Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients
Purpose Although low doses of oxygen ($ FiO_{2} $ <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing $ FiO_{2} $ on pulmonary inflammation in mechanically ventilated patients...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Fernandez, Rafael [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag Berlin Heidelberg and ESICM 2012 |
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| Übergeordnetes Werk: |
Enthalten in: Intensive care medicine - Berlin : Springer, 1975, 39(2013), 4 vom: 08. Jan., Seite 711-716 |
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| Übergeordnetes Werk: |
volume:39 ; year:2013 ; number:4 ; day:08 ; month:01 ; pages:711-716 |
| Links: |
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| DOI / URN: |
10.1007/s00134-012-2801-z |
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| Katalog-ID: |
SPR001219839 |
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| 100 | 1 | |a Fernandez, Rafael |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients |
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| 520 | |a Purpose Although low doses of oxygen ($ FiO_{2} $ <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing $ FiO_{2} $ on pulmonary inflammation in mechanically ventilated patients without respiratory failure. Methods This study was a prospective, single-center crossover study in a medical/surgical intensive care unit at a university hospital. Hemodynamically stable patients under mechanical ventilation for >24 h without severe respiratory failure ($ PaO_{2} $/$ FiO_{2} $ >250). A basal $ FiO_{2} $ of 0.40 was reduced to 0.21 provided $ SpO_{2} $ remained higher than 90 %. Patients who could not tolerate the reduction in $ FiO_{2} $ to 0.21 were excluded. Results We screened 40 patients, but only 28 (70 %) tolerated $ FiO_{2} $ 0.21. We measured common clinical variables and inflammatory mediators in plasma and in exhaled breath condensate (EBC) at the end of three 4-h periods: (1) basal ($ FiO_{2} $ 0.40), (2) after $ FiO_{2} $ reduction to 0.21, and (3) after returning $ FiO_{2} $ 0.40. We used one-way ANOVA for repeated measurements with $ FiO_{2} $ as the grouping variable. Median values of inflammatory mediators in EBC showed nonsignificant changes among the three periods: $ NO_{2} $ + $ NO_{3} $ 17.1, 14.1 and 11.0 μmol/L (p = 0.2), and 8-isoprostane 4.4, 8.2 and 5.3 pg/ml (p = 0.6) for the three periods, respectively. Plasma levels also showed nonsignificant changes during the period of the study: $ NO_{2} $ + $ NO_{3} $ 12.6, 16.3 and 15.0 μmol/L (p = 0.9), TNFα 13.5, 18.0 and 14.5 pg/ml (p = 0.8), IL-4 12.9, 18.7 and 23.9 pg/ml (p = 0.1), IL-6 50.9, 35.1 and 28.3 pg/ml (p = 0.6), and IL-10 15.2, 22.2 and 22.2 pg/ml (p = 0.7) for the three periods, respectively. Conclusion $ FiO_{2} $ 0.40 in mechanically ventilated patients without severe respiratory failure did not increase systemic or pulmonary inflammation. | ||
| 650 | 4 | |a Mechanical ventilation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Oxygen toxicity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pulmonary inflammation |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Gili, Gisela |4 aut | |
| 700 | 1 | |a Villagra, Ana |4 aut | |
| 700 | 1 | |a Lopez-Aguilar, Josefina |4 aut | |
| 700 | 1 | |a Artigas, Antonio |4 aut | |
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10.1007/s00134-012-2801-z doi (DE-627)SPR001219839 (SPR)s00134-012-2801-z-e DE-627 ger DE-627 rakwb eng Fernandez, Rafael verfasserin aut Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg and ESICM 2012 Purpose Although low doses of oxygen ($ FiO_{2} $ <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing $ FiO_{2} $ on pulmonary inflammation in mechanically ventilated patients without respiratory failure. Methods This study was a prospective, single-center crossover study in a medical/surgical intensive care unit at a university hospital. Hemodynamically stable patients under mechanical ventilation for >24 h without severe respiratory failure ($ PaO_{2} $/$ FiO_{2} $ >250). A basal $ FiO_{2} $ of 0.40 was reduced to 0.21 provided $ SpO_{2} $ remained higher than 90 %. Patients who could not tolerate the reduction in $ FiO_{2} $ to 0.21 were excluded. Results We screened 40 patients, but only 28 (70 %) tolerated $ FiO_{2} $ 0.21. We measured common clinical variables and inflammatory mediators in plasma and in exhaled breath condensate (EBC) at the end of three 4-h periods: (1) basal ($ FiO_{2} $ 0.40), (2) after $ FiO_{2} $ reduction to 0.21, and (3) after returning $ FiO_{2} $ 0.40. We used one-way ANOVA for repeated measurements with $ FiO_{2} $ as the grouping variable. Median values of inflammatory mediators in EBC showed nonsignificant changes among the three periods: $ NO_{2} $ + $ NO_{3} $ 17.1, 14.1 and 11.0 μmol/L (p = 0.2), and 8-isoprostane 4.4, 8.2 and 5.3 pg/ml (p = 0.6) for the three periods, respectively. Plasma levels also showed nonsignificant changes during the period of the study: $ NO_{2} $ + $ NO_{3} $ 12.6, 16.3 and 15.0 μmol/L (p = 0.9), TNFα 13.5, 18.0 and 14.5 pg/ml (p = 0.8), IL-4 12.9, 18.7 and 23.9 pg/ml (p = 0.1), IL-6 50.9, 35.1 and 28.3 pg/ml (p = 0.6), and IL-10 15.2, 22.2 and 22.2 pg/ml (p = 0.7) for the three periods, respectively. Conclusion $ FiO_{2} $ 0.40 in mechanically ventilated patients without severe respiratory failure did not increase systemic or pulmonary inflammation. Mechanical ventilation (dpeaa)DE-He213 Oxygen toxicity (dpeaa)DE-He213 Pulmonary inflammation (dpeaa)DE-He213 Gili, Gisela aut Villagra, Ana aut Lopez-Aguilar, Josefina aut Artigas, Antonio aut Enthalten in Intensive care medicine Berlin : Springer, 1975 39(2013), 4 vom: 08. Jan., Seite 711-716 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:39 year:2013 number:4 day:08 month:01 pages:711-716 https://dx.doi.org/10.1007/s00134-012-2801-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 39 2013 4 08 01 711-716 |
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10.1007/s00134-012-2801-z doi (DE-627)SPR001219839 (SPR)s00134-012-2801-z-e DE-627 ger DE-627 rakwb eng Fernandez, Rafael verfasserin aut Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg and ESICM 2012 Purpose Although low doses of oxygen ($ FiO_{2} $ <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing $ FiO_{2} $ on pulmonary inflammation in mechanically ventilated patients without respiratory failure. Methods This study was a prospective, single-center crossover study in a medical/surgical intensive care unit at a university hospital. Hemodynamically stable patients under mechanical ventilation for >24 h without severe respiratory failure ($ PaO_{2} $/$ FiO_{2} $ >250). A basal $ FiO_{2} $ of 0.40 was reduced to 0.21 provided $ SpO_{2} $ remained higher than 90 %. Patients who could not tolerate the reduction in $ FiO_{2} $ to 0.21 were excluded. Results We screened 40 patients, but only 28 (70 %) tolerated $ FiO_{2} $ 0.21. We measured common clinical variables and inflammatory mediators in plasma and in exhaled breath condensate (EBC) at the end of three 4-h periods: (1) basal ($ FiO_{2} $ 0.40), (2) after $ FiO_{2} $ reduction to 0.21, and (3) after returning $ FiO_{2} $ 0.40. We used one-way ANOVA for repeated measurements with $ FiO_{2} $ as the grouping variable. Median values of inflammatory mediators in EBC showed nonsignificant changes among the three periods: $ NO_{2} $ + $ NO_{3} $ 17.1, 14.1 and 11.0 μmol/L (p = 0.2), and 8-isoprostane 4.4, 8.2 and 5.3 pg/ml (p = 0.6) for the three periods, respectively. Plasma levels also showed nonsignificant changes during the period of the study: $ NO_{2} $ + $ NO_{3} $ 12.6, 16.3 and 15.0 μmol/L (p = 0.9), TNFα 13.5, 18.0 and 14.5 pg/ml (p = 0.8), IL-4 12.9, 18.7 and 23.9 pg/ml (p = 0.1), IL-6 50.9, 35.1 and 28.3 pg/ml (p = 0.6), and IL-10 15.2, 22.2 and 22.2 pg/ml (p = 0.7) for the three periods, respectively. Conclusion $ FiO_{2} $ 0.40 in mechanically ventilated patients without severe respiratory failure did not increase systemic or pulmonary inflammation. Mechanical ventilation (dpeaa)DE-He213 Oxygen toxicity (dpeaa)DE-He213 Pulmonary inflammation (dpeaa)DE-He213 Gili, Gisela aut Villagra, Ana aut Lopez-Aguilar, Josefina aut Artigas, Antonio aut Enthalten in Intensive care medicine Berlin : Springer, 1975 39(2013), 4 vom: 08. Jan., Seite 711-716 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:39 year:2013 number:4 day:08 month:01 pages:711-716 https://dx.doi.org/10.1007/s00134-012-2801-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 39 2013 4 08 01 711-716 |
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10.1007/s00134-012-2801-z doi (DE-627)SPR001219839 (SPR)s00134-012-2801-z-e DE-627 ger DE-627 rakwb eng Fernandez, Rafael verfasserin aut Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg and ESICM 2012 Purpose Although low doses of oxygen ($ FiO_{2} $ <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing $ FiO_{2} $ on pulmonary inflammation in mechanically ventilated patients without respiratory failure. Methods This study was a prospective, single-center crossover study in a medical/surgical intensive care unit at a university hospital. Hemodynamically stable patients under mechanical ventilation for >24 h without severe respiratory failure ($ PaO_{2} $/$ FiO_{2} $ >250). A basal $ FiO_{2} $ of 0.40 was reduced to 0.21 provided $ SpO_{2} $ remained higher than 90 %. Patients who could not tolerate the reduction in $ FiO_{2} $ to 0.21 were excluded. Results We screened 40 patients, but only 28 (70 %) tolerated $ FiO_{2} $ 0.21. We measured common clinical variables and inflammatory mediators in plasma and in exhaled breath condensate (EBC) at the end of three 4-h periods: (1) basal ($ FiO_{2} $ 0.40), (2) after $ FiO_{2} $ reduction to 0.21, and (3) after returning $ FiO_{2} $ 0.40. We used one-way ANOVA for repeated measurements with $ FiO_{2} $ as the grouping variable. Median values of inflammatory mediators in EBC showed nonsignificant changes among the three periods: $ NO_{2} $ + $ NO_{3} $ 17.1, 14.1 and 11.0 μmol/L (p = 0.2), and 8-isoprostane 4.4, 8.2 and 5.3 pg/ml (p = 0.6) for the three periods, respectively. Plasma levels also showed nonsignificant changes during the period of the study: $ NO_{2} $ + $ NO_{3} $ 12.6, 16.3 and 15.0 μmol/L (p = 0.9), TNFα 13.5, 18.0 and 14.5 pg/ml (p = 0.8), IL-4 12.9, 18.7 and 23.9 pg/ml (p = 0.1), IL-6 50.9, 35.1 and 28.3 pg/ml (p = 0.6), and IL-10 15.2, 22.2 and 22.2 pg/ml (p = 0.7) for the three periods, respectively. Conclusion $ FiO_{2} $ 0.40 in mechanically ventilated patients without severe respiratory failure did not increase systemic or pulmonary inflammation. Mechanical ventilation (dpeaa)DE-He213 Oxygen toxicity (dpeaa)DE-He213 Pulmonary inflammation (dpeaa)DE-He213 Gili, Gisela aut Villagra, Ana aut Lopez-Aguilar, Josefina aut Artigas, Antonio aut Enthalten in Intensive care medicine Berlin : Springer, 1975 39(2013), 4 vom: 08. Jan., Seite 711-716 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:39 year:2013 number:4 day:08 month:01 pages:711-716 https://dx.doi.org/10.1007/s00134-012-2801-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 39 2013 4 08 01 711-716 |
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10.1007/s00134-012-2801-z doi (DE-627)SPR001219839 (SPR)s00134-012-2801-z-e DE-627 ger DE-627 rakwb eng Fernandez, Rafael verfasserin aut Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg and ESICM 2012 Purpose Although low doses of oxygen ($ FiO_{2} $ <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing $ FiO_{2} $ on pulmonary inflammation in mechanically ventilated patients without respiratory failure. Methods This study was a prospective, single-center crossover study in a medical/surgical intensive care unit at a university hospital. Hemodynamically stable patients under mechanical ventilation for >24 h without severe respiratory failure ($ PaO_{2} $/$ FiO_{2} $ >250). A basal $ FiO_{2} $ of 0.40 was reduced to 0.21 provided $ SpO_{2} $ remained higher than 90 %. Patients who could not tolerate the reduction in $ FiO_{2} $ to 0.21 were excluded. Results We screened 40 patients, but only 28 (70 %) tolerated $ FiO_{2} $ 0.21. We measured common clinical variables and inflammatory mediators in plasma and in exhaled breath condensate (EBC) at the end of three 4-h periods: (1) basal ($ FiO_{2} $ 0.40), (2) after $ FiO_{2} $ reduction to 0.21, and (3) after returning $ FiO_{2} $ 0.40. We used one-way ANOVA for repeated measurements with $ FiO_{2} $ as the grouping variable. Median values of inflammatory mediators in EBC showed nonsignificant changes among the three periods: $ NO_{2} $ + $ NO_{3} $ 17.1, 14.1 and 11.0 μmol/L (p = 0.2), and 8-isoprostane 4.4, 8.2 and 5.3 pg/ml (p = 0.6) for the three periods, respectively. Plasma levels also showed nonsignificant changes during the period of the study: $ NO_{2} $ + $ NO_{3} $ 12.6, 16.3 and 15.0 μmol/L (p = 0.9), TNFα 13.5, 18.0 and 14.5 pg/ml (p = 0.8), IL-4 12.9, 18.7 and 23.9 pg/ml (p = 0.1), IL-6 50.9, 35.1 and 28.3 pg/ml (p = 0.6), and IL-10 15.2, 22.2 and 22.2 pg/ml (p = 0.7) for the three periods, respectively. Conclusion $ FiO_{2} $ 0.40 in mechanically ventilated patients without severe respiratory failure did not increase systemic or pulmonary inflammation. Mechanical ventilation (dpeaa)DE-He213 Oxygen toxicity (dpeaa)DE-He213 Pulmonary inflammation (dpeaa)DE-He213 Gili, Gisela aut Villagra, Ana aut Lopez-Aguilar, Josefina aut Artigas, Antonio aut Enthalten in Intensive care medicine Berlin : Springer, 1975 39(2013), 4 vom: 08. Jan., Seite 711-716 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:39 year:2013 number:4 day:08 month:01 pages:711-716 https://dx.doi.org/10.1007/s00134-012-2801-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 39 2013 4 08 01 711-716 |
| allfieldsSound |
10.1007/s00134-012-2801-z doi (DE-627)SPR001219839 (SPR)s00134-012-2801-z-e DE-627 ger DE-627 rakwb eng Fernandez, Rafael verfasserin aut Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg and ESICM 2012 Purpose Although low doses of oxygen ($ FiO_{2} $ <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing $ FiO_{2} $ on pulmonary inflammation in mechanically ventilated patients without respiratory failure. Methods This study was a prospective, single-center crossover study in a medical/surgical intensive care unit at a university hospital. Hemodynamically stable patients under mechanical ventilation for >24 h without severe respiratory failure ($ PaO_{2} $/$ FiO_{2} $ >250). A basal $ FiO_{2} $ of 0.40 was reduced to 0.21 provided $ SpO_{2} $ remained higher than 90 %. Patients who could not tolerate the reduction in $ FiO_{2} $ to 0.21 were excluded. Results We screened 40 patients, but only 28 (70 %) tolerated $ FiO_{2} $ 0.21. We measured common clinical variables and inflammatory mediators in plasma and in exhaled breath condensate (EBC) at the end of three 4-h periods: (1) basal ($ FiO_{2} $ 0.40), (2) after $ FiO_{2} $ reduction to 0.21, and (3) after returning $ FiO_{2} $ 0.40. We used one-way ANOVA for repeated measurements with $ FiO_{2} $ as the grouping variable. Median values of inflammatory mediators in EBC showed nonsignificant changes among the three periods: $ NO_{2} $ + $ NO_{3} $ 17.1, 14.1 and 11.0 μmol/L (p = 0.2), and 8-isoprostane 4.4, 8.2 and 5.3 pg/ml (p = 0.6) for the three periods, respectively. Plasma levels also showed nonsignificant changes during the period of the study: $ NO_{2} $ + $ NO_{3} $ 12.6, 16.3 and 15.0 μmol/L (p = 0.9), TNFα 13.5, 18.0 and 14.5 pg/ml (p = 0.8), IL-4 12.9, 18.7 and 23.9 pg/ml (p = 0.1), IL-6 50.9, 35.1 and 28.3 pg/ml (p = 0.6), and IL-10 15.2, 22.2 and 22.2 pg/ml (p = 0.7) for the three periods, respectively. Conclusion $ FiO_{2} $ 0.40 in mechanically ventilated patients without severe respiratory failure did not increase systemic or pulmonary inflammation. Mechanical ventilation (dpeaa)DE-He213 Oxygen toxicity (dpeaa)DE-He213 Pulmonary inflammation (dpeaa)DE-He213 Gili, Gisela aut Villagra, Ana aut Lopez-Aguilar, Josefina aut Artigas, Antonio aut Enthalten in Intensive care medicine Berlin : Springer, 1975 39(2013), 4 vom: 08. Jan., Seite 711-716 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:39 year:2013 number:4 day:08 month:01 pages:711-716 https://dx.doi.org/10.1007/s00134-012-2801-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 39 2013 4 08 01 711-716 |
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Enthalten in Intensive care medicine 39(2013), 4 vom: 08. Jan., Seite 711-716 volume:39 year:2013 number:4 day:08 month:01 pages:711-716 |
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Enthalten in Intensive care medicine 39(2013), 4 vom: 08. Jan., Seite 711-716 volume:39 year:2013 number:4 day:08 month:01 pages:711-716 |
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Fernandez, Rafael @@aut@@ Gili, Gisela @@aut@@ Villagra, Ana @@aut@@ Lopez-Aguilar, Josefina @@aut@@ Artigas, Antonio @@aut@@ |
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We aimed to evaluate the acute effects of reducing $ FiO_{2} $ on pulmonary inflammation in mechanically ventilated patients without respiratory failure. Methods This study was a prospective, single-center crossover study in a medical/surgical intensive care unit at a university hospital. Hemodynamically stable patients under mechanical ventilation for >24 h without severe respiratory failure ($ PaO_{2} $/$ FiO_{2} $ >250). A basal $ FiO_{2} $ of 0.40 was reduced to 0.21 provided $ SpO_{2} $ remained higher than 90 %. Patients who could not tolerate the reduction in $ FiO_{2} $ to 0.21 were excluded. Results We screened 40 patients, but only 28 (70 %) tolerated $ FiO_{2} $ 0.21. We measured common clinical variables and inflammatory mediators in plasma and in exhaled breath condensate (EBC) at the end of three 4-h periods: (1) basal ($ FiO_{2} $ 0.40), (2) after $ FiO_{2} $ reduction to 0.21, and (3) after returning $ FiO_{2} $ 0.40. We used one-way ANOVA for repeated measurements with $ FiO_{2} $ as the grouping variable. Median values of inflammatory mediators in EBC showed nonsignificant changes among the three periods: $ NO_{2} $ + $ NO_{3} $ 17.1, 14.1 and 11.0 μmol/L (p = 0.2), and 8-isoprostane 4.4, 8.2 and 5.3 pg/ml (p = 0.6) for the three periods, respectively. Plasma levels also showed nonsignificant changes during the period of the study: $ NO_{2} $ + $ NO_{3} $ 12.6, 16.3 and 15.0 μmol/L (p = 0.9), TNFα 13.5, 18.0 and 14.5 pg/ml (p = 0.8), IL-4 12.9, 18.7 and 23.9 pg/ml (p = 0.1), IL-6 50.9, 35.1 and 28.3 pg/ml (p = 0.6), and IL-10 15.2, 22.2 and 22.2 pg/ml (p = 0.7) for the three periods, respectively. Conclusion $ FiO_{2} $ 0.40 in mechanically ventilated patients without severe respiratory failure did not increase systemic or pulmonary inflammation.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mechanical ventilation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oxygen toxicity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pulmonary inflammation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gili, Gisela</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Villagra, Ana</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lopez-Aguilar, Josefina</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Artigas, Antonio</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Intensive care medicine</subfield><subfield code="d">Berlin : Springer, 1975</subfield><subfield code="g">39(2013), 4 vom: 08. 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Fernandez, Rafael |
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Fernandez, Rafael misc Mechanical ventilation misc Oxygen toxicity misc Pulmonary inflammation Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients |
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Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients Mechanical ventilation (dpeaa)DE-He213 Oxygen toxicity (dpeaa)DE-He213 Pulmonary inflammation (dpeaa)DE-He213 |
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misc Mechanical ventilation misc Oxygen toxicity misc Pulmonary inflammation |
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Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients |
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Fernandez, Rafael Gili, Gisela Villagra, Ana Lopez-Aguilar, Josefina Artigas, Antonio |
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Fernandez, Rafael |
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assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients |
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Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients |
| abstract |
Purpose Although low doses of oxygen ($ FiO_{2} $ <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing $ FiO_{2} $ on pulmonary inflammation in mechanically ventilated patients without respiratory failure. Methods This study was a prospective, single-center crossover study in a medical/surgical intensive care unit at a university hospital. Hemodynamically stable patients under mechanical ventilation for >24 h without severe respiratory failure ($ PaO_{2} $/$ FiO_{2} $ >250). A basal $ FiO_{2} $ of 0.40 was reduced to 0.21 provided $ SpO_{2} $ remained higher than 90 %. Patients who could not tolerate the reduction in $ FiO_{2} $ to 0.21 were excluded. Results We screened 40 patients, but only 28 (70 %) tolerated $ FiO_{2} $ 0.21. We measured common clinical variables and inflammatory mediators in plasma and in exhaled breath condensate (EBC) at the end of three 4-h periods: (1) basal ($ FiO_{2} $ 0.40), (2) after $ FiO_{2} $ reduction to 0.21, and (3) after returning $ FiO_{2} $ 0.40. We used one-way ANOVA for repeated measurements with $ FiO_{2} $ as the grouping variable. Median values of inflammatory mediators in EBC showed nonsignificant changes among the three periods: $ NO_{2} $ + $ NO_{3} $ 17.1, 14.1 and 11.0 μmol/L (p = 0.2), and 8-isoprostane 4.4, 8.2 and 5.3 pg/ml (p = 0.6) for the three periods, respectively. Plasma levels also showed nonsignificant changes during the period of the study: $ NO_{2} $ + $ NO_{3} $ 12.6, 16.3 and 15.0 μmol/L (p = 0.9), TNFα 13.5, 18.0 and 14.5 pg/ml (p = 0.8), IL-4 12.9, 18.7 and 23.9 pg/ml (p = 0.1), IL-6 50.9, 35.1 and 28.3 pg/ml (p = 0.6), and IL-10 15.2, 22.2 and 22.2 pg/ml (p = 0.7) for the three periods, respectively. Conclusion $ FiO_{2} $ 0.40 in mechanically ventilated patients without severe respiratory failure did not increase systemic or pulmonary inflammation. © Springer-Verlag Berlin Heidelberg and ESICM 2012 |
| abstractGer |
Purpose Although low doses of oxygen ($ FiO_{2} $ <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing $ FiO_{2} $ on pulmonary inflammation in mechanically ventilated patients without respiratory failure. Methods This study was a prospective, single-center crossover study in a medical/surgical intensive care unit at a university hospital. Hemodynamically stable patients under mechanical ventilation for >24 h without severe respiratory failure ($ PaO_{2} $/$ FiO_{2} $ >250). A basal $ FiO_{2} $ of 0.40 was reduced to 0.21 provided $ SpO_{2} $ remained higher than 90 %. Patients who could not tolerate the reduction in $ FiO_{2} $ to 0.21 were excluded. Results We screened 40 patients, but only 28 (70 %) tolerated $ FiO_{2} $ 0.21. We measured common clinical variables and inflammatory mediators in plasma and in exhaled breath condensate (EBC) at the end of three 4-h periods: (1) basal ($ FiO_{2} $ 0.40), (2) after $ FiO_{2} $ reduction to 0.21, and (3) after returning $ FiO_{2} $ 0.40. We used one-way ANOVA for repeated measurements with $ FiO_{2} $ as the grouping variable. Median values of inflammatory mediators in EBC showed nonsignificant changes among the three periods: $ NO_{2} $ + $ NO_{3} $ 17.1, 14.1 and 11.0 μmol/L (p = 0.2), and 8-isoprostane 4.4, 8.2 and 5.3 pg/ml (p = 0.6) for the three periods, respectively. Plasma levels also showed nonsignificant changes during the period of the study: $ NO_{2} $ + $ NO_{3} $ 12.6, 16.3 and 15.0 μmol/L (p = 0.9), TNFα 13.5, 18.0 and 14.5 pg/ml (p = 0.8), IL-4 12.9, 18.7 and 23.9 pg/ml (p = 0.1), IL-6 50.9, 35.1 and 28.3 pg/ml (p = 0.6), and IL-10 15.2, 22.2 and 22.2 pg/ml (p = 0.7) for the three periods, respectively. Conclusion $ FiO_{2} $ 0.40 in mechanically ventilated patients without severe respiratory failure did not increase systemic or pulmonary inflammation. © Springer-Verlag Berlin Heidelberg and ESICM 2012 |
| abstract_unstemmed |
Purpose Although low doses of oxygen ($ FiO_{2} $ <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing $ FiO_{2} $ on pulmonary inflammation in mechanically ventilated patients without respiratory failure. Methods This study was a prospective, single-center crossover study in a medical/surgical intensive care unit at a university hospital. Hemodynamically stable patients under mechanical ventilation for >24 h without severe respiratory failure ($ PaO_{2} $/$ FiO_{2} $ >250). A basal $ FiO_{2} $ of 0.40 was reduced to 0.21 provided $ SpO_{2} $ remained higher than 90 %. Patients who could not tolerate the reduction in $ FiO_{2} $ to 0.21 were excluded. Results We screened 40 patients, but only 28 (70 %) tolerated $ FiO_{2} $ 0.21. We measured common clinical variables and inflammatory mediators in plasma and in exhaled breath condensate (EBC) at the end of three 4-h periods: (1) basal ($ FiO_{2} $ 0.40), (2) after $ FiO_{2} $ reduction to 0.21, and (3) after returning $ FiO_{2} $ 0.40. We used one-way ANOVA for repeated measurements with $ FiO_{2} $ as the grouping variable. Median values of inflammatory mediators in EBC showed nonsignificant changes among the three periods: $ NO_{2} $ + $ NO_{3} $ 17.1, 14.1 and 11.0 μmol/L (p = 0.2), and 8-isoprostane 4.4, 8.2 and 5.3 pg/ml (p = 0.6) for the three periods, respectively. Plasma levels also showed nonsignificant changes during the period of the study: $ NO_{2} $ + $ NO_{3} $ 12.6, 16.3 and 15.0 μmol/L (p = 0.9), TNFα 13.5, 18.0 and 14.5 pg/ml (p = 0.8), IL-4 12.9, 18.7 and 23.9 pg/ml (p = 0.1), IL-6 50.9, 35.1 and 28.3 pg/ml (p = 0.6), and IL-10 15.2, 22.2 and 22.2 pg/ml (p = 0.7) for the three periods, respectively. Conclusion $ FiO_{2} $ 0.40 in mechanically ventilated patients without severe respiratory failure did not increase systemic or pulmonary inflammation. © Springer-Verlag Berlin Heidelberg and ESICM 2012 |
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Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients |
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Gili, Gisela Villagra, Ana Lopez-Aguilar, Josefina Artigas, Antonio |
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| score |
7.402525 |