Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome
Purpose To investigate whether neuromuscular blocking agents (NMBA) exert beneficial effects in acute respiratory distress syndrome (ARDS) by reason of their action on respiratory mechanics, particularly transpulmonary pressures (PL). Methods A prospective randomised controlled study in patients wit...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Guervilly, Christophe [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag Berlin Heidelberg and ESICM 2016 |
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| Übergeordnetes Werk: |
Enthalten in: Intensive care medicine - Berlin : Springer, 1975, 43(2016), 3 vom: 24. Dez., Seite 408-418 |
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| Übergeordnetes Werk: |
volume:43 ; year:2016 ; number:3 ; day:24 ; month:12 ; pages:408-418 |
| Links: |
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| DOI / URN: |
10.1007/s00134-016-4653-4 |
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| Katalog-ID: |
SPR001237748 |
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| 100 | 1 | |a Guervilly, Christophe |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome |
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| 520 | |a Purpose To investigate whether neuromuscular blocking agents (NMBA) exert beneficial effects in acute respiratory distress syndrome (ARDS) by reason of their action on respiratory mechanics, particularly transpulmonary pressures (PL). Methods A prospective randomised controlled study in patients with moderate to severe ARDS within 48 h of the onset of ARDS. All patients were monitored by means of an oesophageal catheter and followed up for 48 h. Moderate ARDS patients were randomised into two groups according to whether they were given a 48-h continuous infusion of cisatracurium besylate or not (control group). Severe ARDS patients did not undergo randomisation and all received cisatracurium besylate per protocol. The changes during the 48-h study period in oxygenation and in respiratory mechanics, including inspiratory and expiratory PL and driving pressure, were assessed and compared. Delta PL (∆PL) was defined as inspiratory PL minus expiratory PL. Results Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure and total positive end-expiratory pressure. The mean inspiratory and expiratory PL were higher in the moderate ARDS group receiving NMBA than in the control group. In contrast, there was no change in either driving pressure or ∆PL related to NMBA administration. Conclusions NMBA could exert beneficial effects in patients with moderate ARDS, at least in part, by limiting expiratory efforts. | ||
| 650 | 4 | |a Acute respiratory distress syndrome |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neuromuscular blocking agent |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Esophageal pressure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Transpulmonary pressure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Driving pressure |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Bisbal, Magali |4 aut | |
| 700 | 1 | |a Forel, Jean Marie |4 aut | |
| 700 | 1 | |a Mechati, Malika |4 aut | |
| 700 | 1 | |a Lehingue, Samuel |4 aut | |
| 700 | 1 | |a Bourenne, Jeremy |4 aut | |
| 700 | 1 | |a Perrin, Gilles |4 aut | |
| 700 | 1 | |a Rambaud, Romain |4 aut | |
| 700 | 1 | |a Adda, Melanie |4 aut | |
| 700 | 1 | |a Hraiech, Sami |4 aut | |
| 700 | 1 | |a Marchi, Elisa |4 aut | |
| 700 | 1 | |a Roch, Antoine |4 aut | |
| 700 | 1 | |a Gainnier, Marc |4 aut | |
| 700 | 1 | |a Papazian, Laurent |4 aut | |
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10.1007/s00134-016-4653-4 doi (DE-627)SPR001237748 (SPR)s00134-016-4653-4-e DE-627 ger DE-627 rakwb eng Guervilly, Christophe verfasserin aut Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg and ESICM 2016 Purpose To investigate whether neuromuscular blocking agents (NMBA) exert beneficial effects in acute respiratory distress syndrome (ARDS) by reason of their action on respiratory mechanics, particularly transpulmonary pressures (PL). Methods A prospective randomised controlled study in patients with moderate to severe ARDS within 48 h of the onset of ARDS. All patients were monitored by means of an oesophageal catheter and followed up for 48 h. Moderate ARDS patients were randomised into two groups according to whether they were given a 48-h continuous infusion of cisatracurium besylate or not (control group). Severe ARDS patients did not undergo randomisation and all received cisatracurium besylate per protocol. The changes during the 48-h study period in oxygenation and in respiratory mechanics, including inspiratory and expiratory PL and driving pressure, were assessed and compared. Delta PL (∆PL) was defined as inspiratory PL minus expiratory PL. Results Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure and total positive end-expiratory pressure. The mean inspiratory and expiratory PL were higher in the moderate ARDS group receiving NMBA than in the control group. In contrast, there was no change in either driving pressure or ∆PL related to NMBA administration. Conclusions NMBA could exert beneficial effects in patients with moderate ARDS, at least in part, by limiting expiratory efforts. Acute respiratory distress syndrome (dpeaa)DE-He213 Neuromuscular blocking agent (dpeaa)DE-He213 Esophageal pressure (dpeaa)DE-He213 Transpulmonary pressure (dpeaa)DE-He213 Driving pressure (dpeaa)DE-He213 Bisbal, Magali aut Forel, Jean Marie aut Mechati, Malika aut Lehingue, Samuel aut Bourenne, Jeremy aut Perrin, Gilles aut Rambaud, Romain aut Adda, Melanie aut Hraiech, Sami aut Marchi, Elisa aut Roch, Antoine aut Gainnier, Marc aut Papazian, Laurent aut Enthalten in Intensive care medicine Berlin : Springer, 1975 43(2016), 3 vom: 24. Dez., Seite 408-418 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:43 year:2016 number:3 day:24 month:12 pages:408-418 https://dx.doi.org/10.1007/s00134-016-4653-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 43 2016 3 24 12 408-418 |
| spelling |
10.1007/s00134-016-4653-4 doi (DE-627)SPR001237748 (SPR)s00134-016-4653-4-e DE-627 ger DE-627 rakwb eng Guervilly, Christophe verfasserin aut Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg and ESICM 2016 Purpose To investigate whether neuromuscular blocking agents (NMBA) exert beneficial effects in acute respiratory distress syndrome (ARDS) by reason of their action on respiratory mechanics, particularly transpulmonary pressures (PL). Methods A prospective randomised controlled study in patients with moderate to severe ARDS within 48 h of the onset of ARDS. All patients were monitored by means of an oesophageal catheter and followed up for 48 h. Moderate ARDS patients were randomised into two groups according to whether they were given a 48-h continuous infusion of cisatracurium besylate or not (control group). Severe ARDS patients did not undergo randomisation and all received cisatracurium besylate per protocol. The changes during the 48-h study period in oxygenation and in respiratory mechanics, including inspiratory and expiratory PL and driving pressure, were assessed and compared. Delta PL (∆PL) was defined as inspiratory PL minus expiratory PL. Results Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure and total positive end-expiratory pressure. The mean inspiratory and expiratory PL were higher in the moderate ARDS group receiving NMBA than in the control group. In contrast, there was no change in either driving pressure or ∆PL related to NMBA administration. Conclusions NMBA could exert beneficial effects in patients with moderate ARDS, at least in part, by limiting expiratory efforts. Acute respiratory distress syndrome (dpeaa)DE-He213 Neuromuscular blocking agent (dpeaa)DE-He213 Esophageal pressure (dpeaa)DE-He213 Transpulmonary pressure (dpeaa)DE-He213 Driving pressure (dpeaa)DE-He213 Bisbal, Magali aut Forel, Jean Marie aut Mechati, Malika aut Lehingue, Samuel aut Bourenne, Jeremy aut Perrin, Gilles aut Rambaud, Romain aut Adda, Melanie aut Hraiech, Sami aut Marchi, Elisa aut Roch, Antoine aut Gainnier, Marc aut Papazian, Laurent aut Enthalten in Intensive care medicine Berlin : Springer, 1975 43(2016), 3 vom: 24. Dez., Seite 408-418 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:43 year:2016 number:3 day:24 month:12 pages:408-418 https://dx.doi.org/10.1007/s00134-016-4653-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 43 2016 3 24 12 408-418 |
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10.1007/s00134-016-4653-4 doi (DE-627)SPR001237748 (SPR)s00134-016-4653-4-e DE-627 ger DE-627 rakwb eng Guervilly, Christophe verfasserin aut Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg and ESICM 2016 Purpose To investigate whether neuromuscular blocking agents (NMBA) exert beneficial effects in acute respiratory distress syndrome (ARDS) by reason of their action on respiratory mechanics, particularly transpulmonary pressures (PL). Methods A prospective randomised controlled study in patients with moderate to severe ARDS within 48 h of the onset of ARDS. All patients were monitored by means of an oesophageal catheter and followed up for 48 h. Moderate ARDS patients were randomised into two groups according to whether they were given a 48-h continuous infusion of cisatracurium besylate or not (control group). Severe ARDS patients did not undergo randomisation and all received cisatracurium besylate per protocol. The changes during the 48-h study period in oxygenation and in respiratory mechanics, including inspiratory and expiratory PL and driving pressure, were assessed and compared. Delta PL (∆PL) was defined as inspiratory PL minus expiratory PL. Results Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure and total positive end-expiratory pressure. The mean inspiratory and expiratory PL were higher in the moderate ARDS group receiving NMBA than in the control group. In contrast, there was no change in either driving pressure or ∆PL related to NMBA administration. Conclusions NMBA could exert beneficial effects in patients with moderate ARDS, at least in part, by limiting expiratory efforts. Acute respiratory distress syndrome (dpeaa)DE-He213 Neuromuscular blocking agent (dpeaa)DE-He213 Esophageal pressure (dpeaa)DE-He213 Transpulmonary pressure (dpeaa)DE-He213 Driving pressure (dpeaa)DE-He213 Bisbal, Magali aut Forel, Jean Marie aut Mechati, Malika aut Lehingue, Samuel aut Bourenne, Jeremy aut Perrin, Gilles aut Rambaud, Romain aut Adda, Melanie aut Hraiech, Sami aut Marchi, Elisa aut Roch, Antoine aut Gainnier, Marc aut Papazian, Laurent aut Enthalten in Intensive care medicine Berlin : Springer, 1975 43(2016), 3 vom: 24. Dez., Seite 408-418 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:43 year:2016 number:3 day:24 month:12 pages:408-418 https://dx.doi.org/10.1007/s00134-016-4653-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 43 2016 3 24 12 408-418 |
| allfieldsGer |
10.1007/s00134-016-4653-4 doi (DE-627)SPR001237748 (SPR)s00134-016-4653-4-e DE-627 ger DE-627 rakwb eng Guervilly, Christophe verfasserin aut Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg and ESICM 2016 Purpose To investigate whether neuromuscular blocking agents (NMBA) exert beneficial effects in acute respiratory distress syndrome (ARDS) by reason of their action on respiratory mechanics, particularly transpulmonary pressures (PL). Methods A prospective randomised controlled study in patients with moderate to severe ARDS within 48 h of the onset of ARDS. All patients were monitored by means of an oesophageal catheter and followed up for 48 h. Moderate ARDS patients were randomised into two groups according to whether they were given a 48-h continuous infusion of cisatracurium besylate or not (control group). Severe ARDS patients did not undergo randomisation and all received cisatracurium besylate per protocol. The changes during the 48-h study period in oxygenation and in respiratory mechanics, including inspiratory and expiratory PL and driving pressure, were assessed and compared. Delta PL (∆PL) was defined as inspiratory PL minus expiratory PL. Results Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure and total positive end-expiratory pressure. The mean inspiratory and expiratory PL were higher in the moderate ARDS group receiving NMBA than in the control group. In contrast, there was no change in either driving pressure or ∆PL related to NMBA administration. Conclusions NMBA could exert beneficial effects in patients with moderate ARDS, at least in part, by limiting expiratory efforts. Acute respiratory distress syndrome (dpeaa)DE-He213 Neuromuscular blocking agent (dpeaa)DE-He213 Esophageal pressure (dpeaa)DE-He213 Transpulmonary pressure (dpeaa)DE-He213 Driving pressure (dpeaa)DE-He213 Bisbal, Magali aut Forel, Jean Marie aut Mechati, Malika aut Lehingue, Samuel aut Bourenne, Jeremy aut Perrin, Gilles aut Rambaud, Romain aut Adda, Melanie aut Hraiech, Sami aut Marchi, Elisa aut Roch, Antoine aut Gainnier, Marc aut Papazian, Laurent aut Enthalten in Intensive care medicine Berlin : Springer, 1975 43(2016), 3 vom: 24. Dez., Seite 408-418 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:43 year:2016 number:3 day:24 month:12 pages:408-418 https://dx.doi.org/10.1007/s00134-016-4653-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 43 2016 3 24 12 408-418 |
| allfieldsSound |
10.1007/s00134-016-4653-4 doi (DE-627)SPR001237748 (SPR)s00134-016-4653-4-e DE-627 ger DE-627 rakwb eng Guervilly, Christophe verfasserin aut Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg and ESICM 2016 Purpose To investigate whether neuromuscular blocking agents (NMBA) exert beneficial effects in acute respiratory distress syndrome (ARDS) by reason of their action on respiratory mechanics, particularly transpulmonary pressures (PL). Methods A prospective randomised controlled study in patients with moderate to severe ARDS within 48 h of the onset of ARDS. All patients were monitored by means of an oesophageal catheter and followed up for 48 h. Moderate ARDS patients were randomised into two groups according to whether they were given a 48-h continuous infusion of cisatracurium besylate or not (control group). Severe ARDS patients did not undergo randomisation and all received cisatracurium besylate per protocol. The changes during the 48-h study period in oxygenation and in respiratory mechanics, including inspiratory and expiratory PL and driving pressure, were assessed and compared. Delta PL (∆PL) was defined as inspiratory PL minus expiratory PL. Results Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure and total positive end-expiratory pressure. The mean inspiratory and expiratory PL were higher in the moderate ARDS group receiving NMBA than in the control group. In contrast, there was no change in either driving pressure or ∆PL related to NMBA administration. Conclusions NMBA could exert beneficial effects in patients with moderate ARDS, at least in part, by limiting expiratory efforts. Acute respiratory distress syndrome (dpeaa)DE-He213 Neuromuscular blocking agent (dpeaa)DE-He213 Esophageal pressure (dpeaa)DE-He213 Transpulmonary pressure (dpeaa)DE-He213 Driving pressure (dpeaa)DE-He213 Bisbal, Magali aut Forel, Jean Marie aut Mechati, Malika aut Lehingue, Samuel aut Bourenne, Jeremy aut Perrin, Gilles aut Rambaud, Romain aut Adda, Melanie aut Hraiech, Sami aut Marchi, Elisa aut Roch, Antoine aut Gainnier, Marc aut Papazian, Laurent aut Enthalten in Intensive care medicine Berlin : Springer, 1975 43(2016), 3 vom: 24. Dez., Seite 408-418 (DE-627)253724104 (DE-600)1459201-0 1432-1238 nnns volume:43 year:2016 number:3 day:24 month:12 pages:408-418 https://dx.doi.org/10.1007/s00134-016-4653-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 43 2016 3 24 12 408-418 |
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English |
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Enthalten in Intensive care medicine 43(2016), 3 vom: 24. Dez., Seite 408-418 volume:43 year:2016 number:3 day:24 month:12 pages:408-418 |
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Enthalten in Intensive care medicine 43(2016), 3 vom: 24. Dez., Seite 408-418 volume:43 year:2016 number:3 day:24 month:12 pages:408-418 |
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Acute respiratory distress syndrome Neuromuscular blocking agent Esophageal pressure Transpulmonary pressure Driving pressure |
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Intensive care medicine |
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Guervilly, Christophe @@aut@@ Bisbal, Magali @@aut@@ Forel, Jean Marie @@aut@@ Mechati, Malika @@aut@@ Lehingue, Samuel @@aut@@ Bourenne, Jeremy @@aut@@ Perrin, Gilles @@aut@@ Rambaud, Romain @@aut@@ Adda, Melanie @@aut@@ Hraiech, Sami @@aut@@ Marchi, Elisa @@aut@@ Roch, Antoine @@aut@@ Gainnier, Marc @@aut@@ Papazian, Laurent @@aut@@ |
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2016-12-24T00:00:00Z |
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Methods A prospective randomised controlled study in patients with moderate to severe ARDS within 48 h of the onset of ARDS. All patients were monitored by means of an oesophageal catheter and followed up for 48 h. Moderate ARDS patients were randomised into two groups according to whether they were given a 48-h continuous infusion of cisatracurium besylate or not (control group). Severe ARDS patients did not undergo randomisation and all received cisatracurium besylate per protocol. The changes during the 48-h study period in oxygenation and in respiratory mechanics, including inspiratory and expiratory PL and driving pressure, were assessed and compared. Delta PL (∆PL) was defined as inspiratory PL minus expiratory PL. Results Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure and total positive end-expiratory pressure. The mean inspiratory and expiratory PL were higher in the moderate ARDS group receiving NMBA than in the control group. In contrast, there was no change in either driving pressure or ∆PL related to NMBA administration. 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Guervilly, Christophe |
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Guervilly, Christophe misc Acute respiratory distress syndrome misc Neuromuscular blocking agent misc Esophageal pressure misc Transpulmonary pressure misc Driving pressure Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome |
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Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome Acute respiratory distress syndrome (dpeaa)DE-He213 Neuromuscular blocking agent (dpeaa)DE-He213 Esophageal pressure (dpeaa)DE-He213 Transpulmonary pressure (dpeaa)DE-He213 Driving pressure (dpeaa)DE-He213 |
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misc Acute respiratory distress syndrome misc Neuromuscular blocking agent misc Esophageal pressure misc Transpulmonary pressure misc Driving pressure |
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misc Acute respiratory distress syndrome misc Neuromuscular blocking agent misc Esophageal pressure misc Transpulmonary pressure misc Driving pressure |
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Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome |
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Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome |
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Guervilly, Christophe Bisbal, Magali Forel, Jean Marie Mechati, Malika Lehingue, Samuel Bourenne, Jeremy Perrin, Gilles Rambaud, Romain Adda, Melanie Hraiech, Sami Marchi, Elisa Roch, Antoine Gainnier, Marc Papazian, Laurent |
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Elektronische Aufsätze |
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Guervilly, Christophe |
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10.1007/s00134-016-4653-4 |
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effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome |
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Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome |
| abstract |
Purpose To investigate whether neuromuscular blocking agents (NMBA) exert beneficial effects in acute respiratory distress syndrome (ARDS) by reason of their action on respiratory mechanics, particularly transpulmonary pressures (PL). Methods A prospective randomised controlled study in patients with moderate to severe ARDS within 48 h of the onset of ARDS. All patients were monitored by means of an oesophageal catheter and followed up for 48 h. Moderate ARDS patients were randomised into two groups according to whether they were given a 48-h continuous infusion of cisatracurium besylate or not (control group). Severe ARDS patients did not undergo randomisation and all received cisatracurium besylate per protocol. The changes during the 48-h study period in oxygenation and in respiratory mechanics, including inspiratory and expiratory PL and driving pressure, were assessed and compared. Delta PL (∆PL) was defined as inspiratory PL minus expiratory PL. Results Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure and total positive end-expiratory pressure. The mean inspiratory and expiratory PL were higher in the moderate ARDS group receiving NMBA than in the control group. In contrast, there was no change in either driving pressure or ∆PL related to NMBA administration. Conclusions NMBA could exert beneficial effects in patients with moderate ARDS, at least in part, by limiting expiratory efforts. © Springer-Verlag Berlin Heidelberg and ESICM 2016 |
| abstractGer |
Purpose To investigate whether neuromuscular blocking agents (NMBA) exert beneficial effects in acute respiratory distress syndrome (ARDS) by reason of their action on respiratory mechanics, particularly transpulmonary pressures (PL). Methods A prospective randomised controlled study in patients with moderate to severe ARDS within 48 h of the onset of ARDS. All patients were monitored by means of an oesophageal catheter and followed up for 48 h. Moderate ARDS patients were randomised into two groups according to whether they were given a 48-h continuous infusion of cisatracurium besylate or not (control group). Severe ARDS patients did not undergo randomisation and all received cisatracurium besylate per protocol. The changes during the 48-h study period in oxygenation and in respiratory mechanics, including inspiratory and expiratory PL and driving pressure, were assessed and compared. Delta PL (∆PL) was defined as inspiratory PL minus expiratory PL. Results Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure and total positive end-expiratory pressure. The mean inspiratory and expiratory PL were higher in the moderate ARDS group receiving NMBA than in the control group. In contrast, there was no change in either driving pressure or ∆PL related to NMBA administration. Conclusions NMBA could exert beneficial effects in patients with moderate ARDS, at least in part, by limiting expiratory efforts. © Springer-Verlag Berlin Heidelberg and ESICM 2016 |
| abstract_unstemmed |
Purpose To investigate whether neuromuscular blocking agents (NMBA) exert beneficial effects in acute respiratory distress syndrome (ARDS) by reason of their action on respiratory mechanics, particularly transpulmonary pressures (PL). Methods A prospective randomised controlled study in patients with moderate to severe ARDS within 48 h of the onset of ARDS. All patients were monitored by means of an oesophageal catheter and followed up for 48 h. Moderate ARDS patients were randomised into two groups according to whether they were given a 48-h continuous infusion of cisatracurium besylate or not (control group). Severe ARDS patients did not undergo randomisation and all received cisatracurium besylate per protocol. The changes during the 48-h study period in oxygenation and in respiratory mechanics, including inspiratory and expiratory PL and driving pressure, were assessed and compared. Delta PL (∆PL) was defined as inspiratory PL minus expiratory PL. Results Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure and total positive end-expiratory pressure. The mean inspiratory and expiratory PL were higher in the moderate ARDS group receiving NMBA than in the control group. In contrast, there was no change in either driving pressure or ∆PL related to NMBA administration. Conclusions NMBA could exert beneficial effects in patients with moderate ARDS, at least in part, by limiting expiratory efforts. © Springer-Verlag Berlin Heidelberg and ESICM 2016 |
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Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome |
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Bisbal, Magali Forel, Jean Marie Mechati, Malika Lehingue, Samuel Bourenne, Jeremy Perrin, Gilles Rambaud, Romain Adda, Melanie Hraiech, Sami Marchi, Elisa Roch, Antoine Gainnier, Marc Papazian, Laurent |
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| score |
7.4000654 |