Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388
Purpose The β-adrenoceptor (β-AR) plays an important role in heart failure. Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac β-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production metho...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
de Jong, Richard M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2004 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2004 |
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| Übergeordnetes Werk: |
Enthalten in: European journal of nuclear medicine and molecular imaging - Heidelberg [u.a.] : Springer-Verl., 2002, 32(2004), 4 vom: 11. Dez., Seite 443-447 |
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| Übergeordnetes Werk: |
volume:32 ; year:2004 ; number:4 ; day:11 ; month:12 ; pages:443-447 |
| Links: |
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| DOI / URN: |
10.1007/s00259-004-1701-z |
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| Katalog-ID: |
SPR003118983 |
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| 100 | 1 | |a de Jong, Richard M. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388 |
| 264 | 1 | |c 2004 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 500 | |a © Springer-Verlag 2004 | ||
| 520 | |a Purpose The β-adrenoceptor (β-AR) plays an important role in heart failure. Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac β-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial β-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[11C]CGP12388 PET. Methods Myocardial β-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[11C]CGP12388 PET. Results β-AR densities of 5.4±1.3 pmol/g (mean ± SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4±1.5 pmol/g, p<0.005). Conclusion This study indicates that PET with (S)-[11C]CGP12388 is applicable for the measurement of myocardial β-AR density in patients. A highly significant reduction in β-AR density was found in patients with IDC compared with healthy controls. | ||
| 650 | 4 | |a Imaging |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Beta-adrenergic receptors |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Heart failure |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Willemsen, Antoon T. M. |4 aut | |
| 700 | 1 | |a Slart, Riemer H. J. A. |4 aut | |
| 700 | 1 | |a Blanksma, Paul K. |4 aut | |
| 700 | 1 | |a van Waarde, Aren |4 aut | |
| 700 | 1 | |a Cornel, Jan Hein |4 aut | |
| 700 | 1 | |a Vaalburg, Willem |4 aut | |
| 700 | 1 | |a van Veldhuisen, Dirk J. |4 aut | |
| 700 | 1 | |a Elsinga, Philip H. |4 aut | |
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10.1007/s00259-004-1701-z doi (DE-627)SPR003118983 (SPR)s00259-004-1701-z-e DE-627 ger DE-627 rakwb eng de Jong, Richard M. verfasserin aut Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2004 Purpose The β-adrenoceptor (β-AR) plays an important role in heart failure. Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac β-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial β-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[11C]CGP12388 PET. Methods Myocardial β-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[11C]CGP12388 PET. Results β-AR densities of 5.4±1.3 pmol/g (mean ± SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4±1.5 pmol/g, p<0.005). Conclusion This study indicates that PET with (S)-[11C]CGP12388 is applicable for the measurement of myocardial β-AR density in patients. A highly significant reduction in β-AR density was found in patients with IDC compared with healthy controls. Imaging (dpeaa)DE-He213 Beta-adrenergic receptors (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 Willemsen, Antoon T. M. aut Slart, Riemer H. J. A. aut Blanksma, Paul K. aut van Waarde, Aren aut Cornel, Jan Hein aut Vaalburg, Willem aut van Veldhuisen, Dirk J. aut Elsinga, Philip H. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 32(2004), 4 vom: 11. Dez., Seite 443-447 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:32 year:2004 number:4 day:11 month:12 pages:443-447 https://dx.doi.org/10.1007/s00259-004-1701-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2004 4 11 12 443-447 |
| spelling |
10.1007/s00259-004-1701-z doi (DE-627)SPR003118983 (SPR)s00259-004-1701-z-e DE-627 ger DE-627 rakwb eng de Jong, Richard M. verfasserin aut Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2004 Purpose The β-adrenoceptor (β-AR) plays an important role in heart failure. Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac β-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial β-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[11C]CGP12388 PET. Methods Myocardial β-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[11C]CGP12388 PET. Results β-AR densities of 5.4±1.3 pmol/g (mean ± SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4±1.5 pmol/g, p<0.005). Conclusion This study indicates that PET with (S)-[11C]CGP12388 is applicable for the measurement of myocardial β-AR density in patients. A highly significant reduction in β-AR density was found in patients with IDC compared with healthy controls. Imaging (dpeaa)DE-He213 Beta-adrenergic receptors (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 Willemsen, Antoon T. M. aut Slart, Riemer H. J. A. aut Blanksma, Paul K. aut van Waarde, Aren aut Cornel, Jan Hein aut Vaalburg, Willem aut van Veldhuisen, Dirk J. aut Elsinga, Philip H. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 32(2004), 4 vom: 11. Dez., Seite 443-447 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:32 year:2004 number:4 day:11 month:12 pages:443-447 https://dx.doi.org/10.1007/s00259-004-1701-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2004 4 11 12 443-447 |
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10.1007/s00259-004-1701-z doi (DE-627)SPR003118983 (SPR)s00259-004-1701-z-e DE-627 ger DE-627 rakwb eng de Jong, Richard M. verfasserin aut Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2004 Purpose The β-adrenoceptor (β-AR) plays an important role in heart failure. Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac β-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial β-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[11C]CGP12388 PET. Methods Myocardial β-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[11C]CGP12388 PET. Results β-AR densities of 5.4±1.3 pmol/g (mean ± SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4±1.5 pmol/g, p<0.005). Conclusion This study indicates that PET with (S)-[11C]CGP12388 is applicable for the measurement of myocardial β-AR density in patients. A highly significant reduction in β-AR density was found in patients with IDC compared with healthy controls. Imaging (dpeaa)DE-He213 Beta-adrenergic receptors (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 Willemsen, Antoon T. M. aut Slart, Riemer H. J. A. aut Blanksma, Paul K. aut van Waarde, Aren aut Cornel, Jan Hein aut Vaalburg, Willem aut van Veldhuisen, Dirk J. aut Elsinga, Philip H. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 32(2004), 4 vom: 11. Dez., Seite 443-447 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:32 year:2004 number:4 day:11 month:12 pages:443-447 https://dx.doi.org/10.1007/s00259-004-1701-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2004 4 11 12 443-447 |
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10.1007/s00259-004-1701-z doi (DE-627)SPR003118983 (SPR)s00259-004-1701-z-e DE-627 ger DE-627 rakwb eng de Jong, Richard M. verfasserin aut Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2004 Purpose The β-adrenoceptor (β-AR) plays an important role in heart failure. Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac β-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial β-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[11C]CGP12388 PET. Methods Myocardial β-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[11C]CGP12388 PET. Results β-AR densities of 5.4±1.3 pmol/g (mean ± SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4±1.5 pmol/g, p<0.005). Conclusion This study indicates that PET with (S)-[11C]CGP12388 is applicable for the measurement of myocardial β-AR density in patients. A highly significant reduction in β-AR density was found in patients with IDC compared with healthy controls. Imaging (dpeaa)DE-He213 Beta-adrenergic receptors (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 Willemsen, Antoon T. M. aut Slart, Riemer H. J. A. aut Blanksma, Paul K. aut van Waarde, Aren aut Cornel, Jan Hein aut Vaalburg, Willem aut van Veldhuisen, Dirk J. aut Elsinga, Philip H. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 32(2004), 4 vom: 11. Dez., Seite 443-447 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:32 year:2004 number:4 day:11 month:12 pages:443-447 https://dx.doi.org/10.1007/s00259-004-1701-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2004 4 11 12 443-447 |
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10.1007/s00259-004-1701-z doi (DE-627)SPR003118983 (SPR)s00259-004-1701-z-e DE-627 ger DE-627 rakwb eng de Jong, Richard M. verfasserin aut Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2004 Purpose The β-adrenoceptor (β-AR) plays an important role in heart failure. Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac β-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial β-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[11C]CGP12388 PET. Methods Myocardial β-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[11C]CGP12388 PET. Results β-AR densities of 5.4±1.3 pmol/g (mean ± SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4±1.5 pmol/g, p<0.005). Conclusion This study indicates that PET with (S)-[11C]CGP12388 is applicable for the measurement of myocardial β-AR density in patients. A highly significant reduction in β-AR density was found in patients with IDC compared with healthy controls. Imaging (dpeaa)DE-He213 Beta-adrenergic receptors (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 Willemsen, Antoon T. M. aut Slart, Riemer H. J. A. aut Blanksma, Paul K. aut van Waarde, Aren aut Cornel, Jan Hein aut Vaalburg, Willem aut van Veldhuisen, Dirk J. aut Elsinga, Philip H. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 32(2004), 4 vom: 11. Dez., Seite 443-447 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:32 year:2004 number:4 day:11 month:12 pages:443-447 https://dx.doi.org/10.1007/s00259-004-1701-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2004 4 11 12 443-447 |
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de Jong, Richard M. @@aut@@ Willemsen, Antoon T. M. @@aut@@ Slart, Riemer H. J. A. @@aut@@ Blanksma, Paul K. @@aut@@ van Waarde, Aren @@aut@@ Cornel, Jan Hein @@aut@@ Vaalburg, Willem @@aut@@ van Veldhuisen, Dirk J. @@aut@@ Elsinga, Philip H. @@aut@@ |
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Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac β-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial β-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[11C]CGP12388 PET. Methods Myocardial β-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[11C]CGP12388 PET. Results β-AR densities of 5.4±1.3 pmol/g (mean ± SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4±1.5 pmol/g, p<0.005). Conclusion This study indicates that PET with (S)-[11C]CGP12388 is applicable for the measurement of myocardial β-AR density in patients. 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de Jong, Richard M. |
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de Jong, Richard M. misc Imaging misc Beta-adrenergic receptors misc Heart failure Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388 |
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Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388 Imaging (dpeaa)DE-He213 Beta-adrenergic receptors (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 |
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misc Imaging misc Beta-adrenergic receptors misc Heart failure |
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Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388 |
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(DE-627)SPR003118983 (SPR)s00259-004-1701-z-e |
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Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388 |
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de Jong, Richard M. |
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European journal of nuclear medicine and molecular imaging |
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de Jong, Richard M. Willemsen, Antoon T. M. Slart, Riemer H. J. A. Blanksma, Paul K. van Waarde, Aren Cornel, Jan Hein Vaalburg, Willem van Veldhuisen, Dirk J. Elsinga, Philip H. |
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de Jong, Richard M. |
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10.1007/s00259-004-1701-z |
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myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with pet using the new radioligand (s)-[11c]cgp12388 |
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Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388 |
| abstract |
Purpose The β-adrenoceptor (β-AR) plays an important role in heart failure. Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac β-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial β-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[11C]CGP12388 PET. Methods Myocardial β-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[11C]CGP12388 PET. Results β-AR densities of 5.4±1.3 pmol/g (mean ± SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4±1.5 pmol/g, p<0.005). Conclusion This study indicates that PET with (S)-[11C]CGP12388 is applicable for the measurement of myocardial β-AR density in patients. A highly significant reduction in β-AR density was found in patients with IDC compared with healthy controls. © Springer-Verlag 2004 |
| abstractGer |
Purpose The β-adrenoceptor (β-AR) plays an important role in heart failure. Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac β-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial β-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[11C]CGP12388 PET. Methods Myocardial β-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[11C]CGP12388 PET. Results β-AR densities of 5.4±1.3 pmol/g (mean ± SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4±1.5 pmol/g, p<0.005). Conclusion This study indicates that PET with (S)-[11C]CGP12388 is applicable for the measurement of myocardial β-AR density in patients. A highly significant reduction in β-AR density was found in patients with IDC compared with healthy controls. © Springer-Verlag 2004 |
| abstract_unstemmed |
Purpose The β-adrenoceptor (β-AR) plays an important role in heart failure. Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac β-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial β-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[11C]CGP12388 PET. Methods Myocardial β-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[11C]CGP12388 PET. Results β-AR densities of 5.4±1.3 pmol/g (mean ± SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4±1.5 pmol/g, p<0.005). Conclusion This study indicates that PET with (S)-[11C]CGP12388 is applicable for the measurement of myocardial β-AR density in patients. A highly significant reduction in β-AR density was found in patients with IDC compared with healthy controls. © Springer-Verlag 2004 |
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| title_short |
Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388 |
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https://dx.doi.org/10.1007/s00259-004-1701-z |
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Willemsen, Antoon T. M. Slart, Riemer H. J. A. Blanksma, Paul K. van Waarde, Aren Cornel, Jan Hein Vaalburg, Willem van Veldhuisen, Dirk J. Elsinga, Philip H. |
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Willemsen, Antoon T. M. Slart, Riemer H. J. A. Blanksma, Paul K. van Waarde, Aren Cornel, Jan Hein Vaalburg, Willem van Veldhuisen, Dirk J. Elsinga, Philip H. |
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2024-07-03T17:25:18.937Z |
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| score |
7.4016542 |