Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol
Abstract Intravenous immunoglobulin (IVIG) use in non-approved indications, the increase in consumption and its high cost recommend rationalisation in its utilisation. Aims To assess the use of IVIG in Spanish hospitals. Methods An observational, prospective and multicentre drug utilisation study wa...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ruiz-Antorán, Belen [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2010 |
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| Übergeordnetes Werk: |
Enthalten in: European journal of clinical pharmacology - Berlin : Springer, 1968, 66(2010), 6 vom: 05. März, Seite 633-641 |
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| Übergeordnetes Werk: |
volume:66 ; year:2010 ; number:6 ; day:05 ; month:03 ; pages:633-641 |
| Links: |
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| DOI / URN: |
10.1007/s00228-010-0800-y |
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| Katalog-ID: |
SPR002576368 |
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| 100 | 1 | |a Ruiz-Antorán, Belen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol |
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| 500 | |a © Springer-Verlag 2010 | ||
| 520 | |a Abstract Intravenous immunoglobulin (IVIG) use in non-approved indications, the increase in consumption and its high cost recommend rationalisation in its utilisation. Aims To assess the use of IVIG in Spanish hospitals. Methods An observational, prospective and multicentre drug utilisation study was conducted in 13 tertiary Spanish hospitals. Data were collected for 3 months in patients receiving any IVIG. Patient demographics, indication for IVIG use, dosage regimen and cost of treatment were collected. Results Five hundred and fifty-four patients (mean age of 52 years) were included in the study. A total of 1,287 prescriptions were administered, and the average number of prescriptions per patient was 2.3. The mean daily dose was 24 g (range 0.6–90 g). Overall, IVIG was prescribed for authorised indications in 335 patients (60%) with 953 prescriptions (74%), for non-authorised indications with scientific evidentiary support in 86 patients (16%) with 137 prescriptions (11%), and non-authorised and non-accepted indications in 133 patients (24%) with 197 prescriptions (15%). The most frequent authorised indications were primary and secondary immunodeficiencies, and the most frequent non-authorised and non-accepted indications were multiple sclerosis and bullous dermatosis. The mean cost of IVIG per patient for authorised indications was 2,636.2 €, non-authorised indications with scientific support 5,262.1 € and non-accepted indications 3,555.8 €. Conclusions IVIG is prescribed for a significant number of non-authorised and non-accepted indications with a notable cost. There is an important variability in IVIG prescriptions between hospitals, indicating room for improvement in IVIG use and the need for a consensus of protocol use. | ||
| 650 | 4 | |a Intravenous immunoglobulin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Drug utilization study |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Off-label use |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Compassionate use |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cost |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Agustí Escasany, Antònia |4 aut | |
| 700 | 1 | |a Vallano Ferraz, Antoni |4 aut | |
| 700 | 1 | |a Danés Carreras, Imma |4 aut | |
| 700 | 1 | |a Riba, Neus |4 aut | |
| 700 | 1 | |a Mateu Escudero, Silvia |4 aut | |
| 700 | 1 | |a Costa, Joan |4 aut | |
| 700 | 1 | |a Sánchez Santiago, Mª Blanca |4 aut | |
| 700 | 1 | |a Laredo, Leonor |4 aut | |
| 700 | 1 | |a Durán Quintana, José Antonio |4 aut | |
| 700 | 1 | |a Castillo, Juan Ramón |4 aut | |
| 700 | 1 | |a Abad-Santos, Francisco |4 aut | |
| 700 | 1 | |a Payares Herrera, Concepción |4 aut | |
| 700 | 1 | |a Sádaba Díaz de Rada, Belén |4 aut | |
| 700 | 1 | |a Gómez Ontañón, Eugenio |4 aut | |
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10.1007/s00228-010-0800-y doi (DE-627)SPR002576368 (SPR)s00228-010-0800-y-e DE-627 ger DE-627 rakwb eng Ruiz-Antorán, Belen verfasserin aut Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Abstract Intravenous immunoglobulin (IVIG) use in non-approved indications, the increase in consumption and its high cost recommend rationalisation in its utilisation. Aims To assess the use of IVIG in Spanish hospitals. Methods An observational, prospective and multicentre drug utilisation study was conducted in 13 tertiary Spanish hospitals. Data were collected for 3 months in patients receiving any IVIG. Patient demographics, indication for IVIG use, dosage regimen and cost of treatment were collected. Results Five hundred and fifty-four patients (mean age of 52 years) were included in the study. A total of 1,287 prescriptions were administered, and the average number of prescriptions per patient was 2.3. The mean daily dose was 24 g (range 0.6–90 g). Overall, IVIG was prescribed for authorised indications in 335 patients (60%) with 953 prescriptions (74%), for non-authorised indications with scientific evidentiary support in 86 patients (16%) with 137 prescriptions (11%), and non-authorised and non-accepted indications in 133 patients (24%) with 197 prescriptions (15%). The most frequent authorised indications were primary and secondary immunodeficiencies, and the most frequent non-authorised and non-accepted indications were multiple sclerosis and bullous dermatosis. The mean cost of IVIG per patient for authorised indications was 2,636.2 €, non-authorised indications with scientific support 5,262.1 € and non-accepted indications 3,555.8 €. Conclusions IVIG is prescribed for a significant number of non-authorised and non-accepted indications with a notable cost. There is an important variability in IVIG prescriptions between hospitals, indicating room for improvement in IVIG use and the need for a consensus of protocol use. Intravenous immunoglobulin (dpeaa)DE-He213 Drug utilization study (dpeaa)DE-He213 Off-label use (dpeaa)DE-He213 Compassionate use (dpeaa)DE-He213 Cost (dpeaa)DE-He213 Agustí Escasany, Antònia aut Vallano Ferraz, Antoni aut Danés Carreras, Imma aut Riba, Neus aut Mateu Escudero, Silvia aut Costa, Joan aut Sánchez Santiago, Mª Blanca aut Laredo, Leonor aut Durán Quintana, José Antonio aut Castillo, Juan Ramón aut Abad-Santos, Francisco aut Payares Herrera, Concepción aut Sádaba Díaz de Rada, Belén aut Gómez Ontañón, Eugenio aut Enthalten in European journal of clinical pharmacology Berlin : Springer, 1968 66(2010), 6 vom: 05. März, Seite 633-641 (DE-627)253722829 (DE-600)1459058-X 1432-1041 nnns volume:66 year:2010 number:6 day:05 month:03 pages:633-641 https://dx.doi.org/10.1007/s00228-010-0800-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 66 2010 6 05 03 633-641 |
| spelling |
10.1007/s00228-010-0800-y doi (DE-627)SPR002576368 (SPR)s00228-010-0800-y-e DE-627 ger DE-627 rakwb eng Ruiz-Antorán, Belen verfasserin aut Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Abstract Intravenous immunoglobulin (IVIG) use in non-approved indications, the increase in consumption and its high cost recommend rationalisation in its utilisation. Aims To assess the use of IVIG in Spanish hospitals. Methods An observational, prospective and multicentre drug utilisation study was conducted in 13 tertiary Spanish hospitals. Data were collected for 3 months in patients receiving any IVIG. Patient demographics, indication for IVIG use, dosage regimen and cost of treatment were collected. Results Five hundred and fifty-four patients (mean age of 52 years) were included in the study. A total of 1,287 prescriptions were administered, and the average number of prescriptions per patient was 2.3. The mean daily dose was 24 g (range 0.6–90 g). Overall, IVIG was prescribed for authorised indications in 335 patients (60%) with 953 prescriptions (74%), for non-authorised indications with scientific evidentiary support in 86 patients (16%) with 137 prescriptions (11%), and non-authorised and non-accepted indications in 133 patients (24%) with 197 prescriptions (15%). The most frequent authorised indications were primary and secondary immunodeficiencies, and the most frequent non-authorised and non-accepted indications were multiple sclerosis and bullous dermatosis. The mean cost of IVIG per patient for authorised indications was 2,636.2 €, non-authorised indications with scientific support 5,262.1 € and non-accepted indications 3,555.8 €. Conclusions IVIG is prescribed for a significant number of non-authorised and non-accepted indications with a notable cost. There is an important variability in IVIG prescriptions between hospitals, indicating room for improvement in IVIG use and the need for a consensus of protocol use. Intravenous immunoglobulin (dpeaa)DE-He213 Drug utilization study (dpeaa)DE-He213 Off-label use (dpeaa)DE-He213 Compassionate use (dpeaa)DE-He213 Cost (dpeaa)DE-He213 Agustí Escasany, Antònia aut Vallano Ferraz, Antoni aut Danés Carreras, Imma aut Riba, Neus aut Mateu Escudero, Silvia aut Costa, Joan aut Sánchez Santiago, Mª Blanca aut Laredo, Leonor aut Durán Quintana, José Antonio aut Castillo, Juan Ramón aut Abad-Santos, Francisco aut Payares Herrera, Concepción aut Sádaba Díaz de Rada, Belén aut Gómez Ontañón, Eugenio aut Enthalten in European journal of clinical pharmacology Berlin : Springer, 1968 66(2010), 6 vom: 05. März, Seite 633-641 (DE-627)253722829 (DE-600)1459058-X 1432-1041 nnns volume:66 year:2010 number:6 day:05 month:03 pages:633-641 https://dx.doi.org/10.1007/s00228-010-0800-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 66 2010 6 05 03 633-641 |
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10.1007/s00228-010-0800-y doi (DE-627)SPR002576368 (SPR)s00228-010-0800-y-e DE-627 ger DE-627 rakwb eng Ruiz-Antorán, Belen verfasserin aut Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Abstract Intravenous immunoglobulin (IVIG) use in non-approved indications, the increase in consumption and its high cost recommend rationalisation in its utilisation. Aims To assess the use of IVIG in Spanish hospitals. Methods An observational, prospective and multicentre drug utilisation study was conducted in 13 tertiary Spanish hospitals. Data were collected for 3 months in patients receiving any IVIG. Patient demographics, indication for IVIG use, dosage regimen and cost of treatment were collected. Results Five hundred and fifty-four patients (mean age of 52 years) were included in the study. A total of 1,287 prescriptions were administered, and the average number of prescriptions per patient was 2.3. The mean daily dose was 24 g (range 0.6–90 g). Overall, IVIG was prescribed for authorised indications in 335 patients (60%) with 953 prescriptions (74%), for non-authorised indications with scientific evidentiary support in 86 patients (16%) with 137 prescriptions (11%), and non-authorised and non-accepted indications in 133 patients (24%) with 197 prescriptions (15%). The most frequent authorised indications were primary and secondary immunodeficiencies, and the most frequent non-authorised and non-accepted indications were multiple sclerosis and bullous dermatosis. The mean cost of IVIG per patient for authorised indications was 2,636.2 €, non-authorised indications with scientific support 5,262.1 € and non-accepted indications 3,555.8 €. Conclusions IVIG is prescribed for a significant number of non-authorised and non-accepted indications with a notable cost. There is an important variability in IVIG prescriptions between hospitals, indicating room for improvement in IVIG use and the need for a consensus of protocol use. Intravenous immunoglobulin (dpeaa)DE-He213 Drug utilization study (dpeaa)DE-He213 Off-label use (dpeaa)DE-He213 Compassionate use (dpeaa)DE-He213 Cost (dpeaa)DE-He213 Agustí Escasany, Antònia aut Vallano Ferraz, Antoni aut Danés Carreras, Imma aut Riba, Neus aut Mateu Escudero, Silvia aut Costa, Joan aut Sánchez Santiago, Mª Blanca aut Laredo, Leonor aut Durán Quintana, José Antonio aut Castillo, Juan Ramón aut Abad-Santos, Francisco aut Payares Herrera, Concepción aut Sádaba Díaz de Rada, Belén aut Gómez Ontañón, Eugenio aut Enthalten in European journal of clinical pharmacology Berlin : Springer, 1968 66(2010), 6 vom: 05. März, Seite 633-641 (DE-627)253722829 (DE-600)1459058-X 1432-1041 nnns volume:66 year:2010 number:6 day:05 month:03 pages:633-641 https://dx.doi.org/10.1007/s00228-010-0800-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 66 2010 6 05 03 633-641 |
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10.1007/s00228-010-0800-y doi (DE-627)SPR002576368 (SPR)s00228-010-0800-y-e DE-627 ger DE-627 rakwb eng Ruiz-Antorán, Belen verfasserin aut Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Abstract Intravenous immunoglobulin (IVIG) use in non-approved indications, the increase in consumption and its high cost recommend rationalisation in its utilisation. Aims To assess the use of IVIG in Spanish hospitals. Methods An observational, prospective and multicentre drug utilisation study was conducted in 13 tertiary Spanish hospitals. Data were collected for 3 months in patients receiving any IVIG. Patient demographics, indication for IVIG use, dosage regimen and cost of treatment were collected. Results Five hundred and fifty-four patients (mean age of 52 years) were included in the study. A total of 1,287 prescriptions were administered, and the average number of prescriptions per patient was 2.3. The mean daily dose was 24 g (range 0.6–90 g). Overall, IVIG was prescribed for authorised indications in 335 patients (60%) with 953 prescriptions (74%), for non-authorised indications with scientific evidentiary support in 86 patients (16%) with 137 prescriptions (11%), and non-authorised and non-accepted indications in 133 patients (24%) with 197 prescriptions (15%). The most frequent authorised indications were primary and secondary immunodeficiencies, and the most frequent non-authorised and non-accepted indications were multiple sclerosis and bullous dermatosis. The mean cost of IVIG per patient for authorised indications was 2,636.2 €, non-authorised indications with scientific support 5,262.1 € and non-accepted indications 3,555.8 €. Conclusions IVIG is prescribed for a significant number of non-authorised and non-accepted indications with a notable cost. There is an important variability in IVIG prescriptions between hospitals, indicating room for improvement in IVIG use and the need for a consensus of protocol use. Intravenous immunoglobulin (dpeaa)DE-He213 Drug utilization study (dpeaa)DE-He213 Off-label use (dpeaa)DE-He213 Compassionate use (dpeaa)DE-He213 Cost (dpeaa)DE-He213 Agustí Escasany, Antònia aut Vallano Ferraz, Antoni aut Danés Carreras, Imma aut Riba, Neus aut Mateu Escudero, Silvia aut Costa, Joan aut Sánchez Santiago, Mª Blanca aut Laredo, Leonor aut Durán Quintana, José Antonio aut Castillo, Juan Ramón aut Abad-Santos, Francisco aut Payares Herrera, Concepción aut Sádaba Díaz de Rada, Belén aut Gómez Ontañón, Eugenio aut Enthalten in European journal of clinical pharmacology Berlin : Springer, 1968 66(2010), 6 vom: 05. März, Seite 633-641 (DE-627)253722829 (DE-600)1459058-X 1432-1041 nnns volume:66 year:2010 number:6 day:05 month:03 pages:633-641 https://dx.doi.org/10.1007/s00228-010-0800-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 66 2010 6 05 03 633-641 |
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10.1007/s00228-010-0800-y doi (DE-627)SPR002576368 (SPR)s00228-010-0800-y-e DE-627 ger DE-627 rakwb eng Ruiz-Antorán, Belen verfasserin aut Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Abstract Intravenous immunoglobulin (IVIG) use in non-approved indications, the increase in consumption and its high cost recommend rationalisation in its utilisation. Aims To assess the use of IVIG in Spanish hospitals. Methods An observational, prospective and multicentre drug utilisation study was conducted in 13 tertiary Spanish hospitals. Data were collected for 3 months in patients receiving any IVIG. Patient demographics, indication for IVIG use, dosage regimen and cost of treatment were collected. Results Five hundred and fifty-four patients (mean age of 52 years) were included in the study. A total of 1,287 prescriptions were administered, and the average number of prescriptions per patient was 2.3. The mean daily dose was 24 g (range 0.6–90 g). Overall, IVIG was prescribed for authorised indications in 335 patients (60%) with 953 prescriptions (74%), for non-authorised indications with scientific evidentiary support in 86 patients (16%) with 137 prescriptions (11%), and non-authorised and non-accepted indications in 133 patients (24%) with 197 prescriptions (15%). The most frequent authorised indications were primary and secondary immunodeficiencies, and the most frequent non-authorised and non-accepted indications were multiple sclerosis and bullous dermatosis. The mean cost of IVIG per patient for authorised indications was 2,636.2 €, non-authorised indications with scientific support 5,262.1 € and non-accepted indications 3,555.8 €. Conclusions IVIG is prescribed for a significant number of non-authorised and non-accepted indications with a notable cost. There is an important variability in IVIG prescriptions between hospitals, indicating room for improvement in IVIG use and the need for a consensus of protocol use. Intravenous immunoglobulin (dpeaa)DE-He213 Drug utilization study (dpeaa)DE-He213 Off-label use (dpeaa)DE-He213 Compassionate use (dpeaa)DE-He213 Cost (dpeaa)DE-He213 Agustí Escasany, Antònia aut Vallano Ferraz, Antoni aut Danés Carreras, Imma aut Riba, Neus aut Mateu Escudero, Silvia aut Costa, Joan aut Sánchez Santiago, Mª Blanca aut Laredo, Leonor aut Durán Quintana, José Antonio aut Castillo, Juan Ramón aut Abad-Santos, Francisco aut Payares Herrera, Concepción aut Sádaba Díaz de Rada, Belén aut Gómez Ontañón, Eugenio aut Enthalten in European journal of clinical pharmacology Berlin : Springer, 1968 66(2010), 6 vom: 05. März, Seite 633-641 (DE-627)253722829 (DE-600)1459058-X 1432-1041 nnns volume:66 year:2010 number:6 day:05 month:03 pages:633-641 https://dx.doi.org/10.1007/s00228-010-0800-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 66 2010 6 05 03 633-641 |
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Ruiz-Antorán, Belen @@aut@@ Agustí Escasany, Antònia @@aut@@ Vallano Ferraz, Antoni @@aut@@ Danés Carreras, Imma @@aut@@ Riba, Neus @@aut@@ Mateu Escudero, Silvia @@aut@@ Costa, Joan @@aut@@ Sánchez Santiago, Mª Blanca @@aut@@ Laredo, Leonor @@aut@@ Durán Quintana, José Antonio @@aut@@ Castillo, Juan Ramón @@aut@@ Abad-Santos, Francisco @@aut@@ Payares Herrera, Concepción @@aut@@ Sádaba Díaz de Rada, Belén @@aut@@ Gómez Ontañón, Eugenio @@aut@@ |
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Aims To assess the use of IVIG in Spanish hospitals. Methods An observational, prospective and multicentre drug utilisation study was conducted in 13 tertiary Spanish hospitals. Data were collected for 3 months in patients receiving any IVIG. Patient demographics, indication for IVIG use, dosage regimen and cost of treatment were collected. Results Five hundred and fifty-four patients (mean age of 52 years) were included in the study. A total of 1,287 prescriptions were administered, and the average number of prescriptions per patient was 2.3. The mean daily dose was 24 g (range 0.6–90 g). Overall, IVIG was prescribed for authorised indications in 335 patients (60%) with 953 prescriptions (74%), for non-authorised indications with scientific evidentiary support in 86 patients (16%) with 137 prescriptions (11%), and non-authorised and non-accepted indications in 133 patients (24%) with 197 prescriptions (15%). The most frequent authorised indications were primary and secondary immunodeficiencies, and the most frequent non-authorised and non-accepted indications were multiple sclerosis and bullous dermatosis. The mean cost of IVIG per patient for authorised indications was 2,636.2 €, non-authorised indications with scientific support 5,262.1 € and non-accepted indications 3,555.8 €. Conclusions IVIG is prescribed for a significant number of non-authorised and non-accepted indications with a notable cost. 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Ruiz-Antorán, Belen |
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Ruiz-Antorán, Belen misc Intravenous immunoglobulin misc Drug utilization study misc Off-label use misc Compassionate use misc Cost Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol |
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Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol Intravenous immunoglobulin (dpeaa)DE-He213 Drug utilization study (dpeaa)DE-He213 Off-label use (dpeaa)DE-He213 Compassionate use (dpeaa)DE-He213 Cost (dpeaa)DE-He213 |
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Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol |
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Ruiz-Antorán, Belen |
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European journal of clinical pharmacology |
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European journal of clinical pharmacology |
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Ruiz-Antorán, Belen Agustí Escasany, Antònia Vallano Ferraz, Antoni Danés Carreras, Imma Riba, Neus Mateu Escudero, Silvia Costa, Joan Sánchez Santiago, Mª Blanca Laredo, Leonor Durán Quintana, José Antonio Castillo, Juan Ramón Abad-Santos, Francisco Payares Herrera, Concepción Sádaba Díaz de Rada, Belén Gómez Ontañón, Eugenio |
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Elektronische Aufsätze |
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Ruiz-Antorán, Belen |
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10.1007/s00228-010-0800-y |
| title_sort |
use of non-specific intravenous human immunoglobulins in spanish hospitals; need for a hospital protocol |
| title_auth |
Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol |
| abstract |
Abstract Intravenous immunoglobulin (IVIG) use in non-approved indications, the increase in consumption and its high cost recommend rationalisation in its utilisation. Aims To assess the use of IVIG in Spanish hospitals. Methods An observational, prospective and multicentre drug utilisation study was conducted in 13 tertiary Spanish hospitals. Data were collected for 3 months in patients receiving any IVIG. Patient demographics, indication for IVIG use, dosage regimen and cost of treatment were collected. Results Five hundred and fifty-four patients (mean age of 52 years) were included in the study. A total of 1,287 prescriptions were administered, and the average number of prescriptions per patient was 2.3. The mean daily dose was 24 g (range 0.6–90 g). Overall, IVIG was prescribed for authorised indications in 335 patients (60%) with 953 prescriptions (74%), for non-authorised indications with scientific evidentiary support in 86 patients (16%) with 137 prescriptions (11%), and non-authorised and non-accepted indications in 133 patients (24%) with 197 prescriptions (15%). The most frequent authorised indications were primary and secondary immunodeficiencies, and the most frequent non-authorised and non-accepted indications were multiple sclerosis and bullous dermatosis. The mean cost of IVIG per patient for authorised indications was 2,636.2 €, non-authorised indications with scientific support 5,262.1 € and non-accepted indications 3,555.8 €. Conclusions IVIG is prescribed for a significant number of non-authorised and non-accepted indications with a notable cost. There is an important variability in IVIG prescriptions between hospitals, indicating room for improvement in IVIG use and the need for a consensus of protocol use. © Springer-Verlag 2010 |
| abstractGer |
Abstract Intravenous immunoglobulin (IVIG) use in non-approved indications, the increase in consumption and its high cost recommend rationalisation in its utilisation. Aims To assess the use of IVIG in Spanish hospitals. Methods An observational, prospective and multicentre drug utilisation study was conducted in 13 tertiary Spanish hospitals. Data were collected for 3 months in patients receiving any IVIG. Patient demographics, indication for IVIG use, dosage regimen and cost of treatment were collected. Results Five hundred and fifty-four patients (mean age of 52 years) were included in the study. A total of 1,287 prescriptions were administered, and the average number of prescriptions per patient was 2.3. The mean daily dose was 24 g (range 0.6–90 g). Overall, IVIG was prescribed for authorised indications in 335 patients (60%) with 953 prescriptions (74%), for non-authorised indications with scientific evidentiary support in 86 patients (16%) with 137 prescriptions (11%), and non-authorised and non-accepted indications in 133 patients (24%) with 197 prescriptions (15%). The most frequent authorised indications were primary and secondary immunodeficiencies, and the most frequent non-authorised and non-accepted indications were multiple sclerosis and bullous dermatosis. The mean cost of IVIG per patient for authorised indications was 2,636.2 €, non-authorised indications with scientific support 5,262.1 € and non-accepted indications 3,555.8 €. Conclusions IVIG is prescribed for a significant number of non-authorised and non-accepted indications with a notable cost. There is an important variability in IVIG prescriptions between hospitals, indicating room for improvement in IVIG use and the need for a consensus of protocol use. © Springer-Verlag 2010 |
| abstract_unstemmed |
Abstract Intravenous immunoglobulin (IVIG) use in non-approved indications, the increase in consumption and its high cost recommend rationalisation in its utilisation. Aims To assess the use of IVIG in Spanish hospitals. Methods An observational, prospective and multicentre drug utilisation study was conducted in 13 tertiary Spanish hospitals. Data were collected for 3 months in patients receiving any IVIG. Patient demographics, indication for IVIG use, dosage regimen and cost of treatment were collected. Results Five hundred and fifty-four patients (mean age of 52 years) were included in the study. A total of 1,287 prescriptions were administered, and the average number of prescriptions per patient was 2.3. The mean daily dose was 24 g (range 0.6–90 g). Overall, IVIG was prescribed for authorised indications in 335 patients (60%) with 953 prescriptions (74%), for non-authorised indications with scientific evidentiary support in 86 patients (16%) with 137 prescriptions (11%), and non-authorised and non-accepted indications in 133 patients (24%) with 197 prescriptions (15%). The most frequent authorised indications were primary and secondary immunodeficiencies, and the most frequent non-authorised and non-accepted indications were multiple sclerosis and bullous dermatosis. The mean cost of IVIG per patient for authorised indications was 2,636.2 €, non-authorised indications with scientific support 5,262.1 € and non-accepted indications 3,555.8 €. Conclusions IVIG is prescribed for a significant number of non-authorised and non-accepted indications with a notable cost. There is an important variability in IVIG prescriptions between hospitals, indicating room for improvement in IVIG use and the need for a consensus of protocol use. © Springer-Verlag 2010 |
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Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol |
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Agustí Escasany, Antònia Vallano Ferraz, Antoni Danés Carreras, Imma Riba, Neus Mateu Escudero, Silvia Costa, Joan Sánchez Santiago, Mª Blanca Laredo, Leonor Durán Quintana, José Antonio Castillo, Juan Ramón Abad-Santos, Francisco Payares Herrera, Concepción Sádaba Díaz de Rada, Belén Gómez Ontañón, Eugenio |
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Agustí Escasany, Antònia Vallano Ferraz, Antoni Danés Carreras, Imma Riba, Neus Mateu Escudero, Silvia Costa, Joan Sánchez Santiago, Mª Blanca Laredo, Leonor Durán Quintana, José Antonio Castillo, Juan Ramón Abad-Santos, Francisco Payares Herrera, Concepción Sádaba Díaz de Rada, Belén Gómez Ontañón, Eugenio |
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| score |
7.3998156 |