Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction
Purpose Dual-isotope simultaneous acquisition (DISA) single-photon emission computed tomography (SPECT) is an attractive technique as it permits assessment of both myocardial glucose metabolism and perfusion within a single session, but few data on its accuracy for the assessment of viability are av...
Ausführliche Beschreibung
Autor*in: |
Slart, Riemer H. J. A. [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2005 |
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Anmerkung: |
© Springer-Verlag 2005 |
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Übergeordnetes Werk: |
Enthalten in: European journal of nuclear medicine and molecular imaging - Heidelberg [u.a.] : Springer-Verl., 2002, 32(2005), 8 vom: 12. Apr., Seite 972-979 |
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Übergeordnetes Werk: |
volume:32 ; year:2005 ; number:8 ; day:12 ; month:04 ; pages:972-979 |
Links: |
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DOI / URN: |
10.1007/s00259-005-1785-0 |
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Katalog-ID: |
SPR003119874 |
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100 | 1 | |a Slart, Riemer H. J. A. |e verfasserin |4 aut | |
245 | 1 | 0 | |a Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction |
264 | 1 | |c 2005 | |
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520 | |a Purpose Dual-isotope simultaneous acquisition (DISA) single-photon emission computed tomography (SPECT) is an attractive technique as it permits assessment of both myocardial glucose metabolism and perfusion within a single session, but few data on its accuracy for the assessment of viability are available as yet. In the present study, DISA SPECT was compared with positron emission tomography (PET) for the detection of myocardial viability in normal and dysfunctional left ventricular (LV) myocardium. Methods Fifty-eight patients with chronic coronary artery disease and LV dysfunction (LV ejection fraction 33±12%) were studied. Patients underwent a 1-day dipyridamole stress 99mTc-sestamibi/18F-fluorodeoxyglucose (18FDG) DISA SPECT and 13N-ammonia/18FDG PET protocol. Within 1 week, resting MRI was performed to assess contractile function. Comparison of PET and SPECT data was performed using both visual and quantitative analysis. Results The correlation of normalised activities of the flow tracers 99mTc-sestamibi and 13N-ammonia was good (r=0.82; p<0.001). The correlation between the two 18FDG studies was also good (r=0.83; p< 0.001). The agreement for the assessment of viability for all segments between DISA SPECT and PET was 82%, with a κ-statistic of 0.59 (95% CI 0.53–0.64), without a significant difference; in dysfunctional segments only, the agreement was 82%, with a κ-statistic of 0.63 (95% CI 0.56–0.70), without a significant difference. When the DISA SPECT data were analysed visually, the agreement between DISA SPECT and PET was 83%, with a κ-statistic of 0.58 (95% CI 0.52–0.63), without a significant difference. Moreover, there was no significant difference between visual and quantitative DISA SPECT analysis for the detection of viability. Conclusion This study shows an overall good agreement between 99mTc-sestamibi/18FDG DISA SPECT and PET for the assessment of myocardial viability in patients with severe LV dysfunction. Quantitative or visual analysis of the SPECT data did not influence the agreement with PET, suggesting that visual assessment may be sufficient for clinical purposes. | ||
650 | 4 | |a Myocardial viability |7 (dpeaa)DE-He213 | |
650 | 4 | |a Acipimox |7 (dpeaa)DE-He213 | |
650 | 4 | |a FDG |7 (dpeaa)DE-He213 | |
650 | 4 | |a DISA SPECT |7 (dpeaa)DE-He213 | |
650 | 4 | |a PET |7 (dpeaa)DE-He213 | |
700 | 1 | |a Bax, Jeroen J. |4 aut | |
700 | 1 | |a de Boer, Jaep |4 aut | |
700 | 1 | |a Willemsen, Antoon T. M. |4 aut | |
700 | 1 | |a Mook, Piet H. |4 aut | |
700 | 1 | |a Oudkerk, Matthijs |4 aut | |
700 | 1 | |a van der Wall, Ernst E. |4 aut | |
700 | 1 | |a van Veldhuisen, Dirk J. |4 aut | |
700 | 1 | |a Jager, Pieter L. |4 aut | |
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10.1007/s00259-005-1785-0 doi (DE-627)SPR003119874 (SPR)s00259-005-1785-0-e DE-627 ger DE-627 rakwb eng Slart, Riemer H. J. A. verfasserin aut Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Purpose Dual-isotope simultaneous acquisition (DISA) single-photon emission computed tomography (SPECT) is an attractive technique as it permits assessment of both myocardial glucose metabolism and perfusion within a single session, but few data on its accuracy for the assessment of viability are available as yet. In the present study, DISA SPECT was compared with positron emission tomography (PET) for the detection of myocardial viability in normal and dysfunctional left ventricular (LV) myocardium. Methods Fifty-eight patients with chronic coronary artery disease and LV dysfunction (LV ejection fraction 33±12%) were studied. Patients underwent a 1-day dipyridamole stress 99mTc-sestamibi/18F-fluorodeoxyglucose (18FDG) DISA SPECT and 13N-ammonia/18FDG PET protocol. Within 1 week, resting MRI was performed to assess contractile function. Comparison of PET and SPECT data was performed using both visual and quantitative analysis. Results The correlation of normalised activities of the flow tracers 99mTc-sestamibi and 13N-ammonia was good (r=0.82; p<0.001). The correlation between the two 18FDG studies was also good (r=0.83; p< 0.001). The agreement for the assessment of viability for all segments between DISA SPECT and PET was 82%, with a κ-statistic of 0.59 (95% CI 0.53–0.64), without a significant difference; in dysfunctional segments only, the agreement was 82%, with a κ-statistic of 0.63 (95% CI 0.56–0.70), without a significant difference. When the DISA SPECT data were analysed visually, the agreement between DISA SPECT and PET was 83%, with a κ-statistic of 0.58 (95% CI 0.52–0.63), without a significant difference. Moreover, there was no significant difference between visual and quantitative DISA SPECT analysis for the detection of viability. Conclusion This study shows an overall good agreement between 99mTc-sestamibi/18FDG DISA SPECT and PET for the assessment of myocardial viability in patients with severe LV dysfunction. Quantitative or visual analysis of the SPECT data did not influence the agreement with PET, suggesting that visual assessment may be sufficient for clinical purposes. Myocardial viability (dpeaa)DE-He213 Acipimox (dpeaa)DE-He213 FDG (dpeaa)DE-He213 DISA SPECT (dpeaa)DE-He213 PET (dpeaa)DE-He213 Bax, Jeroen J. aut de Boer, Jaep aut Willemsen, Antoon T. M. aut Mook, Piet H. aut Oudkerk, Matthijs aut van der Wall, Ernst E. aut van Veldhuisen, Dirk J. aut Jager, Pieter L. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 32(2005), 8 vom: 12. Apr., Seite 972-979 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:32 year:2005 number:8 day:12 month:04 pages:972-979 https://dx.doi.org/10.1007/s00259-005-1785-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2005 8 12 04 972-979 |
spelling |
10.1007/s00259-005-1785-0 doi (DE-627)SPR003119874 (SPR)s00259-005-1785-0-e DE-627 ger DE-627 rakwb eng Slart, Riemer H. J. A. verfasserin aut Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Purpose Dual-isotope simultaneous acquisition (DISA) single-photon emission computed tomography (SPECT) is an attractive technique as it permits assessment of both myocardial glucose metabolism and perfusion within a single session, but few data on its accuracy for the assessment of viability are available as yet. In the present study, DISA SPECT was compared with positron emission tomography (PET) for the detection of myocardial viability in normal and dysfunctional left ventricular (LV) myocardium. Methods Fifty-eight patients with chronic coronary artery disease and LV dysfunction (LV ejection fraction 33±12%) were studied. Patients underwent a 1-day dipyridamole stress 99mTc-sestamibi/18F-fluorodeoxyglucose (18FDG) DISA SPECT and 13N-ammonia/18FDG PET protocol. Within 1 week, resting MRI was performed to assess contractile function. Comparison of PET and SPECT data was performed using both visual and quantitative analysis. Results The correlation of normalised activities of the flow tracers 99mTc-sestamibi and 13N-ammonia was good (r=0.82; p<0.001). The correlation between the two 18FDG studies was also good (r=0.83; p< 0.001). The agreement for the assessment of viability for all segments between DISA SPECT and PET was 82%, with a κ-statistic of 0.59 (95% CI 0.53–0.64), without a significant difference; in dysfunctional segments only, the agreement was 82%, with a κ-statistic of 0.63 (95% CI 0.56–0.70), without a significant difference. When the DISA SPECT data were analysed visually, the agreement between DISA SPECT and PET was 83%, with a κ-statistic of 0.58 (95% CI 0.52–0.63), without a significant difference. Moreover, there was no significant difference between visual and quantitative DISA SPECT analysis for the detection of viability. Conclusion This study shows an overall good agreement between 99mTc-sestamibi/18FDG DISA SPECT and PET for the assessment of myocardial viability in patients with severe LV dysfunction. Quantitative or visual analysis of the SPECT data did not influence the agreement with PET, suggesting that visual assessment may be sufficient for clinical purposes. Myocardial viability (dpeaa)DE-He213 Acipimox (dpeaa)DE-He213 FDG (dpeaa)DE-He213 DISA SPECT (dpeaa)DE-He213 PET (dpeaa)DE-He213 Bax, Jeroen J. aut de Boer, Jaep aut Willemsen, Antoon T. M. aut Mook, Piet H. aut Oudkerk, Matthijs aut van der Wall, Ernst E. aut van Veldhuisen, Dirk J. aut Jager, Pieter L. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 32(2005), 8 vom: 12. Apr., Seite 972-979 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:32 year:2005 number:8 day:12 month:04 pages:972-979 https://dx.doi.org/10.1007/s00259-005-1785-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2005 8 12 04 972-979 |
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10.1007/s00259-005-1785-0 doi (DE-627)SPR003119874 (SPR)s00259-005-1785-0-e DE-627 ger DE-627 rakwb eng Slart, Riemer H. J. A. verfasserin aut Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Purpose Dual-isotope simultaneous acquisition (DISA) single-photon emission computed tomography (SPECT) is an attractive technique as it permits assessment of both myocardial glucose metabolism and perfusion within a single session, but few data on its accuracy for the assessment of viability are available as yet. In the present study, DISA SPECT was compared with positron emission tomography (PET) for the detection of myocardial viability in normal and dysfunctional left ventricular (LV) myocardium. Methods Fifty-eight patients with chronic coronary artery disease and LV dysfunction (LV ejection fraction 33±12%) were studied. Patients underwent a 1-day dipyridamole stress 99mTc-sestamibi/18F-fluorodeoxyglucose (18FDG) DISA SPECT and 13N-ammonia/18FDG PET protocol. Within 1 week, resting MRI was performed to assess contractile function. Comparison of PET and SPECT data was performed using both visual and quantitative analysis. Results The correlation of normalised activities of the flow tracers 99mTc-sestamibi and 13N-ammonia was good (r=0.82; p<0.001). The correlation between the two 18FDG studies was also good (r=0.83; p< 0.001). The agreement for the assessment of viability for all segments between DISA SPECT and PET was 82%, with a κ-statistic of 0.59 (95% CI 0.53–0.64), without a significant difference; in dysfunctional segments only, the agreement was 82%, with a κ-statistic of 0.63 (95% CI 0.56–0.70), without a significant difference. When the DISA SPECT data were analysed visually, the agreement between DISA SPECT and PET was 83%, with a κ-statistic of 0.58 (95% CI 0.52–0.63), without a significant difference. Moreover, there was no significant difference between visual and quantitative DISA SPECT analysis for the detection of viability. Conclusion This study shows an overall good agreement between 99mTc-sestamibi/18FDG DISA SPECT and PET for the assessment of myocardial viability in patients with severe LV dysfunction. Quantitative or visual analysis of the SPECT data did not influence the agreement with PET, suggesting that visual assessment may be sufficient for clinical purposes. Myocardial viability (dpeaa)DE-He213 Acipimox (dpeaa)DE-He213 FDG (dpeaa)DE-He213 DISA SPECT (dpeaa)DE-He213 PET (dpeaa)DE-He213 Bax, Jeroen J. aut de Boer, Jaep aut Willemsen, Antoon T. M. aut Mook, Piet H. aut Oudkerk, Matthijs aut van der Wall, Ernst E. aut van Veldhuisen, Dirk J. aut Jager, Pieter L. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 32(2005), 8 vom: 12. Apr., Seite 972-979 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:32 year:2005 number:8 day:12 month:04 pages:972-979 https://dx.doi.org/10.1007/s00259-005-1785-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2005 8 12 04 972-979 |
allfieldsGer |
10.1007/s00259-005-1785-0 doi (DE-627)SPR003119874 (SPR)s00259-005-1785-0-e DE-627 ger DE-627 rakwb eng Slart, Riemer H. J. A. verfasserin aut Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Purpose Dual-isotope simultaneous acquisition (DISA) single-photon emission computed tomography (SPECT) is an attractive technique as it permits assessment of both myocardial glucose metabolism and perfusion within a single session, but few data on its accuracy for the assessment of viability are available as yet. In the present study, DISA SPECT was compared with positron emission tomography (PET) for the detection of myocardial viability in normal and dysfunctional left ventricular (LV) myocardium. Methods Fifty-eight patients with chronic coronary artery disease and LV dysfunction (LV ejection fraction 33±12%) were studied. Patients underwent a 1-day dipyridamole stress 99mTc-sestamibi/18F-fluorodeoxyglucose (18FDG) DISA SPECT and 13N-ammonia/18FDG PET protocol. Within 1 week, resting MRI was performed to assess contractile function. Comparison of PET and SPECT data was performed using both visual and quantitative analysis. Results The correlation of normalised activities of the flow tracers 99mTc-sestamibi and 13N-ammonia was good (r=0.82; p<0.001). The correlation between the two 18FDG studies was also good (r=0.83; p< 0.001). The agreement for the assessment of viability for all segments between DISA SPECT and PET was 82%, with a κ-statistic of 0.59 (95% CI 0.53–0.64), without a significant difference; in dysfunctional segments only, the agreement was 82%, with a κ-statistic of 0.63 (95% CI 0.56–0.70), without a significant difference. When the DISA SPECT data were analysed visually, the agreement between DISA SPECT and PET was 83%, with a κ-statistic of 0.58 (95% CI 0.52–0.63), without a significant difference. Moreover, there was no significant difference between visual and quantitative DISA SPECT analysis for the detection of viability. Conclusion This study shows an overall good agreement between 99mTc-sestamibi/18FDG DISA SPECT and PET for the assessment of myocardial viability in patients with severe LV dysfunction. Quantitative or visual analysis of the SPECT data did not influence the agreement with PET, suggesting that visual assessment may be sufficient for clinical purposes. Myocardial viability (dpeaa)DE-He213 Acipimox (dpeaa)DE-He213 FDG (dpeaa)DE-He213 DISA SPECT (dpeaa)DE-He213 PET (dpeaa)DE-He213 Bax, Jeroen J. aut de Boer, Jaep aut Willemsen, Antoon T. M. aut Mook, Piet H. aut Oudkerk, Matthijs aut van der Wall, Ernst E. aut van Veldhuisen, Dirk J. aut Jager, Pieter L. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 32(2005), 8 vom: 12. Apr., Seite 972-979 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:32 year:2005 number:8 day:12 month:04 pages:972-979 https://dx.doi.org/10.1007/s00259-005-1785-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2005 8 12 04 972-979 |
allfieldsSound |
10.1007/s00259-005-1785-0 doi (DE-627)SPR003119874 (SPR)s00259-005-1785-0-e DE-627 ger DE-627 rakwb eng Slart, Riemer H. J. A. verfasserin aut Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Purpose Dual-isotope simultaneous acquisition (DISA) single-photon emission computed tomography (SPECT) is an attractive technique as it permits assessment of both myocardial glucose metabolism and perfusion within a single session, but few data on its accuracy for the assessment of viability are available as yet. In the present study, DISA SPECT was compared with positron emission tomography (PET) for the detection of myocardial viability in normal and dysfunctional left ventricular (LV) myocardium. Methods Fifty-eight patients with chronic coronary artery disease and LV dysfunction (LV ejection fraction 33±12%) were studied. Patients underwent a 1-day dipyridamole stress 99mTc-sestamibi/18F-fluorodeoxyglucose (18FDG) DISA SPECT and 13N-ammonia/18FDG PET protocol. Within 1 week, resting MRI was performed to assess contractile function. Comparison of PET and SPECT data was performed using both visual and quantitative analysis. Results The correlation of normalised activities of the flow tracers 99mTc-sestamibi and 13N-ammonia was good (r=0.82; p<0.001). The correlation between the two 18FDG studies was also good (r=0.83; p< 0.001). The agreement for the assessment of viability for all segments between DISA SPECT and PET was 82%, with a κ-statistic of 0.59 (95% CI 0.53–0.64), without a significant difference; in dysfunctional segments only, the agreement was 82%, with a κ-statistic of 0.63 (95% CI 0.56–0.70), without a significant difference. When the DISA SPECT data were analysed visually, the agreement between DISA SPECT and PET was 83%, with a κ-statistic of 0.58 (95% CI 0.52–0.63), without a significant difference. Moreover, there was no significant difference between visual and quantitative DISA SPECT analysis for the detection of viability. Conclusion This study shows an overall good agreement between 99mTc-sestamibi/18FDG DISA SPECT and PET for the assessment of myocardial viability in patients with severe LV dysfunction. Quantitative or visual analysis of the SPECT data did not influence the agreement with PET, suggesting that visual assessment may be sufficient for clinical purposes. Myocardial viability (dpeaa)DE-He213 Acipimox (dpeaa)DE-He213 FDG (dpeaa)DE-He213 DISA SPECT (dpeaa)DE-He213 PET (dpeaa)DE-He213 Bax, Jeroen J. aut de Boer, Jaep aut Willemsen, Antoon T. M. aut Mook, Piet H. aut Oudkerk, Matthijs aut van der Wall, Ernst E. aut van Veldhuisen, Dirk J. aut Jager, Pieter L. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 32(2005), 8 vom: 12. Apr., Seite 972-979 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:32 year:2005 number:8 day:12 month:04 pages:972-979 https://dx.doi.org/10.1007/s00259-005-1785-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2005 8 12 04 972-979 |
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Enthalten in European journal of nuclear medicine and molecular imaging 32(2005), 8 vom: 12. Apr., Seite 972-979 volume:32 year:2005 number:8 day:12 month:04 pages:972-979 |
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Enthalten in European journal of nuclear medicine and molecular imaging 32(2005), 8 vom: 12. Apr., Seite 972-979 volume:32 year:2005 number:8 day:12 month:04 pages:972-979 |
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Myocardial viability Acipimox FDG DISA SPECT PET |
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European journal of nuclear medicine and molecular imaging |
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Slart, Riemer H. J. A. @@aut@@ Bax, Jeroen J. @@aut@@ de Boer, Jaep @@aut@@ Willemsen, Antoon T. M. @@aut@@ Mook, Piet H. @@aut@@ Oudkerk, Matthijs @@aut@@ van der Wall, Ernst E. @@aut@@ van Veldhuisen, Dirk J. @@aut@@ Jager, Pieter L. @@aut@@ |
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2005-04-12T00:00:00Z |
hierarchy_top_id |
359787258 |
id |
SPR003119874 |
language_de |
englisch |
fullrecord |
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A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2005</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer-Verlag 2005</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose Dual-isotope simultaneous acquisition (DISA) single-photon emission computed tomography (SPECT) is an attractive technique as it permits assessment of both myocardial glucose metabolism and perfusion within a single session, but few data on its accuracy for the assessment of viability are available as yet. In the present study, DISA SPECT was compared with positron emission tomography (PET) for the detection of myocardial viability in normal and dysfunctional left ventricular (LV) myocardium. Methods Fifty-eight patients with chronic coronary artery disease and LV dysfunction (LV ejection fraction 33±12%) were studied. Patients underwent a 1-day dipyridamole stress 99mTc-sestamibi/18F-fluorodeoxyglucose (18FDG) DISA SPECT and 13N-ammonia/18FDG PET protocol. Within 1 week, resting MRI was performed to assess contractile function. Comparison of PET and SPECT data was performed using both visual and quantitative analysis. Results The correlation of normalised activities of the flow tracers 99mTc-sestamibi and 13N-ammonia was good (r=0.82; p<0.001). The correlation between the two 18FDG studies was also good (r=0.83; p< 0.001). The agreement for the assessment of viability for all segments between DISA SPECT and PET was 82%, with a κ-statistic of 0.59 (95% CI 0.53–0.64), without a significant difference; in dysfunctional segments only, the agreement was 82%, with a κ-statistic of 0.63 (95% CI 0.56–0.70), without a significant difference. When the DISA SPECT data were analysed visually, the agreement between DISA SPECT and PET was 83%, with a κ-statistic of 0.58 (95% CI 0.52–0.63), without a significant difference. Moreover, there was no significant difference between visual and quantitative DISA SPECT analysis for the detection of viability. Conclusion This study shows an overall good agreement between 99mTc-sestamibi/18FDG DISA SPECT and PET for the assessment of myocardial viability in patients with severe LV dysfunction. 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Slart, Riemer H. J. A. |
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Slart, Riemer H. J. A. misc Myocardial viability misc Acipimox misc FDG misc DISA SPECT misc PET Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction |
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Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction Myocardial viability (dpeaa)DE-He213 Acipimox (dpeaa)DE-He213 FDG (dpeaa)DE-He213 DISA SPECT (dpeaa)DE-He213 PET (dpeaa)DE-He213 |
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misc Myocardial viability misc Acipimox misc FDG misc DISA SPECT misc PET |
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misc Myocardial viability misc Acipimox misc FDG misc DISA SPECT misc PET |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction |
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title_full |
Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction |
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Slart, Riemer H. J. A. |
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European journal of nuclear medicine and molecular imaging |
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European journal of nuclear medicine and molecular imaging |
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eng |
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2005 |
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Slart, Riemer H. J. A. Bax, Jeroen J. de Boer, Jaep Willemsen, Antoon T. M. Mook, Piet H. Oudkerk, Matthijs van der Wall, Ernst E. van Veldhuisen, Dirk J. Jager, Pieter L. |
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32 |
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Elektronische Aufsätze |
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Slart, Riemer H. J. A. |
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10.1007/s00259-005-1785-0 |
title_sort |
comparison of 99mtc-sestamibi/18fdg disa spect with pet for the detection of viability in patients with coronary artery disease and left ventricular dysfunction |
title_auth |
Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction |
abstract |
Purpose Dual-isotope simultaneous acquisition (DISA) single-photon emission computed tomography (SPECT) is an attractive technique as it permits assessment of both myocardial glucose metabolism and perfusion within a single session, but few data on its accuracy for the assessment of viability are available as yet. In the present study, DISA SPECT was compared with positron emission tomography (PET) for the detection of myocardial viability in normal and dysfunctional left ventricular (LV) myocardium. Methods Fifty-eight patients with chronic coronary artery disease and LV dysfunction (LV ejection fraction 33±12%) were studied. Patients underwent a 1-day dipyridamole stress 99mTc-sestamibi/18F-fluorodeoxyglucose (18FDG) DISA SPECT and 13N-ammonia/18FDG PET protocol. Within 1 week, resting MRI was performed to assess contractile function. Comparison of PET and SPECT data was performed using both visual and quantitative analysis. Results The correlation of normalised activities of the flow tracers 99mTc-sestamibi and 13N-ammonia was good (r=0.82; p<0.001). The correlation between the two 18FDG studies was also good (r=0.83; p< 0.001). The agreement for the assessment of viability for all segments between DISA SPECT and PET was 82%, with a κ-statistic of 0.59 (95% CI 0.53–0.64), without a significant difference; in dysfunctional segments only, the agreement was 82%, with a κ-statistic of 0.63 (95% CI 0.56–0.70), without a significant difference. When the DISA SPECT data were analysed visually, the agreement between DISA SPECT and PET was 83%, with a κ-statistic of 0.58 (95% CI 0.52–0.63), without a significant difference. Moreover, there was no significant difference between visual and quantitative DISA SPECT analysis for the detection of viability. Conclusion This study shows an overall good agreement between 99mTc-sestamibi/18FDG DISA SPECT and PET for the assessment of myocardial viability in patients with severe LV dysfunction. Quantitative or visual analysis of the SPECT data did not influence the agreement with PET, suggesting that visual assessment may be sufficient for clinical purposes. © Springer-Verlag 2005 |
abstractGer |
Purpose Dual-isotope simultaneous acquisition (DISA) single-photon emission computed tomography (SPECT) is an attractive technique as it permits assessment of both myocardial glucose metabolism and perfusion within a single session, but few data on its accuracy for the assessment of viability are available as yet. In the present study, DISA SPECT was compared with positron emission tomography (PET) for the detection of myocardial viability in normal and dysfunctional left ventricular (LV) myocardium. Methods Fifty-eight patients with chronic coronary artery disease and LV dysfunction (LV ejection fraction 33±12%) were studied. Patients underwent a 1-day dipyridamole stress 99mTc-sestamibi/18F-fluorodeoxyglucose (18FDG) DISA SPECT and 13N-ammonia/18FDG PET protocol. Within 1 week, resting MRI was performed to assess contractile function. Comparison of PET and SPECT data was performed using both visual and quantitative analysis. Results The correlation of normalised activities of the flow tracers 99mTc-sestamibi and 13N-ammonia was good (r=0.82; p<0.001). The correlation between the two 18FDG studies was also good (r=0.83; p< 0.001). The agreement for the assessment of viability for all segments between DISA SPECT and PET was 82%, with a κ-statistic of 0.59 (95% CI 0.53–0.64), without a significant difference; in dysfunctional segments only, the agreement was 82%, with a κ-statistic of 0.63 (95% CI 0.56–0.70), without a significant difference. When the DISA SPECT data were analysed visually, the agreement between DISA SPECT and PET was 83%, with a κ-statistic of 0.58 (95% CI 0.52–0.63), without a significant difference. Moreover, there was no significant difference between visual and quantitative DISA SPECT analysis for the detection of viability. Conclusion This study shows an overall good agreement between 99mTc-sestamibi/18FDG DISA SPECT and PET for the assessment of myocardial viability in patients with severe LV dysfunction. Quantitative or visual analysis of the SPECT data did not influence the agreement with PET, suggesting that visual assessment may be sufficient for clinical purposes. © Springer-Verlag 2005 |
abstract_unstemmed |
Purpose Dual-isotope simultaneous acquisition (DISA) single-photon emission computed tomography (SPECT) is an attractive technique as it permits assessment of both myocardial glucose metabolism and perfusion within a single session, but few data on its accuracy for the assessment of viability are available as yet. In the present study, DISA SPECT was compared with positron emission tomography (PET) for the detection of myocardial viability in normal and dysfunctional left ventricular (LV) myocardium. Methods Fifty-eight patients with chronic coronary artery disease and LV dysfunction (LV ejection fraction 33±12%) were studied. Patients underwent a 1-day dipyridamole stress 99mTc-sestamibi/18F-fluorodeoxyglucose (18FDG) DISA SPECT and 13N-ammonia/18FDG PET protocol. Within 1 week, resting MRI was performed to assess contractile function. Comparison of PET and SPECT data was performed using both visual and quantitative analysis. Results The correlation of normalised activities of the flow tracers 99mTc-sestamibi and 13N-ammonia was good (r=0.82; p<0.001). The correlation between the two 18FDG studies was also good (r=0.83; p< 0.001). The agreement for the assessment of viability for all segments between DISA SPECT and PET was 82%, with a κ-statistic of 0.59 (95% CI 0.53–0.64), without a significant difference; in dysfunctional segments only, the agreement was 82%, with a κ-statistic of 0.63 (95% CI 0.56–0.70), without a significant difference. When the DISA SPECT data were analysed visually, the agreement between DISA SPECT and PET was 83%, with a κ-statistic of 0.58 (95% CI 0.52–0.63), without a significant difference. Moreover, there was no significant difference between visual and quantitative DISA SPECT analysis for the detection of viability. Conclusion This study shows an overall good agreement between 99mTc-sestamibi/18FDG DISA SPECT and PET for the assessment of myocardial viability in patients with severe LV dysfunction. Quantitative or visual analysis of the SPECT data did not influence the agreement with PET, suggesting that visual assessment may be sufficient for clinical purposes. © Springer-Verlag 2005 |
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title_short |
Comparison of 99mTc-sestamibi/18FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction |
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https://dx.doi.org/10.1007/s00259-005-1785-0 |
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score |
7.400199 |