Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients
Purpose The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on 18F-FDG PET/CT could give a better evaluation of the total tumour burden...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Meignan, Michel [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag Berlin Heidelberg 2014 |
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| Übergeordnetes Werk: |
Enthalten in: European journal of nuclear medicine and molecular imaging - Heidelberg [u.a.] : Springer-Verl., 2002, 41(2014), 6 vom: 26. Feb., Seite 1113-1122 |
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| Übergeordnetes Werk: |
volume:41 ; year:2014 ; number:6 ; day:26 ; month:02 ; pages:1113-1122 |
| Links: |
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| DOI / URN: |
10.1007/s00259-014-2705-y |
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| Katalog-ID: |
SPR003151891 |
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| 041 | |a eng | ||
| 100 | 1 | |a Meignan, Michel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients |
| 264 | 1 | |c 2014 | |
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| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 500 | |a © Springer-Verlag Berlin Heidelberg 2014 | ||
| 520 | |a Purpose The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on 18F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma. Methods Data were processed by two nuclear medicine physicians in Reggio Emilia and Créteil. Nineteen phantoms filled with 18F-saline were scanned; these comprised spherical or irregular volumes from 0.5 to 650 $ cm^{3} $ with tumour-to-background ratios from 1.65 to 40. Volumes were measured with different SUVmax thresholds. In patients, TMTV was measured on PET at staging by two methods: volumes of individual lesions were measured using a fixed 41 % SUVmax threshold ($ TMTV_{41} $) and a variable visually adjusted SUVmax threshold ($ TMTV_{var} $). Results In phantoms, the 41 % threshold gave the best concordance between measured and actual volumes. Interobserver agreement was almost perfect. In patients, the agreement between the reviewers for $ TMTV_{41} $ measurement was substantial (ρc = 0.986, CI 0.97 – 0.99) and the difference between the means was not significant (212 ± 218 $ cm^{3} $ for Créteil vs. 206 ± 219 $ cm^{3} $ for Reggio Emilia, P = 0.65). By contrast the agreement was poor for $ TMTV_{var} $. There was a significant direct correlation between $ TMTV_{41} $ and normalized LDH (r = 0.652, CI 0.42 – 0.8, P <0.001). Higher disease stages and bulky tumour were associated with higher $ TMTV_{41} $, but high $ TMTV_{41} $ could be found in patients with stage 1/2 or nonbulky tumour. Conclusion Measurement of baseline TMTV in lymphoma using a fixed 41% SUVmax threshold is reproducible and correlates with the other parameters for tumour mass evaluation. It should be evaluated in prospective studies. | ||
| 650 | 4 | |a Metabolic volume |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Lymphoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Prognosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a PET/CT |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Sasanelli, Myriam |4 aut | |
| 700 | 1 | |a Casasnovas, René Olivier |4 aut | |
| 700 | 1 | |a Luminari, Stefano |4 aut | |
| 700 | 1 | |a Fioroni, Federica |4 aut | |
| 700 | 1 | |a Coriani, Chiara |4 aut | |
| 700 | 1 | |a Masset, Helene |4 aut | |
| 700 | 1 | |a Itti, Emmanuel |4 aut | |
| 700 | 1 | |a Gobbi, Paolo G. |4 aut | |
| 700 | 1 | |a Merli, Francesco |4 aut | |
| 700 | 1 | |a Versari, Annibale |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of nuclear medicine and molecular imaging |d Heidelberg [u.a.] : Springer-Verl., 2002 |g 41(2014), 6 vom: 26. Feb., Seite 1113-1122 |w (DE-627)359787258 |w (DE-600)2098375-X |x 1619-7089 |7 nnns |
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2014 |
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10.1007/s00259-014-2705-y doi (DE-627)SPR003151891 (SPR)s00259-014-2705-y-e DE-627 ger DE-627 rakwb eng Meignan, Michel verfasserin aut Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2014 Purpose The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on 18F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma. Methods Data were processed by two nuclear medicine physicians in Reggio Emilia and Créteil. Nineteen phantoms filled with 18F-saline were scanned; these comprised spherical or irregular volumes from 0.5 to 650 $ cm^{3} $ with tumour-to-background ratios from 1.65 to 40. Volumes were measured with different SUVmax thresholds. In patients, TMTV was measured on PET at staging by two methods: volumes of individual lesions were measured using a fixed 41 % SUVmax threshold ($ TMTV_{41} $) and a variable visually adjusted SUVmax threshold ($ TMTV_{var} $). Results In phantoms, the 41 % threshold gave the best concordance between measured and actual volumes. Interobserver agreement was almost perfect. In patients, the agreement between the reviewers for $ TMTV_{41} $ measurement was substantial (ρc = 0.986, CI 0.97 – 0.99) and the difference between the means was not significant (212 ± 218 $ cm^{3} $ for Créteil vs. 206 ± 219 $ cm^{3} $ for Reggio Emilia, P = 0.65). By contrast the agreement was poor for $ TMTV_{var} $. There was a significant direct correlation between $ TMTV_{41} $ and normalized LDH (r = 0.652, CI 0.42 – 0.8, P <0.001). Higher disease stages and bulky tumour were associated with higher $ TMTV_{41} $, but high $ TMTV_{41} $ could be found in patients with stage 1/2 or nonbulky tumour. Conclusion Measurement of baseline TMTV in lymphoma using a fixed 41% SUVmax threshold is reproducible and correlates with the other parameters for tumour mass evaluation. It should be evaluated in prospective studies. Metabolic volume (dpeaa)DE-He213 Lymphoma (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 PET/CT (dpeaa)DE-He213 Sasanelli, Myriam aut Casasnovas, René Olivier aut Luminari, Stefano aut Fioroni, Federica aut Coriani, Chiara aut Masset, Helene aut Itti, Emmanuel aut Gobbi, Paolo G. aut Merli, Francesco aut Versari, Annibale aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 41(2014), 6 vom: 26. Feb., Seite 1113-1122 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:41 year:2014 number:6 day:26 month:02 pages:1113-1122 https://dx.doi.org/10.1007/s00259-014-2705-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2014 6 26 02 1113-1122 |
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10.1007/s00259-014-2705-y doi (DE-627)SPR003151891 (SPR)s00259-014-2705-y-e DE-627 ger DE-627 rakwb eng Meignan, Michel verfasserin aut Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2014 Purpose The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on 18F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma. Methods Data were processed by two nuclear medicine physicians in Reggio Emilia and Créteil. Nineteen phantoms filled with 18F-saline were scanned; these comprised spherical or irregular volumes from 0.5 to 650 $ cm^{3} $ with tumour-to-background ratios from 1.65 to 40. Volumes were measured with different SUVmax thresholds. In patients, TMTV was measured on PET at staging by two methods: volumes of individual lesions were measured using a fixed 41 % SUVmax threshold ($ TMTV_{41} $) and a variable visually adjusted SUVmax threshold ($ TMTV_{var} $). Results In phantoms, the 41 % threshold gave the best concordance between measured and actual volumes. Interobserver agreement was almost perfect. In patients, the agreement between the reviewers for $ TMTV_{41} $ measurement was substantial (ρc = 0.986, CI 0.97 – 0.99) and the difference between the means was not significant (212 ± 218 $ cm^{3} $ for Créteil vs. 206 ± 219 $ cm^{3} $ for Reggio Emilia, P = 0.65). By contrast the agreement was poor for $ TMTV_{var} $. There was a significant direct correlation between $ TMTV_{41} $ and normalized LDH (r = 0.652, CI 0.42 – 0.8, P <0.001). Higher disease stages and bulky tumour were associated with higher $ TMTV_{41} $, but high $ TMTV_{41} $ could be found in patients with stage 1/2 or nonbulky tumour. Conclusion Measurement of baseline TMTV in lymphoma using a fixed 41% SUVmax threshold is reproducible and correlates with the other parameters for tumour mass evaluation. It should be evaluated in prospective studies. Metabolic volume (dpeaa)DE-He213 Lymphoma (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 PET/CT (dpeaa)DE-He213 Sasanelli, Myriam aut Casasnovas, René Olivier aut Luminari, Stefano aut Fioroni, Federica aut Coriani, Chiara aut Masset, Helene aut Itti, Emmanuel aut Gobbi, Paolo G. aut Merli, Francesco aut Versari, Annibale aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 41(2014), 6 vom: 26. Feb., Seite 1113-1122 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:41 year:2014 number:6 day:26 month:02 pages:1113-1122 https://dx.doi.org/10.1007/s00259-014-2705-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2014 6 26 02 1113-1122 |
| allfields_unstemmed |
10.1007/s00259-014-2705-y doi (DE-627)SPR003151891 (SPR)s00259-014-2705-y-e DE-627 ger DE-627 rakwb eng Meignan, Michel verfasserin aut Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2014 Purpose The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on 18F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma. Methods Data were processed by two nuclear medicine physicians in Reggio Emilia and Créteil. Nineteen phantoms filled with 18F-saline were scanned; these comprised spherical or irregular volumes from 0.5 to 650 $ cm^{3} $ with tumour-to-background ratios from 1.65 to 40. Volumes were measured with different SUVmax thresholds. In patients, TMTV was measured on PET at staging by two methods: volumes of individual lesions were measured using a fixed 41 % SUVmax threshold ($ TMTV_{41} $) and a variable visually adjusted SUVmax threshold ($ TMTV_{var} $). Results In phantoms, the 41 % threshold gave the best concordance between measured and actual volumes. Interobserver agreement was almost perfect. In patients, the agreement between the reviewers for $ TMTV_{41} $ measurement was substantial (ρc = 0.986, CI 0.97 – 0.99) and the difference between the means was not significant (212 ± 218 $ cm^{3} $ for Créteil vs. 206 ± 219 $ cm^{3} $ for Reggio Emilia, P = 0.65). By contrast the agreement was poor for $ TMTV_{var} $. There was a significant direct correlation between $ TMTV_{41} $ and normalized LDH (r = 0.652, CI 0.42 – 0.8, P <0.001). Higher disease stages and bulky tumour were associated with higher $ TMTV_{41} $, but high $ TMTV_{41} $ could be found in patients with stage 1/2 or nonbulky tumour. Conclusion Measurement of baseline TMTV in lymphoma using a fixed 41% SUVmax threshold is reproducible and correlates with the other parameters for tumour mass evaluation. It should be evaluated in prospective studies. Metabolic volume (dpeaa)DE-He213 Lymphoma (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 PET/CT (dpeaa)DE-He213 Sasanelli, Myriam aut Casasnovas, René Olivier aut Luminari, Stefano aut Fioroni, Federica aut Coriani, Chiara aut Masset, Helene aut Itti, Emmanuel aut Gobbi, Paolo G. aut Merli, Francesco aut Versari, Annibale aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 41(2014), 6 vom: 26. Feb., Seite 1113-1122 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:41 year:2014 number:6 day:26 month:02 pages:1113-1122 https://dx.doi.org/10.1007/s00259-014-2705-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2014 6 26 02 1113-1122 |
| allfieldsGer |
10.1007/s00259-014-2705-y doi (DE-627)SPR003151891 (SPR)s00259-014-2705-y-e DE-627 ger DE-627 rakwb eng Meignan, Michel verfasserin aut Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2014 Purpose The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on 18F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma. Methods Data were processed by two nuclear medicine physicians in Reggio Emilia and Créteil. Nineteen phantoms filled with 18F-saline were scanned; these comprised spherical or irregular volumes from 0.5 to 650 $ cm^{3} $ with tumour-to-background ratios from 1.65 to 40. Volumes were measured with different SUVmax thresholds. In patients, TMTV was measured on PET at staging by two methods: volumes of individual lesions were measured using a fixed 41 % SUVmax threshold ($ TMTV_{41} $) and a variable visually adjusted SUVmax threshold ($ TMTV_{var} $). Results In phantoms, the 41 % threshold gave the best concordance between measured and actual volumes. Interobserver agreement was almost perfect. In patients, the agreement between the reviewers for $ TMTV_{41} $ measurement was substantial (ρc = 0.986, CI 0.97 – 0.99) and the difference between the means was not significant (212 ± 218 $ cm^{3} $ for Créteil vs. 206 ± 219 $ cm^{3} $ for Reggio Emilia, P = 0.65). By contrast the agreement was poor for $ TMTV_{var} $. There was a significant direct correlation between $ TMTV_{41} $ and normalized LDH (r = 0.652, CI 0.42 – 0.8, P <0.001). Higher disease stages and bulky tumour were associated with higher $ TMTV_{41} $, but high $ TMTV_{41} $ could be found in patients with stage 1/2 or nonbulky tumour. Conclusion Measurement of baseline TMTV in lymphoma using a fixed 41% SUVmax threshold is reproducible and correlates with the other parameters for tumour mass evaluation. It should be evaluated in prospective studies. Metabolic volume (dpeaa)DE-He213 Lymphoma (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 PET/CT (dpeaa)DE-He213 Sasanelli, Myriam aut Casasnovas, René Olivier aut Luminari, Stefano aut Fioroni, Federica aut Coriani, Chiara aut Masset, Helene aut Itti, Emmanuel aut Gobbi, Paolo G. aut Merli, Francesco aut Versari, Annibale aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 41(2014), 6 vom: 26. Feb., Seite 1113-1122 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:41 year:2014 number:6 day:26 month:02 pages:1113-1122 https://dx.doi.org/10.1007/s00259-014-2705-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2014 6 26 02 1113-1122 |
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10.1007/s00259-014-2705-y doi (DE-627)SPR003151891 (SPR)s00259-014-2705-y-e DE-627 ger DE-627 rakwb eng Meignan, Michel verfasserin aut Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2014 Purpose The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on 18F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma. Methods Data were processed by two nuclear medicine physicians in Reggio Emilia and Créteil. Nineteen phantoms filled with 18F-saline were scanned; these comprised spherical or irregular volumes from 0.5 to 650 $ cm^{3} $ with tumour-to-background ratios from 1.65 to 40. Volumes were measured with different SUVmax thresholds. In patients, TMTV was measured on PET at staging by two methods: volumes of individual lesions were measured using a fixed 41 % SUVmax threshold ($ TMTV_{41} $) and a variable visually adjusted SUVmax threshold ($ TMTV_{var} $). Results In phantoms, the 41 % threshold gave the best concordance between measured and actual volumes. Interobserver agreement was almost perfect. In patients, the agreement between the reviewers for $ TMTV_{41} $ measurement was substantial (ρc = 0.986, CI 0.97 – 0.99) and the difference between the means was not significant (212 ± 218 $ cm^{3} $ for Créteil vs. 206 ± 219 $ cm^{3} $ for Reggio Emilia, P = 0.65). By contrast the agreement was poor for $ TMTV_{var} $. There was a significant direct correlation between $ TMTV_{41} $ and normalized LDH (r = 0.652, CI 0.42 – 0.8, P <0.001). Higher disease stages and bulky tumour were associated with higher $ TMTV_{41} $, but high $ TMTV_{41} $ could be found in patients with stage 1/2 or nonbulky tumour. Conclusion Measurement of baseline TMTV in lymphoma using a fixed 41% SUVmax threshold is reproducible and correlates with the other parameters for tumour mass evaluation. It should be evaluated in prospective studies. Metabolic volume (dpeaa)DE-He213 Lymphoma (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 PET/CT (dpeaa)DE-He213 Sasanelli, Myriam aut Casasnovas, René Olivier aut Luminari, Stefano aut Fioroni, Federica aut Coriani, Chiara aut Masset, Helene aut Itti, Emmanuel aut Gobbi, Paolo G. aut Merli, Francesco aut Versari, Annibale aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 41(2014), 6 vom: 26. Feb., Seite 1113-1122 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:41 year:2014 number:6 day:26 month:02 pages:1113-1122 https://dx.doi.org/10.1007/s00259-014-2705-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2014 6 26 02 1113-1122 |
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Meignan, Michel @@aut@@ Sasanelli, Myriam @@aut@@ Casasnovas, René Olivier @@aut@@ Luminari, Stefano @@aut@@ Fioroni, Federica @@aut@@ Coriani, Chiara @@aut@@ Masset, Helene @@aut@@ Itti, Emmanuel @@aut@@ Gobbi, Paolo G. @@aut@@ Merli, Francesco @@aut@@ Versari, Annibale @@aut@@ |
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However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on 18F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma. Methods Data were processed by two nuclear medicine physicians in Reggio Emilia and Créteil. Nineteen phantoms filled with 18F-saline were scanned; these comprised spherical or irregular volumes from 0.5 to 650 $ cm^{3} $ with tumour-to-background ratios from 1.65 to 40. Volumes were measured with different SUVmax thresholds. In patients, TMTV was measured on PET at staging by two methods: volumes of individual lesions were measured using a fixed 41 % SUVmax threshold ($ TMTV_{41} $) and a variable visually adjusted SUVmax threshold ($ TMTV_{var} $). 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Meignan, Michel |
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Meignan, Michel misc Metabolic volume misc Lymphoma misc Prognosis misc PET/CT Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients |
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Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients Metabolic volume (dpeaa)DE-He213 Lymphoma (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 PET/CT (dpeaa)DE-He213 |
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Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients |
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Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients |
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Meignan, Michel |
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European journal of nuclear medicine and molecular imaging |
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Meignan, Michel Sasanelli, Myriam Casasnovas, René Olivier Luminari, Stefano Fioroni, Federica Coriani, Chiara Masset, Helene Itti, Emmanuel Gobbi, Paolo G. Merli, Francesco Versari, Annibale |
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10.1007/s00259-014-2705-y |
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metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients |
| title_auth |
Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients |
| abstract |
Purpose The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on 18F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma. Methods Data were processed by two nuclear medicine physicians in Reggio Emilia and Créteil. Nineteen phantoms filled with 18F-saline were scanned; these comprised spherical or irregular volumes from 0.5 to 650 $ cm^{3} $ with tumour-to-background ratios from 1.65 to 40. Volumes were measured with different SUVmax thresholds. In patients, TMTV was measured on PET at staging by two methods: volumes of individual lesions were measured using a fixed 41 % SUVmax threshold ($ TMTV_{41} $) and a variable visually adjusted SUVmax threshold ($ TMTV_{var} $). Results In phantoms, the 41 % threshold gave the best concordance between measured and actual volumes. Interobserver agreement was almost perfect. In patients, the agreement between the reviewers for $ TMTV_{41} $ measurement was substantial (ρc = 0.986, CI 0.97 – 0.99) and the difference between the means was not significant (212 ± 218 $ cm^{3} $ for Créteil vs. 206 ± 219 $ cm^{3} $ for Reggio Emilia, P = 0.65). By contrast the agreement was poor for $ TMTV_{var} $. There was a significant direct correlation between $ TMTV_{41} $ and normalized LDH (r = 0.652, CI 0.42 – 0.8, P <0.001). Higher disease stages and bulky tumour were associated with higher $ TMTV_{41} $, but high $ TMTV_{41} $ could be found in patients with stage 1/2 or nonbulky tumour. Conclusion Measurement of baseline TMTV in lymphoma using a fixed 41% SUVmax threshold is reproducible and correlates with the other parameters for tumour mass evaluation. It should be evaluated in prospective studies. © Springer-Verlag Berlin Heidelberg 2014 |
| abstractGer |
Purpose The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on 18F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma. Methods Data were processed by two nuclear medicine physicians in Reggio Emilia and Créteil. Nineteen phantoms filled with 18F-saline were scanned; these comprised spherical or irregular volumes from 0.5 to 650 $ cm^{3} $ with tumour-to-background ratios from 1.65 to 40. Volumes were measured with different SUVmax thresholds. In patients, TMTV was measured on PET at staging by two methods: volumes of individual lesions were measured using a fixed 41 % SUVmax threshold ($ TMTV_{41} $) and a variable visually adjusted SUVmax threshold ($ TMTV_{var} $). Results In phantoms, the 41 % threshold gave the best concordance between measured and actual volumes. Interobserver agreement was almost perfect. In patients, the agreement between the reviewers for $ TMTV_{41} $ measurement was substantial (ρc = 0.986, CI 0.97 – 0.99) and the difference between the means was not significant (212 ± 218 $ cm^{3} $ for Créteil vs. 206 ± 219 $ cm^{3} $ for Reggio Emilia, P = 0.65). By contrast the agreement was poor for $ TMTV_{var} $. There was a significant direct correlation between $ TMTV_{41} $ and normalized LDH (r = 0.652, CI 0.42 – 0.8, P <0.001). Higher disease stages and bulky tumour were associated with higher $ TMTV_{41} $, but high $ TMTV_{41} $ could be found in patients with stage 1/2 or nonbulky tumour. Conclusion Measurement of baseline TMTV in lymphoma using a fixed 41% SUVmax threshold is reproducible and correlates with the other parameters for tumour mass evaluation. It should be evaluated in prospective studies. © Springer-Verlag Berlin Heidelberg 2014 |
| abstract_unstemmed |
Purpose The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on 18F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma. Methods Data were processed by two nuclear medicine physicians in Reggio Emilia and Créteil. Nineteen phantoms filled with 18F-saline were scanned; these comprised spherical or irregular volumes from 0.5 to 650 $ cm^{3} $ with tumour-to-background ratios from 1.65 to 40. Volumes were measured with different SUVmax thresholds. In patients, TMTV was measured on PET at staging by two methods: volumes of individual lesions were measured using a fixed 41 % SUVmax threshold ($ TMTV_{41} $) and a variable visually adjusted SUVmax threshold ($ TMTV_{var} $). Results In phantoms, the 41 % threshold gave the best concordance between measured and actual volumes. Interobserver agreement was almost perfect. In patients, the agreement between the reviewers for $ TMTV_{41} $ measurement was substantial (ρc = 0.986, CI 0.97 – 0.99) and the difference between the means was not significant (212 ± 218 $ cm^{3} $ for Créteil vs. 206 ± 219 $ cm^{3} $ for Reggio Emilia, P = 0.65). By contrast the agreement was poor for $ TMTV_{var} $. There was a significant direct correlation between $ TMTV_{41} $ and normalized LDH (r = 0.652, CI 0.42 – 0.8, P <0.001). Higher disease stages and bulky tumour were associated with higher $ TMTV_{41} $, but high $ TMTV_{41} $ could be found in patients with stage 1/2 or nonbulky tumour. Conclusion Measurement of baseline TMTV in lymphoma using a fixed 41% SUVmax threshold is reproducible and correlates with the other parameters for tumour mass evaluation. It should be evaluated in prospective studies. © Springer-Verlag Berlin Heidelberg 2014 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR003151891</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519124822.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2014 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00259-014-2705-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR003151891</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00259-014-2705-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Meignan, Michel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer-Verlag Berlin Heidelberg 2014</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on 18F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma. Methods Data were processed by two nuclear medicine physicians in Reggio Emilia and Créteil. Nineteen phantoms filled with 18F-saline were scanned; these comprised spherical or irregular volumes from 0.5 to 650 $ cm^{3} $ with tumour-to-background ratios from 1.65 to 40. Volumes were measured with different SUVmax thresholds. In patients, TMTV was measured on PET at staging by two methods: volumes of individual lesions were measured using a fixed 41 % SUVmax threshold ($ TMTV_{41} $) and a variable visually adjusted SUVmax threshold ($ TMTV_{var} $). Results In phantoms, the 41 % threshold gave the best concordance between measured and actual volumes. Interobserver agreement was almost perfect. In patients, the agreement between the reviewers for $ TMTV_{41} $ measurement was substantial (ρc = 0.986, CI 0.97 – 0.99) and the difference between the means was not significant (212 ± 218 $ cm^{3} $ for Créteil vs. 206 ± 219 $ cm^{3} $ for Reggio Emilia, P = 0.65). By contrast the agreement was poor for $ TMTV_{var} $. There was a significant direct correlation between $ TMTV_{41} $ and normalized LDH (r = 0.652, CI 0.42 – 0.8, P <0.001). Higher disease stages and bulky tumour were associated with higher $ TMTV_{41} $, but high $ TMTV_{41} $ could be found in patients with stage 1/2 or nonbulky tumour. Conclusion Measurement of baseline TMTV in lymphoma using a fixed 41% SUVmax threshold is reproducible and correlates with the other parameters for tumour mass evaluation. 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