CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro
Abstract Calcium oxalate monohydrate (COM) stones are often resistant to breakage using shock wave (SW) lithotripsy. It would be useful to identify by computed tomography (CT) those COM stones that are susceptible to SW’s. For this study, 47 COM stones (4–10 mm in diameter) were scanned with micro C...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zarse, Chad A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2007 |
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| Übergeordnetes Werk: |
Enthalten in: Urological research - Berlin : Springer, 1973, 35(2007), 4 vom: 13. Juni, Seite 201-206 |
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| Übergeordnetes Werk: |
volume:35 ; year:2007 ; number:4 ; day:13 ; month:06 ; pages:201-206 |
| Links: |
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| DOI / URN: |
10.1007/s00240-007-0104-6 |
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| Katalog-ID: |
SPR002716119 |
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| 100 | 1 | |a Zarse, Chad A. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro |
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| 520 | |a Abstract Calcium oxalate monohydrate (COM) stones are often resistant to breakage using shock wave (SW) lithotripsy. It would be useful to identify by computed tomography (CT) those COM stones that are susceptible to SW’s. For this study, 47 COM stones (4–10 mm in diameter) were scanned with micro CT to verify composition and also for assessment of heterogeneity (presence of pronounced lobulation, voids, or apatite inclusions) by blinded observers. Stones were then placed in water and scanned using 64-channel helical CT. As with micro CT, heterogeneity was assessed by blinded observers, using high-bone viewing windows. Then stones were broken in a lithotripter (Dornier Doli-50) over 2 mm mesh, and SW’s counted. Results showed that classification of stones using micro CT was highly repeatable among observers (κ = 0.81), and also predictive of stone fragility. Stones graded as homogeneous required 1,874 ± 821 SW/g for comminution, while stones with visible structure required half as many SW/g, 912 ± 678. Similarly, when stones were graded by appearance on helical CT, classification was repeatable (κ = 0.40), and homogeneous stones required more SW’s for comminution than did heterogeneous stones (1,702 ± 993 SW/g, compared to 907 ± 773). Stone fragility normalized to stone size did not correlate with Hounsfield units (P = 0.85). In conclusion, COM stones of homogeneous structure require almost twice as many SW’s to comminute than stones of similar mineral composition that exhibit internal structural features that are visible by CT. This suggests that stone fragility in patients could be predicted using pre-treatment CT imaging. The findings also show that Hounsfield unit values of COM stones did not correlate with stone fragility. Thus, it is stone morphology, rather than X-ray attenuation, which correlates with fragility to SW’s in this common stone type. | ||
| 650 | 4 | |a Kidney calculi |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Tomography, X-ray computed |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Micro CT |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Hameed, Tariq A. |4 aut | |
| 700 | 1 | |a Jackson, Molly E. |4 aut | |
| 700 | 1 | |a Pishchalnikov, Yuri A. |4 aut | |
| 700 | 1 | |a Lingeman, James E. |4 aut | |
| 700 | 1 | |a McAteer, James A. |4 aut | |
| 700 | 1 | |a Williams, James C. |4 aut | |
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10.1007/s00240-007-0104-6 doi (DE-627)SPR002716119 (SPR)s00240-007-0104-6-e DE-627 ger DE-627 rakwb eng Zarse, Chad A. verfasserin aut CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract Calcium oxalate monohydrate (COM) stones are often resistant to breakage using shock wave (SW) lithotripsy. It would be useful to identify by computed tomography (CT) those COM stones that are susceptible to SW’s. For this study, 47 COM stones (4–10 mm in diameter) were scanned with micro CT to verify composition and also for assessment of heterogeneity (presence of pronounced lobulation, voids, or apatite inclusions) by blinded observers. Stones were then placed in water and scanned using 64-channel helical CT. As with micro CT, heterogeneity was assessed by blinded observers, using high-bone viewing windows. Then stones were broken in a lithotripter (Dornier Doli-50) over 2 mm mesh, and SW’s counted. Results showed that classification of stones using micro CT was highly repeatable among observers (κ = 0.81), and also predictive of stone fragility. Stones graded as homogeneous required 1,874 ± 821 SW/g for comminution, while stones with visible structure required half as many SW/g, 912 ± 678. Similarly, when stones were graded by appearance on helical CT, classification was repeatable (κ = 0.40), and homogeneous stones required more SW’s for comminution than did heterogeneous stones (1,702 ± 993 SW/g, compared to 907 ± 773). Stone fragility normalized to stone size did not correlate with Hounsfield units (P = 0.85). In conclusion, COM stones of homogeneous structure require almost twice as many SW’s to comminute than stones of similar mineral composition that exhibit internal structural features that are visible by CT. This suggests that stone fragility in patients could be predicted using pre-treatment CT imaging. The findings also show that Hounsfield unit values of COM stones did not correlate with stone fragility. Thus, it is stone morphology, rather than X-ray attenuation, which correlates with fragility to SW’s in this common stone type. Kidney calculi (dpeaa)DE-He213 Tomography, X-ray computed (dpeaa)DE-He213 Micro CT (dpeaa)DE-He213 Hameed, Tariq A. aut Jackson, Molly E. aut Pishchalnikov, Yuri A. aut Lingeman, James E. aut McAteer, James A. aut Williams, James C. aut Enthalten in Urological research Berlin : Springer, 1973 35(2007), 4 vom: 13. Juni, Seite 201-206 (DE-627)254236901 (DE-600)1461962-3 1434-0879 nnns volume:35 year:2007 number:4 day:13 month:06 pages:201-206 https://dx.doi.org/10.1007/s00240-007-0104-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2007 4 13 06 201-206 |
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10.1007/s00240-007-0104-6 doi (DE-627)SPR002716119 (SPR)s00240-007-0104-6-e DE-627 ger DE-627 rakwb eng Zarse, Chad A. verfasserin aut CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract Calcium oxalate monohydrate (COM) stones are often resistant to breakage using shock wave (SW) lithotripsy. It would be useful to identify by computed tomography (CT) those COM stones that are susceptible to SW’s. For this study, 47 COM stones (4–10 mm in diameter) were scanned with micro CT to verify composition and also for assessment of heterogeneity (presence of pronounced lobulation, voids, or apatite inclusions) by blinded observers. Stones were then placed in water and scanned using 64-channel helical CT. As with micro CT, heterogeneity was assessed by blinded observers, using high-bone viewing windows. Then stones were broken in a lithotripter (Dornier Doli-50) over 2 mm mesh, and SW’s counted. Results showed that classification of stones using micro CT was highly repeatable among observers (κ = 0.81), and also predictive of stone fragility. Stones graded as homogeneous required 1,874 ± 821 SW/g for comminution, while stones with visible structure required half as many SW/g, 912 ± 678. Similarly, when stones were graded by appearance on helical CT, classification was repeatable (κ = 0.40), and homogeneous stones required more SW’s for comminution than did heterogeneous stones (1,702 ± 993 SW/g, compared to 907 ± 773). Stone fragility normalized to stone size did not correlate with Hounsfield units (P = 0.85). In conclusion, COM stones of homogeneous structure require almost twice as many SW’s to comminute than stones of similar mineral composition that exhibit internal structural features that are visible by CT. This suggests that stone fragility in patients could be predicted using pre-treatment CT imaging. The findings also show that Hounsfield unit values of COM stones did not correlate with stone fragility. Thus, it is stone morphology, rather than X-ray attenuation, which correlates with fragility to SW’s in this common stone type. Kidney calculi (dpeaa)DE-He213 Tomography, X-ray computed (dpeaa)DE-He213 Micro CT (dpeaa)DE-He213 Hameed, Tariq A. aut Jackson, Molly E. aut Pishchalnikov, Yuri A. aut Lingeman, James E. aut McAteer, James A. aut Williams, James C. aut Enthalten in Urological research Berlin : Springer, 1973 35(2007), 4 vom: 13. Juni, Seite 201-206 (DE-627)254236901 (DE-600)1461962-3 1434-0879 nnns volume:35 year:2007 number:4 day:13 month:06 pages:201-206 https://dx.doi.org/10.1007/s00240-007-0104-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2007 4 13 06 201-206 |
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10.1007/s00240-007-0104-6 doi (DE-627)SPR002716119 (SPR)s00240-007-0104-6-e DE-627 ger DE-627 rakwb eng Zarse, Chad A. verfasserin aut CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract Calcium oxalate monohydrate (COM) stones are often resistant to breakage using shock wave (SW) lithotripsy. It would be useful to identify by computed tomography (CT) those COM stones that are susceptible to SW’s. For this study, 47 COM stones (4–10 mm in diameter) were scanned with micro CT to verify composition and also for assessment of heterogeneity (presence of pronounced lobulation, voids, or apatite inclusions) by blinded observers. Stones were then placed in water and scanned using 64-channel helical CT. As with micro CT, heterogeneity was assessed by blinded observers, using high-bone viewing windows. Then stones were broken in a lithotripter (Dornier Doli-50) over 2 mm mesh, and SW’s counted. Results showed that classification of stones using micro CT was highly repeatable among observers (κ = 0.81), and also predictive of stone fragility. Stones graded as homogeneous required 1,874 ± 821 SW/g for comminution, while stones with visible structure required half as many SW/g, 912 ± 678. Similarly, when stones were graded by appearance on helical CT, classification was repeatable (κ = 0.40), and homogeneous stones required more SW’s for comminution than did heterogeneous stones (1,702 ± 993 SW/g, compared to 907 ± 773). Stone fragility normalized to stone size did not correlate with Hounsfield units (P = 0.85). In conclusion, COM stones of homogeneous structure require almost twice as many SW’s to comminute than stones of similar mineral composition that exhibit internal structural features that are visible by CT. This suggests that stone fragility in patients could be predicted using pre-treatment CT imaging. The findings also show that Hounsfield unit values of COM stones did not correlate with stone fragility. Thus, it is stone morphology, rather than X-ray attenuation, which correlates with fragility to SW’s in this common stone type. Kidney calculi (dpeaa)DE-He213 Tomography, X-ray computed (dpeaa)DE-He213 Micro CT (dpeaa)DE-He213 Hameed, Tariq A. aut Jackson, Molly E. aut Pishchalnikov, Yuri A. aut Lingeman, James E. aut McAteer, James A. aut Williams, James C. aut Enthalten in Urological research Berlin : Springer, 1973 35(2007), 4 vom: 13. Juni, Seite 201-206 (DE-627)254236901 (DE-600)1461962-3 1434-0879 nnns volume:35 year:2007 number:4 day:13 month:06 pages:201-206 https://dx.doi.org/10.1007/s00240-007-0104-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2007 4 13 06 201-206 |
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10.1007/s00240-007-0104-6 doi (DE-627)SPR002716119 (SPR)s00240-007-0104-6-e DE-627 ger DE-627 rakwb eng Zarse, Chad A. verfasserin aut CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract Calcium oxalate monohydrate (COM) stones are often resistant to breakage using shock wave (SW) lithotripsy. It would be useful to identify by computed tomography (CT) those COM stones that are susceptible to SW’s. For this study, 47 COM stones (4–10 mm in diameter) were scanned with micro CT to verify composition and also for assessment of heterogeneity (presence of pronounced lobulation, voids, or apatite inclusions) by blinded observers. Stones were then placed in water and scanned using 64-channel helical CT. As with micro CT, heterogeneity was assessed by blinded observers, using high-bone viewing windows. Then stones were broken in a lithotripter (Dornier Doli-50) over 2 mm mesh, and SW’s counted. Results showed that classification of stones using micro CT was highly repeatable among observers (κ = 0.81), and also predictive of stone fragility. Stones graded as homogeneous required 1,874 ± 821 SW/g for comminution, while stones with visible structure required half as many SW/g, 912 ± 678. Similarly, when stones were graded by appearance on helical CT, classification was repeatable (κ = 0.40), and homogeneous stones required more SW’s for comminution than did heterogeneous stones (1,702 ± 993 SW/g, compared to 907 ± 773). Stone fragility normalized to stone size did not correlate with Hounsfield units (P = 0.85). In conclusion, COM stones of homogeneous structure require almost twice as many SW’s to comminute than stones of similar mineral composition that exhibit internal structural features that are visible by CT. This suggests that stone fragility in patients could be predicted using pre-treatment CT imaging. The findings also show that Hounsfield unit values of COM stones did not correlate with stone fragility. Thus, it is stone morphology, rather than X-ray attenuation, which correlates with fragility to SW’s in this common stone type. Kidney calculi (dpeaa)DE-He213 Tomography, X-ray computed (dpeaa)DE-He213 Micro CT (dpeaa)DE-He213 Hameed, Tariq A. aut Jackson, Molly E. aut Pishchalnikov, Yuri A. aut Lingeman, James E. aut McAteer, James A. aut Williams, James C. aut Enthalten in Urological research Berlin : Springer, 1973 35(2007), 4 vom: 13. Juni, Seite 201-206 (DE-627)254236901 (DE-600)1461962-3 1434-0879 nnns volume:35 year:2007 number:4 day:13 month:06 pages:201-206 https://dx.doi.org/10.1007/s00240-007-0104-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2007 4 13 06 201-206 |
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10.1007/s00240-007-0104-6 doi (DE-627)SPR002716119 (SPR)s00240-007-0104-6-e DE-627 ger DE-627 rakwb eng Zarse, Chad A. verfasserin aut CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract Calcium oxalate monohydrate (COM) stones are often resistant to breakage using shock wave (SW) lithotripsy. It would be useful to identify by computed tomography (CT) those COM stones that are susceptible to SW’s. For this study, 47 COM stones (4–10 mm in diameter) were scanned with micro CT to verify composition and also for assessment of heterogeneity (presence of pronounced lobulation, voids, or apatite inclusions) by blinded observers. Stones were then placed in water and scanned using 64-channel helical CT. As with micro CT, heterogeneity was assessed by blinded observers, using high-bone viewing windows. Then stones were broken in a lithotripter (Dornier Doli-50) over 2 mm mesh, and SW’s counted. Results showed that classification of stones using micro CT was highly repeatable among observers (κ = 0.81), and also predictive of stone fragility. Stones graded as homogeneous required 1,874 ± 821 SW/g for comminution, while stones with visible structure required half as many SW/g, 912 ± 678. Similarly, when stones were graded by appearance on helical CT, classification was repeatable (κ = 0.40), and homogeneous stones required more SW’s for comminution than did heterogeneous stones (1,702 ± 993 SW/g, compared to 907 ± 773). Stone fragility normalized to stone size did not correlate with Hounsfield units (P = 0.85). In conclusion, COM stones of homogeneous structure require almost twice as many SW’s to comminute than stones of similar mineral composition that exhibit internal structural features that are visible by CT. This suggests that stone fragility in patients could be predicted using pre-treatment CT imaging. The findings also show that Hounsfield unit values of COM stones did not correlate with stone fragility. Thus, it is stone morphology, rather than X-ray attenuation, which correlates with fragility to SW’s in this common stone type. Kidney calculi (dpeaa)DE-He213 Tomography, X-ray computed (dpeaa)DE-He213 Micro CT (dpeaa)DE-He213 Hameed, Tariq A. aut Jackson, Molly E. aut Pishchalnikov, Yuri A. aut Lingeman, James E. aut McAteer, James A. aut Williams, James C. aut Enthalten in Urological research Berlin : Springer, 1973 35(2007), 4 vom: 13. Juni, Seite 201-206 (DE-627)254236901 (DE-600)1461962-3 1434-0879 nnns volume:35 year:2007 number:4 day:13 month:06 pages:201-206 https://dx.doi.org/10.1007/s00240-007-0104-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2007 4 13 06 201-206 |
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Enthalten in Urological research 35(2007), 4 vom: 13. Juni, Seite 201-206 volume:35 year:2007 number:4 day:13 month:06 pages:201-206 |
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Enthalten in Urological research 35(2007), 4 vom: 13. Juni, Seite 201-206 volume:35 year:2007 number:4 day:13 month:06 pages:201-206 |
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Kidney calculi Tomography, X-ray computed Micro CT |
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Zarse, Chad A. @@aut@@ Hameed, Tariq A. @@aut@@ Jackson, Molly E. @@aut@@ Pishchalnikov, Yuri A. @@aut@@ Lingeman, James E. @@aut@@ McAteer, James A. @@aut@@ Williams, James C. @@aut@@ |
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It would be useful to identify by computed tomography (CT) those COM stones that are susceptible to SW’s. For this study, 47 COM stones (4–10 mm in diameter) were scanned with micro CT to verify composition and also for assessment of heterogeneity (presence of pronounced lobulation, voids, or apatite inclusions) by blinded observers. Stones were then placed in water and scanned using 64-channel helical CT. As with micro CT, heterogeneity was assessed by blinded observers, using high-bone viewing windows. Then stones were broken in a lithotripter (Dornier Doli-50) over 2 mm mesh, and SW’s counted. Results showed that classification of stones using micro CT was highly repeatable among observers (κ = 0.81), and also predictive of stone fragility. Stones graded as homogeneous required 1,874 ± 821 SW/g for comminution, while stones with visible structure required half as many SW/g, 912 ± 678. Similarly, when stones were graded by appearance on helical CT, classification was repeatable (κ = 0.40), and homogeneous stones required more SW’s for comminution than did heterogeneous stones (1,702 ± 993 SW/g, compared to 907 ± 773). Stone fragility normalized to stone size did not correlate with Hounsfield units (P = 0.85). In conclusion, COM stones of homogeneous structure require almost twice as many SW’s to comminute than stones of similar mineral composition that exhibit internal structural features that are visible by CT. This suggests that stone fragility in patients could be predicted using pre-treatment CT imaging. The findings also show that Hounsfield unit values of COM stones did not correlate with stone fragility. 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|
| author |
Zarse, Chad A. |
| spellingShingle |
Zarse, Chad A. misc Kidney calculi misc Tomography, X-ray computed misc Micro CT CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro |
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Zarse, Chad A. |
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1434-0879 |
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CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro Kidney calculi (dpeaa)DE-He213 Tomography, X-ray computed (dpeaa)DE-He213 Micro CT (dpeaa)DE-He213 |
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misc Kidney calculi misc Tomography, X-ray computed misc Micro CT |
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misc Kidney calculi misc Tomography, X-ray computed misc Micro CT |
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misc Kidney calculi misc Tomography, X-ray computed misc Micro CT |
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CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro |
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CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro |
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Zarse, Chad A. |
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Urological research |
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Zarse, Chad A. Hameed, Tariq A. Jackson, Molly E. Pishchalnikov, Yuri A. Lingeman, James E. McAteer, James A. Williams, James C. |
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Zarse, Chad A. |
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10.1007/s00240-007-0104-6 |
| title_sort |
ct visible internal stone structure, but not hounsfield unit value, of calcium oxalate monohydrate (com) calculi predicts lithotripsy fragility in vitro |
| title_auth |
CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro |
| abstract |
Abstract Calcium oxalate monohydrate (COM) stones are often resistant to breakage using shock wave (SW) lithotripsy. It would be useful to identify by computed tomography (CT) those COM stones that are susceptible to SW’s. For this study, 47 COM stones (4–10 mm in diameter) were scanned with micro CT to verify composition and also for assessment of heterogeneity (presence of pronounced lobulation, voids, or apatite inclusions) by blinded observers. Stones were then placed in water and scanned using 64-channel helical CT. As with micro CT, heterogeneity was assessed by blinded observers, using high-bone viewing windows. Then stones were broken in a lithotripter (Dornier Doli-50) over 2 mm mesh, and SW’s counted. Results showed that classification of stones using micro CT was highly repeatable among observers (κ = 0.81), and also predictive of stone fragility. Stones graded as homogeneous required 1,874 ± 821 SW/g for comminution, while stones with visible structure required half as many SW/g, 912 ± 678. Similarly, when stones were graded by appearance on helical CT, classification was repeatable (κ = 0.40), and homogeneous stones required more SW’s for comminution than did heterogeneous stones (1,702 ± 993 SW/g, compared to 907 ± 773). Stone fragility normalized to stone size did not correlate with Hounsfield units (P = 0.85). In conclusion, COM stones of homogeneous structure require almost twice as many SW’s to comminute than stones of similar mineral composition that exhibit internal structural features that are visible by CT. This suggests that stone fragility in patients could be predicted using pre-treatment CT imaging. The findings also show that Hounsfield unit values of COM stones did not correlate with stone fragility. Thus, it is stone morphology, rather than X-ray attenuation, which correlates with fragility to SW’s in this common stone type. © Springer-Verlag 2007 |
| abstractGer |
Abstract Calcium oxalate monohydrate (COM) stones are often resistant to breakage using shock wave (SW) lithotripsy. It would be useful to identify by computed tomography (CT) those COM stones that are susceptible to SW’s. For this study, 47 COM stones (4–10 mm in diameter) were scanned with micro CT to verify composition and also for assessment of heterogeneity (presence of pronounced lobulation, voids, or apatite inclusions) by blinded observers. Stones were then placed in water and scanned using 64-channel helical CT. As with micro CT, heterogeneity was assessed by blinded observers, using high-bone viewing windows. Then stones were broken in a lithotripter (Dornier Doli-50) over 2 mm mesh, and SW’s counted. Results showed that classification of stones using micro CT was highly repeatable among observers (κ = 0.81), and also predictive of stone fragility. Stones graded as homogeneous required 1,874 ± 821 SW/g for comminution, while stones with visible structure required half as many SW/g, 912 ± 678. Similarly, when stones were graded by appearance on helical CT, classification was repeatable (κ = 0.40), and homogeneous stones required more SW’s for comminution than did heterogeneous stones (1,702 ± 993 SW/g, compared to 907 ± 773). Stone fragility normalized to stone size did not correlate with Hounsfield units (P = 0.85). In conclusion, COM stones of homogeneous structure require almost twice as many SW’s to comminute than stones of similar mineral composition that exhibit internal structural features that are visible by CT. This suggests that stone fragility in patients could be predicted using pre-treatment CT imaging. The findings also show that Hounsfield unit values of COM stones did not correlate with stone fragility. Thus, it is stone morphology, rather than X-ray attenuation, which correlates with fragility to SW’s in this common stone type. © Springer-Verlag 2007 |
| abstract_unstemmed |
Abstract Calcium oxalate monohydrate (COM) stones are often resistant to breakage using shock wave (SW) lithotripsy. It would be useful to identify by computed tomography (CT) those COM stones that are susceptible to SW’s. For this study, 47 COM stones (4–10 mm in diameter) were scanned with micro CT to verify composition and also for assessment of heterogeneity (presence of pronounced lobulation, voids, or apatite inclusions) by blinded observers. Stones were then placed in water and scanned using 64-channel helical CT. As with micro CT, heterogeneity was assessed by blinded observers, using high-bone viewing windows. Then stones were broken in a lithotripter (Dornier Doli-50) over 2 mm mesh, and SW’s counted. Results showed that classification of stones using micro CT was highly repeatable among observers (κ = 0.81), and also predictive of stone fragility. Stones graded as homogeneous required 1,874 ± 821 SW/g for comminution, while stones with visible structure required half as many SW/g, 912 ± 678. Similarly, when stones were graded by appearance on helical CT, classification was repeatable (κ = 0.40), and homogeneous stones required more SW’s for comminution than did heterogeneous stones (1,702 ± 993 SW/g, compared to 907 ± 773). Stone fragility normalized to stone size did not correlate with Hounsfield units (P = 0.85). In conclusion, COM stones of homogeneous structure require almost twice as many SW’s to comminute than stones of similar mineral composition that exhibit internal structural features that are visible by CT. This suggests that stone fragility in patients could be predicted using pre-treatment CT imaging. The findings also show that Hounsfield unit values of COM stones did not correlate with stone fragility. Thus, it is stone morphology, rather than X-ray attenuation, which correlates with fragility to SW’s in this common stone type. © Springer-Verlag 2007 |
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4 |
| title_short |
CT visible internal stone structure, but not Hounsfield unit value, of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro |
| url |
https://dx.doi.org/10.1007/s00240-007-0104-6 |
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Hameed, Tariq A. Jackson, Molly E. Pishchalnikov, Yuri A. Lingeman, James E. McAteer, James A. Williams, James C. |
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Hameed, Tariq A. Jackson, Molly E. Pishchalnikov, Yuri A. Lingeman, James E. McAteer, James A. Williams, James C. |
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| doi_str |
10.1007/s00240-007-0104-6 |
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2024-07-03T14:44:41.339Z |
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| score |
7.400174 |