Serotonin transporter binding after recovery from eating disorders
Rationale Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). Objectives We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricti...
Ausführliche Beschreibung
Autor*in: |
Bailer, Ursula F. [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2007 |
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Schlagwörter: |
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Anmerkung: |
© Springer-Verlag 2007 |
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Übergeordnetes Werk: |
Enthalten in: Psychopharmacology - Berlin : Springer, 1959, 195(2007), 3 vom: 11. Aug., Seite 315-324 |
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Übergeordnetes Werk: |
volume:195 ; year:2007 ; number:3 ; day:11 ; month:08 ; pages:315-324 |
Links: |
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DOI / URN: |
10.1007/s00213-007-0896-7 |
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Katalog-ID: |
SPR002005042 |
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100 | 1 | |a Bailer, Ursula F. |e verfasserin |4 aut | |
245 | 1 | 0 | |a Serotonin transporter binding after recovery from eating disorders |
264 | 1 | |c 2007 | |
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520 | |a Rationale Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). Objectives We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW). Materials and methods Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP = $ DV_{region of interest} $/$ DV_{cerebellum} $ − 1). Results After correction for multiple comparisons, the four groups showed significant (p < 0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions. Conclusions Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control. | ||
650 | 4 | |a Anorexia nervosa |7 (dpeaa)DE-He213 | |
650 | 4 | |a Bulimia nervosa |7 (dpeaa)DE-He213 | |
650 | 4 | |a Serotonin transporter |7 (dpeaa)DE-He213 | |
650 | 4 | |a Positron emission tomography |7 (dpeaa)DE-He213 | |
650 | 4 | |a Serotonin |7 (dpeaa)DE-He213 | |
650 | 4 | |a 5-HTTLPR |7 (dpeaa)DE-He213 | |
700 | 1 | |a Frank, Guido K. |4 aut | |
700 | 1 | |a Henry, Shannan E. |4 aut | |
700 | 1 | |a Price, Julie C. |4 aut | |
700 | 1 | |a Meltzer, Carolyn C. |4 aut | |
700 | 1 | |a Becker, Carl |4 aut | |
700 | 1 | |a Ziolko, Scott K. |4 aut | |
700 | 1 | |a Mathis, Chester A. |4 aut | |
700 | 1 | |a Wagner, Angela |4 aut | |
700 | 1 | |a Barbarich-Marsteller, Nicole C. |4 aut | |
700 | 1 | |a Putnam, Karen |4 aut | |
700 | 1 | |a Kaye, Walter H. |4 aut | |
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10.1007/s00213-007-0896-7 doi (DE-627)SPR002005042 (SPR)s00213-007-0896-7-e DE-627 ger DE-627 rakwb eng Bailer, Ursula F. verfasserin aut Serotonin transporter binding after recovery from eating disorders 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Rationale Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). Objectives We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW). Materials and methods Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP = $ DV_{region of interest} $/$ DV_{cerebellum} $ − 1). Results After correction for multiple comparisons, the four groups showed significant (p < 0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions. Conclusions Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control. Anorexia nervosa (dpeaa)DE-He213 Bulimia nervosa (dpeaa)DE-He213 Serotonin transporter (dpeaa)DE-He213 Positron emission tomography (dpeaa)DE-He213 Serotonin (dpeaa)DE-He213 5-HTTLPR (dpeaa)DE-He213 Frank, Guido K. aut Henry, Shannan E. aut Price, Julie C. aut Meltzer, Carolyn C. aut Becker, Carl aut Ziolko, Scott K. aut Mathis, Chester A. aut Wagner, Angela aut Barbarich-Marsteller, Nicole C. aut Putnam, Karen aut Kaye, Walter H. aut Enthalten in Psychopharmacology Berlin : Springer, 1959 195(2007), 3 vom: 11. Aug., Seite 315-324 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:195 year:2007 number:3 day:11 month:08 pages:315-324 https://dx.doi.org/10.1007/s00213-007-0896-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 195 2007 3 11 08 315-324 |
spelling |
10.1007/s00213-007-0896-7 doi (DE-627)SPR002005042 (SPR)s00213-007-0896-7-e DE-627 ger DE-627 rakwb eng Bailer, Ursula F. verfasserin aut Serotonin transporter binding after recovery from eating disorders 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Rationale Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). Objectives We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW). Materials and methods Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP = $ DV_{region of interest} $/$ DV_{cerebellum} $ − 1). Results After correction for multiple comparisons, the four groups showed significant (p < 0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions. Conclusions Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control. Anorexia nervosa (dpeaa)DE-He213 Bulimia nervosa (dpeaa)DE-He213 Serotonin transporter (dpeaa)DE-He213 Positron emission tomography (dpeaa)DE-He213 Serotonin (dpeaa)DE-He213 5-HTTLPR (dpeaa)DE-He213 Frank, Guido K. aut Henry, Shannan E. aut Price, Julie C. aut Meltzer, Carolyn C. aut Becker, Carl aut Ziolko, Scott K. aut Mathis, Chester A. aut Wagner, Angela aut Barbarich-Marsteller, Nicole C. aut Putnam, Karen aut Kaye, Walter H. aut Enthalten in Psychopharmacology Berlin : Springer, 1959 195(2007), 3 vom: 11. Aug., Seite 315-324 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:195 year:2007 number:3 day:11 month:08 pages:315-324 https://dx.doi.org/10.1007/s00213-007-0896-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 195 2007 3 11 08 315-324 |
allfields_unstemmed |
10.1007/s00213-007-0896-7 doi (DE-627)SPR002005042 (SPR)s00213-007-0896-7-e DE-627 ger DE-627 rakwb eng Bailer, Ursula F. verfasserin aut Serotonin transporter binding after recovery from eating disorders 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Rationale Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). Objectives We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW). Materials and methods Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP = $ DV_{region of interest} $/$ DV_{cerebellum} $ − 1). Results After correction for multiple comparisons, the four groups showed significant (p < 0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions. Conclusions Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control. Anorexia nervosa (dpeaa)DE-He213 Bulimia nervosa (dpeaa)DE-He213 Serotonin transporter (dpeaa)DE-He213 Positron emission tomography (dpeaa)DE-He213 Serotonin (dpeaa)DE-He213 5-HTTLPR (dpeaa)DE-He213 Frank, Guido K. aut Henry, Shannan E. aut Price, Julie C. aut Meltzer, Carolyn C. aut Becker, Carl aut Ziolko, Scott K. aut Mathis, Chester A. aut Wagner, Angela aut Barbarich-Marsteller, Nicole C. aut Putnam, Karen aut Kaye, Walter H. aut Enthalten in Psychopharmacology Berlin : Springer, 1959 195(2007), 3 vom: 11. Aug., Seite 315-324 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:195 year:2007 number:3 day:11 month:08 pages:315-324 https://dx.doi.org/10.1007/s00213-007-0896-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 195 2007 3 11 08 315-324 |
allfieldsGer |
10.1007/s00213-007-0896-7 doi (DE-627)SPR002005042 (SPR)s00213-007-0896-7-e DE-627 ger DE-627 rakwb eng Bailer, Ursula F. verfasserin aut Serotonin transporter binding after recovery from eating disorders 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Rationale Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). Objectives We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW). Materials and methods Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP = $ DV_{region of interest} $/$ DV_{cerebellum} $ − 1). Results After correction for multiple comparisons, the four groups showed significant (p < 0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions. Conclusions Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control. Anorexia nervosa (dpeaa)DE-He213 Bulimia nervosa (dpeaa)DE-He213 Serotonin transporter (dpeaa)DE-He213 Positron emission tomography (dpeaa)DE-He213 Serotonin (dpeaa)DE-He213 5-HTTLPR (dpeaa)DE-He213 Frank, Guido K. aut Henry, Shannan E. aut Price, Julie C. aut Meltzer, Carolyn C. aut Becker, Carl aut Ziolko, Scott K. aut Mathis, Chester A. aut Wagner, Angela aut Barbarich-Marsteller, Nicole C. aut Putnam, Karen aut Kaye, Walter H. aut Enthalten in Psychopharmacology Berlin : Springer, 1959 195(2007), 3 vom: 11. Aug., Seite 315-324 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:195 year:2007 number:3 day:11 month:08 pages:315-324 https://dx.doi.org/10.1007/s00213-007-0896-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 195 2007 3 11 08 315-324 |
allfieldsSound |
10.1007/s00213-007-0896-7 doi (DE-627)SPR002005042 (SPR)s00213-007-0896-7-e DE-627 ger DE-627 rakwb eng Bailer, Ursula F. verfasserin aut Serotonin transporter binding after recovery from eating disorders 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Rationale Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). Objectives We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW). Materials and methods Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP = $ DV_{region of interest} $/$ DV_{cerebellum} $ − 1). Results After correction for multiple comparisons, the four groups showed significant (p < 0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions. Conclusions Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control. Anorexia nervosa (dpeaa)DE-He213 Bulimia nervosa (dpeaa)DE-He213 Serotonin transporter (dpeaa)DE-He213 Positron emission tomography (dpeaa)DE-He213 Serotonin (dpeaa)DE-He213 5-HTTLPR (dpeaa)DE-He213 Frank, Guido K. aut Henry, Shannan E. aut Price, Julie C. aut Meltzer, Carolyn C. aut Becker, Carl aut Ziolko, Scott K. aut Mathis, Chester A. aut Wagner, Angela aut Barbarich-Marsteller, Nicole C. aut Putnam, Karen aut Kaye, Walter H. aut Enthalten in Psychopharmacology Berlin : Springer, 1959 195(2007), 3 vom: 11. Aug., Seite 315-324 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:195 year:2007 number:3 day:11 month:08 pages:315-324 https://dx.doi.org/10.1007/s00213-007-0896-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 195 2007 3 11 08 315-324 |
language |
English |
source |
Enthalten in Psychopharmacology 195(2007), 3 vom: 11. Aug., Seite 315-324 volume:195 year:2007 number:3 day:11 month:08 pages:315-324 |
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Enthalten in Psychopharmacology 195(2007), 3 vom: 11. Aug., Seite 315-324 volume:195 year:2007 number:3 day:11 month:08 pages:315-324 |
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Article |
institution |
findex.gbv.de |
topic_facet |
Anorexia nervosa Bulimia nervosa Serotonin transporter Positron emission tomography Serotonin 5-HTTLPR |
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false |
container_title |
Psychopharmacology |
authorswithroles_txt_mv |
Bailer, Ursula F. @@aut@@ Frank, Guido K. @@aut@@ Henry, Shannan E. @@aut@@ Price, Julie C. @@aut@@ Meltzer, Carolyn C. @@aut@@ Becker, Carl @@aut@@ Ziolko, Scott K. @@aut@@ Mathis, Chester A. @@aut@@ Wagner, Angela @@aut@@ Barbarich-Marsteller, Nicole C. @@aut@@ Putnam, Karen @@aut@@ Kaye, Walter H. @@aut@@ |
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2007-08-11T00:00:00Z |
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341342254 |
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SPR002005042 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR002005042</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519193709.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2007 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00213-007-0896-7</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR002005042</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00213-007-0896-7-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bailer, Ursula F.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Serotonin transporter binding after recovery from eating disorders</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2007</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer-Verlag 2007</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Rationale Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). Objectives We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW). Materials and methods Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP = $ DV_{region of interest} $/$ DV_{cerebellum} $ − 1). Results After correction for multiple comparisons, the four groups showed significant (p < 0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions. 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author |
Bailer, Ursula F. |
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Bailer, Ursula F. misc Anorexia nervosa misc Bulimia nervosa misc Serotonin transporter misc Positron emission tomography misc Serotonin misc 5-HTTLPR Serotonin transporter binding after recovery from eating disorders |
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Serotonin transporter binding after recovery from eating disorders Anorexia nervosa (dpeaa)DE-He213 Bulimia nervosa (dpeaa)DE-He213 Serotonin transporter (dpeaa)DE-He213 Positron emission tomography (dpeaa)DE-He213 Serotonin (dpeaa)DE-He213 5-HTTLPR (dpeaa)DE-He213 |
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misc Anorexia nervosa misc Bulimia nervosa misc Serotonin transporter misc Positron emission tomography misc Serotonin misc 5-HTTLPR |
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misc Anorexia nervosa misc Bulimia nervosa misc Serotonin transporter misc Positron emission tomography misc Serotonin misc 5-HTTLPR |
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misc Anorexia nervosa misc Bulimia nervosa misc Serotonin transporter misc Positron emission tomography misc Serotonin misc 5-HTTLPR |
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Serotonin transporter binding after recovery from eating disorders |
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315 |
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Bailer, Ursula F. Frank, Guido K. Henry, Shannan E. Price, Julie C. Meltzer, Carolyn C. Becker, Carl Ziolko, Scott K. Mathis, Chester A. Wagner, Angela Barbarich-Marsteller, Nicole C. Putnam, Karen Kaye, Walter H. |
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195 |
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Elektronische Aufsätze |
author-letter |
Bailer, Ursula F. |
doi_str_mv |
10.1007/s00213-007-0896-7 |
title_sort |
serotonin transporter binding after recovery from eating disorders |
title_auth |
Serotonin transporter binding after recovery from eating disorders |
abstract |
Rationale Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). Objectives We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW). Materials and methods Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP = $ DV_{region of interest} $/$ DV_{cerebellum} $ − 1). Results After correction for multiple comparisons, the four groups showed significant (p < 0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions. Conclusions Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control. © Springer-Verlag 2007 |
abstractGer |
Rationale Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). Objectives We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW). Materials and methods Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP = $ DV_{region of interest} $/$ DV_{cerebellum} $ − 1). Results After correction for multiple comparisons, the four groups showed significant (p < 0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions. Conclusions Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control. © Springer-Verlag 2007 |
abstract_unstemmed |
Rationale Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). Objectives We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW). Materials and methods Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP = $ DV_{region of interest} $/$ DV_{cerebellum} $ − 1). Results After correction for multiple comparisons, the four groups showed significant (p < 0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions. Conclusions Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control. © Springer-Verlag 2007 |
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Serotonin transporter binding after recovery from eating disorders |
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Frank, Guido K. Henry, Shannan E. Price, Julie C. Meltzer, Carolyn C. Becker, Carl Ziolko, Scott K. Mathis, Chester A. Wagner, Angela Barbarich-Marsteller, Nicole C. Putnam, Karen Kaye, Walter H. |
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Frank, Guido K. Henry, Shannan E. Price, Julie C. Meltzer, Carolyn C. Becker, Carl Ziolko, Scott K. Mathis, Chester A. Wagner, Angela Barbarich-Marsteller, Nicole C. Putnam, Karen Kaye, Walter H. |
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|
score |
7.401434 |