children with severe malaria |
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https://dx.doi.org/10.1007/s00134-012-2676-z |
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Feldt, Torsten Hoffmann, Steffi Pelletier, Daniel Ansong, Daniel Sylverken, Justice Mehrfar, Parisa Herr, Johanna Thiel, Christian Ehrhardt, Stephan Burchard, Gerd D. Cramer, Jakob P. |
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Feldt, Torsten Hoffmann, Steffi Pelletier, Daniel Ansong, Daniel Sylverken, Justice Mehrfar, Parisa Herr, Johanna Thiel, Christian Ehrhardt, Stephan Burchard, Gerd D. Cramer, Jakob P. |
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2024-07-03T21:05:17.772Z |
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| score |
7.4024706 |