Early discontinuation: more frequent among general practitioners with high levels of prescribing

Abstract Introduction Discontinuation of medical drug treatment is a serious problem in primary care. The need for a better understanding of the processes, including physician-specific mechanisms, is apparent. The aim of this study was to analyse the association between general practitioners’ prescribing prevalence and rate of early discontinuation of different drugs consisting of, in this study, lipid-lowering drugs, antihypertensive drugs, antidepressants, antidiabetics and drugs against osteoporosis. Material and methods This was a register study based on prescription data covering a 4-year period and consisting of 470,000 citizens. For each practice and group of drug, a 1-year prevalence for 2002 and the rate of early discontinuation among new users in 2002–2003 were estimated. Early discontinuation was defined as no prescriptions during the second half-year following the first prescription, with the exception of new users of antidepressants for whom it was the first half-year. Correlations were analysed using the SAS ver. 9.1PROC MIXED procedure. The association with the total prescribing prevalence (all drugs) was also analysed. Results A total of 141 general practices were included in the study. There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 –0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence of all drugs and drug-specific early discontinuation showed some degree of positive association – strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates of early discontinuation compared with colleagues with low levels of prescribing, not only with respect to antidepressants but also for various groups of drugs. A common underlying mechanism is suggested but has to be verified in future studies. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hansen, Dorte Gilså [verfasserIn] Gichangi, Anthony Vach, Werner Felde, Lina Hoel Larsen, John

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	Antidepressive agents Compliance Drug prescription Family practice Physician’s practice patterns

Anmerkung:	© Springer-Verlag 2007

Übergeordnetes Werk:	Enthalten in: European journal of clinical pharmacology - Berlin : Springer, 1968, 63(2007), 9 vom: 06. Juli, Seite 861-865
Übergeordnetes Werk:	volume:63 ; year:2007 ; number:9 ; day:06 ; month:07 ; pages:861-865

Links:	Volltext

DOI / URN:	10.1007/s00228-007-0330-4

Katalog-ID:	SPR002571765

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245	1	0	\|a Early discontinuation: more frequent among general practitioners with high levels of prescribing
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520			\|a Abstract Introduction Discontinuation of medical drug treatment is a serious problem in primary care. The need for a better understanding of the processes, including physician-specific mechanisms, is apparent. The aim of this study was to analyse the association between general practitioners’ prescribing prevalence and rate of early discontinuation of different drugs consisting of, in this study, lipid-lowering drugs, antihypertensive drugs, antidepressants, antidiabetics and drugs against osteoporosis. Material and methods This was a register study based on prescription data covering a 4-year period and consisting of 470,000 citizens. For each practice and group of drug, a 1-year prevalence for 2002 and the rate of early discontinuation among new users in 2002–2003 were estimated. Early discontinuation was defined as no prescriptions during the second half-year following the first prescription, with the exception of new users of antidepressants for whom it was the first half-year. Correlations were analysed using the SAS ver. 9.1PROC MIXED procedure. The association with the total prescribing prevalence (all drugs) was also analysed. Results A total of 141 general practices were included in the study. There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 –0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence of all drugs and drug-specific early discontinuation showed some degree of positive association – strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates of early discontinuation compared with colleagues with low levels of prescribing, not only with respect to antidepressants but also for various groups of drugs. A common underlying mechanism is suggested but has to be verified in future studies.
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Indexfelder

author_variant	d g h dg dgh a g ag w v wv l h f lh lhf j l jl
matchkey_str	article:14321041:2007----::aldsotnainoerqetmngnrlrciinrwth
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publishDate	2007
allfields	10.1007/s00228-007-0330-4 doi (DE-627)SPR002571765 (SPR)s00228-007-0330-4-e DE-627 ger DE-627 rakwb eng Hansen, Dorte Gilså verfasserin aut Early discontinuation: more frequent among general practitioners with high levels of prescribing 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract Introduction Discontinuation of medical drug treatment is a serious problem in primary care. The need for a better understanding of the processes, including physician-specific mechanisms, is apparent. The aim of this study was to analyse the association between general practitioners’ prescribing prevalence and rate of early discontinuation of different drugs consisting of, in this study, lipid-lowering drugs, antihypertensive drugs, antidepressants, antidiabetics and drugs against osteoporosis. Material and methods This was a register study based on prescription data covering a 4-year period and consisting of 470,000 citizens. For each practice and group of drug, a 1-year prevalence for 2002 and the rate of early discontinuation among new users in 2002–2003 were estimated. Early discontinuation was defined as no prescriptions during the second half-year following the first prescription, with the exception of new users of antidepressants for whom it was the first half-year. Correlations were analysed using the SAS ver. 9.1PROC MIXED procedure. The association with the total prescribing prevalence (all drugs) was also analysed. Results A total of 141 general practices were included in the study. There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 –0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence of all drugs and drug-specific early discontinuation showed some degree of positive association – strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates of early discontinuation compared with colleagues with low levels of prescribing, not only with respect to antidepressants but also for various groups of drugs. A common underlying mechanism is suggested but has to be verified in future studies. Antidepressive agents (dpeaa)DE-He213 Compliance (dpeaa)DE-He213 Drug prescription (dpeaa)DE-He213 Family practice (dpeaa)DE-He213 Physician’s practice patterns (dpeaa)DE-He213 Gichangi, Anthony aut Vach, Werner aut Felde, Lina Hoel aut Larsen, John aut Enthalten in European journal of clinical pharmacology Berlin : Springer, 1968 63(2007), 9 vom: 06. Juli, Seite 861-865 (DE-627)253722829 (DE-600)1459058-X 1432-1041 nnns volume:63 year:2007 number:9 day:06 month:07 pages:861-865 https://dx.doi.org/10.1007/s00228-007-0330-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 63 2007 9 06 07 861-865
spelling	10.1007/s00228-007-0330-4 doi (DE-627)SPR002571765 (SPR)s00228-007-0330-4-e DE-627 ger DE-627 rakwb eng Hansen, Dorte Gilså verfasserin aut Early discontinuation: more frequent among general practitioners with high levels of prescribing 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract Introduction Discontinuation of medical drug treatment is a serious problem in primary care. The need for a better understanding of the processes, including physician-specific mechanisms, is apparent. The aim of this study was to analyse the association between general practitioners’ prescribing prevalence and rate of early discontinuation of different drugs consisting of, in this study, lipid-lowering drugs, antihypertensive drugs, antidepressants, antidiabetics and drugs against osteoporosis. Material and methods This was a register study based on prescription data covering a 4-year period and consisting of 470,000 citizens. For each practice and group of drug, a 1-year prevalence for 2002 and the rate of early discontinuation among new users in 2002–2003 were estimated. Early discontinuation was defined as no prescriptions during the second half-year following the first prescription, with the exception of new users of antidepressants for whom it was the first half-year. Correlations were analysed using the SAS ver. 9.1PROC MIXED procedure. The association with the total prescribing prevalence (all drugs) was also analysed. Results A total of 141 general practices were included in the study. There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 –0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence of all drugs and drug-specific early discontinuation showed some degree of positive association – strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates of early discontinuation compared with colleagues with low levels of prescribing, not only with respect to antidepressants but also for various groups of drugs. A common underlying mechanism is suggested but has to be verified in future studies. Antidepressive agents (dpeaa)DE-He213 Compliance (dpeaa)DE-He213 Drug prescription (dpeaa)DE-He213 Family practice (dpeaa)DE-He213 Physician’s practice patterns (dpeaa)DE-He213 Gichangi, Anthony aut Vach, Werner aut Felde, Lina Hoel aut Larsen, John aut Enthalten in European journal of clinical pharmacology Berlin : Springer, 1968 63(2007), 9 vom: 06. Juli, Seite 861-865 (DE-627)253722829 (DE-600)1459058-X 1432-1041 nnns volume:63 year:2007 number:9 day:06 month:07 pages:861-865 https://dx.doi.org/10.1007/s00228-007-0330-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 63 2007 9 06 07 861-865
allfields_unstemmed	10.1007/s00228-007-0330-4 doi (DE-627)SPR002571765 (SPR)s00228-007-0330-4-e DE-627 ger DE-627 rakwb eng Hansen, Dorte Gilså verfasserin aut Early discontinuation: more frequent among general practitioners with high levels of prescribing 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract Introduction Discontinuation of medical drug treatment is a serious problem in primary care. The need for a better understanding of the processes, including physician-specific mechanisms, is apparent. The aim of this study was to analyse the association between general practitioners’ prescribing prevalence and rate of early discontinuation of different drugs consisting of, in this study, lipid-lowering drugs, antihypertensive drugs, antidepressants, antidiabetics and drugs against osteoporosis. Material and methods This was a register study based on prescription data covering a 4-year period and consisting of 470,000 citizens. For each practice and group of drug, a 1-year prevalence for 2002 and the rate of early discontinuation among new users in 2002–2003 were estimated. Early discontinuation was defined as no prescriptions during the second half-year following the first prescription, with the exception of new users of antidepressants for whom it was the first half-year. Correlations were analysed using the SAS ver. 9.1PROC MIXED procedure. The association with the total prescribing prevalence (all drugs) was also analysed. Results A total of 141 general practices were included in the study. There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 –0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence of all drugs and drug-specific early discontinuation showed some degree of positive association – strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates of early discontinuation compared with colleagues with low levels of prescribing, not only with respect to antidepressants but also for various groups of drugs. A common underlying mechanism is suggested but has to be verified in future studies. Antidepressive agents (dpeaa)DE-He213 Compliance (dpeaa)DE-He213 Drug prescription (dpeaa)DE-He213 Family practice (dpeaa)DE-He213 Physician’s practice patterns (dpeaa)DE-He213 Gichangi, Anthony aut Vach, Werner aut Felde, Lina Hoel aut Larsen, John aut Enthalten in European journal of clinical pharmacology Berlin : Springer, 1968 63(2007), 9 vom: 06. Juli, Seite 861-865 (DE-627)253722829 (DE-600)1459058-X 1432-1041 nnns volume:63 year:2007 number:9 day:06 month:07 pages:861-865 https://dx.doi.org/10.1007/s00228-007-0330-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 63 2007 9 06 07 861-865
allfieldsGer	10.1007/s00228-007-0330-4 doi (DE-627)SPR002571765 (SPR)s00228-007-0330-4-e DE-627 ger DE-627 rakwb eng Hansen, Dorte Gilså verfasserin aut Early discontinuation: more frequent among general practitioners with high levels of prescribing 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract Introduction Discontinuation of medical drug treatment is a serious problem in primary care. The need for a better understanding of the processes, including physician-specific mechanisms, is apparent. The aim of this study was to analyse the association between general practitioners’ prescribing prevalence and rate of early discontinuation of different drugs consisting of, in this study, lipid-lowering drugs, antihypertensive drugs, antidepressants, antidiabetics and drugs against osteoporosis. Material and methods This was a register study based on prescription data covering a 4-year period and consisting of 470,000 citizens. For each practice and group of drug, a 1-year prevalence for 2002 and the rate of early discontinuation among new users in 2002–2003 were estimated. Early discontinuation was defined as no prescriptions during the second half-year following the first prescription, with the exception of new users of antidepressants for whom it was the first half-year. Correlations were analysed using the SAS ver. 9.1PROC MIXED procedure. The association with the total prescribing prevalence (all drugs) was also analysed. Results A total of 141 general practices were included in the study. There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 –0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence of all drugs and drug-specific early discontinuation showed some degree of positive association – strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates of early discontinuation compared with colleagues with low levels of prescribing, not only with respect to antidepressants but also for various groups of drugs. A common underlying mechanism is suggested but has to be verified in future studies. Antidepressive agents (dpeaa)DE-He213 Compliance (dpeaa)DE-He213 Drug prescription (dpeaa)DE-He213 Family practice (dpeaa)DE-He213 Physician’s practice patterns (dpeaa)DE-He213 Gichangi, Anthony aut Vach, Werner aut Felde, Lina Hoel aut Larsen, John aut Enthalten in European journal of clinical pharmacology Berlin : Springer, 1968 63(2007), 9 vom: 06. Juli, Seite 861-865 (DE-627)253722829 (DE-600)1459058-X 1432-1041 nnns volume:63 year:2007 number:9 day:06 month:07 pages:861-865 https://dx.doi.org/10.1007/s00228-007-0330-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 63 2007 9 06 07 861-865
allfieldsSound	10.1007/s00228-007-0330-4 doi (DE-627)SPR002571765 (SPR)s00228-007-0330-4-e DE-627 ger DE-627 rakwb eng Hansen, Dorte Gilså verfasserin aut Early discontinuation: more frequent among general practitioners with high levels of prescribing 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract Introduction Discontinuation of medical drug treatment is a serious problem in primary care. The need for a better understanding of the processes, including physician-specific mechanisms, is apparent. The aim of this study was to analyse the association between general practitioners’ prescribing prevalence and rate of early discontinuation of different drugs consisting of, in this study, lipid-lowering drugs, antihypertensive drugs, antidepressants, antidiabetics and drugs against osteoporosis. Material and methods This was a register study based on prescription data covering a 4-year period and consisting of 470,000 citizens. For each practice and group of drug, a 1-year prevalence for 2002 and the rate of early discontinuation among new users in 2002–2003 were estimated. Early discontinuation was defined as no prescriptions during the second half-year following the first prescription, with the exception of new users of antidepressants for whom it was the first half-year. Correlations were analysed using the SAS ver. 9.1PROC MIXED procedure. The association with the total prescribing prevalence (all drugs) was also analysed. Results A total of 141 general practices were included in the study. There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 –0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence of all drugs and drug-specific early discontinuation showed some degree of positive association – strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates of early discontinuation compared with colleagues with low levels of prescribing, not only with respect to antidepressants but also for various groups of drugs. A common underlying mechanism is suggested but has to be verified in future studies. Antidepressive agents (dpeaa)DE-He213 Compliance (dpeaa)DE-He213 Drug prescription (dpeaa)DE-He213 Family practice (dpeaa)DE-He213 Physician’s practice patterns (dpeaa)DE-He213 Gichangi, Anthony aut Vach, Werner aut Felde, Lina Hoel aut Larsen, John aut Enthalten in European journal of clinical pharmacology Berlin : Springer, 1968 63(2007), 9 vom: 06. Juli, Seite 861-865 (DE-627)253722829 (DE-600)1459058-X 1432-1041 nnns volume:63 year:2007 number:9 day:06 month:07 pages:861-865 https://dx.doi.org/10.1007/s00228-007-0330-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 63 2007 9 06 07 861-865
language	English
source	Enthalten in European journal of clinical pharmacology 63(2007), 9 vom: 06. Juli, Seite 861-865 volume:63 year:2007 number:9 day:06 month:07 pages:861-865
sourceStr	Enthalten in European journal of clinical pharmacology 63(2007), 9 vom: 06. Juli, Seite 861-865 volume:63 year:2007 number:9 day:06 month:07 pages:861-865
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Antidepressive agents Compliance Drug prescription Family practice Physician’s practice patterns
isfreeaccess_bool	false
container_title	European journal of clinical pharmacology
authorswithroles_txt_mv	Hansen, Dorte Gilså @@aut@@ Gichangi, Anthony @@aut@@ Vach, Werner @@aut@@ Felde, Lina Hoel @@aut@@ Larsen, John @@aut@@
publishDateDaySort_date	2007-07-06T00:00:00Z
hierarchy_top_id	253722829
id	SPR002571765
language_de	englisch
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The association with the total prescribing prevalence (all drugs) was also analysed. Results A total of 141 general practices were included in the study. There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 –0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence of all drugs and drug-specific early discontinuation showed some degree of positive association – strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates of early discontinuation compared with colleagues with low levels of prescribing, not only with respect to antidepressants but also for various groups of drugs. 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author	Hansen, Dorte Gilså
spellingShingle	Hansen, Dorte Gilså misc Antidepressive agents misc Compliance misc Drug prescription misc Family practice misc Physician’s practice patterns Early discontinuation: more frequent among general practitioners with high levels of prescribing
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topic_title	Early discontinuation: more frequent among general practitioners with high levels of prescribing Antidepressive agents (dpeaa)DE-He213 Compliance (dpeaa)DE-He213 Drug prescription (dpeaa)DE-He213 Family practice (dpeaa)DE-He213 Physician’s practice patterns (dpeaa)DE-He213
topic	misc Antidepressive agents misc Compliance misc Drug prescription misc Family practice misc Physician’s practice patterns
topic_unstemmed	misc Antidepressive agents misc Compliance misc Drug prescription misc Family practice misc Physician’s practice patterns
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title	Early discontinuation: more frequent among general practitioners with high levels of prescribing
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title_full	Early discontinuation: more frequent among general practitioners with high levels of prescribing
author_sort	Hansen, Dorte Gilså
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author_browse	Hansen, Dorte Gilså Gichangi, Anthony Vach, Werner Felde, Lina Hoel Larsen, John
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doi_str_mv	10.1007/s00228-007-0330-4
title_sort	early discontinuation: more frequent among general practitioners with high levels of prescribing
title_auth	Early discontinuation: more frequent among general practitioners with high levels of prescribing
abstract	Abstract Introduction Discontinuation of medical drug treatment is a serious problem in primary care. The need for a better understanding of the processes, including physician-specific mechanisms, is apparent. The aim of this study was to analyse the association between general practitioners’ prescribing prevalence and rate of early discontinuation of different drugs consisting of, in this study, lipid-lowering drugs, antihypertensive drugs, antidepressants, antidiabetics and drugs against osteoporosis. Material and methods This was a register study based on prescription data covering a 4-year period and consisting of 470,000 citizens. For each practice and group of drug, a 1-year prevalence for 2002 and the rate of early discontinuation among new users in 2002–2003 were estimated. Early discontinuation was defined as no prescriptions during the second half-year following the first prescription, with the exception of new users of antidepressants for whom it was the first half-year. Correlations were analysed using the SAS ver. 9.1PROC MIXED procedure. The association with the total prescribing prevalence (all drugs) was also analysed. Results A total of 141 general practices were included in the study. There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 –0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence of all drugs and drug-specific early discontinuation showed some degree of positive association – strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates of early discontinuation compared with colleagues with low levels of prescribing, not only with respect to antidepressants but also for various groups of drugs. A common underlying mechanism is suggested but has to be verified in future studies. © Springer-Verlag 2007
abstractGer	Abstract Introduction Discontinuation of medical drug treatment is a serious problem in primary care. The need for a better understanding of the processes, including physician-specific mechanisms, is apparent. The aim of this study was to analyse the association between general practitioners’ prescribing prevalence and rate of early discontinuation of different drugs consisting of, in this study, lipid-lowering drugs, antihypertensive drugs, antidepressants, antidiabetics and drugs against osteoporosis. Material and methods This was a register study based on prescription data covering a 4-year period and consisting of 470,000 citizens. For each practice and group of drug, a 1-year prevalence for 2002 and the rate of early discontinuation among new users in 2002–2003 were estimated. Early discontinuation was defined as no prescriptions during the second half-year following the first prescription, with the exception of new users of antidepressants for whom it was the first half-year. Correlations were analysed using the SAS ver. 9.1PROC MIXED procedure. The association with the total prescribing prevalence (all drugs) was also analysed. Results A total of 141 general practices were included in the study. There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 –0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence of all drugs and drug-specific early discontinuation showed some degree of positive association – strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates of early discontinuation compared with colleagues with low levels of prescribing, not only with respect to antidepressants but also for various groups of drugs. A common underlying mechanism is suggested but has to be verified in future studies. © Springer-Verlag 2007
abstract_unstemmed	Abstract Introduction Discontinuation of medical drug treatment is a serious problem in primary care. The need for a better understanding of the processes, including physician-specific mechanisms, is apparent. The aim of this study was to analyse the association between general practitioners’ prescribing prevalence and rate of early discontinuation of different drugs consisting of, in this study, lipid-lowering drugs, antihypertensive drugs, antidepressants, antidiabetics and drugs against osteoporosis. Material and methods This was a register study based on prescription data covering a 4-year period and consisting of 470,000 citizens. For each practice and group of drug, a 1-year prevalence for 2002 and the rate of early discontinuation among new users in 2002–2003 were estimated. Early discontinuation was defined as no prescriptions during the second half-year following the first prescription, with the exception of new users of antidepressants for whom it was the first half-year. Correlations were analysed using the SAS ver. 9.1PROC MIXED procedure. The association with the total prescribing prevalence (all drugs) was also analysed. Results A total of 141 general practices were included in the study. There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 –0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence of all drugs and drug-specific early discontinuation showed some degree of positive association – strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates of early discontinuation compared with colleagues with low levels of prescribing, not only with respect to antidepressants but also for various groups of drugs. A common underlying mechanism is suggested but has to be verified in future studies. © Springer-Verlag 2007
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title_short	Early discontinuation: more frequent among general practitioners with high levels of prescribing
url	https://dx.doi.org/10.1007/s00228-007-0330-4
remote_bool	true
author2	Gichangi, Anthony Vach, Werner Felde, Lina Hoel Larsen, John
author2Str	Gichangi, Anthony Vach, Werner Felde, Lina Hoel Larsen, John
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doi_str	10.1007/s00228-007-0330-4
up_date	2024-07-03T13:49:53.789Z
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The association with the total prescribing prevalence (all drugs) was also analysed. Results A total of 141 general practices were included in the study. There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 –0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence of all drugs and drug-specific early discontinuation showed some degree of positive association – strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates of early discontinuation compared with colleagues with low levels of prescribing, not only with respect to antidepressants but also for various groups of drugs. 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score	7.398802

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Early discontinuation: more frequent among general practitioners with high levels of prescribing

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Zugang & Verfügbarkeit

Vorhandene Bände

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