Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats
Rationale Sardinian alcohol-preferring (sP) rats displayed high sensitivity to time schedule and consumed intoxicating amounts of alcohol during the last portion of the dark phase of the light/dark cycle when exposed to daily drinking sessions of 1 h, with concurrent availability of multiple alcohol...
Ausführliche Beschreibung
Autor*in: |
Maccioni, Paola [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2015 |
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Anmerkung: |
© Springer-Verlag Berlin Heidelberg 2015 |
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Übergeordnetes Werk: |
Enthalten in: Psychopharmacology - Berlin : Springer, 1959, 232(2015), 19 vom: 07. Juli, Seite 3585-3595 |
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Übergeordnetes Werk: |
volume:232 ; year:2015 ; number:19 ; day:07 ; month:07 ; pages:3585-3595 |
Links: |
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DOI / URN: |
10.1007/s00213-015-4010-2 |
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Katalog-ID: |
SPR002034840 |
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100 | 1 | |a Maccioni, Paola |e verfasserin |4 aut | |
245 | 1 | 0 | |a Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats |
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520 | |a Rationale Sardinian alcohol-preferring (sP) rats displayed high sensitivity to time schedule and consumed intoxicating amounts of alcohol during the last portion of the dark phase of the light/dark cycle when exposed to daily drinking sessions of 1 h, with concurrent availability of multiple alcohol concentrations and unpredictability of time of alcohol access. Objectives The present study investigated whether sensitivity of sP rats to time schedule extended to operant procedures of alcohol self-administration. Methods In experiment 1, three different alcohol solutions (10, 20, and 30 %, v/v) were concurrently available under a fixed ratio 4 schedule of reinforcement and with unpredictable time schedule; water was available uncontingently. Experiments 2 and 3 assessed the sensitivity of the motivational properties of alcohol to time schedule; rats were exposed to (a) self-administration sessions under the progressive ratio (PR) schedule of reinforcement and (b) sessions of alcohol seeking under the extinction responding (ER) schedule. Results In experiment 1, number of lever responses and amount of self-administered alcohol were positively correlated with time of alcohol access during the dark phase. When the self-administration session occurred at the first and latest hours of the dark phase, the amount of self-administered alcohol averaged 0.95–1.0 and 1.55–1.65 g/kg, respectively. In experiments 2 and 3, values of breakpoint and ER for alcohol were approximately 50 % higher when the sessions occurred at the last than first hour of the dark phase. Conclusions The reinforcing and motivational properties of alcohol were sensitive to time schedule and stronger at the end of the dark phase. | ||
650 | 4 | |a Unpredictability of alcohol access |7 (dpeaa)DE-He213 | |
650 | 4 | |a Alcohol self-administration |7 (dpeaa)DE-He213 | |
650 | 4 | |a Fixed ratio |7 (dpeaa)DE-He213 | |
650 | 4 | |a Progressive ratio |7 (dpeaa)DE-He213 | |
650 | 4 | |a Extinction responding |7 (dpeaa)DE-He213 | |
650 | 4 | |a Reinforcing properties |7 (dpeaa)DE-He213 | |
650 | 4 | |a Motivational properties |7 (dpeaa)DE-He213 | |
650 | 4 | |a Binge-like drinking |7 (dpeaa)DE-He213 | |
650 | 4 | |a Sardinian alcohol-preferring rats |7 (dpeaa)DE-He213 | |
700 | 1 | |a Lorrai, Irene |4 aut | |
700 | 1 | |a Marras, Maria Francesca |4 aut | |
700 | 1 | |a Contini, Andrea |4 aut | |
700 | 1 | |a Capra, Alessandro |4 aut | |
700 | 1 | |a Piras, Gessica |4 aut | |
700 | 1 | |a Caboni, Pierluigi |4 aut | |
700 | 1 | |a Gessa, Gian Luigi |4 aut | |
700 | 1 | |a Colombo, Giancarlo |4 aut | |
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10.1007/s00213-015-4010-2 doi (DE-627)SPR002034840 (SPR)s00213-015-4010-2-e DE-627 ger DE-627 rakwb eng Maccioni, Paola verfasserin aut Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Rationale Sardinian alcohol-preferring (sP) rats displayed high sensitivity to time schedule and consumed intoxicating amounts of alcohol during the last portion of the dark phase of the light/dark cycle when exposed to daily drinking sessions of 1 h, with concurrent availability of multiple alcohol concentrations and unpredictability of time of alcohol access. Objectives The present study investigated whether sensitivity of sP rats to time schedule extended to operant procedures of alcohol self-administration. Methods In experiment 1, three different alcohol solutions (10, 20, and 30 %, v/v) were concurrently available under a fixed ratio 4 schedule of reinforcement and with unpredictable time schedule; water was available uncontingently. Experiments 2 and 3 assessed the sensitivity of the motivational properties of alcohol to time schedule; rats were exposed to (a) self-administration sessions under the progressive ratio (PR) schedule of reinforcement and (b) sessions of alcohol seeking under the extinction responding (ER) schedule. Results In experiment 1, number of lever responses and amount of self-administered alcohol were positively correlated with time of alcohol access during the dark phase. When the self-administration session occurred at the first and latest hours of the dark phase, the amount of self-administered alcohol averaged 0.95–1.0 and 1.55–1.65 g/kg, respectively. In experiments 2 and 3, values of breakpoint and ER for alcohol were approximately 50 % higher when the sessions occurred at the last than first hour of the dark phase. Conclusions The reinforcing and motivational properties of alcohol were sensitive to time schedule and stronger at the end of the dark phase. Unpredictability of alcohol access (dpeaa)DE-He213 Alcohol self-administration (dpeaa)DE-He213 Fixed ratio (dpeaa)DE-He213 Progressive ratio (dpeaa)DE-He213 Extinction responding (dpeaa)DE-He213 Reinforcing properties (dpeaa)DE-He213 Motivational properties (dpeaa)DE-He213 Binge-like drinking (dpeaa)DE-He213 Sardinian alcohol-preferring rats (dpeaa)DE-He213 Lorrai, Irene aut Marras, Maria Francesca aut Contini, Andrea aut Capra, Alessandro aut Piras, Gessica aut Caboni, Pierluigi aut Gessa, Gian Luigi aut Colombo, Giancarlo aut Enthalten in Psychopharmacology Berlin : Springer, 1959 232(2015), 19 vom: 07. Juli, Seite 3585-3595 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:232 year:2015 number:19 day:07 month:07 pages:3585-3595 https://dx.doi.org/10.1007/s00213-015-4010-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 232 2015 19 07 07 3585-3595 |
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10.1007/s00213-015-4010-2 doi (DE-627)SPR002034840 (SPR)s00213-015-4010-2-e DE-627 ger DE-627 rakwb eng Maccioni, Paola verfasserin aut Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Rationale Sardinian alcohol-preferring (sP) rats displayed high sensitivity to time schedule and consumed intoxicating amounts of alcohol during the last portion of the dark phase of the light/dark cycle when exposed to daily drinking sessions of 1 h, with concurrent availability of multiple alcohol concentrations and unpredictability of time of alcohol access. Objectives The present study investigated whether sensitivity of sP rats to time schedule extended to operant procedures of alcohol self-administration. Methods In experiment 1, three different alcohol solutions (10, 20, and 30 %, v/v) were concurrently available under a fixed ratio 4 schedule of reinforcement and with unpredictable time schedule; water was available uncontingently. Experiments 2 and 3 assessed the sensitivity of the motivational properties of alcohol to time schedule; rats were exposed to (a) self-administration sessions under the progressive ratio (PR) schedule of reinforcement and (b) sessions of alcohol seeking under the extinction responding (ER) schedule. Results In experiment 1, number of lever responses and amount of self-administered alcohol were positively correlated with time of alcohol access during the dark phase. When the self-administration session occurred at the first and latest hours of the dark phase, the amount of self-administered alcohol averaged 0.95–1.0 and 1.55–1.65 g/kg, respectively. In experiments 2 and 3, values of breakpoint and ER for alcohol were approximately 50 % higher when the sessions occurred at the last than first hour of the dark phase. Conclusions The reinforcing and motivational properties of alcohol were sensitive to time schedule and stronger at the end of the dark phase. Unpredictability of alcohol access (dpeaa)DE-He213 Alcohol self-administration (dpeaa)DE-He213 Fixed ratio (dpeaa)DE-He213 Progressive ratio (dpeaa)DE-He213 Extinction responding (dpeaa)DE-He213 Reinforcing properties (dpeaa)DE-He213 Motivational properties (dpeaa)DE-He213 Binge-like drinking (dpeaa)DE-He213 Sardinian alcohol-preferring rats (dpeaa)DE-He213 Lorrai, Irene aut Marras, Maria Francesca aut Contini, Andrea aut Capra, Alessandro aut Piras, Gessica aut Caboni, Pierluigi aut Gessa, Gian Luigi aut Colombo, Giancarlo aut Enthalten in Psychopharmacology Berlin : Springer, 1959 232(2015), 19 vom: 07. Juli, Seite 3585-3595 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:232 year:2015 number:19 day:07 month:07 pages:3585-3595 https://dx.doi.org/10.1007/s00213-015-4010-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 232 2015 19 07 07 3585-3595 |
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10.1007/s00213-015-4010-2 doi (DE-627)SPR002034840 (SPR)s00213-015-4010-2-e DE-627 ger DE-627 rakwb eng Maccioni, Paola verfasserin aut Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Rationale Sardinian alcohol-preferring (sP) rats displayed high sensitivity to time schedule and consumed intoxicating amounts of alcohol during the last portion of the dark phase of the light/dark cycle when exposed to daily drinking sessions of 1 h, with concurrent availability of multiple alcohol concentrations and unpredictability of time of alcohol access. Objectives The present study investigated whether sensitivity of sP rats to time schedule extended to operant procedures of alcohol self-administration. Methods In experiment 1, three different alcohol solutions (10, 20, and 30 %, v/v) were concurrently available under a fixed ratio 4 schedule of reinforcement and with unpredictable time schedule; water was available uncontingently. Experiments 2 and 3 assessed the sensitivity of the motivational properties of alcohol to time schedule; rats were exposed to (a) self-administration sessions under the progressive ratio (PR) schedule of reinforcement and (b) sessions of alcohol seeking under the extinction responding (ER) schedule. Results In experiment 1, number of lever responses and amount of self-administered alcohol were positively correlated with time of alcohol access during the dark phase. When the self-administration session occurred at the first and latest hours of the dark phase, the amount of self-administered alcohol averaged 0.95–1.0 and 1.55–1.65 g/kg, respectively. In experiments 2 and 3, values of breakpoint and ER for alcohol were approximately 50 % higher when the sessions occurred at the last than first hour of the dark phase. Conclusions The reinforcing and motivational properties of alcohol were sensitive to time schedule and stronger at the end of the dark phase. Unpredictability of alcohol access (dpeaa)DE-He213 Alcohol self-administration (dpeaa)DE-He213 Fixed ratio (dpeaa)DE-He213 Progressive ratio (dpeaa)DE-He213 Extinction responding (dpeaa)DE-He213 Reinforcing properties (dpeaa)DE-He213 Motivational properties (dpeaa)DE-He213 Binge-like drinking (dpeaa)DE-He213 Sardinian alcohol-preferring rats (dpeaa)DE-He213 Lorrai, Irene aut Marras, Maria Francesca aut Contini, Andrea aut Capra, Alessandro aut Piras, Gessica aut Caboni, Pierluigi aut Gessa, Gian Luigi aut Colombo, Giancarlo aut Enthalten in Psychopharmacology Berlin : Springer, 1959 232(2015), 19 vom: 07. Juli, Seite 3585-3595 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:232 year:2015 number:19 day:07 month:07 pages:3585-3595 https://dx.doi.org/10.1007/s00213-015-4010-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 232 2015 19 07 07 3585-3595 |
allfieldsGer |
10.1007/s00213-015-4010-2 doi (DE-627)SPR002034840 (SPR)s00213-015-4010-2-e DE-627 ger DE-627 rakwb eng Maccioni, Paola verfasserin aut Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Rationale Sardinian alcohol-preferring (sP) rats displayed high sensitivity to time schedule and consumed intoxicating amounts of alcohol during the last portion of the dark phase of the light/dark cycle when exposed to daily drinking sessions of 1 h, with concurrent availability of multiple alcohol concentrations and unpredictability of time of alcohol access. Objectives The present study investigated whether sensitivity of sP rats to time schedule extended to operant procedures of alcohol self-administration. Methods In experiment 1, three different alcohol solutions (10, 20, and 30 %, v/v) were concurrently available under a fixed ratio 4 schedule of reinforcement and with unpredictable time schedule; water was available uncontingently. Experiments 2 and 3 assessed the sensitivity of the motivational properties of alcohol to time schedule; rats were exposed to (a) self-administration sessions under the progressive ratio (PR) schedule of reinforcement and (b) sessions of alcohol seeking under the extinction responding (ER) schedule. Results In experiment 1, number of lever responses and amount of self-administered alcohol were positively correlated with time of alcohol access during the dark phase. When the self-administration session occurred at the first and latest hours of the dark phase, the amount of self-administered alcohol averaged 0.95–1.0 and 1.55–1.65 g/kg, respectively. In experiments 2 and 3, values of breakpoint and ER for alcohol were approximately 50 % higher when the sessions occurred at the last than first hour of the dark phase. Conclusions The reinforcing and motivational properties of alcohol were sensitive to time schedule and stronger at the end of the dark phase. Unpredictability of alcohol access (dpeaa)DE-He213 Alcohol self-administration (dpeaa)DE-He213 Fixed ratio (dpeaa)DE-He213 Progressive ratio (dpeaa)DE-He213 Extinction responding (dpeaa)DE-He213 Reinforcing properties (dpeaa)DE-He213 Motivational properties (dpeaa)DE-He213 Binge-like drinking (dpeaa)DE-He213 Sardinian alcohol-preferring rats (dpeaa)DE-He213 Lorrai, Irene aut Marras, Maria Francesca aut Contini, Andrea aut Capra, Alessandro aut Piras, Gessica aut Caboni, Pierluigi aut Gessa, Gian Luigi aut Colombo, Giancarlo aut Enthalten in Psychopharmacology Berlin : Springer, 1959 232(2015), 19 vom: 07. Juli, Seite 3585-3595 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:232 year:2015 number:19 day:07 month:07 pages:3585-3595 https://dx.doi.org/10.1007/s00213-015-4010-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 232 2015 19 07 07 3585-3595 |
allfieldsSound |
10.1007/s00213-015-4010-2 doi (DE-627)SPR002034840 (SPR)s00213-015-4010-2-e DE-627 ger DE-627 rakwb eng Maccioni, Paola verfasserin aut Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2015 Rationale Sardinian alcohol-preferring (sP) rats displayed high sensitivity to time schedule and consumed intoxicating amounts of alcohol during the last portion of the dark phase of the light/dark cycle when exposed to daily drinking sessions of 1 h, with concurrent availability of multiple alcohol concentrations and unpredictability of time of alcohol access. Objectives The present study investigated whether sensitivity of sP rats to time schedule extended to operant procedures of alcohol self-administration. Methods In experiment 1, three different alcohol solutions (10, 20, and 30 %, v/v) were concurrently available under a fixed ratio 4 schedule of reinforcement and with unpredictable time schedule; water was available uncontingently. Experiments 2 and 3 assessed the sensitivity of the motivational properties of alcohol to time schedule; rats were exposed to (a) self-administration sessions under the progressive ratio (PR) schedule of reinforcement and (b) sessions of alcohol seeking under the extinction responding (ER) schedule. Results In experiment 1, number of lever responses and amount of self-administered alcohol were positively correlated with time of alcohol access during the dark phase. When the self-administration session occurred at the first and latest hours of the dark phase, the amount of self-administered alcohol averaged 0.95–1.0 and 1.55–1.65 g/kg, respectively. In experiments 2 and 3, values of breakpoint and ER for alcohol were approximately 50 % higher when the sessions occurred at the last than first hour of the dark phase. Conclusions The reinforcing and motivational properties of alcohol were sensitive to time schedule and stronger at the end of the dark phase. Unpredictability of alcohol access (dpeaa)DE-He213 Alcohol self-administration (dpeaa)DE-He213 Fixed ratio (dpeaa)DE-He213 Progressive ratio (dpeaa)DE-He213 Extinction responding (dpeaa)DE-He213 Reinforcing properties (dpeaa)DE-He213 Motivational properties (dpeaa)DE-He213 Binge-like drinking (dpeaa)DE-He213 Sardinian alcohol-preferring rats (dpeaa)DE-He213 Lorrai, Irene aut Marras, Maria Francesca aut Contini, Andrea aut Capra, Alessandro aut Piras, Gessica aut Caboni, Pierluigi aut Gessa, Gian Luigi aut Colombo, Giancarlo aut Enthalten in Psychopharmacology Berlin : Springer, 1959 232(2015), 19 vom: 07. Juli, Seite 3585-3595 (DE-627)341342254 (DE-600)2066933-1 1432-2072 nnns volume:232 year:2015 number:19 day:07 month:07 pages:3585-3595 https://dx.doi.org/10.1007/s00213-015-4010-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 232 2015 19 07 07 3585-3595 |
language |
English |
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Enthalten in Psychopharmacology 232(2015), 19 vom: 07. Juli, Seite 3585-3595 volume:232 year:2015 number:19 day:07 month:07 pages:3585-3595 |
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Enthalten in Psychopharmacology 232(2015), 19 vom: 07. Juli, Seite 3585-3595 volume:232 year:2015 number:19 day:07 month:07 pages:3585-3595 |
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Unpredictability of alcohol access Alcohol self-administration Fixed ratio Progressive ratio Extinction responding Reinforcing properties Motivational properties Binge-like drinking Sardinian alcohol-preferring rats |
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Psychopharmacology |
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Maccioni, Paola @@aut@@ Lorrai, Irene @@aut@@ Marras, Maria Francesca @@aut@@ Contini, Andrea @@aut@@ Capra, Alessandro @@aut@@ Piras, Gessica @@aut@@ Caboni, Pierluigi @@aut@@ Gessa, Gian Luigi @@aut@@ Colombo, Giancarlo @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR002034840</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519084951.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2015 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00213-015-4010-2</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR002034840</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00213-015-4010-2-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Maccioni, Paola</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer-Verlag Berlin Heidelberg 2015</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Rationale Sardinian alcohol-preferring (sP) rats displayed high sensitivity to time schedule and consumed intoxicating amounts of alcohol during the last portion of the dark phase of the light/dark cycle when exposed to daily drinking sessions of 1 h, with concurrent availability of multiple alcohol concentrations and unpredictability of time of alcohol access. Objectives The present study investigated whether sensitivity of sP rats to time schedule extended to operant procedures of alcohol self-administration. Methods In experiment 1, three different alcohol solutions (10, 20, and 30 %, v/v) were concurrently available under a fixed ratio 4 schedule of reinforcement and with unpredictable time schedule; water was available uncontingently. Experiments 2 and 3 assessed the sensitivity of the motivational properties of alcohol to time schedule; rats were exposed to (a) self-administration sessions under the progressive ratio (PR) schedule of reinforcement and (b) sessions of alcohol seeking under the extinction responding (ER) schedule. Results In experiment 1, number of lever responses and amount of self-administered alcohol were positively correlated with time of alcohol access during the dark phase. When the self-administration session occurred at the first and latest hours of the dark phase, the amount of self-administered alcohol averaged 0.95–1.0 and 1.55–1.65 g/kg, respectively. In experiments 2 and 3, values of breakpoint and ER for alcohol were approximately 50 % higher when the sessions occurred at the last than first hour of the dark phase. 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author |
Maccioni, Paola |
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Maccioni, Paola misc Unpredictability of alcohol access misc Alcohol self-administration misc Fixed ratio misc Progressive ratio misc Extinction responding misc Reinforcing properties misc Motivational properties misc Binge-like drinking misc Sardinian alcohol-preferring rats Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats |
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Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats Unpredictability of alcohol access (dpeaa)DE-He213 Alcohol self-administration (dpeaa)DE-He213 Fixed ratio (dpeaa)DE-He213 Progressive ratio (dpeaa)DE-He213 Extinction responding (dpeaa)DE-He213 Reinforcing properties (dpeaa)DE-He213 Motivational properties (dpeaa)DE-He213 Binge-like drinking (dpeaa)DE-He213 Sardinian alcohol-preferring rats (dpeaa)DE-He213 |
topic |
misc Unpredictability of alcohol access misc Alcohol self-administration misc Fixed ratio misc Progressive ratio misc Extinction responding misc Reinforcing properties misc Motivational properties misc Binge-like drinking misc Sardinian alcohol-preferring rats |
topic_unstemmed |
misc Unpredictability of alcohol access misc Alcohol self-administration misc Fixed ratio misc Progressive ratio misc Extinction responding misc Reinforcing properties misc Motivational properties misc Binge-like drinking misc Sardinian alcohol-preferring rats |
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misc Unpredictability of alcohol access misc Alcohol self-administration misc Fixed ratio misc Progressive ratio misc Extinction responding misc Reinforcing properties misc Motivational properties misc Binge-like drinking misc Sardinian alcohol-preferring rats |
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Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats |
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Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats |
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Maccioni, Paola |
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Psychopharmacology |
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2015 |
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Maccioni, Paola Lorrai, Irene Marras, Maria Francesca Contini, Andrea Capra, Alessandro Piras, Gessica Caboni, Pierluigi Gessa, Gian Luigi Colombo, Giancarlo |
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232 |
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Elektronische Aufsätze |
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Maccioni, Paola |
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10.1007/s00213-015-4010-2 |
title_sort |
elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sp rats |
title_auth |
Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats |
abstract |
Rationale Sardinian alcohol-preferring (sP) rats displayed high sensitivity to time schedule and consumed intoxicating amounts of alcohol during the last portion of the dark phase of the light/dark cycle when exposed to daily drinking sessions of 1 h, with concurrent availability of multiple alcohol concentrations and unpredictability of time of alcohol access. Objectives The present study investigated whether sensitivity of sP rats to time schedule extended to operant procedures of alcohol self-administration. Methods In experiment 1, three different alcohol solutions (10, 20, and 30 %, v/v) were concurrently available under a fixed ratio 4 schedule of reinforcement and with unpredictable time schedule; water was available uncontingently. Experiments 2 and 3 assessed the sensitivity of the motivational properties of alcohol to time schedule; rats were exposed to (a) self-administration sessions under the progressive ratio (PR) schedule of reinforcement and (b) sessions of alcohol seeking under the extinction responding (ER) schedule. Results In experiment 1, number of lever responses and amount of self-administered alcohol were positively correlated with time of alcohol access during the dark phase. When the self-administration session occurred at the first and latest hours of the dark phase, the amount of self-administered alcohol averaged 0.95–1.0 and 1.55–1.65 g/kg, respectively. In experiments 2 and 3, values of breakpoint and ER for alcohol were approximately 50 % higher when the sessions occurred at the last than first hour of the dark phase. Conclusions The reinforcing and motivational properties of alcohol were sensitive to time schedule and stronger at the end of the dark phase. © Springer-Verlag Berlin Heidelberg 2015 |
abstractGer |
Rationale Sardinian alcohol-preferring (sP) rats displayed high sensitivity to time schedule and consumed intoxicating amounts of alcohol during the last portion of the dark phase of the light/dark cycle when exposed to daily drinking sessions of 1 h, with concurrent availability of multiple alcohol concentrations and unpredictability of time of alcohol access. Objectives The present study investigated whether sensitivity of sP rats to time schedule extended to operant procedures of alcohol self-administration. Methods In experiment 1, three different alcohol solutions (10, 20, and 30 %, v/v) were concurrently available under a fixed ratio 4 schedule of reinforcement and with unpredictable time schedule; water was available uncontingently. Experiments 2 and 3 assessed the sensitivity of the motivational properties of alcohol to time schedule; rats were exposed to (a) self-administration sessions under the progressive ratio (PR) schedule of reinforcement and (b) sessions of alcohol seeking under the extinction responding (ER) schedule. Results In experiment 1, number of lever responses and amount of self-administered alcohol were positively correlated with time of alcohol access during the dark phase. When the self-administration session occurred at the first and latest hours of the dark phase, the amount of self-administered alcohol averaged 0.95–1.0 and 1.55–1.65 g/kg, respectively. In experiments 2 and 3, values of breakpoint and ER for alcohol were approximately 50 % higher when the sessions occurred at the last than first hour of the dark phase. Conclusions The reinforcing and motivational properties of alcohol were sensitive to time schedule and stronger at the end of the dark phase. © Springer-Verlag Berlin Heidelberg 2015 |
abstract_unstemmed |
Rationale Sardinian alcohol-preferring (sP) rats displayed high sensitivity to time schedule and consumed intoxicating amounts of alcohol during the last portion of the dark phase of the light/dark cycle when exposed to daily drinking sessions of 1 h, with concurrent availability of multiple alcohol concentrations and unpredictability of time of alcohol access. Objectives The present study investigated whether sensitivity of sP rats to time schedule extended to operant procedures of alcohol self-administration. Methods In experiment 1, three different alcohol solutions (10, 20, and 30 %, v/v) were concurrently available under a fixed ratio 4 schedule of reinforcement and with unpredictable time schedule; water was available uncontingently. Experiments 2 and 3 assessed the sensitivity of the motivational properties of alcohol to time schedule; rats were exposed to (a) self-administration sessions under the progressive ratio (PR) schedule of reinforcement and (b) sessions of alcohol seeking under the extinction responding (ER) schedule. Results In experiment 1, number of lever responses and amount of self-administered alcohol were positively correlated with time of alcohol access during the dark phase. When the self-administration session occurred at the first and latest hours of the dark phase, the amount of self-administered alcohol averaged 0.95–1.0 and 1.55–1.65 g/kg, respectively. In experiments 2 and 3, values of breakpoint and ER for alcohol were approximately 50 % higher when the sessions occurred at the last than first hour of the dark phase. Conclusions The reinforcing and motivational properties of alcohol were sensitive to time schedule and stronger at the end of the dark phase. © Springer-Verlag Berlin Heidelberg 2015 |
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title_short |
Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats |
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https://dx.doi.org/10.1007/s00213-015-4010-2 |
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Lorrai, Irene Marras, Maria Francesca Contini, Andrea Capra, Alessandro Piras, Gessica Caboni, Pierluigi Gessa, Gian Luigi Colombo, Giancarlo |
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Lorrai, Irene Marras, Maria Francesca Contini, Andrea Capra, Alessandro Piras, Gessica Caboni, Pierluigi Gessa, Gian Luigi Colombo, Giancarlo |
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|
score |
7.399932 |