Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT
Purpose The iodinated cocaine derivative [123I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [123I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119–271]. The ai...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ziebell, Morten [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2006 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2006 |
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| Übergeordnetes Werk: |
Enthalten in: European journal of nuclear medicine and molecular imaging - Heidelberg [u.a.] : Springer-Verl., 2002, 34(2006), 1 vom: 29. Juli, Seite 101-109 |
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| Übergeordnetes Werk: |
volume:34 ; year:2006 ; number:1 ; day:29 ; month:07 ; pages:101-109 |
| Links: |
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| DOI / URN: |
10.1007/s00259-006-0161-z |
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| Katalog-ID: |
SPR003123529 |
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| 100 | 1 | |a Ziebell, Morten |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT |
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| 520 | |a Purpose The iodinated cocaine derivative [123I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [123I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119–271]. The aims of this study were, firstly, to evaluate the test–retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, $ BP_{1} $ ($ C_{ROI} $/$ C_{plasma} $) and $ BP_{2} $ ($ C_{ROI} $/$ C_{REF} $). Methods Seven healthy subjects were subjected to [123I]PE2I SPECT scanning twice. For both studies, the two outcome parameters $ BP_{1} $ and $ BP_{2} $ were calculated based on two different methods for region of interest (ROI) delineation, namely manual delineation and probability map-based automatic delineation with MRI co-registration. Results With manual delineation, striatal test–retest variability (absolute difference between first and second scan as a percentage of the mean) of $ BP_{1} $ and $ BP_{2} $ was 13.9% (range 1.8–35.7%) and 4.1% (range 0.5–9.7%) respectively. The probability map-based automatic delineation resulted in striatal test–retest variability of 17.2% (range 4.3–40.5%) and 5.2% (range 0.1–10.9%) respectively. The B/I approach provided stable brain activity from 120 to 180 min post injection in both high- and low-count regions with a mean % change/hour in striatal $ BP_{2} $ of 10.6. Conclusion [123I]PE2I SPECT with the B/I approach yields a highly reproducible measure of striatal dopamine transporter binding. The appropriateness of a B/I protocol with a B/I ratio of 2.7 h (i.e. with a bolus worth 2.7 h of infusion) was confirmed in an independent sample of healthy subjects. | ||
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| 650 | 4 | |a I]PE2I |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dopamine transporters |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a SPECT |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Reproducibility |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Bolus/infusion |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Thomsen, Gerda |4 aut | |
| 700 | 1 | |a Knudsen, Gitte M. |4 aut | |
| 700 | 1 | |a de Nijs, Robin |4 aut | |
| 700 | 1 | |a Svarer, Claus |4 aut | |
| 700 | 1 | |a Wagner, Aase |4 aut | |
| 700 | 1 | |a Pinborg, Lars H. |4 aut | |
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10.1007/s00259-006-0161-z doi (DE-627)SPR003123529 (SPR)s00259-006-0161-z-e DE-627 ger DE-627 rakwb eng Ziebell, Morten verfasserin aut Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2006 Purpose The iodinated cocaine derivative [123I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [123I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119–271]. The aims of this study were, firstly, to evaluate the test–retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, $ BP_{1} $ ($ C_{ROI} $/$ C_{plasma} $) and $ BP_{2} $ ($ C_{ROI} $/$ C_{REF} $). Methods Seven healthy subjects were subjected to [123I]PE2I SPECT scanning twice. For both studies, the two outcome parameters $ BP_{1} $ and $ BP_{2} $ were calculated based on two different methods for region of interest (ROI) delineation, namely manual delineation and probability map-based automatic delineation with MRI co-registration. Results With manual delineation, striatal test–retest variability (absolute difference between first and second scan as a percentage of the mean) of $ BP_{1} $ and $ BP_{2} $ was 13.9% (range 1.8–35.7%) and 4.1% (range 0.5–9.7%) respectively. The probability map-based automatic delineation resulted in striatal test–retest variability of 17.2% (range 4.3–40.5%) and 5.2% (range 0.1–10.9%) respectively. The B/I approach provided stable brain activity from 120 to 180 min post injection in both high- and low-count regions with a mean % change/hour in striatal $ BP_{2} $ of 10.6. Conclusion [123I]PE2I SPECT with the B/I approach yields a highly reproducible measure of striatal dopamine transporter binding. The appropriateness of a B/I protocol with a B/I ratio of 2.7 h (i.e. with a bolus worth 2.7 h of infusion) was confirmed in an independent sample of healthy subjects. [ (dpeaa)DE-He213 I]PE2I (dpeaa)DE-He213 Dopamine transporters (dpeaa)DE-He213 SPECT (dpeaa)DE-He213 Reproducibility (dpeaa)DE-He213 Bolus/infusion (dpeaa)DE-He213 Thomsen, Gerda aut Knudsen, Gitte M. aut de Nijs, Robin aut Svarer, Claus aut Wagner, Aase aut Pinborg, Lars H. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 34(2006), 1 vom: 29. Juli, Seite 101-109 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:34 year:2006 number:1 day:29 month:07 pages:101-109 https://dx.doi.org/10.1007/s00259-006-0161-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 34 2006 1 29 07 101-109 |
| spelling |
10.1007/s00259-006-0161-z doi (DE-627)SPR003123529 (SPR)s00259-006-0161-z-e DE-627 ger DE-627 rakwb eng Ziebell, Morten verfasserin aut Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2006 Purpose The iodinated cocaine derivative [123I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [123I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119–271]. The aims of this study were, firstly, to evaluate the test–retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, $ BP_{1} $ ($ C_{ROI} $/$ C_{plasma} $) and $ BP_{2} $ ($ C_{ROI} $/$ C_{REF} $). Methods Seven healthy subjects were subjected to [123I]PE2I SPECT scanning twice. For both studies, the two outcome parameters $ BP_{1} $ and $ BP_{2} $ were calculated based on two different methods for region of interest (ROI) delineation, namely manual delineation and probability map-based automatic delineation with MRI co-registration. Results With manual delineation, striatal test–retest variability (absolute difference between first and second scan as a percentage of the mean) of $ BP_{1} $ and $ BP_{2} $ was 13.9% (range 1.8–35.7%) and 4.1% (range 0.5–9.7%) respectively. The probability map-based automatic delineation resulted in striatal test–retest variability of 17.2% (range 4.3–40.5%) and 5.2% (range 0.1–10.9%) respectively. The B/I approach provided stable brain activity from 120 to 180 min post injection in both high- and low-count regions with a mean % change/hour in striatal $ BP_{2} $ of 10.6. Conclusion [123I]PE2I SPECT with the B/I approach yields a highly reproducible measure of striatal dopamine transporter binding. The appropriateness of a B/I protocol with a B/I ratio of 2.7 h (i.e. with a bolus worth 2.7 h of infusion) was confirmed in an independent sample of healthy subjects. [ (dpeaa)DE-He213 I]PE2I (dpeaa)DE-He213 Dopamine transporters (dpeaa)DE-He213 SPECT (dpeaa)DE-He213 Reproducibility (dpeaa)DE-He213 Bolus/infusion (dpeaa)DE-He213 Thomsen, Gerda aut Knudsen, Gitte M. aut de Nijs, Robin aut Svarer, Claus aut Wagner, Aase aut Pinborg, Lars H. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 34(2006), 1 vom: 29. Juli, Seite 101-109 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:34 year:2006 number:1 day:29 month:07 pages:101-109 https://dx.doi.org/10.1007/s00259-006-0161-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 34 2006 1 29 07 101-109 |
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10.1007/s00259-006-0161-z doi (DE-627)SPR003123529 (SPR)s00259-006-0161-z-e DE-627 ger DE-627 rakwb eng Ziebell, Morten verfasserin aut Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2006 Purpose The iodinated cocaine derivative [123I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [123I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119–271]. The aims of this study were, firstly, to evaluate the test–retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, $ BP_{1} $ ($ C_{ROI} $/$ C_{plasma} $) and $ BP_{2} $ ($ C_{ROI} $/$ C_{REF} $). Methods Seven healthy subjects were subjected to [123I]PE2I SPECT scanning twice. For both studies, the two outcome parameters $ BP_{1} $ and $ BP_{2} $ were calculated based on two different methods for region of interest (ROI) delineation, namely manual delineation and probability map-based automatic delineation with MRI co-registration. Results With manual delineation, striatal test–retest variability (absolute difference between first and second scan as a percentage of the mean) of $ BP_{1} $ and $ BP_{2} $ was 13.9% (range 1.8–35.7%) and 4.1% (range 0.5–9.7%) respectively. The probability map-based automatic delineation resulted in striatal test–retest variability of 17.2% (range 4.3–40.5%) and 5.2% (range 0.1–10.9%) respectively. The B/I approach provided stable brain activity from 120 to 180 min post injection in both high- and low-count regions with a mean % change/hour in striatal $ BP_{2} $ of 10.6. Conclusion [123I]PE2I SPECT with the B/I approach yields a highly reproducible measure of striatal dopamine transporter binding. The appropriateness of a B/I protocol with a B/I ratio of 2.7 h (i.e. with a bolus worth 2.7 h of infusion) was confirmed in an independent sample of healthy subjects. [ (dpeaa)DE-He213 I]PE2I (dpeaa)DE-He213 Dopamine transporters (dpeaa)DE-He213 SPECT (dpeaa)DE-He213 Reproducibility (dpeaa)DE-He213 Bolus/infusion (dpeaa)DE-He213 Thomsen, Gerda aut Knudsen, Gitte M. aut de Nijs, Robin aut Svarer, Claus aut Wagner, Aase aut Pinborg, Lars H. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 34(2006), 1 vom: 29. Juli, Seite 101-109 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:34 year:2006 number:1 day:29 month:07 pages:101-109 https://dx.doi.org/10.1007/s00259-006-0161-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 34 2006 1 29 07 101-109 |
| allfieldsGer |
10.1007/s00259-006-0161-z doi (DE-627)SPR003123529 (SPR)s00259-006-0161-z-e DE-627 ger DE-627 rakwb eng Ziebell, Morten verfasserin aut Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2006 Purpose The iodinated cocaine derivative [123I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [123I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119–271]. The aims of this study were, firstly, to evaluate the test–retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, $ BP_{1} $ ($ C_{ROI} $/$ C_{plasma} $) and $ BP_{2} $ ($ C_{ROI} $/$ C_{REF} $). Methods Seven healthy subjects were subjected to [123I]PE2I SPECT scanning twice. For both studies, the two outcome parameters $ BP_{1} $ and $ BP_{2} $ were calculated based on two different methods for region of interest (ROI) delineation, namely manual delineation and probability map-based automatic delineation with MRI co-registration. Results With manual delineation, striatal test–retest variability (absolute difference between first and second scan as a percentage of the mean) of $ BP_{1} $ and $ BP_{2} $ was 13.9% (range 1.8–35.7%) and 4.1% (range 0.5–9.7%) respectively. The probability map-based automatic delineation resulted in striatal test–retest variability of 17.2% (range 4.3–40.5%) and 5.2% (range 0.1–10.9%) respectively. The B/I approach provided stable brain activity from 120 to 180 min post injection in both high- and low-count regions with a mean % change/hour in striatal $ BP_{2} $ of 10.6. Conclusion [123I]PE2I SPECT with the B/I approach yields a highly reproducible measure of striatal dopamine transporter binding. The appropriateness of a B/I protocol with a B/I ratio of 2.7 h (i.e. with a bolus worth 2.7 h of infusion) was confirmed in an independent sample of healthy subjects. [ (dpeaa)DE-He213 I]PE2I (dpeaa)DE-He213 Dopamine transporters (dpeaa)DE-He213 SPECT (dpeaa)DE-He213 Reproducibility (dpeaa)DE-He213 Bolus/infusion (dpeaa)DE-He213 Thomsen, Gerda aut Knudsen, Gitte M. aut de Nijs, Robin aut Svarer, Claus aut Wagner, Aase aut Pinborg, Lars H. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 34(2006), 1 vom: 29. Juli, Seite 101-109 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:34 year:2006 number:1 day:29 month:07 pages:101-109 https://dx.doi.org/10.1007/s00259-006-0161-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 34 2006 1 29 07 101-109 |
| allfieldsSound |
10.1007/s00259-006-0161-z doi (DE-627)SPR003123529 (SPR)s00259-006-0161-z-e DE-627 ger DE-627 rakwb eng Ziebell, Morten verfasserin aut Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2006 Purpose The iodinated cocaine derivative [123I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [123I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119–271]. The aims of this study were, firstly, to evaluate the test–retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, $ BP_{1} $ ($ C_{ROI} $/$ C_{plasma} $) and $ BP_{2} $ ($ C_{ROI} $/$ C_{REF} $). Methods Seven healthy subjects were subjected to [123I]PE2I SPECT scanning twice. For both studies, the two outcome parameters $ BP_{1} $ and $ BP_{2} $ were calculated based on two different methods for region of interest (ROI) delineation, namely manual delineation and probability map-based automatic delineation with MRI co-registration. Results With manual delineation, striatal test–retest variability (absolute difference between first and second scan as a percentage of the mean) of $ BP_{1} $ and $ BP_{2} $ was 13.9% (range 1.8–35.7%) and 4.1% (range 0.5–9.7%) respectively. The probability map-based automatic delineation resulted in striatal test–retest variability of 17.2% (range 4.3–40.5%) and 5.2% (range 0.1–10.9%) respectively. The B/I approach provided stable brain activity from 120 to 180 min post injection in both high- and low-count regions with a mean % change/hour in striatal $ BP_{2} $ of 10.6. Conclusion [123I]PE2I SPECT with the B/I approach yields a highly reproducible measure of striatal dopamine transporter binding. The appropriateness of a B/I protocol with a B/I ratio of 2.7 h (i.e. with a bolus worth 2.7 h of infusion) was confirmed in an independent sample of healthy subjects. [ (dpeaa)DE-He213 I]PE2I (dpeaa)DE-He213 Dopamine transporters (dpeaa)DE-He213 SPECT (dpeaa)DE-He213 Reproducibility (dpeaa)DE-He213 Bolus/infusion (dpeaa)DE-He213 Thomsen, Gerda aut Knudsen, Gitte M. aut de Nijs, Robin aut Svarer, Claus aut Wagner, Aase aut Pinborg, Lars H. aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 34(2006), 1 vom: 29. Juli, Seite 101-109 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:34 year:2006 number:1 day:29 month:07 pages:101-109 https://dx.doi.org/10.1007/s00259-006-0161-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 34 2006 1 29 07 101-109 |
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English |
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Enthalten in European journal of nuclear medicine and molecular imaging 34(2006), 1 vom: 29. Juli, Seite 101-109 volume:34 year:2006 number:1 day:29 month:07 pages:101-109 |
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Enthalten in European journal of nuclear medicine and molecular imaging 34(2006), 1 vom: 29. Juli, Seite 101-109 volume:34 year:2006 number:1 day:29 month:07 pages:101-109 |
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[ I]PE2I Dopamine transporters SPECT Reproducibility Bolus/infusion |
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European journal of nuclear medicine and molecular imaging |
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Ziebell, Morten @@aut@@ Thomsen, Gerda @@aut@@ Knudsen, Gitte M. @@aut@@ de Nijs, Robin @@aut@@ Svarer, Claus @@aut@@ Wagner, Aase @@aut@@ Pinborg, Lars H. @@aut@@ |
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2006-07-29T00:00:00Z |
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Recently, a bolus/infusion (B/I) protocol for [123I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119–271]. The aims of this study were, firstly, to evaluate the test–retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, $ BP_{1} $ ($ C_{ROI} $/$ C_{plasma} $) and $ BP_{2} $ ($ C_{ROI} $/$ C_{REF} $). Methods Seven healthy subjects were subjected to [123I]PE2I SPECT scanning twice. For both studies, the two outcome parameters $ BP_{1} $ and $ BP_{2} $ were calculated based on two different methods for region of interest (ROI) delineation, namely manual delineation and probability map-based automatic delineation with MRI co-registration. Results With manual delineation, striatal test–retest variability (absolute difference between first and second scan as a percentage of the mean) of $ BP_{1} $ and $ BP_{2} $ was 13.9% (range 1.8–35.7%) and 4.1% (range 0.5–9.7%) respectively. The probability map-based automatic delineation resulted in striatal test–retest variability of 17.2% (range 4.3–40.5%) and 5.2% (range 0.1–10.9%) respectively. The B/I approach provided stable brain activity from 120 to 180 min post injection in both high- and low-count regions with a mean % change/hour in striatal $ BP_{2} $ of 10.6. Conclusion [123I]PE2I SPECT with the B/I approach yields a highly reproducible measure of striatal dopamine transporter binding. 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Ziebell, Morten |
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Ziebell, Morten misc [ misc I]PE2I misc Dopamine transporters misc SPECT misc Reproducibility misc Bolus/infusion Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT |
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Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT (dpeaa)DE-He213 I]PE2I (dpeaa)DE-He213 Dopamine transporters (dpeaa)DE-He213 SPECT (dpeaa)DE-He213 Reproducibility (dpeaa)DE-He213 Bolus/infusion (dpeaa)DE-He213 |
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Elektronische Aufsätze |
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Ziebell, Morten |
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10.1007/s00259-006-0161-z |
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reproducibility of [123i]pe2i binding to dopamine transporters with spect |
| title_auth |
Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT |
| abstract |
Purpose The iodinated cocaine derivative [123I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [123I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119–271]. The aims of this study were, firstly, to evaluate the test–retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, $ BP_{1} $ ($ C_{ROI} $/$ C_{plasma} $) and $ BP_{2} $ ($ C_{ROI} $/$ C_{REF} $). Methods Seven healthy subjects were subjected to [123I]PE2I SPECT scanning twice. For both studies, the two outcome parameters $ BP_{1} $ and $ BP_{2} $ were calculated based on two different methods for region of interest (ROI) delineation, namely manual delineation and probability map-based automatic delineation with MRI co-registration. Results With manual delineation, striatal test–retest variability (absolute difference between first and second scan as a percentage of the mean) of $ BP_{1} $ and $ BP_{2} $ was 13.9% (range 1.8–35.7%) and 4.1% (range 0.5–9.7%) respectively. The probability map-based automatic delineation resulted in striatal test–retest variability of 17.2% (range 4.3–40.5%) and 5.2% (range 0.1–10.9%) respectively. The B/I approach provided stable brain activity from 120 to 180 min post injection in both high- and low-count regions with a mean % change/hour in striatal $ BP_{2} $ of 10.6. Conclusion [123I]PE2I SPECT with the B/I approach yields a highly reproducible measure of striatal dopamine transporter binding. The appropriateness of a B/I protocol with a B/I ratio of 2.7 h (i.e. with a bolus worth 2.7 h of infusion) was confirmed in an independent sample of healthy subjects. © Springer-Verlag 2006 |
| abstractGer |
Purpose The iodinated cocaine derivative [123I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [123I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119–271]. The aims of this study were, firstly, to evaluate the test–retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, $ BP_{1} $ ($ C_{ROI} $/$ C_{plasma} $) and $ BP_{2} $ ($ C_{ROI} $/$ C_{REF} $). Methods Seven healthy subjects were subjected to [123I]PE2I SPECT scanning twice. For both studies, the two outcome parameters $ BP_{1} $ and $ BP_{2} $ were calculated based on two different methods for region of interest (ROI) delineation, namely manual delineation and probability map-based automatic delineation with MRI co-registration. Results With manual delineation, striatal test–retest variability (absolute difference between first and second scan as a percentage of the mean) of $ BP_{1} $ and $ BP_{2} $ was 13.9% (range 1.8–35.7%) and 4.1% (range 0.5–9.7%) respectively. The probability map-based automatic delineation resulted in striatal test–retest variability of 17.2% (range 4.3–40.5%) and 5.2% (range 0.1–10.9%) respectively. The B/I approach provided stable brain activity from 120 to 180 min post injection in both high- and low-count regions with a mean % change/hour in striatal $ BP_{2} $ of 10.6. Conclusion [123I]PE2I SPECT with the B/I approach yields a highly reproducible measure of striatal dopamine transporter binding. The appropriateness of a B/I protocol with a B/I ratio of 2.7 h (i.e. with a bolus worth 2.7 h of infusion) was confirmed in an independent sample of healthy subjects. © Springer-Verlag 2006 |
| abstract_unstemmed |
Purpose The iodinated cocaine derivative [123I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [123I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119–271]. The aims of this study were, firstly, to evaluate the test–retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, $ BP_{1} $ ($ C_{ROI} $/$ C_{plasma} $) and $ BP_{2} $ ($ C_{ROI} $/$ C_{REF} $). Methods Seven healthy subjects were subjected to [123I]PE2I SPECT scanning twice. For both studies, the two outcome parameters $ BP_{1} $ and $ BP_{2} $ were calculated based on two different methods for region of interest (ROI) delineation, namely manual delineation and probability map-based automatic delineation with MRI co-registration. Results With manual delineation, striatal test–retest variability (absolute difference between first and second scan as a percentage of the mean) of $ BP_{1} $ and $ BP_{2} $ was 13.9% (range 1.8–35.7%) and 4.1% (range 0.5–9.7%) respectively. The probability map-based automatic delineation resulted in striatal test–retest variability of 17.2% (range 4.3–40.5%) and 5.2% (range 0.1–10.9%) respectively. The B/I approach provided stable brain activity from 120 to 180 min post injection in both high- and low-count regions with a mean % change/hour in striatal $ BP_{2} $ of 10.6. Conclusion [123I]PE2I SPECT with the B/I approach yields a highly reproducible measure of striatal dopamine transporter binding. The appropriateness of a B/I protocol with a B/I ratio of 2.7 h (i.e. with a bolus worth 2.7 h of infusion) was confirmed in an independent sample of healthy subjects. © Springer-Verlag 2006 |
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Thomsen, Gerda Knudsen, Gitte M. de Nijs, Robin Svarer, Claus Wagner, Aase Pinborg, Lars H. |
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| score |
7.401374 |