Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity
Rationale Cocaine-induced changes in $ D_{2} $ receptors have been implicated in the expression of sensitized behavioral responses and addiction-like behaviors; however, the influence of $ D_{3} $ receptors is less clear. Objectives To characterize the effects of repeated cocaine administration on t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Collins, Gregory T. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2010 |
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| Übergeordnetes Werk: |
Enthalten in: Psychopharmacology - Berlin : Springer, 1959, 215(2011), 4 vom: 05. Jan., Seite 609-620 |
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| Übergeordnetes Werk: |
volume:215 ; year:2011 ; number:4 ; day:05 ; month:01 ; pages:609-620 |
| Links: |
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| DOI / URN: |
10.1007/s00213-010-2154-7 |
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SPR00201792X |
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| 100 | 1 | |a Collins, Gregory T. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity |
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| 520 | |a Rationale Cocaine-induced changes in $ D_{2} $ receptors have been implicated in the expression of sensitized behavioral responses and addiction-like behaviors; however, the influence of $ D_{3} $ receptors is less clear. Objectives To characterize the effects of repeated cocaine administration on the sensitivity of rats to $ D_{2} $- and $ D_{3} $-mediated behaviors, as well as the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors. Methods Pramipexole was used to assess the sensitivity of rats to $ D_{3} $/$ D_{2} $ agonist-induced yawning, hypothermia, and locomotor activity, 24 h, 72 h, 10, 21, and 42 days after repeated cocaine or saline administration. The locomotor effects of cocaine (42 day) and the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors (24 h and 42 days) were also evaluated. Results Cocaine-treated rats displayed an enhanced locomotor response to cocaine, as well as a progressive and persistent leftward/upward shift of the ascending limb (72 h–42 day) and leftward shift of the descending limb (42 days) of the pramipexole-induced yawning dose–response curve. Cocaine treatment also decreased Bmax and Kd for $ D_{2} $-like receptors and increased $ D_{3} $ receptor binding at 42 days. Cocaine treatment did not change pramipexole-induced hypothermia or locomotor activity or yawning induced by cholinergic or serotonergic agonists. Conclusions These studies suggest that temporal differences exist in the development of cocaine-induced sensitization of $ D_{3} $ and $ D_{2} $ receptors, with enhancements of $ D_{3} $-mediated behavioral effects observed within 72 h and enhancements of $ D_{2} $-mediated behavioral effects apparent 42 days after cocaine. These findings highlight the need to consider changes in $ D_{3} $ receptor function when thinking about the behavioral plasticity that occurs during abstinence from cocaine use. | ||
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| 650 | 4 | |a Sensitization |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dopamine D2 receptor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dopamine D |7 (dpeaa)DE-He213 | |
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| 650 | 4 | |a Yawning |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pramipexole |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Truong, Yen Nhu-Thi |4 aut | |
| 700 | 1 | |a Levant, Beth |4 aut | |
| 700 | 1 | |a Chen, Jianyong |4 aut | |
| 700 | 1 | |a Wang, Shaomeng |4 aut | |
| 700 | 1 | |a Woods, James H. |4 aut | |
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10.1007/s00213-010-2154-7 doi (DE-627)SPR00201792X (SPR)s00213-010-2154-7-e DE-627 ger DE-627 rakwb eng Collins, Gregory T. verfasserin aut Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Rationale Cocaine-induced changes in $ D_{2} $ receptors have been implicated in the expression of sensitized behavioral responses and addiction-like behaviors; however, the influence of $ D_{3} $ receptors is less clear. Objectives To characterize the effects of repeated cocaine administration on the sensitivity of rats to $ D_{2} $- and $ D_{3} $-mediated behaviors, as well as the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors. Methods Pramipexole was used to assess the sensitivity of rats to $ D_{3} $/$ D_{2} $ agonist-induced yawning, hypothermia, and locomotor activity, 24 h, 72 h, 10, 21, and 42 days after repeated cocaine or saline administration. The locomotor effects of cocaine (42 day) and the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors (24 h and 42 days) were also evaluated. Results Cocaine-treated rats displayed an enhanced locomotor response to cocaine, as well as a progressive and persistent leftward/upward shift of the ascending limb (72 h–42 day) and leftward shift of the descending limb (42 days) of the pramipexole-induced yawning dose–response curve. Cocaine treatment also decreased Bmax and Kd for $ D_{2} $-like receptors and increased $ D_{3} $ receptor binding at 42 days. Cocaine treatment did not change pramipexole-induced hypothermia or locomotor activity or yawning induced by cholinergic or serotonergic agonists. Conclusions These studies suggest that temporal differences exist in the development of cocaine-induced sensitization of $ D_{3} $ and $ D_{2} $ receptors, with enhancements of $ D_{3} $-mediated behavioral effects observed within 72 h and enhancements of $ D_{2} $-mediated behavioral effects apparent 42 days after cocaine. These findings highlight the need to consider changes in $ D_{3} $ receptor function when thinking about the behavioral plasticity that occurs during abstinence from cocaine use. Cocaine (dpeaa)DE-He213 Sensitization (dpeaa)DE-He213 Dopamine D2 receptor (dpeaa)DE-He213 Dopamine D (dpeaa)DE-He213 receptor (dpeaa)DE-He213 Yawning (dpeaa)DE-He213 Pramipexole (dpeaa)DE-He213 Truong, Yen Nhu-Thi aut Levant, Beth aut Chen, Jianyong aut Wang, Shaomeng aut Woods, James H. aut Enthalten in Psychopharmacology Berlin : Springer, 1959 215(2011), 4 vom: 05. Jan., Seite 609-620 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:215 year:2011 number:4 day:05 month:01 pages:609-620 https://dx.doi.org/10.1007/s00213-010-2154-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 215 2011 4 05 01 609-620 |
| spelling |
10.1007/s00213-010-2154-7 doi (DE-627)SPR00201792X (SPR)s00213-010-2154-7-e DE-627 ger DE-627 rakwb eng Collins, Gregory T. verfasserin aut Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Rationale Cocaine-induced changes in $ D_{2} $ receptors have been implicated in the expression of sensitized behavioral responses and addiction-like behaviors; however, the influence of $ D_{3} $ receptors is less clear. Objectives To characterize the effects of repeated cocaine administration on the sensitivity of rats to $ D_{2} $- and $ D_{3} $-mediated behaviors, as well as the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors. Methods Pramipexole was used to assess the sensitivity of rats to $ D_{3} $/$ D_{2} $ agonist-induced yawning, hypothermia, and locomotor activity, 24 h, 72 h, 10, 21, and 42 days after repeated cocaine or saline administration. The locomotor effects of cocaine (42 day) and the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors (24 h and 42 days) were also evaluated. Results Cocaine-treated rats displayed an enhanced locomotor response to cocaine, as well as a progressive and persistent leftward/upward shift of the ascending limb (72 h–42 day) and leftward shift of the descending limb (42 days) of the pramipexole-induced yawning dose–response curve. Cocaine treatment also decreased Bmax and Kd for $ D_{2} $-like receptors and increased $ D_{3} $ receptor binding at 42 days. Cocaine treatment did not change pramipexole-induced hypothermia or locomotor activity or yawning induced by cholinergic or serotonergic agonists. Conclusions These studies suggest that temporal differences exist in the development of cocaine-induced sensitization of $ D_{3} $ and $ D_{2} $ receptors, with enhancements of $ D_{3} $-mediated behavioral effects observed within 72 h and enhancements of $ D_{2} $-mediated behavioral effects apparent 42 days after cocaine. These findings highlight the need to consider changes in $ D_{3} $ receptor function when thinking about the behavioral plasticity that occurs during abstinence from cocaine use. Cocaine (dpeaa)DE-He213 Sensitization (dpeaa)DE-He213 Dopamine D2 receptor (dpeaa)DE-He213 Dopamine D (dpeaa)DE-He213 receptor (dpeaa)DE-He213 Yawning (dpeaa)DE-He213 Pramipexole (dpeaa)DE-He213 Truong, Yen Nhu-Thi aut Levant, Beth aut Chen, Jianyong aut Wang, Shaomeng aut Woods, James H. aut Enthalten in Psychopharmacology Berlin : Springer, 1959 215(2011), 4 vom: 05. Jan., Seite 609-620 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:215 year:2011 number:4 day:05 month:01 pages:609-620 https://dx.doi.org/10.1007/s00213-010-2154-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 215 2011 4 05 01 609-620 |
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10.1007/s00213-010-2154-7 doi (DE-627)SPR00201792X (SPR)s00213-010-2154-7-e DE-627 ger DE-627 rakwb eng Collins, Gregory T. verfasserin aut Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Rationale Cocaine-induced changes in $ D_{2} $ receptors have been implicated in the expression of sensitized behavioral responses and addiction-like behaviors; however, the influence of $ D_{3} $ receptors is less clear. Objectives To characterize the effects of repeated cocaine administration on the sensitivity of rats to $ D_{2} $- and $ D_{3} $-mediated behaviors, as well as the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors. Methods Pramipexole was used to assess the sensitivity of rats to $ D_{3} $/$ D_{2} $ agonist-induced yawning, hypothermia, and locomotor activity, 24 h, 72 h, 10, 21, and 42 days after repeated cocaine or saline administration. The locomotor effects of cocaine (42 day) and the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors (24 h and 42 days) were also evaluated. Results Cocaine-treated rats displayed an enhanced locomotor response to cocaine, as well as a progressive and persistent leftward/upward shift of the ascending limb (72 h–42 day) and leftward shift of the descending limb (42 days) of the pramipexole-induced yawning dose–response curve. Cocaine treatment also decreased Bmax and Kd for $ D_{2} $-like receptors and increased $ D_{3} $ receptor binding at 42 days. Cocaine treatment did not change pramipexole-induced hypothermia or locomotor activity or yawning induced by cholinergic or serotonergic agonists. Conclusions These studies suggest that temporal differences exist in the development of cocaine-induced sensitization of $ D_{3} $ and $ D_{2} $ receptors, with enhancements of $ D_{3} $-mediated behavioral effects observed within 72 h and enhancements of $ D_{2} $-mediated behavioral effects apparent 42 days after cocaine. These findings highlight the need to consider changes in $ D_{3} $ receptor function when thinking about the behavioral plasticity that occurs during abstinence from cocaine use. Cocaine (dpeaa)DE-He213 Sensitization (dpeaa)DE-He213 Dopamine D2 receptor (dpeaa)DE-He213 Dopamine D (dpeaa)DE-He213 receptor (dpeaa)DE-He213 Yawning (dpeaa)DE-He213 Pramipexole (dpeaa)DE-He213 Truong, Yen Nhu-Thi aut Levant, Beth aut Chen, Jianyong aut Wang, Shaomeng aut Woods, James H. aut Enthalten in Psychopharmacology Berlin : Springer, 1959 215(2011), 4 vom: 05. Jan., Seite 609-620 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:215 year:2011 number:4 day:05 month:01 pages:609-620 https://dx.doi.org/10.1007/s00213-010-2154-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 215 2011 4 05 01 609-620 |
| allfieldsGer |
10.1007/s00213-010-2154-7 doi (DE-627)SPR00201792X (SPR)s00213-010-2154-7-e DE-627 ger DE-627 rakwb eng Collins, Gregory T. verfasserin aut Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Rationale Cocaine-induced changes in $ D_{2} $ receptors have been implicated in the expression of sensitized behavioral responses and addiction-like behaviors; however, the influence of $ D_{3} $ receptors is less clear. Objectives To characterize the effects of repeated cocaine administration on the sensitivity of rats to $ D_{2} $- and $ D_{3} $-mediated behaviors, as well as the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors. Methods Pramipexole was used to assess the sensitivity of rats to $ D_{3} $/$ D_{2} $ agonist-induced yawning, hypothermia, and locomotor activity, 24 h, 72 h, 10, 21, and 42 days after repeated cocaine or saline administration. The locomotor effects of cocaine (42 day) and the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors (24 h and 42 days) were also evaluated. Results Cocaine-treated rats displayed an enhanced locomotor response to cocaine, as well as a progressive and persistent leftward/upward shift of the ascending limb (72 h–42 day) and leftward shift of the descending limb (42 days) of the pramipexole-induced yawning dose–response curve. Cocaine treatment also decreased Bmax and Kd for $ D_{2} $-like receptors and increased $ D_{3} $ receptor binding at 42 days. Cocaine treatment did not change pramipexole-induced hypothermia or locomotor activity or yawning induced by cholinergic or serotonergic agonists. Conclusions These studies suggest that temporal differences exist in the development of cocaine-induced sensitization of $ D_{3} $ and $ D_{2} $ receptors, with enhancements of $ D_{3} $-mediated behavioral effects observed within 72 h and enhancements of $ D_{2} $-mediated behavioral effects apparent 42 days after cocaine. These findings highlight the need to consider changes in $ D_{3} $ receptor function when thinking about the behavioral plasticity that occurs during abstinence from cocaine use. Cocaine (dpeaa)DE-He213 Sensitization (dpeaa)DE-He213 Dopamine D2 receptor (dpeaa)DE-He213 Dopamine D (dpeaa)DE-He213 receptor (dpeaa)DE-He213 Yawning (dpeaa)DE-He213 Pramipexole (dpeaa)DE-He213 Truong, Yen Nhu-Thi aut Levant, Beth aut Chen, Jianyong aut Wang, Shaomeng aut Woods, James H. aut Enthalten in Psychopharmacology Berlin : Springer, 1959 215(2011), 4 vom: 05. Jan., Seite 609-620 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:215 year:2011 number:4 day:05 month:01 pages:609-620 https://dx.doi.org/10.1007/s00213-010-2154-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 215 2011 4 05 01 609-620 |
| allfieldsSound |
10.1007/s00213-010-2154-7 doi (DE-627)SPR00201792X (SPR)s00213-010-2154-7-e DE-627 ger DE-627 rakwb eng Collins, Gregory T. verfasserin aut Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Rationale Cocaine-induced changes in $ D_{2} $ receptors have been implicated in the expression of sensitized behavioral responses and addiction-like behaviors; however, the influence of $ D_{3} $ receptors is less clear. Objectives To characterize the effects of repeated cocaine administration on the sensitivity of rats to $ D_{2} $- and $ D_{3} $-mediated behaviors, as well as the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors. Methods Pramipexole was used to assess the sensitivity of rats to $ D_{3} $/$ D_{2} $ agonist-induced yawning, hypothermia, and locomotor activity, 24 h, 72 h, 10, 21, and 42 days after repeated cocaine or saline administration. The locomotor effects of cocaine (42 day) and the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors (24 h and 42 days) were also evaluated. Results Cocaine-treated rats displayed an enhanced locomotor response to cocaine, as well as a progressive and persistent leftward/upward shift of the ascending limb (72 h–42 day) and leftward shift of the descending limb (42 days) of the pramipexole-induced yawning dose–response curve. Cocaine treatment also decreased Bmax and Kd for $ D_{2} $-like receptors and increased $ D_{3} $ receptor binding at 42 days. Cocaine treatment did not change pramipexole-induced hypothermia or locomotor activity or yawning induced by cholinergic or serotonergic agonists. Conclusions These studies suggest that temporal differences exist in the development of cocaine-induced sensitization of $ D_{3} $ and $ D_{2} $ receptors, with enhancements of $ D_{3} $-mediated behavioral effects observed within 72 h and enhancements of $ D_{2} $-mediated behavioral effects apparent 42 days after cocaine. These findings highlight the need to consider changes in $ D_{3} $ receptor function when thinking about the behavioral plasticity that occurs during abstinence from cocaine use. Cocaine (dpeaa)DE-He213 Sensitization (dpeaa)DE-He213 Dopamine D2 receptor (dpeaa)DE-He213 Dopamine D (dpeaa)DE-He213 receptor (dpeaa)DE-He213 Yawning (dpeaa)DE-He213 Pramipexole (dpeaa)DE-He213 Truong, Yen Nhu-Thi aut Levant, Beth aut Chen, Jianyong aut Wang, Shaomeng aut Woods, James H. aut Enthalten in Psychopharmacology Berlin : Springer, 1959 215(2011), 4 vom: 05. Jan., Seite 609-620 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:215 year:2011 number:4 day:05 month:01 pages:609-620 https://dx.doi.org/10.1007/s00213-010-2154-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 215 2011 4 05 01 609-620 |
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Enthalten in Psychopharmacology 215(2011), 4 vom: 05. Jan., Seite 609-620 volume:215 year:2011 number:4 day:05 month:01 pages:609-620 |
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Enthalten in Psychopharmacology 215(2011), 4 vom: 05. Jan., Seite 609-620 volume:215 year:2011 number:4 day:05 month:01 pages:609-620 |
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Cocaine Sensitization Dopamine D2 receptor Dopamine D receptor Yawning Pramipexole |
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Psychopharmacology |
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Collins, Gregory T. @@aut@@ Truong, Yen Nhu-Thi @@aut@@ Levant, Beth @@aut@@ Chen, Jianyong @@aut@@ Wang, Shaomeng @@aut@@ Woods, James H. @@aut@@ |
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Objectives To characterize the effects of repeated cocaine administration on the sensitivity of rats to $ D_{2} $- and $ D_{3} $-mediated behaviors, as well as the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors. Methods Pramipexole was used to assess the sensitivity of rats to $ D_{3} $/$ D_{2} $ agonist-induced yawning, hypothermia, and locomotor activity, 24 h, 72 h, 10, 21, and 42 days after repeated cocaine or saline administration. The locomotor effects of cocaine (42 day) and the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors (24 h and 42 days) were also evaluated. Results Cocaine-treated rats displayed an enhanced locomotor response to cocaine, as well as a progressive and persistent leftward/upward shift of the ascending limb (72 h–42 day) and leftward shift of the descending limb (42 days) of the pramipexole-induced yawning dose–response curve. Cocaine treatment also decreased Bmax and Kd for $ D_{2} $-like receptors and increased $ D_{3} $ receptor binding at 42 days. Cocaine treatment did not change pramipexole-induced hypothermia or locomotor activity or yawning induced by cholinergic or serotonergic agonists. Conclusions These studies suggest that temporal differences exist in the development of cocaine-induced sensitization of $ D_{3} $ and $ D_{2} $ receptors, with enhancements of $ D_{3} $-mediated behavioral effects observed within 72 h and enhancements of $ D_{2} $-mediated behavioral effects apparent 42 days after cocaine. 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Collins, Gregory T. |
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Collins, Gregory T. misc Cocaine misc Sensitization misc Dopamine D2 receptor misc Dopamine D misc receptor misc Yawning misc Pramipexole Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity |
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Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity Cocaine (dpeaa)DE-He213 Sensitization (dpeaa)DE-He213 Dopamine D2 receptor (dpeaa)DE-He213 Dopamine D (dpeaa)DE-He213 receptor (dpeaa)DE-He213 Yawning (dpeaa)DE-He213 Pramipexole (dpeaa)DE-He213 |
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Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity |
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Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity |
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Collins, Gregory T. Truong, Yen Nhu-Thi Levant, Beth Chen, Jianyong Wang, Shaomeng Woods, James H. |
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Elektronische Aufsätze |
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Collins, Gregory T. |
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10.1007/s00213-010-2154-7 |
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behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ d_{3} $ and $ d_{2} $ receptor sensitivity |
| title_auth |
Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity |
| abstract |
Rationale Cocaine-induced changes in $ D_{2} $ receptors have been implicated in the expression of sensitized behavioral responses and addiction-like behaviors; however, the influence of $ D_{3} $ receptors is less clear. Objectives To characterize the effects of repeated cocaine administration on the sensitivity of rats to $ D_{2} $- and $ D_{3} $-mediated behaviors, as well as the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors. Methods Pramipexole was used to assess the sensitivity of rats to $ D_{3} $/$ D_{2} $ agonist-induced yawning, hypothermia, and locomotor activity, 24 h, 72 h, 10, 21, and 42 days after repeated cocaine or saline administration. The locomotor effects of cocaine (42 day) and the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors (24 h and 42 days) were also evaluated. Results Cocaine-treated rats displayed an enhanced locomotor response to cocaine, as well as a progressive and persistent leftward/upward shift of the ascending limb (72 h–42 day) and leftward shift of the descending limb (42 days) of the pramipexole-induced yawning dose–response curve. Cocaine treatment also decreased Bmax and Kd for $ D_{2} $-like receptors and increased $ D_{3} $ receptor binding at 42 days. Cocaine treatment did not change pramipexole-induced hypothermia or locomotor activity or yawning induced by cholinergic or serotonergic agonists. Conclusions These studies suggest that temporal differences exist in the development of cocaine-induced sensitization of $ D_{3} $ and $ D_{2} $ receptors, with enhancements of $ D_{3} $-mediated behavioral effects observed within 72 h and enhancements of $ D_{2} $-mediated behavioral effects apparent 42 days after cocaine. These findings highlight the need to consider changes in $ D_{3} $ receptor function when thinking about the behavioral plasticity that occurs during abstinence from cocaine use. © Springer-Verlag 2010 |
| abstractGer |
Rationale Cocaine-induced changes in $ D_{2} $ receptors have been implicated in the expression of sensitized behavioral responses and addiction-like behaviors; however, the influence of $ D_{3} $ receptors is less clear. Objectives To characterize the effects of repeated cocaine administration on the sensitivity of rats to $ D_{2} $- and $ D_{3} $-mediated behaviors, as well as the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors. Methods Pramipexole was used to assess the sensitivity of rats to $ D_{3} $/$ D_{2} $ agonist-induced yawning, hypothermia, and locomotor activity, 24 h, 72 h, 10, 21, and 42 days after repeated cocaine or saline administration. The locomotor effects of cocaine (42 day) and the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors (24 h and 42 days) were also evaluated. Results Cocaine-treated rats displayed an enhanced locomotor response to cocaine, as well as a progressive and persistent leftward/upward shift of the ascending limb (72 h–42 day) and leftward shift of the descending limb (42 days) of the pramipexole-induced yawning dose–response curve. Cocaine treatment also decreased Bmax and Kd for $ D_{2} $-like receptors and increased $ D_{3} $ receptor binding at 42 days. Cocaine treatment did not change pramipexole-induced hypothermia or locomotor activity or yawning induced by cholinergic or serotonergic agonists. Conclusions These studies suggest that temporal differences exist in the development of cocaine-induced sensitization of $ D_{3} $ and $ D_{2} $ receptors, with enhancements of $ D_{3} $-mediated behavioral effects observed within 72 h and enhancements of $ D_{2} $-mediated behavioral effects apparent 42 days after cocaine. These findings highlight the need to consider changes in $ D_{3} $ receptor function when thinking about the behavioral plasticity that occurs during abstinence from cocaine use. © Springer-Verlag 2010 |
| abstract_unstemmed |
Rationale Cocaine-induced changes in $ D_{2} $ receptors have been implicated in the expression of sensitized behavioral responses and addiction-like behaviors; however, the influence of $ D_{3} $ receptors is less clear. Objectives To characterize the effects of repeated cocaine administration on the sensitivity of rats to $ D_{2} $- and $ D_{3} $-mediated behaviors, as well as the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors. Methods Pramipexole was used to assess the sensitivity of rats to $ D_{3} $/$ D_{2} $ agonist-induced yawning, hypothermia, and locomotor activity, 24 h, 72 h, 10, 21, and 42 days after repeated cocaine or saline administration. The locomotor effects of cocaine (42 day) and the binding properties of ventral striatal $ D_{2} $-like and $ D_{3} $ receptors (24 h and 42 days) were also evaluated. Results Cocaine-treated rats displayed an enhanced locomotor response to cocaine, as well as a progressive and persistent leftward/upward shift of the ascending limb (72 h–42 day) and leftward shift of the descending limb (42 days) of the pramipexole-induced yawning dose–response curve. Cocaine treatment also decreased Bmax and Kd for $ D_{2} $-like receptors and increased $ D_{3} $ receptor binding at 42 days. Cocaine treatment did not change pramipexole-induced hypothermia or locomotor activity or yawning induced by cholinergic or serotonergic agonists. Conclusions These studies suggest that temporal differences exist in the development of cocaine-induced sensitization of $ D_{3} $ and $ D_{2} $ receptors, with enhancements of $ D_{3} $-mediated behavioral effects observed within 72 h and enhancements of $ D_{2} $-mediated behavioral effects apparent 42 days after cocaine. These findings highlight the need to consider changes in $ D_{3} $ receptor function when thinking about the behavioral plasticity that occurs during abstinence from cocaine use. © Springer-Verlag 2010 |
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Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine $ D_{3} $ and $ D_{2} $ receptor sensitivity |
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| score |
7.400613 |