Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm
Rationale Early ethanol exposure promotes ethanol reinforcement, mediated perhaps by ethanol’s motivational effects. The opioid system mediates ethanol reinforcement, at least in part. Objectives Modulation of consummatory and seeking behaviors by the opioid system was tested in terms of ethanol or...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Miranda-Morales, Roberto Sebastián [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2011 |
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| Übergeordnetes Werk: |
Enthalten in: Psychopharmacology - Berlin : Springer, 1959, 219(2011), 1 vom: 13. Juli, Seite 235-246 |
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| Übergeordnetes Werk: |
volume:219 ; year:2011 ; number:1 ; day:13 ; month:07 ; pages:235-246 |
| Links: |
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| DOI / URN: |
10.1007/s00213-011-2402-5 |
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| Katalog-ID: |
SPR002020149 |
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| 100 | 1 | |a Miranda-Morales, Roberto Sebastián |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm |
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| 520 | |a Rationale Early ethanol exposure promotes ethanol reinforcement, mediated perhaps by ethanol’s motivational effects. The opioid system mediates ethanol reinforcement, at least in part. Objectives Modulation of consummatory and seeking behaviors by the opioid system was tested in terms of ethanol or sucrose operant self-administration. Methods Wistar-derived infant rats were tested in an operant conditioning task. (1) Infants were trained on postnatal days (PDs) 14–17 to obtain 5% sucrose and 3.75% ethanol or water, and evaluated in an extinction session at PD 18. (2) Ethanol (3.75%) was used as reinforcer. At PDs 16–17, 6 h before operant task, pups were re-exposed to ethanol after naloxone injection (0 or 1 mg/kg). (3) Sucrose (5%) acted as reinforcer. Pups were re-exposed to sucrose after naloxone injection. (4) A PD 18 re-exposure trial in which pups were injected with naloxone and re-exposed to ethanol was added. Results Sucrose and ethanol promoted higher levels of operant responding than water during training and extinction. Re-exposure to ethanol preceded by naloxone decreased nose-poking. A similar profile was observed towards sucrose. No seeking behavior was observed in pups re-exposed to ethanol following naloxone injection during PDs 16–18. Conclusions Self-administration of ethanol was established in terms of operant responding in preweanling rats with no previous exposure to the drug. Pairing of naloxone with ethanol, at a point separate in time from operant responding, reduced ethanol reinforcement. This indicated participation of the opioid system in ethanol reinforcement. This effect seems not to be unique to ethanol but also is observable when sucrose acts as reinforcer. | ||
| 650 | 4 | |a Ethanol reinforcement |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Infant rat |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Opioid system |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Operant conditioning |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Appetitive behaviors |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Consummatory behaviors |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Naloxone |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Molina, Juan Carlos |4 aut | |
| 700 | 1 | |a Spear, Norman E. |4 aut | |
| 700 | 1 | |a Abate, Paula |4 aut | |
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10.1007/s00213-011-2402-5 doi (DE-627)SPR002020149 (SPR)s00213-011-2402-5-e DE-627 ger DE-627 rakwb eng Miranda-Morales, Roberto Sebastián verfasserin aut Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2011 Rationale Early ethanol exposure promotes ethanol reinforcement, mediated perhaps by ethanol’s motivational effects. The opioid system mediates ethanol reinforcement, at least in part. Objectives Modulation of consummatory and seeking behaviors by the opioid system was tested in terms of ethanol or sucrose operant self-administration. Methods Wistar-derived infant rats were tested in an operant conditioning task. (1) Infants were trained on postnatal days (PDs) 14–17 to obtain 5% sucrose and 3.75% ethanol or water, and evaluated in an extinction session at PD 18. (2) Ethanol (3.75%) was used as reinforcer. At PDs 16–17, 6 h before operant task, pups were re-exposed to ethanol after naloxone injection (0 or 1 mg/kg). (3) Sucrose (5%) acted as reinforcer. Pups were re-exposed to sucrose after naloxone injection. (4) A PD 18 re-exposure trial in which pups were injected with naloxone and re-exposed to ethanol was added. Results Sucrose and ethanol promoted higher levels of operant responding than water during training and extinction. Re-exposure to ethanol preceded by naloxone decreased nose-poking. A similar profile was observed towards sucrose. No seeking behavior was observed in pups re-exposed to ethanol following naloxone injection during PDs 16–18. Conclusions Self-administration of ethanol was established in terms of operant responding in preweanling rats with no previous exposure to the drug. Pairing of naloxone with ethanol, at a point separate in time from operant responding, reduced ethanol reinforcement. This indicated participation of the opioid system in ethanol reinforcement. This effect seems not to be unique to ethanol but also is observable when sucrose acts as reinforcer. Ethanol reinforcement (dpeaa)DE-He213 Infant rat (dpeaa)DE-He213 Opioid system (dpeaa)DE-He213 Operant conditioning (dpeaa)DE-He213 Appetitive behaviors (dpeaa)DE-He213 Consummatory behaviors (dpeaa)DE-He213 Naloxone (dpeaa)DE-He213 Molina, Juan Carlos aut Spear, Norman E. aut Abate, Paula aut Enthalten in Psychopharmacology Berlin : Springer, 1959 219(2011), 1 vom: 13. Juli, Seite 235-246 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:219 year:2011 number:1 day:13 month:07 pages:235-246 https://dx.doi.org/10.1007/s00213-011-2402-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 219 2011 1 13 07 235-246 |
| spelling |
10.1007/s00213-011-2402-5 doi (DE-627)SPR002020149 (SPR)s00213-011-2402-5-e DE-627 ger DE-627 rakwb eng Miranda-Morales, Roberto Sebastián verfasserin aut Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2011 Rationale Early ethanol exposure promotes ethanol reinforcement, mediated perhaps by ethanol’s motivational effects. The opioid system mediates ethanol reinforcement, at least in part. Objectives Modulation of consummatory and seeking behaviors by the opioid system was tested in terms of ethanol or sucrose operant self-administration. Methods Wistar-derived infant rats were tested in an operant conditioning task. (1) Infants were trained on postnatal days (PDs) 14–17 to obtain 5% sucrose and 3.75% ethanol or water, and evaluated in an extinction session at PD 18. (2) Ethanol (3.75%) was used as reinforcer. At PDs 16–17, 6 h before operant task, pups were re-exposed to ethanol after naloxone injection (0 or 1 mg/kg). (3) Sucrose (5%) acted as reinforcer. Pups were re-exposed to sucrose after naloxone injection. (4) A PD 18 re-exposure trial in which pups were injected with naloxone and re-exposed to ethanol was added. Results Sucrose and ethanol promoted higher levels of operant responding than water during training and extinction. Re-exposure to ethanol preceded by naloxone decreased nose-poking. A similar profile was observed towards sucrose. No seeking behavior was observed in pups re-exposed to ethanol following naloxone injection during PDs 16–18. Conclusions Self-administration of ethanol was established in terms of operant responding in preweanling rats with no previous exposure to the drug. Pairing of naloxone with ethanol, at a point separate in time from operant responding, reduced ethanol reinforcement. This indicated participation of the opioid system in ethanol reinforcement. This effect seems not to be unique to ethanol but also is observable when sucrose acts as reinforcer. Ethanol reinforcement (dpeaa)DE-He213 Infant rat (dpeaa)DE-He213 Opioid system (dpeaa)DE-He213 Operant conditioning (dpeaa)DE-He213 Appetitive behaviors (dpeaa)DE-He213 Consummatory behaviors (dpeaa)DE-He213 Naloxone (dpeaa)DE-He213 Molina, Juan Carlos aut Spear, Norman E. aut Abate, Paula aut Enthalten in Psychopharmacology Berlin : Springer, 1959 219(2011), 1 vom: 13. Juli, Seite 235-246 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:219 year:2011 number:1 day:13 month:07 pages:235-246 https://dx.doi.org/10.1007/s00213-011-2402-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 219 2011 1 13 07 235-246 |
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10.1007/s00213-011-2402-5 doi (DE-627)SPR002020149 (SPR)s00213-011-2402-5-e DE-627 ger DE-627 rakwb eng Miranda-Morales, Roberto Sebastián verfasserin aut Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2011 Rationale Early ethanol exposure promotes ethanol reinforcement, mediated perhaps by ethanol’s motivational effects. The opioid system mediates ethanol reinforcement, at least in part. Objectives Modulation of consummatory and seeking behaviors by the opioid system was tested in terms of ethanol or sucrose operant self-administration. Methods Wistar-derived infant rats were tested in an operant conditioning task. (1) Infants were trained on postnatal days (PDs) 14–17 to obtain 5% sucrose and 3.75% ethanol or water, and evaluated in an extinction session at PD 18. (2) Ethanol (3.75%) was used as reinforcer. At PDs 16–17, 6 h before operant task, pups were re-exposed to ethanol after naloxone injection (0 or 1 mg/kg). (3) Sucrose (5%) acted as reinforcer. Pups were re-exposed to sucrose after naloxone injection. (4) A PD 18 re-exposure trial in which pups were injected with naloxone and re-exposed to ethanol was added. Results Sucrose and ethanol promoted higher levels of operant responding than water during training and extinction. Re-exposure to ethanol preceded by naloxone decreased nose-poking. A similar profile was observed towards sucrose. No seeking behavior was observed in pups re-exposed to ethanol following naloxone injection during PDs 16–18. Conclusions Self-administration of ethanol was established in terms of operant responding in preweanling rats with no previous exposure to the drug. Pairing of naloxone with ethanol, at a point separate in time from operant responding, reduced ethanol reinforcement. This indicated participation of the opioid system in ethanol reinforcement. This effect seems not to be unique to ethanol but also is observable when sucrose acts as reinforcer. Ethanol reinforcement (dpeaa)DE-He213 Infant rat (dpeaa)DE-He213 Opioid system (dpeaa)DE-He213 Operant conditioning (dpeaa)DE-He213 Appetitive behaviors (dpeaa)DE-He213 Consummatory behaviors (dpeaa)DE-He213 Naloxone (dpeaa)DE-He213 Molina, Juan Carlos aut Spear, Norman E. aut Abate, Paula aut Enthalten in Psychopharmacology Berlin : Springer, 1959 219(2011), 1 vom: 13. Juli, Seite 235-246 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:219 year:2011 number:1 day:13 month:07 pages:235-246 https://dx.doi.org/10.1007/s00213-011-2402-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 219 2011 1 13 07 235-246 |
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10.1007/s00213-011-2402-5 doi (DE-627)SPR002020149 (SPR)s00213-011-2402-5-e DE-627 ger DE-627 rakwb eng Miranda-Morales, Roberto Sebastián verfasserin aut Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2011 Rationale Early ethanol exposure promotes ethanol reinforcement, mediated perhaps by ethanol’s motivational effects. The opioid system mediates ethanol reinforcement, at least in part. Objectives Modulation of consummatory and seeking behaviors by the opioid system was tested in terms of ethanol or sucrose operant self-administration. Methods Wistar-derived infant rats were tested in an operant conditioning task. (1) Infants were trained on postnatal days (PDs) 14–17 to obtain 5% sucrose and 3.75% ethanol or water, and evaluated in an extinction session at PD 18. (2) Ethanol (3.75%) was used as reinforcer. At PDs 16–17, 6 h before operant task, pups were re-exposed to ethanol after naloxone injection (0 or 1 mg/kg). (3) Sucrose (5%) acted as reinforcer. Pups were re-exposed to sucrose after naloxone injection. (4) A PD 18 re-exposure trial in which pups were injected with naloxone and re-exposed to ethanol was added. Results Sucrose and ethanol promoted higher levels of operant responding than water during training and extinction. Re-exposure to ethanol preceded by naloxone decreased nose-poking. A similar profile was observed towards sucrose. No seeking behavior was observed in pups re-exposed to ethanol following naloxone injection during PDs 16–18. Conclusions Self-administration of ethanol was established in terms of operant responding in preweanling rats with no previous exposure to the drug. Pairing of naloxone with ethanol, at a point separate in time from operant responding, reduced ethanol reinforcement. This indicated participation of the opioid system in ethanol reinforcement. This effect seems not to be unique to ethanol but also is observable when sucrose acts as reinforcer. Ethanol reinforcement (dpeaa)DE-He213 Infant rat (dpeaa)DE-He213 Opioid system (dpeaa)DE-He213 Operant conditioning (dpeaa)DE-He213 Appetitive behaviors (dpeaa)DE-He213 Consummatory behaviors (dpeaa)DE-He213 Naloxone (dpeaa)DE-He213 Molina, Juan Carlos aut Spear, Norman E. aut Abate, Paula aut Enthalten in Psychopharmacology Berlin : Springer, 1959 219(2011), 1 vom: 13. Juli, Seite 235-246 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:219 year:2011 number:1 day:13 month:07 pages:235-246 https://dx.doi.org/10.1007/s00213-011-2402-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 219 2011 1 13 07 235-246 |
| allfieldsSound |
10.1007/s00213-011-2402-5 doi (DE-627)SPR002020149 (SPR)s00213-011-2402-5-e DE-627 ger DE-627 rakwb eng Miranda-Morales, Roberto Sebastián verfasserin aut Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2011 Rationale Early ethanol exposure promotes ethanol reinforcement, mediated perhaps by ethanol’s motivational effects. The opioid system mediates ethanol reinforcement, at least in part. Objectives Modulation of consummatory and seeking behaviors by the opioid system was tested in terms of ethanol or sucrose operant self-administration. Methods Wistar-derived infant rats were tested in an operant conditioning task. (1) Infants were trained on postnatal days (PDs) 14–17 to obtain 5% sucrose and 3.75% ethanol or water, and evaluated in an extinction session at PD 18. (2) Ethanol (3.75%) was used as reinforcer. At PDs 16–17, 6 h before operant task, pups were re-exposed to ethanol after naloxone injection (0 or 1 mg/kg). (3) Sucrose (5%) acted as reinforcer. Pups were re-exposed to sucrose after naloxone injection. (4) A PD 18 re-exposure trial in which pups were injected with naloxone and re-exposed to ethanol was added. Results Sucrose and ethanol promoted higher levels of operant responding than water during training and extinction. Re-exposure to ethanol preceded by naloxone decreased nose-poking. A similar profile was observed towards sucrose. No seeking behavior was observed in pups re-exposed to ethanol following naloxone injection during PDs 16–18. Conclusions Self-administration of ethanol was established in terms of operant responding in preweanling rats with no previous exposure to the drug. Pairing of naloxone with ethanol, at a point separate in time from operant responding, reduced ethanol reinforcement. This indicated participation of the opioid system in ethanol reinforcement. This effect seems not to be unique to ethanol but also is observable when sucrose acts as reinforcer. Ethanol reinforcement (dpeaa)DE-He213 Infant rat (dpeaa)DE-He213 Opioid system (dpeaa)DE-He213 Operant conditioning (dpeaa)DE-He213 Appetitive behaviors (dpeaa)DE-He213 Consummatory behaviors (dpeaa)DE-He213 Naloxone (dpeaa)DE-He213 Molina, Juan Carlos aut Spear, Norman E. aut Abate, Paula aut Enthalten in Psychopharmacology Berlin : Springer, 1959 219(2011), 1 vom: 13. Juli, Seite 235-246 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:219 year:2011 number:1 day:13 month:07 pages:235-246 https://dx.doi.org/10.1007/s00213-011-2402-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 219 2011 1 13 07 235-246 |
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English |
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Enthalten in Psychopharmacology 219(2011), 1 vom: 13. Juli, Seite 235-246 volume:219 year:2011 number:1 day:13 month:07 pages:235-246 |
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Enthalten in Psychopharmacology 219(2011), 1 vom: 13. Juli, Seite 235-246 volume:219 year:2011 number:1 day:13 month:07 pages:235-246 |
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Ethanol reinforcement Infant rat Opioid system Operant conditioning Appetitive behaviors Consummatory behaviors Naloxone |
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Psychopharmacology |
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Miranda-Morales, Roberto Sebastián @@aut@@ Molina, Juan Carlos @@aut@@ Spear, Norman E. @@aut@@ Abate, Paula @@aut@@ |
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2011-07-13T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR002020149</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519154514.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2011 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00213-011-2402-5</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR002020149</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00213-011-2402-5-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Miranda-Morales, Roberto Sebastián</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2011</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer-Verlag 2011</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Rationale Early ethanol exposure promotes ethanol reinforcement, mediated perhaps by ethanol’s motivational effects. The opioid system mediates ethanol reinforcement, at least in part. Objectives Modulation of consummatory and seeking behaviors by the opioid system was tested in terms of ethanol or sucrose operant self-administration. Methods Wistar-derived infant rats were tested in an operant conditioning task. (1) Infants were trained on postnatal days (PDs) 14–17 to obtain 5% sucrose and 3.75% ethanol or water, and evaluated in an extinction session at PD 18. (2) Ethanol (3.75%) was used as reinforcer. At PDs 16–17, 6 h before operant task, pups were re-exposed to ethanol after naloxone injection (0 or 1 mg/kg). (3) Sucrose (5%) acted as reinforcer. Pups were re-exposed to sucrose after naloxone injection. (4) A PD 18 re-exposure trial in which pups were injected with naloxone and re-exposed to ethanol was added. Results Sucrose and ethanol promoted higher levels of operant responding than water during training and extinction. Re-exposure to ethanol preceded by naloxone decreased nose-poking. A similar profile was observed towards sucrose. No seeking behavior was observed in pups re-exposed to ethanol following naloxone injection during PDs 16–18. Conclusions Self-administration of ethanol was established in terms of operant responding in preweanling rats with no previous exposure to the drug. Pairing of naloxone with ethanol, at a point separate in time from operant responding, reduced ethanol reinforcement. This indicated participation of the opioid system in ethanol reinforcement. 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Miranda-Morales, Roberto Sebastián |
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Miranda-Morales, Roberto Sebastián misc Ethanol reinforcement misc Infant rat misc Opioid system misc Operant conditioning misc Appetitive behaviors misc Consummatory behaviors misc Naloxone Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm |
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Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm Ethanol reinforcement (dpeaa)DE-He213 Infant rat (dpeaa)DE-He213 Opioid system (dpeaa)DE-He213 Operant conditioning (dpeaa)DE-He213 Appetitive behaviors (dpeaa)DE-He213 Consummatory behaviors (dpeaa)DE-He213 Naloxone (dpeaa)DE-He213 |
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misc Ethanol reinforcement misc Infant rat misc Opioid system misc Operant conditioning misc Appetitive behaviors misc Consummatory behaviors misc Naloxone |
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10.1007/s00213-011-2402-5 |
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naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm |
| title_auth |
Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm |
| abstract |
Rationale Early ethanol exposure promotes ethanol reinforcement, mediated perhaps by ethanol’s motivational effects. The opioid system mediates ethanol reinforcement, at least in part. Objectives Modulation of consummatory and seeking behaviors by the opioid system was tested in terms of ethanol or sucrose operant self-administration. Methods Wistar-derived infant rats were tested in an operant conditioning task. (1) Infants were trained on postnatal days (PDs) 14–17 to obtain 5% sucrose and 3.75% ethanol or water, and evaluated in an extinction session at PD 18. (2) Ethanol (3.75%) was used as reinforcer. At PDs 16–17, 6 h before operant task, pups were re-exposed to ethanol after naloxone injection (0 or 1 mg/kg). (3) Sucrose (5%) acted as reinforcer. Pups were re-exposed to sucrose after naloxone injection. (4) A PD 18 re-exposure trial in which pups were injected with naloxone and re-exposed to ethanol was added. Results Sucrose and ethanol promoted higher levels of operant responding than water during training and extinction. Re-exposure to ethanol preceded by naloxone decreased nose-poking. A similar profile was observed towards sucrose. No seeking behavior was observed in pups re-exposed to ethanol following naloxone injection during PDs 16–18. Conclusions Self-administration of ethanol was established in terms of operant responding in preweanling rats with no previous exposure to the drug. Pairing of naloxone with ethanol, at a point separate in time from operant responding, reduced ethanol reinforcement. This indicated participation of the opioid system in ethanol reinforcement. This effect seems not to be unique to ethanol but also is observable when sucrose acts as reinforcer. © Springer-Verlag 2011 |
| abstractGer |
Rationale Early ethanol exposure promotes ethanol reinforcement, mediated perhaps by ethanol’s motivational effects. The opioid system mediates ethanol reinforcement, at least in part. Objectives Modulation of consummatory and seeking behaviors by the opioid system was tested in terms of ethanol or sucrose operant self-administration. Methods Wistar-derived infant rats were tested in an operant conditioning task. (1) Infants were trained on postnatal days (PDs) 14–17 to obtain 5% sucrose and 3.75% ethanol or water, and evaluated in an extinction session at PD 18. (2) Ethanol (3.75%) was used as reinforcer. At PDs 16–17, 6 h before operant task, pups were re-exposed to ethanol after naloxone injection (0 or 1 mg/kg). (3) Sucrose (5%) acted as reinforcer. Pups were re-exposed to sucrose after naloxone injection. (4) A PD 18 re-exposure trial in which pups were injected with naloxone and re-exposed to ethanol was added. Results Sucrose and ethanol promoted higher levels of operant responding than water during training and extinction. Re-exposure to ethanol preceded by naloxone decreased nose-poking. A similar profile was observed towards sucrose. No seeking behavior was observed in pups re-exposed to ethanol following naloxone injection during PDs 16–18. Conclusions Self-administration of ethanol was established in terms of operant responding in preweanling rats with no previous exposure to the drug. Pairing of naloxone with ethanol, at a point separate in time from operant responding, reduced ethanol reinforcement. This indicated participation of the opioid system in ethanol reinforcement. This effect seems not to be unique to ethanol but also is observable when sucrose acts as reinforcer. © Springer-Verlag 2011 |
| abstract_unstemmed |
Rationale Early ethanol exposure promotes ethanol reinforcement, mediated perhaps by ethanol’s motivational effects. The opioid system mediates ethanol reinforcement, at least in part. Objectives Modulation of consummatory and seeking behaviors by the opioid system was tested in terms of ethanol or sucrose operant self-administration. Methods Wistar-derived infant rats were tested in an operant conditioning task. (1) Infants were trained on postnatal days (PDs) 14–17 to obtain 5% sucrose and 3.75% ethanol or water, and evaluated in an extinction session at PD 18. (2) Ethanol (3.75%) was used as reinforcer. At PDs 16–17, 6 h before operant task, pups were re-exposed to ethanol after naloxone injection (0 or 1 mg/kg). (3) Sucrose (5%) acted as reinforcer. Pups were re-exposed to sucrose after naloxone injection. (4) A PD 18 re-exposure trial in which pups were injected with naloxone and re-exposed to ethanol was added. Results Sucrose and ethanol promoted higher levels of operant responding than water during training and extinction. Re-exposure to ethanol preceded by naloxone decreased nose-poking. A similar profile was observed towards sucrose. No seeking behavior was observed in pups re-exposed to ethanol following naloxone injection during PDs 16–18. Conclusions Self-administration of ethanol was established in terms of operant responding in preweanling rats with no previous exposure to the drug. Pairing of naloxone with ethanol, at a point separate in time from operant responding, reduced ethanol reinforcement. This indicated participation of the opioid system in ethanol reinforcement. This effect seems not to be unique to ethanol but also is observable when sucrose acts as reinforcer. © Springer-Verlag 2011 |
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Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm |
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Molina, Juan Carlos Spear, Norman E. Abate, Paula |
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| score |
7.399846 |