Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions
Introduction Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ramenghi, Luca A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2006 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2006 |
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| Übergeordnetes Werk: |
Enthalten in: Neuroradiology - Berlin : Springer, 1970, 49(2006), 2 vom: 22. Nov., Seite 161-167 |
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| Übergeordnetes Werk: |
volume:49 ; year:2006 ; number:2 ; day:22 ; month:11 ; pages:161-167 |
| Links: |
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| DOI / URN: |
10.1007/s00234-006-0176-y |
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| Katalog-ID: |
SPR003093883 |
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| 100 | 1 | |a Ramenghi, Luca A. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions |
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| 520 | |a Introduction Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Methods Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glial cell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR appearance. Results The two groups were comparable concerning gestational age, birth weight and PMA. TMS was significantly lower in the PWML group than in the control group (mean TMS 12.44 ± 2.31 vs 14.00 ± 1.44; P = 0.011). Myelination (mean 2.76 ± 0.42 PWML group vs 3.32 ± 0.55 control group, P = 0.003) and cortical folding (3.64 ± 0.79 vs 4.09 ± 0.43, P = 0.027) appeared to be significantly delayed in babies with PWML. Conclusion Conventional MRI appears able to quantify morphological changes in brain maturation of preterm babies with PWML; delayed myelination and reduced cortical infolding seem to be the most significant aspects. | ||
| 650 | 4 | |a Preterm |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a White matter disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Brain maturation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Magnetic resonance imaging |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Fumagalli, Monica |4 aut | |
| 700 | 1 | |a Righini, Andrea |4 aut | |
| 700 | 1 | |a Bassi, Laura |4 aut | |
| 700 | 1 | |a Groppo, Michela |4 aut | |
| 700 | 1 | |a Parazzini, Cecilia |4 aut | |
| 700 | 1 | |a Bianchini, Elena |4 aut | |
| 700 | 1 | |a Triulzi, Fabio |4 aut | |
| 700 | 1 | |a Mosca, Fabio |4 aut | |
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10.1007/s00234-006-0176-y doi (DE-627)SPR003093883 (SPR)s00234-006-0176-y-e DE-627 ger DE-627 rakwb eng Ramenghi, Luca A. verfasserin aut Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2006 Introduction Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Methods Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glial cell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR appearance. Results The two groups were comparable concerning gestational age, birth weight and PMA. TMS was significantly lower in the PWML group than in the control group (mean TMS 12.44 ± 2.31 vs 14.00 ± 1.44; P = 0.011). Myelination (mean 2.76 ± 0.42 PWML group vs 3.32 ± 0.55 control group, P = 0.003) and cortical folding (3.64 ± 0.79 vs 4.09 ± 0.43, P = 0.027) appeared to be significantly delayed in babies with PWML. Conclusion Conventional MRI appears able to quantify morphological changes in brain maturation of preterm babies with PWML; delayed myelination and reduced cortical infolding seem to be the most significant aspects. Preterm (dpeaa)DE-He213 White matter disease (dpeaa)DE-He213 Brain maturation (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Fumagalli, Monica aut Righini, Andrea aut Bassi, Laura aut Groppo, Michela aut Parazzini, Cecilia aut Bianchini, Elena aut Triulzi, Fabio aut Mosca, Fabio aut Enthalten in Neuroradiology Berlin : Springer, 1970 49(2006), 2 vom: 22. Nov., Seite 161-167 (DE-627)254638430 (DE-600)1462953-7 1432-1920 nnns volume:49 year:2006 number:2 day:22 month:11 pages:161-167 https://dx.doi.org/10.1007/s00234-006-0176-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 49 2006 2 22 11 161-167 |
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10.1007/s00234-006-0176-y doi (DE-627)SPR003093883 (SPR)s00234-006-0176-y-e DE-627 ger DE-627 rakwb eng Ramenghi, Luca A. verfasserin aut Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2006 Introduction Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Methods Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glial cell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR appearance. Results The two groups were comparable concerning gestational age, birth weight and PMA. TMS was significantly lower in the PWML group than in the control group (mean TMS 12.44 ± 2.31 vs 14.00 ± 1.44; P = 0.011). Myelination (mean 2.76 ± 0.42 PWML group vs 3.32 ± 0.55 control group, P = 0.003) and cortical folding (3.64 ± 0.79 vs 4.09 ± 0.43, P = 0.027) appeared to be significantly delayed in babies with PWML. Conclusion Conventional MRI appears able to quantify morphological changes in brain maturation of preterm babies with PWML; delayed myelination and reduced cortical infolding seem to be the most significant aspects. Preterm (dpeaa)DE-He213 White matter disease (dpeaa)DE-He213 Brain maturation (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Fumagalli, Monica aut Righini, Andrea aut Bassi, Laura aut Groppo, Michela aut Parazzini, Cecilia aut Bianchini, Elena aut Triulzi, Fabio aut Mosca, Fabio aut Enthalten in Neuroradiology Berlin : Springer, 1970 49(2006), 2 vom: 22. Nov., Seite 161-167 (DE-627)254638430 (DE-600)1462953-7 1432-1920 nnns volume:49 year:2006 number:2 day:22 month:11 pages:161-167 https://dx.doi.org/10.1007/s00234-006-0176-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 49 2006 2 22 11 161-167 |
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10.1007/s00234-006-0176-y doi (DE-627)SPR003093883 (SPR)s00234-006-0176-y-e DE-627 ger DE-627 rakwb eng Ramenghi, Luca A. verfasserin aut Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2006 Introduction Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Methods Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glial cell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR appearance. Results The two groups were comparable concerning gestational age, birth weight and PMA. TMS was significantly lower in the PWML group than in the control group (mean TMS 12.44 ± 2.31 vs 14.00 ± 1.44; P = 0.011). Myelination (mean 2.76 ± 0.42 PWML group vs 3.32 ± 0.55 control group, P = 0.003) and cortical folding (3.64 ± 0.79 vs 4.09 ± 0.43, P = 0.027) appeared to be significantly delayed in babies with PWML. Conclusion Conventional MRI appears able to quantify morphological changes in brain maturation of preterm babies with PWML; delayed myelination and reduced cortical infolding seem to be the most significant aspects. Preterm (dpeaa)DE-He213 White matter disease (dpeaa)DE-He213 Brain maturation (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Fumagalli, Monica aut Righini, Andrea aut Bassi, Laura aut Groppo, Michela aut Parazzini, Cecilia aut Bianchini, Elena aut Triulzi, Fabio aut Mosca, Fabio aut Enthalten in Neuroradiology Berlin : Springer, 1970 49(2006), 2 vom: 22. Nov., Seite 161-167 (DE-627)254638430 (DE-600)1462953-7 1432-1920 nnns volume:49 year:2006 number:2 day:22 month:11 pages:161-167 https://dx.doi.org/10.1007/s00234-006-0176-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 49 2006 2 22 11 161-167 |
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10.1007/s00234-006-0176-y doi (DE-627)SPR003093883 (SPR)s00234-006-0176-y-e DE-627 ger DE-627 rakwb eng Ramenghi, Luca A. verfasserin aut Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2006 Introduction Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Methods Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glial cell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR appearance. Results The two groups were comparable concerning gestational age, birth weight and PMA. TMS was significantly lower in the PWML group than in the control group (mean TMS 12.44 ± 2.31 vs 14.00 ± 1.44; P = 0.011). Myelination (mean 2.76 ± 0.42 PWML group vs 3.32 ± 0.55 control group, P = 0.003) and cortical folding (3.64 ± 0.79 vs 4.09 ± 0.43, P = 0.027) appeared to be significantly delayed in babies with PWML. Conclusion Conventional MRI appears able to quantify morphological changes in brain maturation of preterm babies with PWML; delayed myelination and reduced cortical infolding seem to be the most significant aspects. Preterm (dpeaa)DE-He213 White matter disease (dpeaa)DE-He213 Brain maturation (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Fumagalli, Monica aut Righini, Andrea aut Bassi, Laura aut Groppo, Michela aut Parazzini, Cecilia aut Bianchini, Elena aut Triulzi, Fabio aut Mosca, Fabio aut Enthalten in Neuroradiology Berlin : Springer, 1970 49(2006), 2 vom: 22. Nov., Seite 161-167 (DE-627)254638430 (DE-600)1462953-7 1432-1920 nnns volume:49 year:2006 number:2 day:22 month:11 pages:161-167 https://dx.doi.org/10.1007/s00234-006-0176-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 49 2006 2 22 11 161-167 |
| allfieldsSound |
10.1007/s00234-006-0176-y doi (DE-627)SPR003093883 (SPR)s00234-006-0176-y-e DE-627 ger DE-627 rakwb eng Ramenghi, Luca A. verfasserin aut Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2006 Introduction Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Methods Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glial cell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR appearance. Results The two groups were comparable concerning gestational age, birth weight and PMA. TMS was significantly lower in the PWML group than in the control group (mean TMS 12.44 ± 2.31 vs 14.00 ± 1.44; P = 0.011). Myelination (mean 2.76 ± 0.42 PWML group vs 3.32 ± 0.55 control group, P = 0.003) and cortical folding (3.64 ± 0.79 vs 4.09 ± 0.43, P = 0.027) appeared to be significantly delayed in babies with PWML. Conclusion Conventional MRI appears able to quantify morphological changes in brain maturation of preterm babies with PWML; delayed myelination and reduced cortical infolding seem to be the most significant aspects. Preterm (dpeaa)DE-He213 White matter disease (dpeaa)DE-He213 Brain maturation (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Fumagalli, Monica aut Righini, Andrea aut Bassi, Laura aut Groppo, Michela aut Parazzini, Cecilia aut Bianchini, Elena aut Triulzi, Fabio aut Mosca, Fabio aut Enthalten in Neuroradiology Berlin : Springer, 1970 49(2006), 2 vom: 22. Nov., Seite 161-167 (DE-627)254638430 (DE-600)1462953-7 1432-1920 nnns volume:49 year:2006 number:2 day:22 month:11 pages:161-167 https://dx.doi.org/10.1007/s00234-006-0176-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 49 2006 2 22 11 161-167 |
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English |
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Enthalten in Neuroradiology 49(2006), 2 vom: 22. Nov., Seite 161-167 volume:49 year:2006 number:2 day:22 month:11 pages:161-167 |
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Enthalten in Neuroradiology 49(2006), 2 vom: 22. Nov., Seite 161-167 volume:49 year:2006 number:2 day:22 month:11 pages:161-167 |
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Preterm White matter disease Brain maturation Magnetic resonance imaging |
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Ramenghi, Luca A. @@aut@@ Fumagalli, Monica @@aut@@ Righini, Andrea @@aut@@ Bassi, Laura @@aut@@ Groppo, Michela @@aut@@ Parazzini, Cecilia @@aut@@ Bianchini, Elena @@aut@@ Triulzi, Fabio @@aut@@ Mosca, Fabio @@aut@@ |
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The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Methods Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glial cell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR appearance. Results The two groups were comparable concerning gestational age, birth weight and PMA. TMS was significantly lower in the PWML group than in the control group (mean TMS 12.44 ± 2.31 vs 14.00 ± 1.44; P = 0.011). Myelination (mean 2.76 ± 0.42 PWML group vs 3.32 ± 0.55 control group, P = 0.003) and cortical folding (3.64 ± 0.79 vs 4.09 ± 0.43, P = 0.027) appeared to be significantly delayed in babies with PWML. 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|
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Ramenghi, Luca A. |
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Ramenghi, Luca A. misc Preterm misc White matter disease misc Brain maturation misc Magnetic resonance imaging Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions |
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Ramenghi, Luca A. |
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Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions Preterm (dpeaa)DE-He213 White matter disease (dpeaa)DE-He213 Brain maturation (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 |
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misc Preterm misc White matter disease misc Brain maturation misc Magnetic resonance imaging |
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misc Preterm misc White matter disease misc Brain maturation misc Magnetic resonance imaging |
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misc Preterm misc White matter disease misc Brain maturation misc Magnetic resonance imaging |
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Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions |
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Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions |
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Ramenghi, Luca A. |
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Neuroradiology |
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Ramenghi, Luca A. Fumagalli, Monica Righini, Andrea Bassi, Laura Groppo, Michela Parazzini, Cecilia Bianchini, Elena Triulzi, Fabio Mosca, Fabio |
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Ramenghi, Luca A. |
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10.1007/s00234-006-0176-y |
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magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions |
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Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions |
| abstract |
Introduction Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Methods Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glial cell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR appearance. Results The two groups were comparable concerning gestational age, birth weight and PMA. TMS was significantly lower in the PWML group than in the control group (mean TMS 12.44 ± 2.31 vs 14.00 ± 1.44; P = 0.011). Myelination (mean 2.76 ± 0.42 PWML group vs 3.32 ± 0.55 control group, P = 0.003) and cortical folding (3.64 ± 0.79 vs 4.09 ± 0.43, P = 0.027) appeared to be significantly delayed in babies with PWML. Conclusion Conventional MRI appears able to quantify morphological changes in brain maturation of preterm babies with PWML; delayed myelination and reduced cortical infolding seem to be the most significant aspects. © Springer-Verlag 2006 |
| abstractGer |
Introduction Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Methods Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glial cell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR appearance. Results The two groups were comparable concerning gestational age, birth weight and PMA. TMS was significantly lower in the PWML group than in the control group (mean TMS 12.44 ± 2.31 vs 14.00 ± 1.44; P = 0.011). Myelination (mean 2.76 ± 0.42 PWML group vs 3.32 ± 0.55 control group, P = 0.003) and cortical folding (3.64 ± 0.79 vs 4.09 ± 0.43, P = 0.027) appeared to be significantly delayed in babies with PWML. Conclusion Conventional MRI appears able to quantify morphological changes in brain maturation of preterm babies with PWML; delayed myelination and reduced cortical infolding seem to be the most significant aspects. © Springer-Verlag 2006 |
| abstract_unstemmed |
Introduction Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Methods Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glial cell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR appearance. Results The two groups were comparable concerning gestational age, birth weight and PMA. TMS was significantly lower in the PWML group than in the control group (mean TMS 12.44 ± 2.31 vs 14.00 ± 1.44; P = 0.011). Myelination (mean 2.76 ± 0.42 PWML group vs 3.32 ± 0.55 control group, P = 0.003) and cortical folding (3.64 ± 0.79 vs 4.09 ± 0.43, P = 0.027) appeared to be significantly delayed in babies with PWML. Conclusion Conventional MRI appears able to quantify morphological changes in brain maturation of preterm babies with PWML; delayed myelination and reduced cortical infolding seem to be the most significant aspects. © Springer-Verlag 2006 |
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Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions |
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https://dx.doi.org/10.1007/s00234-006-0176-y |
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Fumagalli, Monica Righini, Andrea Bassi, Laura Groppo, Michela Parazzini, Cecilia Bianchini, Elena Triulzi, Fabio Mosca, Fabio |
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Fumagalli, Monica Righini, Andrea Bassi, Laura Groppo, Michela Parazzini, Cecilia Bianchini, Elena Triulzi, Fabio Mosca, Fabio |
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10.1007/s00234-006-0176-y |
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| score |
7.4011974 |