$ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices

Abstract Recent observations indicate the presence of hyperpolarization-activated cation channels ($ I_{h} $ channels) in presynaptic terminals of central neurons, but their functional impact is still unclear. To investigate whether there are operative $ I_{h} $ channels on presynaptic terminals of...
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Gespeichert in:

Autor*in:	Klar, Maximilian [verfasserIn] Surges, Rainer Feuerstein, Thomas J.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2003

Schlagwörter:	I channel Noradrenaline release NMDA ZD7288 Presynaptic function

Anmerkung:	© Springer-Verlag 2003

Übergeordnetes Werk:	Enthalten in: Naunyn-Schmiedeberg's archives of pharmacology - Berlin : Springer, 1873, 367(2003), 4 vom: 13. März, Seite 422-425
Übergeordnetes Werk:	volume:367 ; year:2003 ; number:4 ; day:13 ; month:03 ; pages:422-425

Links:	Volltext

DOI / URN:	10.1007/s00210-003-0707-6

Katalog-ID:	SPR001946374

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245	1	0	\|a $ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices
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520			\|a Abstract Recent observations indicate the presence of hyperpolarization-activated cation channels ($ I_{h} $ channels) in presynaptic terminals of central neurons, but their functional impact is still unclear. To investigate whether there are operative $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons, the effect of the $ I_{h} $ channel blocker ZD7288 on the N-methyl-D-aspartate (NMDA)-evoked [3H]-noradrenaline release ([3H]-NA release) was tested. Neocortical slices of the rat, preloaded with [3H]-NA, were superfused in the presence of TTX (0.32 µM) and stimulated twice by addition of 300 µM NMDA. Application of 1 and 10 µM ZD7288 increased the NMDA-evoked [3H]-NA release by 29 and 44%, respectively, in the presence of 3 mM external $ K^{+} $. Elevation of external $ K^{+} $ to 6 mM significantly reduced the increasing effect of 10 µM ZD7288 to 15% only. Our results indicate the presence of $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons and suggest that presynaptic $ I_{h} $ channels may attenuate transmitter release, at least under the present test conditions.
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700	1		\|a Feuerstein, Thomas J. \|4 aut
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publishDate	2003
allfields	10.1007/s00210-003-0707-6 doi (DE-627)SPR001946374 (SPR)s00210-003-0707-6-e DE-627 ger DE-627 rakwb eng Klar, Maximilian verfasserin aut $ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Abstract Recent observations indicate the presence of hyperpolarization-activated cation channels ($ I_{h} $ channels) in presynaptic terminals of central neurons, but their functional impact is still unclear. To investigate whether there are operative $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons, the effect of the $ I_{h} $ channel blocker ZD7288 on the N-methyl-D-aspartate (NMDA)-evoked [3H]-noradrenaline release ([3H]-NA release) was tested. Neocortical slices of the rat, preloaded with [3H]-NA, were superfused in the presence of TTX (0.32 µM) and stimulated twice by addition of 300 µM NMDA. Application of 1 and 10 µM ZD7288 increased the NMDA-evoked [3H]-NA release by 29 and 44%, respectively, in the presence of 3 mM external $ K^{+} $. Elevation of external $ K^{+} $ to 6 mM significantly reduced the increasing effect of 10 µM ZD7288 to 15% only. Our results indicate the presence of $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons and suggest that presynaptic $ I_{h} $ channels may attenuate transmitter release, at least under the present test conditions. I (dpeaa)DE-He213 channel (dpeaa)DE-He213 Noradrenaline release (dpeaa)DE-He213 NMDA (dpeaa)DE-He213 ZD7288 (dpeaa)DE-He213 Presynaptic function (dpeaa)DE-He213 Surges, Rainer aut Feuerstein, Thomas J. aut Enthalten in Naunyn-Schmiedeberg's archives of pharmacology Berlin : Springer, 1873 367(2003), 4 vom: 13. März, Seite 422-425 (DE-627)254638309 (DE-600)1462940-9 1432-1912 nnns volume:367 year:2003 number:4 day:13 month:03 pages:422-425 https://dx.doi.org/10.1007/s00210-003-0707-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 367 2003 4 13 03 422-425
spelling	10.1007/s00210-003-0707-6 doi (DE-627)SPR001946374 (SPR)s00210-003-0707-6-e DE-627 ger DE-627 rakwb eng Klar, Maximilian verfasserin aut $ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Abstract Recent observations indicate the presence of hyperpolarization-activated cation channels ($ I_{h} $ channels) in presynaptic terminals of central neurons, but their functional impact is still unclear. To investigate whether there are operative $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons, the effect of the $ I_{h} $ channel blocker ZD7288 on the N-methyl-D-aspartate (NMDA)-evoked [3H]-noradrenaline release ([3H]-NA release) was tested. Neocortical slices of the rat, preloaded with [3H]-NA, were superfused in the presence of TTX (0.32 µM) and stimulated twice by addition of 300 µM NMDA. Application of 1 and 10 µM ZD7288 increased the NMDA-evoked [3H]-NA release by 29 and 44%, respectively, in the presence of 3 mM external $ K^{+} $. Elevation of external $ K^{+} $ to 6 mM significantly reduced the increasing effect of 10 µM ZD7288 to 15% only. Our results indicate the presence of $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons and suggest that presynaptic $ I_{h} $ channels may attenuate transmitter release, at least under the present test conditions. I (dpeaa)DE-He213 channel (dpeaa)DE-He213 Noradrenaline release (dpeaa)DE-He213 NMDA (dpeaa)DE-He213 ZD7288 (dpeaa)DE-He213 Presynaptic function (dpeaa)DE-He213 Surges, Rainer aut Feuerstein, Thomas J. aut Enthalten in Naunyn-Schmiedeberg's archives of pharmacology Berlin : Springer, 1873 367(2003), 4 vom: 13. März, Seite 422-425 (DE-627)254638309 (DE-600)1462940-9 1432-1912 nnns volume:367 year:2003 number:4 day:13 month:03 pages:422-425 https://dx.doi.org/10.1007/s00210-003-0707-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 367 2003 4 13 03 422-425
allfields_unstemmed	10.1007/s00210-003-0707-6 doi (DE-627)SPR001946374 (SPR)s00210-003-0707-6-e DE-627 ger DE-627 rakwb eng Klar, Maximilian verfasserin aut $ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Abstract Recent observations indicate the presence of hyperpolarization-activated cation channels ($ I_{h} $ channels) in presynaptic terminals of central neurons, but their functional impact is still unclear. To investigate whether there are operative $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons, the effect of the $ I_{h} $ channel blocker ZD7288 on the N-methyl-D-aspartate (NMDA)-evoked [3H]-noradrenaline release ([3H]-NA release) was tested. Neocortical slices of the rat, preloaded with [3H]-NA, were superfused in the presence of TTX (0.32 µM) and stimulated twice by addition of 300 µM NMDA. Application of 1 and 10 µM ZD7288 increased the NMDA-evoked [3H]-NA release by 29 and 44%, respectively, in the presence of 3 mM external $ K^{+} $. Elevation of external $ K^{+} $ to 6 mM significantly reduced the increasing effect of 10 µM ZD7288 to 15% only. Our results indicate the presence of $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons and suggest that presynaptic $ I_{h} $ channels may attenuate transmitter release, at least under the present test conditions. I (dpeaa)DE-He213 channel (dpeaa)DE-He213 Noradrenaline release (dpeaa)DE-He213 NMDA (dpeaa)DE-He213 ZD7288 (dpeaa)DE-He213 Presynaptic function (dpeaa)DE-He213 Surges, Rainer aut Feuerstein, Thomas J. aut Enthalten in Naunyn-Schmiedeberg's archives of pharmacology Berlin : Springer, 1873 367(2003), 4 vom: 13. März, Seite 422-425 (DE-627)254638309 (DE-600)1462940-9 1432-1912 nnns volume:367 year:2003 number:4 day:13 month:03 pages:422-425 https://dx.doi.org/10.1007/s00210-003-0707-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 367 2003 4 13 03 422-425
allfieldsGer	10.1007/s00210-003-0707-6 doi (DE-627)SPR001946374 (SPR)s00210-003-0707-6-e DE-627 ger DE-627 rakwb eng Klar, Maximilian verfasserin aut $ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Abstract Recent observations indicate the presence of hyperpolarization-activated cation channels ($ I_{h} $ channels) in presynaptic terminals of central neurons, but their functional impact is still unclear. To investigate whether there are operative $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons, the effect of the $ I_{h} $ channel blocker ZD7288 on the N-methyl-D-aspartate (NMDA)-evoked [3H]-noradrenaline release ([3H]-NA release) was tested. Neocortical slices of the rat, preloaded with [3H]-NA, were superfused in the presence of TTX (0.32 µM) and stimulated twice by addition of 300 µM NMDA. Application of 1 and 10 µM ZD7288 increased the NMDA-evoked [3H]-NA release by 29 and 44%, respectively, in the presence of 3 mM external $ K^{+} $. Elevation of external $ K^{+} $ to 6 mM significantly reduced the increasing effect of 10 µM ZD7288 to 15% only. Our results indicate the presence of $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons and suggest that presynaptic $ I_{h} $ channels may attenuate transmitter release, at least under the present test conditions. I (dpeaa)DE-He213 channel (dpeaa)DE-He213 Noradrenaline release (dpeaa)DE-He213 NMDA (dpeaa)DE-He213 ZD7288 (dpeaa)DE-He213 Presynaptic function (dpeaa)DE-He213 Surges, Rainer aut Feuerstein, Thomas J. aut Enthalten in Naunyn-Schmiedeberg's archives of pharmacology Berlin : Springer, 1873 367(2003), 4 vom: 13. März, Seite 422-425 (DE-627)254638309 (DE-600)1462940-9 1432-1912 nnns volume:367 year:2003 number:4 day:13 month:03 pages:422-425 https://dx.doi.org/10.1007/s00210-003-0707-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 367 2003 4 13 03 422-425
allfieldsSound	10.1007/s00210-003-0707-6 doi (DE-627)SPR001946374 (SPR)s00210-003-0707-6-e DE-627 ger DE-627 rakwb eng Klar, Maximilian verfasserin aut $ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Abstract Recent observations indicate the presence of hyperpolarization-activated cation channels ($ I_{h} $ channels) in presynaptic terminals of central neurons, but their functional impact is still unclear. To investigate whether there are operative $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons, the effect of the $ I_{h} $ channel blocker ZD7288 on the N-methyl-D-aspartate (NMDA)-evoked [3H]-noradrenaline release ([3H]-NA release) was tested. Neocortical slices of the rat, preloaded with [3H]-NA, were superfused in the presence of TTX (0.32 µM) and stimulated twice by addition of 300 µM NMDA. Application of 1 and 10 µM ZD7288 increased the NMDA-evoked [3H]-NA release by 29 and 44%, respectively, in the presence of 3 mM external $ K^{+} $. Elevation of external $ K^{+} $ to 6 mM significantly reduced the increasing effect of 10 µM ZD7288 to 15% only. Our results indicate the presence of $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons and suggest that presynaptic $ I_{h} $ channels may attenuate transmitter release, at least under the present test conditions. I (dpeaa)DE-He213 channel (dpeaa)DE-He213 Noradrenaline release (dpeaa)DE-He213 NMDA (dpeaa)DE-He213 ZD7288 (dpeaa)DE-He213 Presynaptic function (dpeaa)DE-He213 Surges, Rainer aut Feuerstein, Thomas J. aut Enthalten in Naunyn-Schmiedeberg's archives of pharmacology Berlin : Springer, 1873 367(2003), 4 vom: 13. März, Seite 422-425 (DE-627)254638309 (DE-600)1462940-9 1432-1912 nnns volume:367 year:2003 number:4 day:13 month:03 pages:422-425 https://dx.doi.org/10.1007/s00210-003-0707-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 367 2003 4 13 03 422-425
language	English
source	Enthalten in Naunyn-Schmiedeberg's archives of pharmacology 367(2003), 4 vom: 13. März, Seite 422-425 volume:367 year:2003 number:4 day:13 month:03 pages:422-425
sourceStr	Enthalten in Naunyn-Schmiedeberg's archives of pharmacology 367(2003), 4 vom: 13. März, Seite 422-425 volume:367 year:2003 number:4 day:13 month:03 pages:422-425
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	I channel Noradrenaline release NMDA ZD7288 Presynaptic function
isfreeaccess_bool	false
container_title	Naunyn-Schmiedeberg's archives of pharmacology
authorswithroles_txt_mv	Klar, Maximilian @@aut@@ Surges, Rainer @@aut@@ Feuerstein, Thomas J. @@aut@@
publishDateDaySort_date	2003-03-13T00:00:00Z
hierarchy_top_id	254638309
id	SPR001946374
language_de	englisch
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author	Klar, Maximilian
spellingShingle	Klar, Maximilian misc I misc channel misc Noradrenaline release misc NMDA misc ZD7288 misc Presynaptic function $ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices
authorStr	Klar, Maximilian
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topic_title	$ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices I (dpeaa)DE-He213 channel (dpeaa)DE-He213 Noradrenaline release (dpeaa)DE-He213 NMDA (dpeaa)DE-He213 ZD7288 (dpeaa)DE-He213 Presynaptic function (dpeaa)DE-He213
topic	misc I misc channel misc Noradrenaline release misc NMDA misc ZD7288 misc Presynaptic function
topic_unstemmed	misc I misc channel misc Noradrenaline release misc NMDA misc ZD7288 misc Presynaptic function
topic_browse	misc I misc channel misc Noradrenaline release misc NMDA misc ZD7288 misc Presynaptic function
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title	$ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices
ctrlnum	(DE-627)SPR001946374 (SPR)s00210-003-0707-6-e
title_full	$ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices
author_sort	Klar, Maximilian
journal	Naunyn-Schmiedeberg's archives of pharmacology
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author_browse	Klar, Maximilian Surges, Rainer Feuerstein, Thomas J.
container_volume	367
format_se	Elektronische Aufsätze
author-letter	Klar, Maximilian
doi_str_mv	10.1007/s00210-003-0707-6
title_sort	$ i_{h} $ channels as modulators of presynaptic terminal function: zd7288 increases nmda-evoked [3h]-noradrenaline release in rat neocortex slices
title_auth	$ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices
abstract	Abstract Recent observations indicate the presence of hyperpolarization-activated cation channels ($ I_{h} $ channels) in presynaptic terminals of central neurons, but their functional impact is still unclear. To investigate whether there are operative $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons, the effect of the $ I_{h} $ channel blocker ZD7288 on the N-methyl-D-aspartate (NMDA)-evoked [3H]-noradrenaline release ([3H]-NA release) was tested. Neocortical slices of the rat, preloaded with [3H]-NA, were superfused in the presence of TTX (0.32 µM) and stimulated twice by addition of 300 µM NMDA. Application of 1 and 10 µM ZD7288 increased the NMDA-evoked [3H]-NA release by 29 and 44%, respectively, in the presence of 3 mM external $ K^{+} $. Elevation of external $ K^{+} $ to 6 mM significantly reduced the increasing effect of 10 µM ZD7288 to 15% only. Our results indicate the presence of $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons and suggest that presynaptic $ I_{h} $ channels may attenuate transmitter release, at least under the present test conditions. © Springer-Verlag 2003
abstractGer	Abstract Recent observations indicate the presence of hyperpolarization-activated cation channels ($ I_{h} $ channels) in presynaptic terminals of central neurons, but their functional impact is still unclear. To investigate whether there are operative $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons, the effect of the $ I_{h} $ channel blocker ZD7288 on the N-methyl-D-aspartate (NMDA)-evoked [3H]-noradrenaline release ([3H]-NA release) was tested. Neocortical slices of the rat, preloaded with [3H]-NA, were superfused in the presence of TTX (0.32 µM) and stimulated twice by addition of 300 µM NMDA. Application of 1 and 10 µM ZD7288 increased the NMDA-evoked [3H]-NA release by 29 and 44%, respectively, in the presence of 3 mM external $ K^{+} $. Elevation of external $ K^{+} $ to 6 mM significantly reduced the increasing effect of 10 µM ZD7288 to 15% only. Our results indicate the presence of $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons and suggest that presynaptic $ I_{h} $ channels may attenuate transmitter release, at least under the present test conditions. © Springer-Verlag 2003
abstract_unstemmed	Abstract Recent observations indicate the presence of hyperpolarization-activated cation channels ($ I_{h} $ channels) in presynaptic terminals of central neurons, but their functional impact is still unclear. To investigate whether there are operative $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons, the effect of the $ I_{h} $ channel blocker ZD7288 on the N-methyl-D-aspartate (NMDA)-evoked [3H]-noradrenaline release ([3H]-NA release) was tested. Neocortical slices of the rat, preloaded with [3H]-NA, were superfused in the presence of TTX (0.32 µM) and stimulated twice by addition of 300 µM NMDA. Application of 1 and 10 µM ZD7288 increased the NMDA-evoked [3H]-NA release by 29 and 44%, respectively, in the presence of 3 mM external $ K^{+} $. Elevation of external $ K^{+} $ to 6 mM significantly reduced the increasing effect of 10 µM ZD7288 to 15% only. Our results indicate the presence of $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons and suggest that presynaptic $ I_{h} $ channels may attenuate transmitter release, at least under the present test conditions. © Springer-Verlag 2003
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title_short	$ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices
url	https://dx.doi.org/10.1007/s00210-003-0707-6
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author2	Surges, Rainer Feuerstein, Thomas J.
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doi_str	10.1007/s00210-003-0707-6
up_date	2024-07-04T01:05:33.868Z
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To investigate whether there are operative $ I_{h} $ channels on presynaptic terminals of noradrenergic neurons, the effect of the $ I_{h} $ channel blocker ZD7288 on the N-methyl-D-aspartate (NMDA)-evoked [3H]-noradrenaline release ([3H]-NA release) was tested. Neocortical slices of the rat, preloaded with [3H]-NA, were superfused in the presence of TTX (0.32 µM) and stimulated twice by addition of 300 µM NMDA. Application of 1 and 10 µM ZD7288 increased the NMDA-evoked [3H]-NA release by 29 and 44%, respectively, in the presence of 3 mM external $ K^{+} $. Elevation of external $ K^{+} $ to 6 mM significantly reduced the increasing effect of 10 µM ZD7288 to 15% only. 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$ I_{h} $ channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices

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