Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study
Summary Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization ana...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Oei, L. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Anmerkung: |
© International Osteoporosis Foundation and National Osteoporosis Foundation 2013 |
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| Übergeordnetes Werk: |
Enthalten in: Osteoporosis international - London : Springer, 1990, 25(2013), 4 vom: 13. Dez., Seite 1247-1254 |
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| Übergeordnetes Werk: |
volume:25 ; year:2013 ; number:4 ; day:13 ; month:12 ; pages:1247-1254 |
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| DOI / URN: |
10.1007/s00198-013-2578-0 |
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| Katalog-ID: |
SPR001717847 |
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| 100 | 1 | |a Oei, L. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study |
| 264 | 1 | |c 2013 | |
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| 520 | |a Summary Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Introduction Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort. Methods At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years). Results CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 $ cm^{3} $; −0.020 to −0.003 $ cm^{3} $) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (p = 9 × $ 10^{−56} $), but not with fracture risk (HR = 1.00; 0.99–1.00; p = 0.23). Conclusions Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk. | ||
| 650 | 4 | |a C-reactive protein |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Diseases and disorders of/related to bone |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Epidemiology |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Fracture risk assessment |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a General population studies |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Osteoimmunology |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Campos-Obando, N. |4 aut | |
| 700 | 1 | |a Dehghan, A. |4 aut | |
| 700 | 1 | |a Oei, E. H. G. |4 aut | |
| 700 | 1 | |a Stolk, L. |4 aut | |
| 700 | 1 | |a van Meurs, J. B. J. |4 aut | |
| 700 | 1 | |a Hofman, A. |4 aut | |
| 700 | 1 | |a Uitterlinden, A. G. |4 aut | |
| 700 | 1 | |a Franco, O. H. |4 aut | |
| 700 | 1 | |a Zillikens, M. C. |4 aut | |
| 700 | 1 | |a Rivadeneira, F. |4 aut | |
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10.1007/s00198-013-2578-0 doi (DE-627)SPR001717847 (SPR)s00198-013-2578-0-e DE-627 ger DE-627 rakwb eng Oei, L. verfasserin aut Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Osteoporosis Foundation and National Osteoporosis Foundation 2013 Summary Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Introduction Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort. Methods At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years). Results CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 $ cm^{3} $; −0.020 to −0.003 $ cm^{3} $) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (p = 9 × $ 10^{−56} $), but not with fracture risk (HR = 1.00; 0.99–1.00; p = 0.23). Conclusions Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk. C-reactive protein (dpeaa)DE-He213 Diseases and disorders of/related to bone (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Fracture risk assessment (dpeaa)DE-He213 General population studies (dpeaa)DE-He213 Osteoimmunology (dpeaa)DE-He213 Campos-Obando, N. aut Dehghan, A. aut Oei, E. H. G. aut Stolk, L. aut van Meurs, J. B. J. aut Hofman, A. aut Uitterlinden, A. G. aut Franco, O. H. aut Zillikens, M. C. aut Rivadeneira, F. aut Enthalten in Osteoporosis international London : Springer, 1990 25(2013), 4 vom: 13. Dez., Seite 1247-1254 (DE-627)271596597 (DE-600)1480645-9 1433-2965 nnns volume:25 year:2013 number:4 day:13 month:12 pages:1247-1254 https://dx.doi.org/10.1007/s00198-013-2578-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 25 2013 4 13 12 1247-1254 |
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10.1007/s00198-013-2578-0 doi (DE-627)SPR001717847 (SPR)s00198-013-2578-0-e DE-627 ger DE-627 rakwb eng Oei, L. verfasserin aut Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Osteoporosis Foundation and National Osteoporosis Foundation 2013 Summary Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Introduction Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort. Methods At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years). Results CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 $ cm^{3} $; −0.020 to −0.003 $ cm^{3} $) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (p = 9 × $ 10^{−56} $), but not with fracture risk (HR = 1.00; 0.99–1.00; p = 0.23). Conclusions Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk. C-reactive protein (dpeaa)DE-He213 Diseases and disorders of/related to bone (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Fracture risk assessment (dpeaa)DE-He213 General population studies (dpeaa)DE-He213 Osteoimmunology (dpeaa)DE-He213 Campos-Obando, N. aut Dehghan, A. aut Oei, E. H. G. aut Stolk, L. aut van Meurs, J. B. J. aut Hofman, A. aut Uitterlinden, A. G. aut Franco, O. H. aut Zillikens, M. C. aut Rivadeneira, F. aut Enthalten in Osteoporosis international London : Springer, 1990 25(2013), 4 vom: 13. Dez., Seite 1247-1254 (DE-627)271596597 (DE-600)1480645-9 1433-2965 nnns volume:25 year:2013 number:4 day:13 month:12 pages:1247-1254 https://dx.doi.org/10.1007/s00198-013-2578-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 25 2013 4 13 12 1247-1254 |
| allfields_unstemmed |
10.1007/s00198-013-2578-0 doi (DE-627)SPR001717847 (SPR)s00198-013-2578-0-e DE-627 ger DE-627 rakwb eng Oei, L. verfasserin aut Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Osteoporosis Foundation and National Osteoporosis Foundation 2013 Summary Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Introduction Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort. Methods At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years). Results CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 $ cm^{3} $; −0.020 to −0.003 $ cm^{3} $) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (p = 9 × $ 10^{−56} $), but not with fracture risk (HR = 1.00; 0.99–1.00; p = 0.23). Conclusions Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk. C-reactive protein (dpeaa)DE-He213 Diseases and disorders of/related to bone (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Fracture risk assessment (dpeaa)DE-He213 General population studies (dpeaa)DE-He213 Osteoimmunology (dpeaa)DE-He213 Campos-Obando, N. aut Dehghan, A. aut Oei, E. H. G. aut Stolk, L. aut van Meurs, J. B. J. aut Hofman, A. aut Uitterlinden, A. G. aut Franco, O. H. aut Zillikens, M. C. aut Rivadeneira, F. aut Enthalten in Osteoporosis international London : Springer, 1990 25(2013), 4 vom: 13. Dez., Seite 1247-1254 (DE-627)271596597 (DE-600)1480645-9 1433-2965 nnns volume:25 year:2013 number:4 day:13 month:12 pages:1247-1254 https://dx.doi.org/10.1007/s00198-013-2578-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 25 2013 4 13 12 1247-1254 |
| allfieldsGer |
10.1007/s00198-013-2578-0 doi (DE-627)SPR001717847 (SPR)s00198-013-2578-0-e DE-627 ger DE-627 rakwb eng Oei, L. verfasserin aut Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Osteoporosis Foundation and National Osteoporosis Foundation 2013 Summary Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Introduction Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort. Methods At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years). Results CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 $ cm^{3} $; −0.020 to −0.003 $ cm^{3} $) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (p = 9 × $ 10^{−56} $), but not with fracture risk (HR = 1.00; 0.99–1.00; p = 0.23). Conclusions Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk. C-reactive protein (dpeaa)DE-He213 Diseases and disorders of/related to bone (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Fracture risk assessment (dpeaa)DE-He213 General population studies (dpeaa)DE-He213 Osteoimmunology (dpeaa)DE-He213 Campos-Obando, N. aut Dehghan, A. aut Oei, E. H. G. aut Stolk, L. aut van Meurs, J. B. J. aut Hofman, A. aut Uitterlinden, A. G. aut Franco, O. H. aut Zillikens, M. C. aut Rivadeneira, F. aut Enthalten in Osteoporosis international London : Springer, 1990 25(2013), 4 vom: 13. Dez., Seite 1247-1254 (DE-627)271596597 (DE-600)1480645-9 1433-2965 nnns volume:25 year:2013 number:4 day:13 month:12 pages:1247-1254 https://dx.doi.org/10.1007/s00198-013-2578-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 25 2013 4 13 12 1247-1254 |
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10.1007/s00198-013-2578-0 doi (DE-627)SPR001717847 (SPR)s00198-013-2578-0-e DE-627 ger DE-627 rakwb eng Oei, L. verfasserin aut Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Osteoporosis Foundation and National Osteoporosis Foundation 2013 Summary Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Introduction Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort. Methods At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years). Results CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 $ cm^{3} $; −0.020 to −0.003 $ cm^{3} $) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (p = 9 × $ 10^{−56} $), but not with fracture risk (HR = 1.00; 0.99–1.00; p = 0.23). Conclusions Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk. C-reactive protein (dpeaa)DE-He213 Diseases and disorders of/related to bone (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Fracture risk assessment (dpeaa)DE-He213 General population studies (dpeaa)DE-He213 Osteoimmunology (dpeaa)DE-He213 Campos-Obando, N. aut Dehghan, A. aut Oei, E. H. G. aut Stolk, L. aut van Meurs, J. B. J. aut Hofman, A. aut Uitterlinden, A. G. aut Franco, O. H. aut Zillikens, M. C. aut Rivadeneira, F. aut Enthalten in Osteoporosis international London : Springer, 1990 25(2013), 4 vom: 13. Dez., Seite 1247-1254 (DE-627)271596597 (DE-600)1480645-9 1433-2965 nnns volume:25 year:2013 number:4 day:13 month:12 pages:1247-1254 https://dx.doi.org/10.1007/s00198-013-2578-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 25 2013 4 13 12 1247-1254 |
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We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Introduction Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort. Methods At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years). Results CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 $ cm^{3} $; −0.020 to −0.003 $ cm^{3} $) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (p = 9 × $ 10^{−56} $), but not with fracture risk (HR = 1.00; 0.99–1.00; p = 0.23). Conclusions Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. 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Oei, L. |
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Oei, L. misc C-reactive protein misc Diseases and disorders of/related to bone misc Epidemiology misc Fracture risk assessment misc General population studies misc Osteoimmunology Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study |
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Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study C-reactive protein (dpeaa)DE-He213 Diseases and disorders of/related to bone (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Fracture risk assessment (dpeaa)DE-He213 General population studies (dpeaa)DE-He213 Osteoimmunology (dpeaa)DE-He213 |
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misc C-reactive protein misc Diseases and disorders of/related to bone misc Epidemiology misc Fracture risk assessment misc General population studies misc Osteoimmunology |
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Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study |
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Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study |
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Oei, L. |
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Oei, L. Campos-Obando, N. Dehghan, A. Oei, E. H. G. Stolk, L. van Meurs, J. B. J. Hofman, A. Uitterlinden, A. G. Franco, O. H. Zillikens, M. C. Rivadeneira, F. |
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Oei, L. |
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10.1007/s00198-013-2578-0 |
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dissecting the relationship between high-sensitivity serum c-reactive protein and increased fracture risk: the rotterdam study |
| title_auth |
Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study |
| abstract |
Summary Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Introduction Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort. Methods At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years). Results CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 $ cm^{3} $; −0.020 to −0.003 $ cm^{3} $) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (p = 9 × $ 10^{−56} $), but not with fracture risk (HR = 1.00; 0.99–1.00; p = 0.23). Conclusions Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk. © International Osteoporosis Foundation and National Osteoporosis Foundation 2013 |
| abstractGer |
Summary Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Introduction Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort. Methods At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years). Results CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 $ cm^{3} $; −0.020 to −0.003 $ cm^{3} $) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (p = 9 × $ 10^{−56} $), but not with fracture risk (HR = 1.00; 0.99–1.00; p = 0.23). Conclusions Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk. © International Osteoporosis Foundation and National Osteoporosis Foundation 2013 |
| abstract_unstemmed |
Summary Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Introduction Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort. Methods At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years). Results CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 $ cm^{3} $; −0.020 to −0.003 $ cm^{3} $) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (p = 9 × $ 10^{−56} $), but not with fracture risk (HR = 1.00; 0.99–1.00; p = 0.23). Conclusions Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk. © International Osteoporosis Foundation and National Osteoporosis Foundation 2013 |
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Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study |
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https://dx.doi.org/10.1007/s00198-013-2578-0 |
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Campos-Obando, N. Dehghan, A. Oei, E. H. G. Stolk, L. van Meurs, J. B. J. Hofman, A. Uitterlinden, A. G. Franco, O. H. Zillikens, M. C. Rivadeneira, F. |
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Campos-Obando, N. Dehghan, A. Oei, E. H. G. Stolk, L. van Meurs, J. B. J. Hofman, A. Uitterlinden, A. G. Franco, O. H. Zillikens, M. C. Rivadeneira, F. |
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10.1007/s00198-013-2578-0 |
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2024-07-04T00:04:36.658Z |
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We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Introduction Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort. Methods At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years). Results CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 $ cm^{3} $; −0.020 to −0.003 $ cm^{3} $) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (p = 9 × $ 10^{−56} $), but not with fracture risk (HR = 1.00; 0.99–1.00; p = 0.23). Conclusions Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. 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| score |
7.3980913 |