Multi-layer microfluidic glass chips for microanalytical applications
Abstract. A new, versatile architecture is presented for microfluidic devices made entirely from glass, for use with reagents which would prove highly corrosive for silicon. Chips consist of three layers of glass wafers bonded together by fusion bonding. On the inside wafer faces a network of microf...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Daridon, Antoine [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2001 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2001 |
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| Übergeordnetes Werk: |
Enthalten in: Analytical and bioanalytical chemistry - Berlin : Springer, 2002, 371(2001), 2 vom: Sept., Seite 261-269 |
|---|---|
| Übergeordnetes Werk: |
volume:371 ; year:2001 ; number:2 ; month:09 ; pages:261-269 |
| Links: |
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| DOI / URN: |
10.1007/s002160101004 |
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| 520 | |a Abstract. A new, versatile architecture is presented for microfluidic devices made entirely from glass, for use with reagents which would prove highly corrosive for silicon. Chips consist of three layers of glass wafers bonded together by fusion bonding. On the inside wafer faces a network of microfluidic channels is created by photolithography and wet chemical etching. Low dead-volume fluidic connections between the layers are fabricated by spark-assisted etching (SAE), a computer numerical controlled (CNC)-like machining technique new to microfluidic system fabrication. This method is also used to form a vertical, long path-length, optical cuvette through the middle wafer for optical absorbance detection of low-concentration compounds. Advantages of this technique compared with other, more standard, methods are discussed. When the new glass-based device for flow-injection analysis of ammonia was compared with our first-generation chips based on silicon micromachining, concentration sensitivity was higher, because of the longer path-length of the optical cuvette. The dependence of dispersion on velocity profile and on channel cross-sectional geometry is discussed. The rapid implementation of the devices for an organic synthesis reaction, the Wittig reaction, is also briefly described. | ||
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| 700 | 1 | |a Verpoorte, Elisabeth |4 aut | |
| 700 | 1 | |a de Rooij, Nico F. |4 aut | |
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10.1007/s002160101004 doi (DE-627)SPR002131692 (SPR)s002160101004-e DE-627 ger DE-627 rakwb eng Daridon, Antoine verfasserin aut Multi-layer microfluidic glass chips for microanalytical applications 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2001 Abstract. A new, versatile architecture is presented for microfluidic devices made entirely from glass, for use with reagents which would prove highly corrosive for silicon. Chips consist of three layers of glass wafers bonded together by fusion bonding. On the inside wafer faces a network of microfluidic channels is created by photolithography and wet chemical etching. Low dead-volume fluidic connections between the layers are fabricated by spark-assisted etching (SAE), a computer numerical controlled (CNC)-like machining technique new to microfluidic system fabrication. This method is also used to form a vertical, long path-length, optical cuvette through the middle wafer for optical absorbance detection of low-concentration compounds. Advantages of this technique compared with other, more standard, methods are discussed. When the new glass-based device for flow-injection analysis of ammonia was compared with our first-generation chips based on silicon micromachining, concentration sensitivity was higher, because of the longer path-length of the optical cuvette. The dependence of dispersion on velocity profile and on channel cross-sectional geometry is discussed. The rapid implementation of the devices for an organic synthesis reaction, the Wittig reaction, is also briefly described. Microfluidic Device (dpeaa)DE-He213 Computer Numerical Control (dpeaa)DE-He213 Microfluidic Chip (dpeaa)DE-He213 Glass Wafer (dpeaa)DE-He213 Reaction Coil (dpeaa)DE-He213 Fascio, Valia aut Lichtenberg, Jan aut Wütrich, Rolf aut Langen, Hans aut Verpoorte, Elisabeth aut de Rooij, Nico F. aut Enthalten in Analytical and bioanalytical chemistry Berlin : Springer, 2002 371(2001), 2 vom: Sept., Seite 261-269 (DE-627)25372337X (DE-600)1459122-4 1618-2650 nnns volume:371 year:2001 number:2 month:09 pages:261-269 https://dx.doi.org/10.1007/s002160101004 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 AR 371 2001 2 09 261-269 |
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10.1007/s002160101004 doi (DE-627)SPR002131692 (SPR)s002160101004-e DE-627 ger DE-627 rakwb eng Daridon, Antoine verfasserin aut Multi-layer microfluidic glass chips for microanalytical applications 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2001 Abstract. A new, versatile architecture is presented for microfluidic devices made entirely from glass, for use with reagents which would prove highly corrosive for silicon. Chips consist of three layers of glass wafers bonded together by fusion bonding. On the inside wafer faces a network of microfluidic channels is created by photolithography and wet chemical etching. Low dead-volume fluidic connections between the layers are fabricated by spark-assisted etching (SAE), a computer numerical controlled (CNC)-like machining technique new to microfluidic system fabrication. This method is also used to form a vertical, long path-length, optical cuvette through the middle wafer for optical absorbance detection of low-concentration compounds. Advantages of this technique compared with other, more standard, methods are discussed. When the new glass-based device for flow-injection analysis of ammonia was compared with our first-generation chips based on silicon micromachining, concentration sensitivity was higher, because of the longer path-length of the optical cuvette. The dependence of dispersion on velocity profile and on channel cross-sectional geometry is discussed. The rapid implementation of the devices for an organic synthesis reaction, the Wittig reaction, is also briefly described. Microfluidic Device (dpeaa)DE-He213 Computer Numerical Control (dpeaa)DE-He213 Microfluidic Chip (dpeaa)DE-He213 Glass Wafer (dpeaa)DE-He213 Reaction Coil (dpeaa)DE-He213 Fascio, Valia aut Lichtenberg, Jan aut Wütrich, Rolf aut Langen, Hans aut Verpoorte, Elisabeth aut de Rooij, Nico F. aut Enthalten in Analytical and bioanalytical chemistry Berlin : Springer, 2002 371(2001), 2 vom: Sept., Seite 261-269 (DE-627)25372337X (DE-600)1459122-4 1618-2650 nnns volume:371 year:2001 number:2 month:09 pages:261-269 https://dx.doi.org/10.1007/s002160101004 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 AR 371 2001 2 09 261-269 |
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10.1007/s002160101004 doi (DE-627)SPR002131692 (SPR)s002160101004-e DE-627 ger DE-627 rakwb eng Daridon, Antoine verfasserin aut Multi-layer microfluidic glass chips for microanalytical applications 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2001 Abstract. A new, versatile architecture is presented for microfluidic devices made entirely from glass, for use with reagents which would prove highly corrosive for silicon. Chips consist of three layers of glass wafers bonded together by fusion bonding. On the inside wafer faces a network of microfluidic channels is created by photolithography and wet chemical etching. Low dead-volume fluidic connections between the layers are fabricated by spark-assisted etching (SAE), a computer numerical controlled (CNC)-like machining technique new to microfluidic system fabrication. This method is also used to form a vertical, long path-length, optical cuvette through the middle wafer for optical absorbance detection of low-concentration compounds. Advantages of this technique compared with other, more standard, methods are discussed. When the new glass-based device for flow-injection analysis of ammonia was compared with our first-generation chips based on silicon micromachining, concentration sensitivity was higher, because of the longer path-length of the optical cuvette. The dependence of dispersion on velocity profile and on channel cross-sectional geometry is discussed. The rapid implementation of the devices for an organic synthesis reaction, the Wittig reaction, is also briefly described. Microfluidic Device (dpeaa)DE-He213 Computer Numerical Control (dpeaa)DE-He213 Microfluidic Chip (dpeaa)DE-He213 Glass Wafer (dpeaa)DE-He213 Reaction Coil (dpeaa)DE-He213 Fascio, Valia aut Lichtenberg, Jan aut Wütrich, Rolf aut Langen, Hans aut Verpoorte, Elisabeth aut de Rooij, Nico F. aut Enthalten in Analytical and bioanalytical chemistry Berlin : Springer, 2002 371(2001), 2 vom: Sept., Seite 261-269 (DE-627)25372337X (DE-600)1459122-4 1618-2650 nnns volume:371 year:2001 number:2 month:09 pages:261-269 https://dx.doi.org/10.1007/s002160101004 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 AR 371 2001 2 09 261-269 |
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Multi-layer microfluidic glass chips for microanalytical applications |
| abstract |
Abstract. A new, versatile architecture is presented for microfluidic devices made entirely from glass, for use with reagents which would prove highly corrosive for silicon. Chips consist of three layers of glass wafers bonded together by fusion bonding. On the inside wafer faces a network of microfluidic channels is created by photolithography and wet chemical etching. Low dead-volume fluidic connections between the layers are fabricated by spark-assisted etching (SAE), a computer numerical controlled (CNC)-like machining technique new to microfluidic system fabrication. This method is also used to form a vertical, long path-length, optical cuvette through the middle wafer for optical absorbance detection of low-concentration compounds. Advantages of this technique compared with other, more standard, methods are discussed. When the new glass-based device for flow-injection analysis of ammonia was compared with our first-generation chips based on silicon micromachining, concentration sensitivity was higher, because of the longer path-length of the optical cuvette. The dependence of dispersion on velocity profile and on channel cross-sectional geometry is discussed. The rapid implementation of the devices for an organic synthesis reaction, the Wittig reaction, is also briefly described. © Springer-Verlag 2001 |
| abstractGer |
Abstract. A new, versatile architecture is presented for microfluidic devices made entirely from glass, for use with reagents which would prove highly corrosive for silicon. Chips consist of three layers of glass wafers bonded together by fusion bonding. On the inside wafer faces a network of microfluidic channels is created by photolithography and wet chemical etching. Low dead-volume fluidic connections between the layers are fabricated by spark-assisted etching (SAE), a computer numerical controlled (CNC)-like machining technique new to microfluidic system fabrication. This method is also used to form a vertical, long path-length, optical cuvette through the middle wafer for optical absorbance detection of low-concentration compounds. Advantages of this technique compared with other, more standard, methods are discussed. When the new glass-based device for flow-injection analysis of ammonia was compared with our first-generation chips based on silicon micromachining, concentration sensitivity was higher, because of the longer path-length of the optical cuvette. The dependence of dispersion on velocity profile and on channel cross-sectional geometry is discussed. The rapid implementation of the devices for an organic synthesis reaction, the Wittig reaction, is also briefly described. © Springer-Verlag 2001 |
| abstract_unstemmed |
Abstract. A new, versatile architecture is presented for microfluidic devices made entirely from glass, for use with reagents which would prove highly corrosive for silicon. Chips consist of three layers of glass wafers bonded together by fusion bonding. On the inside wafer faces a network of microfluidic channels is created by photolithography and wet chemical etching. Low dead-volume fluidic connections between the layers are fabricated by spark-assisted etching (SAE), a computer numerical controlled (CNC)-like machining technique new to microfluidic system fabrication. This method is also used to form a vertical, long path-length, optical cuvette through the middle wafer for optical absorbance detection of low-concentration compounds. Advantages of this technique compared with other, more standard, methods are discussed. When the new glass-based device for flow-injection analysis of ammonia was compared with our first-generation chips based on silicon micromachining, concentration sensitivity was higher, because of the longer path-length of the optical cuvette. The dependence of dispersion on velocity profile and on channel cross-sectional geometry is discussed. The rapid implementation of the devices for an organic synthesis reaction, the Wittig reaction, is also briefly described. © Springer-Verlag 2001 |
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| title_short |
Multi-layer microfluidic glass chips for microanalytical applications |
| url |
https://dx.doi.org/10.1007/s002160101004 |
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| author2 |
Fascio, Valia Lichtenberg, Jan Wütrich, Rolf Langen, Hans Verpoorte, Elisabeth de Rooij, Nico F. |
| author2Str |
Fascio, Valia Lichtenberg, Jan Wütrich, Rolf Langen, Hans Verpoorte, Elisabeth de Rooij, Nico F. |
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25372337X |
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| doi_str |
10.1007/s002160101004 |
| up_date |
2024-07-04T01:50:16.308Z |
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7.400463 |