Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice
Abstract Brain trauma may alter the function of the blood-brain barrier (BBB) and affect psychomotor activity. We have shown that the transport system for tumor necrosis factor α (TNFα) at the BBB undergoes regulatory changes after spinal cord injury. In this study, we show in CD1 mice that mild tra...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pan, Weihong [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2003 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2003 |
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| Übergeordnetes Werk: |
Enthalten in: Experimental brain research - Berlin : Springer, 1966, 149(2003), 2 vom: 25. Jan., Seite 195-199 |
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| Übergeordnetes Werk: |
volume:149 ; year:2003 ; number:2 ; day:25 ; month:01 ; pages:195-199 |
| Links: |
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| DOI / URN: |
10.1007/s00221-002-1355-7 |
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SPR002378450 |
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| 520 | |a Abstract Brain trauma may alter the function of the blood-brain barrier (BBB) and affect psychomotor activity. We have shown that the transport system for tumor necrosis factor α (TNFα) at the BBB undergoes regulatory changes after spinal cord injury. In this study, we show in CD1 mice that mild trauma by weight-drop to the right temporal region specifically increases the uptake of blood-borne TNFα. This increase, measured by use of radiolabeled murine TNFα, occurred only in the right hippocampus 24 h after injury and returned to normal at 1 week. There was no increase in the uptake of the vascular marker albumin at 1 h, 24 h, or 1 week postinjury, indicating that the BBB remained relatively intact. Human interleukin-1β, which does not cross the BBB by saturable transport, showed no significant changes in brain uptake after trauma. Therefore, the selective entry of TNFα in the injured right hippocampus may be explained by enhanced transport across the BBB. To explore the functional relevance of this transport regulation, we measured mouse behavior by the staircase test. The number of rearings, mainly reflective of exploratory behavior, decreased at 1 h and 1 day after injury but increased at 1 week after a 30-g weight-drop injury. The number of stairs ascended, mainly indicative of locomotor activity, was unchanged at all times tested. We conclude that mild, blunt brain trauma involving the hippocampus causes specific upregulation of TNFα transport and a selective change in exploratory behavior. Although no causal relationship can be established at this time, the behavioral changes might be related to the increased TNFα transport after trauma. | ||
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| 650 | 4 | |a Blood-brain barrier |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Transport |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a TNFα |7 (dpeaa)DE-He213 | |
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| 650 | 4 | |a Behavior |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hippocampus |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kastin, Abba J. |4 aut | |
| 700 | 1 | |a Rigai, Tova |4 aut | |
| 700 | 1 | |a McLay, Robert |4 aut | |
| 700 | 1 | |a Pick, Chaim G. |4 aut | |
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10.1007/s00221-002-1355-7 doi (DE-627)SPR002378450 (SPR)s00221-002-1355-7-e DE-627 ger DE-627 rakwb eng Pan, Weihong verfasserin aut Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Abstract Brain trauma may alter the function of the blood-brain barrier (BBB) and affect psychomotor activity. We have shown that the transport system for tumor necrosis factor α (TNFα) at the BBB undergoes regulatory changes after spinal cord injury. In this study, we show in CD1 mice that mild trauma by weight-drop to the right temporal region specifically increases the uptake of blood-borne TNFα. This increase, measured by use of radiolabeled murine TNFα, occurred only in the right hippocampus 24 h after injury and returned to normal at 1 week. There was no increase in the uptake of the vascular marker albumin at 1 h, 24 h, or 1 week postinjury, indicating that the BBB remained relatively intact. Human interleukin-1β, which does not cross the BBB by saturable transport, showed no significant changes in brain uptake after trauma. Therefore, the selective entry of TNFα in the injured right hippocampus may be explained by enhanced transport across the BBB. To explore the functional relevance of this transport regulation, we measured mouse behavior by the staircase test. The number of rearings, mainly reflective of exploratory behavior, decreased at 1 h and 1 day after injury but increased at 1 week after a 30-g weight-drop injury. The number of stairs ascended, mainly indicative of locomotor activity, was unchanged at all times tested. We conclude that mild, blunt brain trauma involving the hippocampus causes specific upregulation of TNFα transport and a selective change in exploratory behavior. Although no causal relationship can be established at this time, the behavioral changes might be related to the increased TNFα transport after trauma. Traumatic brain injury (dpeaa)DE-He213 Staircase test (dpeaa)DE-He213 Blood-brain barrier (dpeaa)DE-He213 Transport (dpeaa)DE-He213 TNFα (dpeaa)DE-He213 IL1β (dpeaa)DE-He213 Behavior (dpeaa)DE-He213 Hippocampus (dpeaa)DE-He213 Kastin, Abba J. aut Rigai, Tova aut McLay, Robert aut Pick, Chaim G. aut Enthalten in Experimental brain research Berlin : Springer, 1966 149(2003), 2 vom: 25. Jan., Seite 195-199 (DE-627)253723159 (DE-600)1459099-2 1432-1106 nnns volume:149 year:2003 number:2 day:25 month:01 pages:195-199 https://dx.doi.org/10.1007/s00221-002-1355-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 149 2003 2 25 01 195-199 |
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10.1007/s00221-002-1355-7 doi (DE-627)SPR002378450 (SPR)s00221-002-1355-7-e DE-627 ger DE-627 rakwb eng Pan, Weihong verfasserin aut Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Abstract Brain trauma may alter the function of the blood-brain barrier (BBB) and affect psychomotor activity. We have shown that the transport system for tumor necrosis factor α (TNFα) at the BBB undergoes regulatory changes after spinal cord injury. In this study, we show in CD1 mice that mild trauma by weight-drop to the right temporal region specifically increases the uptake of blood-borne TNFα. This increase, measured by use of radiolabeled murine TNFα, occurred only in the right hippocampus 24 h after injury and returned to normal at 1 week. There was no increase in the uptake of the vascular marker albumin at 1 h, 24 h, or 1 week postinjury, indicating that the BBB remained relatively intact. Human interleukin-1β, which does not cross the BBB by saturable transport, showed no significant changes in brain uptake after trauma. Therefore, the selective entry of TNFα in the injured right hippocampus may be explained by enhanced transport across the BBB. To explore the functional relevance of this transport regulation, we measured mouse behavior by the staircase test. The number of rearings, mainly reflective of exploratory behavior, decreased at 1 h and 1 day after injury but increased at 1 week after a 30-g weight-drop injury. The number of stairs ascended, mainly indicative of locomotor activity, was unchanged at all times tested. We conclude that mild, blunt brain trauma involving the hippocampus causes specific upregulation of TNFα transport and a selective change in exploratory behavior. Although no causal relationship can be established at this time, the behavioral changes might be related to the increased TNFα transport after trauma. Traumatic brain injury (dpeaa)DE-He213 Staircase test (dpeaa)DE-He213 Blood-brain barrier (dpeaa)DE-He213 Transport (dpeaa)DE-He213 TNFα (dpeaa)DE-He213 IL1β (dpeaa)DE-He213 Behavior (dpeaa)DE-He213 Hippocampus (dpeaa)DE-He213 Kastin, Abba J. aut Rigai, Tova aut McLay, Robert aut Pick, Chaim G. aut Enthalten in Experimental brain research Berlin : Springer, 1966 149(2003), 2 vom: 25. Jan., Seite 195-199 (DE-627)253723159 (DE-600)1459099-2 1432-1106 nnns volume:149 year:2003 number:2 day:25 month:01 pages:195-199 https://dx.doi.org/10.1007/s00221-002-1355-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 149 2003 2 25 01 195-199 |
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10.1007/s00221-002-1355-7 doi (DE-627)SPR002378450 (SPR)s00221-002-1355-7-e DE-627 ger DE-627 rakwb eng Pan, Weihong verfasserin aut Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Abstract Brain trauma may alter the function of the blood-brain barrier (BBB) and affect psychomotor activity. We have shown that the transport system for tumor necrosis factor α (TNFα) at the BBB undergoes regulatory changes after spinal cord injury. In this study, we show in CD1 mice that mild trauma by weight-drop to the right temporal region specifically increases the uptake of blood-borne TNFα. This increase, measured by use of radiolabeled murine TNFα, occurred only in the right hippocampus 24 h after injury and returned to normal at 1 week. There was no increase in the uptake of the vascular marker albumin at 1 h, 24 h, or 1 week postinjury, indicating that the BBB remained relatively intact. Human interleukin-1β, which does not cross the BBB by saturable transport, showed no significant changes in brain uptake after trauma. Therefore, the selective entry of TNFα in the injured right hippocampus may be explained by enhanced transport across the BBB. To explore the functional relevance of this transport regulation, we measured mouse behavior by the staircase test. The number of rearings, mainly reflective of exploratory behavior, decreased at 1 h and 1 day after injury but increased at 1 week after a 30-g weight-drop injury. The number of stairs ascended, mainly indicative of locomotor activity, was unchanged at all times tested. We conclude that mild, blunt brain trauma involving the hippocampus causes specific upregulation of TNFα transport and a selective change in exploratory behavior. Although no causal relationship can be established at this time, the behavioral changes might be related to the increased TNFα transport after trauma. Traumatic brain injury (dpeaa)DE-He213 Staircase test (dpeaa)DE-He213 Blood-brain barrier (dpeaa)DE-He213 Transport (dpeaa)DE-He213 TNFα (dpeaa)DE-He213 IL1β (dpeaa)DE-He213 Behavior (dpeaa)DE-He213 Hippocampus (dpeaa)DE-He213 Kastin, Abba J. aut Rigai, Tova aut McLay, Robert aut Pick, Chaim G. aut Enthalten in Experimental brain research Berlin : Springer, 1966 149(2003), 2 vom: 25. Jan., Seite 195-199 (DE-627)253723159 (DE-600)1459099-2 1432-1106 nnns volume:149 year:2003 number:2 day:25 month:01 pages:195-199 https://dx.doi.org/10.1007/s00221-002-1355-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 149 2003 2 25 01 195-199 |
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10.1007/s00221-002-1355-7 doi (DE-627)SPR002378450 (SPR)s00221-002-1355-7-e DE-627 ger DE-627 rakwb eng Pan, Weihong verfasserin aut Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Abstract Brain trauma may alter the function of the blood-brain barrier (BBB) and affect psychomotor activity. We have shown that the transport system for tumor necrosis factor α (TNFα) at the BBB undergoes regulatory changes after spinal cord injury. In this study, we show in CD1 mice that mild trauma by weight-drop to the right temporal region specifically increases the uptake of blood-borne TNFα. This increase, measured by use of radiolabeled murine TNFα, occurred only in the right hippocampus 24 h after injury and returned to normal at 1 week. There was no increase in the uptake of the vascular marker albumin at 1 h, 24 h, or 1 week postinjury, indicating that the BBB remained relatively intact. Human interleukin-1β, which does not cross the BBB by saturable transport, showed no significant changes in brain uptake after trauma. Therefore, the selective entry of TNFα in the injured right hippocampus may be explained by enhanced transport across the BBB. To explore the functional relevance of this transport regulation, we measured mouse behavior by the staircase test. The number of rearings, mainly reflective of exploratory behavior, decreased at 1 h and 1 day after injury but increased at 1 week after a 30-g weight-drop injury. The number of stairs ascended, mainly indicative of locomotor activity, was unchanged at all times tested. We conclude that mild, blunt brain trauma involving the hippocampus causes specific upregulation of TNFα transport and a selective change in exploratory behavior. Although no causal relationship can be established at this time, the behavioral changes might be related to the increased TNFα transport after trauma. Traumatic brain injury (dpeaa)DE-He213 Staircase test (dpeaa)DE-He213 Blood-brain barrier (dpeaa)DE-He213 Transport (dpeaa)DE-He213 TNFα (dpeaa)DE-He213 IL1β (dpeaa)DE-He213 Behavior (dpeaa)DE-He213 Hippocampus (dpeaa)DE-He213 Kastin, Abba J. aut Rigai, Tova aut McLay, Robert aut Pick, Chaim G. aut Enthalten in Experimental brain research Berlin : Springer, 1966 149(2003), 2 vom: 25. Jan., Seite 195-199 (DE-627)253723159 (DE-600)1459099-2 1432-1106 nnns volume:149 year:2003 number:2 day:25 month:01 pages:195-199 https://dx.doi.org/10.1007/s00221-002-1355-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 149 2003 2 25 01 195-199 |
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10.1007/s00221-002-1355-7 doi (DE-627)SPR002378450 (SPR)s00221-002-1355-7-e DE-627 ger DE-627 rakwb eng Pan, Weihong verfasserin aut Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2003 Abstract Brain trauma may alter the function of the blood-brain barrier (BBB) and affect psychomotor activity. We have shown that the transport system for tumor necrosis factor α (TNFα) at the BBB undergoes regulatory changes after spinal cord injury. In this study, we show in CD1 mice that mild trauma by weight-drop to the right temporal region specifically increases the uptake of blood-borne TNFα. This increase, measured by use of radiolabeled murine TNFα, occurred only in the right hippocampus 24 h after injury and returned to normal at 1 week. There was no increase in the uptake of the vascular marker albumin at 1 h, 24 h, or 1 week postinjury, indicating that the BBB remained relatively intact. Human interleukin-1β, which does not cross the BBB by saturable transport, showed no significant changes in brain uptake after trauma. Therefore, the selective entry of TNFα in the injured right hippocampus may be explained by enhanced transport across the BBB. To explore the functional relevance of this transport regulation, we measured mouse behavior by the staircase test. The number of rearings, mainly reflective of exploratory behavior, decreased at 1 h and 1 day after injury but increased at 1 week after a 30-g weight-drop injury. The number of stairs ascended, mainly indicative of locomotor activity, was unchanged at all times tested. We conclude that mild, blunt brain trauma involving the hippocampus causes specific upregulation of TNFα transport and a selective change in exploratory behavior. Although no causal relationship can be established at this time, the behavioral changes might be related to the increased TNFα transport after trauma. Traumatic brain injury (dpeaa)DE-He213 Staircase test (dpeaa)DE-He213 Blood-brain barrier (dpeaa)DE-He213 Transport (dpeaa)DE-He213 TNFα (dpeaa)DE-He213 IL1β (dpeaa)DE-He213 Behavior (dpeaa)DE-He213 Hippocampus (dpeaa)DE-He213 Kastin, Abba J. aut Rigai, Tova aut McLay, Robert aut Pick, Chaim G. aut Enthalten in Experimental brain research Berlin : Springer, 1966 149(2003), 2 vom: 25. Jan., Seite 195-199 (DE-627)253723159 (DE-600)1459099-2 1432-1106 nnns volume:149 year:2003 number:2 day:25 month:01 pages:195-199 https://dx.doi.org/10.1007/s00221-002-1355-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 149 2003 2 25 01 195-199 |
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Enthalten in Experimental brain research 149(2003), 2 vom: 25. Jan., Seite 195-199 volume:149 year:2003 number:2 day:25 month:01 pages:195-199 |
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Enthalten in Experimental brain research 149(2003), 2 vom: 25. Jan., Seite 195-199 volume:149 year:2003 number:2 day:25 month:01 pages:195-199 |
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Traumatic brain injury Staircase test Blood-brain barrier Transport TNFα IL1β Behavior Hippocampus |
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Pan, Weihong @@aut@@ Kastin, Abba J. @@aut@@ Rigai, Tova @@aut@@ McLay, Robert @@aut@@ Pick, Chaim G. @@aut@@ |
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We have shown that the transport system for tumor necrosis factor α (TNFα) at the BBB undergoes regulatory changes after spinal cord injury. In this study, we show in CD1 mice that mild trauma by weight-drop to the right temporal region specifically increases the uptake of blood-borne TNFα. This increase, measured by use of radiolabeled murine TNFα, occurred only in the right hippocampus 24 h after injury and returned to normal at 1 week. There was no increase in the uptake of the vascular marker albumin at 1 h, 24 h, or 1 week postinjury, indicating that the BBB remained relatively intact. Human interleukin-1β, which does not cross the BBB by saturable transport, showed no significant changes in brain uptake after trauma. Therefore, the selective entry of TNFα in the injured right hippocampus may be explained by enhanced transport across the BBB. To explore the functional relevance of this transport regulation, we measured mouse behavior by the staircase test. The number of rearings, mainly reflective of exploratory behavior, decreased at 1 h and 1 day after injury but increased at 1 week after a 30-g weight-drop injury. The number of stairs ascended, mainly indicative of locomotor activity, was unchanged at all times tested. We conclude that mild, blunt brain trauma involving the hippocampus causes specific upregulation of TNFα transport and a selective change in exploratory behavior. 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Pan, Weihong |
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Pan, Weihong misc Traumatic brain injury misc Staircase test misc Blood-brain barrier misc Transport misc TNFα misc IL1β misc Behavior misc Hippocampus Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice |
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Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice Traumatic brain injury (dpeaa)DE-He213 Staircase test (dpeaa)DE-He213 Blood-brain barrier (dpeaa)DE-He213 Transport (dpeaa)DE-He213 TNFα (dpeaa)DE-He213 IL1β (dpeaa)DE-He213 Behavior (dpeaa)DE-He213 Hippocampus (dpeaa)DE-He213 |
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misc Traumatic brain injury misc Staircase test misc Blood-brain barrier misc Transport misc TNFα misc IL1β misc Behavior misc Hippocampus |
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Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice |
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Pan, Weihong |
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Experimental brain research |
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Pan, Weihong Kastin, Abba J. Rigai, Tova McLay, Robert Pick, Chaim G. |
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Pan, Weihong |
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10.1007/s00221-002-1355-7 |
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increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice |
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Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice |
| abstract |
Abstract Brain trauma may alter the function of the blood-brain barrier (BBB) and affect psychomotor activity. We have shown that the transport system for tumor necrosis factor α (TNFα) at the BBB undergoes regulatory changes after spinal cord injury. In this study, we show in CD1 mice that mild trauma by weight-drop to the right temporal region specifically increases the uptake of blood-borne TNFα. This increase, measured by use of radiolabeled murine TNFα, occurred only in the right hippocampus 24 h after injury and returned to normal at 1 week. There was no increase in the uptake of the vascular marker albumin at 1 h, 24 h, or 1 week postinjury, indicating that the BBB remained relatively intact. Human interleukin-1β, which does not cross the BBB by saturable transport, showed no significant changes in brain uptake after trauma. Therefore, the selective entry of TNFα in the injured right hippocampus may be explained by enhanced transport across the BBB. To explore the functional relevance of this transport regulation, we measured mouse behavior by the staircase test. The number of rearings, mainly reflective of exploratory behavior, decreased at 1 h and 1 day after injury but increased at 1 week after a 30-g weight-drop injury. The number of stairs ascended, mainly indicative of locomotor activity, was unchanged at all times tested. We conclude that mild, blunt brain trauma involving the hippocampus causes specific upregulation of TNFα transport and a selective change in exploratory behavior. Although no causal relationship can be established at this time, the behavioral changes might be related to the increased TNFα transport after trauma. © Springer-Verlag 2003 |
| abstractGer |
Abstract Brain trauma may alter the function of the blood-brain barrier (BBB) and affect psychomotor activity. We have shown that the transport system for tumor necrosis factor α (TNFα) at the BBB undergoes regulatory changes after spinal cord injury. In this study, we show in CD1 mice that mild trauma by weight-drop to the right temporal region specifically increases the uptake of blood-borne TNFα. This increase, measured by use of radiolabeled murine TNFα, occurred only in the right hippocampus 24 h after injury and returned to normal at 1 week. There was no increase in the uptake of the vascular marker albumin at 1 h, 24 h, or 1 week postinjury, indicating that the BBB remained relatively intact. Human interleukin-1β, which does not cross the BBB by saturable transport, showed no significant changes in brain uptake after trauma. Therefore, the selective entry of TNFα in the injured right hippocampus may be explained by enhanced transport across the BBB. To explore the functional relevance of this transport regulation, we measured mouse behavior by the staircase test. The number of rearings, mainly reflective of exploratory behavior, decreased at 1 h and 1 day after injury but increased at 1 week after a 30-g weight-drop injury. The number of stairs ascended, mainly indicative of locomotor activity, was unchanged at all times tested. We conclude that mild, blunt brain trauma involving the hippocampus causes specific upregulation of TNFα transport and a selective change in exploratory behavior. Although no causal relationship can be established at this time, the behavioral changes might be related to the increased TNFα transport after trauma. © Springer-Verlag 2003 |
| abstract_unstemmed |
Abstract Brain trauma may alter the function of the blood-brain barrier (BBB) and affect psychomotor activity. We have shown that the transport system for tumor necrosis factor α (TNFα) at the BBB undergoes regulatory changes after spinal cord injury. In this study, we show in CD1 mice that mild trauma by weight-drop to the right temporal region specifically increases the uptake of blood-borne TNFα. This increase, measured by use of radiolabeled murine TNFα, occurred only in the right hippocampus 24 h after injury and returned to normal at 1 week. There was no increase in the uptake of the vascular marker albumin at 1 h, 24 h, or 1 week postinjury, indicating that the BBB remained relatively intact. Human interleukin-1β, which does not cross the BBB by saturable transport, showed no significant changes in brain uptake after trauma. Therefore, the selective entry of TNFα in the injured right hippocampus may be explained by enhanced transport across the BBB. To explore the functional relevance of this transport regulation, we measured mouse behavior by the staircase test. The number of rearings, mainly reflective of exploratory behavior, decreased at 1 h and 1 day after injury but increased at 1 week after a 30-g weight-drop injury. The number of stairs ascended, mainly indicative of locomotor activity, was unchanged at all times tested. We conclude that mild, blunt brain trauma involving the hippocampus causes specific upregulation of TNFα transport and a selective change in exploratory behavior. Although no causal relationship can be established at this time, the behavioral changes might be related to the increased TNFα transport after trauma. © Springer-Verlag 2003 |
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| title_short |
Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice |
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https://dx.doi.org/10.1007/s00221-002-1355-7 |
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Kastin, Abba J. Rigai, Tova McLay, Robert Pick, Chaim G. |
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2024-07-04T02:47:38.111Z |
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| score |
7.3988514 |