Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers
Purpose To analyze Gd-EOB-DTPA-enhanced magnetic resonance (MR) findings of nodules (low-grade dysplastic nodules—LGDNs; high-grade dysplastic nodules—HGDN, and hepatocellular carcinoma—HCC), histologically identified on cirrhotic, explanted livers. Methods IRB approval was obtained for this study....
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bartolozzi, Carlo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science+Business Media, LLC 2012 |
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| Übergeordnetes Werk: |
Enthalten in: Abdominal radiology - [Boston, MA] : Springer US, 2016, 38(2012), 2 vom: 29. Sept., Seite 290-296 |
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| Übergeordnetes Werk: |
volume:38 ; year:2012 ; number:2 ; day:29 ; month:09 ; pages:290-296 |
| Links: |
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| DOI / URN: |
10.1007/s00261-012-9952-9 |
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SPR00319065X |
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| 245 | 1 | 0 | |a Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers |
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| 520 | |a Purpose To analyze Gd-EOB-DTPA-enhanced magnetic resonance (MR) findings of nodules (low-grade dysplastic nodules—LGDNs; high-grade dysplastic nodules—HGDN, and hepatocellular carcinoma—HCC), histologically identified on cirrhotic, explanted livers. Methods IRB approval was obtained for this study. Thirty-four patients underwent Gd-EOB-DTPA-enhanced MR examinations (1.5T system), that included 20-min delayed hepatobiliary (HB) phase imaging, before undergoing orthotopic liver transplantation (OLT; mean time MR-OLT: 2.7 months). A total of 102 hepatic nodules were identified and analyzed at histopathological examination, and classified as LGDN, HGDN, and HCC. Two radiologists by consensus performed a quantitative (enhancement ratios, ERs) and a qualitative analyses of signal intensities of identified nodules on vascular dynamic phases (30–35 s after injection–arterial phase; 180–190 s after injection late phase) and on HB phases. Correlation between nodules MR patterns and histological classification was analyzed by means of dedicated statistical software. Results No differences were appreciable among ERs of HGDN and HCCs on HB phase (P > 0.001). Lesions’ enhancement on vascular dynamic and on HB phases significantly correlated to histological classification of nodules (P < 0.0001). Nodular hyperintensity on arterial phase and hypointensity on late phase were highly predictive for HCC (PPV 100%), with a moderate sensitivity (72.5%). Nodular hypointensity on HB phase was detected on 39/40 HCCs (sensitivity 97.5%) and in 21/30 HGDNs, whereas no LGDN showed it. Conclusions Hyperenhancement on arterial phase and hypointensity on late phase are the most specific clues for the diagnosis of HCC. Hypointensity on HB phase shows a PPV of 100% in suggesting nodular premalignancy/malignancy, independently from nodular dynamic vascular enhancement. | ||
| 650 | 4 | |a HCC |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Magnetic resonance |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Gd-EOB-DTPA |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a High grade dysplastic nodule |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cirrhosis |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Battaglia, Valentina |4 aut | |
| 700 | 1 | |a Bargellini, Irene |4 aut | |
| 700 | 1 | |a Bozzi, Elena |4 aut | |
| 700 | 1 | |a Campani, Daniela |4 aut | |
| 700 | 1 | |a Pollina, Luca Emanuele |4 aut | |
| 700 | 1 | |a Filipponi, Franco |4 aut | |
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10.1007/s00261-012-9952-9 doi (DE-627)SPR00319065X (SPR)s00261-012-9952-9-e DE-627 ger DE-627 rakwb eng Bartolozzi, Carlo verfasserin aut Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC 2012 Purpose To analyze Gd-EOB-DTPA-enhanced magnetic resonance (MR) findings of nodules (low-grade dysplastic nodules—LGDNs; high-grade dysplastic nodules—HGDN, and hepatocellular carcinoma—HCC), histologically identified on cirrhotic, explanted livers. Methods IRB approval was obtained for this study. Thirty-four patients underwent Gd-EOB-DTPA-enhanced MR examinations (1.5T system), that included 20-min delayed hepatobiliary (HB) phase imaging, before undergoing orthotopic liver transplantation (OLT; mean time MR-OLT: 2.7 months). A total of 102 hepatic nodules were identified and analyzed at histopathological examination, and classified as LGDN, HGDN, and HCC. Two radiologists by consensus performed a quantitative (enhancement ratios, ERs) and a qualitative analyses of signal intensities of identified nodules on vascular dynamic phases (30–35 s after injection–arterial phase; 180–190 s after injection late phase) and on HB phases. Correlation between nodules MR patterns and histological classification was analyzed by means of dedicated statistical software. Results No differences were appreciable among ERs of HGDN and HCCs on HB phase (P > 0.001). Lesions’ enhancement on vascular dynamic and on HB phases significantly correlated to histological classification of nodules (P < 0.0001). Nodular hyperintensity on arterial phase and hypointensity on late phase were highly predictive for HCC (PPV 100%), with a moderate sensitivity (72.5%). Nodular hypointensity on HB phase was detected on 39/40 HCCs (sensitivity 97.5%) and in 21/30 HGDNs, whereas no LGDN showed it. Conclusions Hyperenhancement on arterial phase and hypointensity on late phase are the most specific clues for the diagnosis of HCC. Hypointensity on HB phase shows a PPV of 100% in suggesting nodular premalignancy/malignancy, independently from nodular dynamic vascular enhancement. HCC (dpeaa)DE-He213 Magnetic resonance (dpeaa)DE-He213 Gd-EOB-DTPA (dpeaa)DE-He213 High grade dysplastic nodule (dpeaa)DE-He213 Cirrhosis (dpeaa)DE-He213 Battaglia, Valentina aut Bargellini, Irene aut Bozzi, Elena aut Campani, Daniela aut Pollina, Luca Emanuele aut Filipponi, Franco aut Enthalten in Abdominal radiology [Boston, MA] : Springer US, 2016 38(2012), 2 vom: 29. Sept., Seite 290-296 (DE-627)847023133 (DE-600)2845742-0 2366-0058 nnns volume:38 year:2012 number:2 day:29 month:09 pages:290-296 https://dx.doi.org/10.1007/s00261-012-9952-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_150 GBV_ILN_2113 AR 38 2012 2 29 09 290-296 |
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10.1007/s00261-012-9952-9 doi (DE-627)SPR00319065X (SPR)s00261-012-9952-9-e DE-627 ger DE-627 rakwb eng Bartolozzi, Carlo verfasserin aut Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC 2012 Purpose To analyze Gd-EOB-DTPA-enhanced magnetic resonance (MR) findings of nodules (low-grade dysplastic nodules—LGDNs; high-grade dysplastic nodules—HGDN, and hepatocellular carcinoma—HCC), histologically identified on cirrhotic, explanted livers. Methods IRB approval was obtained for this study. Thirty-four patients underwent Gd-EOB-DTPA-enhanced MR examinations (1.5T system), that included 20-min delayed hepatobiliary (HB) phase imaging, before undergoing orthotopic liver transplantation (OLT; mean time MR-OLT: 2.7 months). A total of 102 hepatic nodules were identified and analyzed at histopathological examination, and classified as LGDN, HGDN, and HCC. Two radiologists by consensus performed a quantitative (enhancement ratios, ERs) and a qualitative analyses of signal intensities of identified nodules on vascular dynamic phases (30–35 s after injection–arterial phase; 180–190 s after injection late phase) and on HB phases. Correlation between nodules MR patterns and histological classification was analyzed by means of dedicated statistical software. Results No differences were appreciable among ERs of HGDN and HCCs on HB phase (P > 0.001). Lesions’ enhancement on vascular dynamic and on HB phases significantly correlated to histological classification of nodules (P < 0.0001). Nodular hyperintensity on arterial phase and hypointensity on late phase were highly predictive for HCC (PPV 100%), with a moderate sensitivity (72.5%). Nodular hypointensity on HB phase was detected on 39/40 HCCs (sensitivity 97.5%) and in 21/30 HGDNs, whereas no LGDN showed it. Conclusions Hyperenhancement on arterial phase and hypointensity on late phase are the most specific clues for the diagnosis of HCC. Hypointensity on HB phase shows a PPV of 100% in suggesting nodular premalignancy/malignancy, independently from nodular dynamic vascular enhancement. HCC (dpeaa)DE-He213 Magnetic resonance (dpeaa)DE-He213 Gd-EOB-DTPA (dpeaa)DE-He213 High grade dysplastic nodule (dpeaa)DE-He213 Cirrhosis (dpeaa)DE-He213 Battaglia, Valentina aut Bargellini, Irene aut Bozzi, Elena aut Campani, Daniela aut Pollina, Luca Emanuele aut Filipponi, Franco aut Enthalten in Abdominal radiology [Boston, MA] : Springer US, 2016 38(2012), 2 vom: 29. Sept., Seite 290-296 (DE-627)847023133 (DE-600)2845742-0 2366-0058 nnns volume:38 year:2012 number:2 day:29 month:09 pages:290-296 https://dx.doi.org/10.1007/s00261-012-9952-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_150 GBV_ILN_2113 AR 38 2012 2 29 09 290-296 |
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10.1007/s00261-012-9952-9 doi (DE-627)SPR00319065X (SPR)s00261-012-9952-9-e DE-627 ger DE-627 rakwb eng Bartolozzi, Carlo verfasserin aut Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC 2012 Purpose To analyze Gd-EOB-DTPA-enhanced magnetic resonance (MR) findings of nodules (low-grade dysplastic nodules—LGDNs; high-grade dysplastic nodules—HGDN, and hepatocellular carcinoma—HCC), histologically identified on cirrhotic, explanted livers. Methods IRB approval was obtained for this study. Thirty-four patients underwent Gd-EOB-DTPA-enhanced MR examinations (1.5T system), that included 20-min delayed hepatobiliary (HB) phase imaging, before undergoing orthotopic liver transplantation (OLT; mean time MR-OLT: 2.7 months). A total of 102 hepatic nodules were identified and analyzed at histopathological examination, and classified as LGDN, HGDN, and HCC. Two radiologists by consensus performed a quantitative (enhancement ratios, ERs) and a qualitative analyses of signal intensities of identified nodules on vascular dynamic phases (30–35 s after injection–arterial phase; 180–190 s after injection late phase) and on HB phases. Correlation between nodules MR patterns and histological classification was analyzed by means of dedicated statistical software. Results No differences were appreciable among ERs of HGDN and HCCs on HB phase (P > 0.001). Lesions’ enhancement on vascular dynamic and on HB phases significantly correlated to histological classification of nodules (P < 0.0001). Nodular hyperintensity on arterial phase and hypointensity on late phase were highly predictive for HCC (PPV 100%), with a moderate sensitivity (72.5%). Nodular hypointensity on HB phase was detected on 39/40 HCCs (sensitivity 97.5%) and in 21/30 HGDNs, whereas no LGDN showed it. Conclusions Hyperenhancement on arterial phase and hypointensity on late phase are the most specific clues for the diagnosis of HCC. Hypointensity on HB phase shows a PPV of 100% in suggesting nodular premalignancy/malignancy, independently from nodular dynamic vascular enhancement. HCC (dpeaa)DE-He213 Magnetic resonance (dpeaa)DE-He213 Gd-EOB-DTPA (dpeaa)DE-He213 High grade dysplastic nodule (dpeaa)DE-He213 Cirrhosis (dpeaa)DE-He213 Battaglia, Valentina aut Bargellini, Irene aut Bozzi, Elena aut Campani, Daniela aut Pollina, Luca Emanuele aut Filipponi, Franco aut Enthalten in Abdominal radiology [Boston, MA] : Springer US, 2016 38(2012), 2 vom: 29. Sept., Seite 290-296 (DE-627)847023133 (DE-600)2845742-0 2366-0058 nnns volume:38 year:2012 number:2 day:29 month:09 pages:290-296 https://dx.doi.org/10.1007/s00261-012-9952-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_150 GBV_ILN_2113 AR 38 2012 2 29 09 290-296 |
| allfieldsGer |
10.1007/s00261-012-9952-9 doi (DE-627)SPR00319065X (SPR)s00261-012-9952-9-e DE-627 ger DE-627 rakwb eng Bartolozzi, Carlo verfasserin aut Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC 2012 Purpose To analyze Gd-EOB-DTPA-enhanced magnetic resonance (MR) findings of nodules (low-grade dysplastic nodules—LGDNs; high-grade dysplastic nodules—HGDN, and hepatocellular carcinoma—HCC), histologically identified on cirrhotic, explanted livers. Methods IRB approval was obtained for this study. Thirty-four patients underwent Gd-EOB-DTPA-enhanced MR examinations (1.5T system), that included 20-min delayed hepatobiliary (HB) phase imaging, before undergoing orthotopic liver transplantation (OLT; mean time MR-OLT: 2.7 months). A total of 102 hepatic nodules were identified and analyzed at histopathological examination, and classified as LGDN, HGDN, and HCC. Two radiologists by consensus performed a quantitative (enhancement ratios, ERs) and a qualitative analyses of signal intensities of identified nodules on vascular dynamic phases (30–35 s after injection–arterial phase; 180–190 s after injection late phase) and on HB phases. Correlation between nodules MR patterns and histological classification was analyzed by means of dedicated statistical software. Results No differences were appreciable among ERs of HGDN and HCCs on HB phase (P > 0.001). Lesions’ enhancement on vascular dynamic and on HB phases significantly correlated to histological classification of nodules (P < 0.0001). Nodular hyperintensity on arterial phase and hypointensity on late phase were highly predictive for HCC (PPV 100%), with a moderate sensitivity (72.5%). Nodular hypointensity on HB phase was detected on 39/40 HCCs (sensitivity 97.5%) and in 21/30 HGDNs, whereas no LGDN showed it. Conclusions Hyperenhancement on arterial phase and hypointensity on late phase are the most specific clues for the diagnosis of HCC. Hypointensity on HB phase shows a PPV of 100% in suggesting nodular premalignancy/malignancy, independently from nodular dynamic vascular enhancement. HCC (dpeaa)DE-He213 Magnetic resonance (dpeaa)DE-He213 Gd-EOB-DTPA (dpeaa)DE-He213 High grade dysplastic nodule (dpeaa)DE-He213 Cirrhosis (dpeaa)DE-He213 Battaglia, Valentina aut Bargellini, Irene aut Bozzi, Elena aut Campani, Daniela aut Pollina, Luca Emanuele aut Filipponi, Franco aut Enthalten in Abdominal radiology [Boston, MA] : Springer US, 2016 38(2012), 2 vom: 29. Sept., Seite 290-296 (DE-627)847023133 (DE-600)2845742-0 2366-0058 nnns volume:38 year:2012 number:2 day:29 month:09 pages:290-296 https://dx.doi.org/10.1007/s00261-012-9952-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_150 GBV_ILN_2113 AR 38 2012 2 29 09 290-296 |
| allfieldsSound |
10.1007/s00261-012-9952-9 doi (DE-627)SPR00319065X (SPR)s00261-012-9952-9-e DE-627 ger DE-627 rakwb eng Bartolozzi, Carlo verfasserin aut Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC 2012 Purpose To analyze Gd-EOB-DTPA-enhanced magnetic resonance (MR) findings of nodules (low-grade dysplastic nodules—LGDNs; high-grade dysplastic nodules—HGDN, and hepatocellular carcinoma—HCC), histologically identified on cirrhotic, explanted livers. Methods IRB approval was obtained for this study. Thirty-four patients underwent Gd-EOB-DTPA-enhanced MR examinations (1.5T system), that included 20-min delayed hepatobiliary (HB) phase imaging, before undergoing orthotopic liver transplantation (OLT; mean time MR-OLT: 2.7 months). A total of 102 hepatic nodules were identified and analyzed at histopathological examination, and classified as LGDN, HGDN, and HCC. Two radiologists by consensus performed a quantitative (enhancement ratios, ERs) and a qualitative analyses of signal intensities of identified nodules on vascular dynamic phases (30–35 s after injection–arterial phase; 180–190 s after injection late phase) and on HB phases. Correlation between nodules MR patterns and histological classification was analyzed by means of dedicated statistical software. Results No differences were appreciable among ERs of HGDN and HCCs on HB phase (P > 0.001). Lesions’ enhancement on vascular dynamic and on HB phases significantly correlated to histological classification of nodules (P < 0.0001). Nodular hyperintensity on arterial phase and hypointensity on late phase were highly predictive for HCC (PPV 100%), with a moderate sensitivity (72.5%). Nodular hypointensity on HB phase was detected on 39/40 HCCs (sensitivity 97.5%) and in 21/30 HGDNs, whereas no LGDN showed it. Conclusions Hyperenhancement on arterial phase and hypointensity on late phase are the most specific clues for the diagnosis of HCC. Hypointensity on HB phase shows a PPV of 100% in suggesting nodular premalignancy/malignancy, independently from nodular dynamic vascular enhancement. HCC (dpeaa)DE-He213 Magnetic resonance (dpeaa)DE-He213 Gd-EOB-DTPA (dpeaa)DE-He213 High grade dysplastic nodule (dpeaa)DE-He213 Cirrhosis (dpeaa)DE-He213 Battaglia, Valentina aut Bargellini, Irene aut Bozzi, Elena aut Campani, Daniela aut Pollina, Luca Emanuele aut Filipponi, Franco aut Enthalten in Abdominal radiology [Boston, MA] : Springer US, 2016 38(2012), 2 vom: 29. Sept., Seite 290-296 (DE-627)847023133 (DE-600)2845742-0 2366-0058 nnns volume:38 year:2012 number:2 day:29 month:09 pages:290-296 https://dx.doi.org/10.1007/s00261-012-9952-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_150 GBV_ILN_2113 AR 38 2012 2 29 09 290-296 |
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Enthalten in Abdominal radiology 38(2012), 2 vom: 29. Sept., Seite 290-296 volume:38 year:2012 number:2 day:29 month:09 pages:290-296 |
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Methods IRB approval was obtained for this study. Thirty-four patients underwent Gd-EOB-DTPA-enhanced MR examinations (1.5T system), that included 20-min delayed hepatobiliary (HB) phase imaging, before undergoing orthotopic liver transplantation (OLT; mean time MR-OLT: 2.7 months). A total of 102 hepatic nodules were identified and analyzed at histopathological examination, and classified as LGDN, HGDN, and HCC. Two radiologists by consensus performed a quantitative (enhancement ratios, ERs) and a qualitative analyses of signal intensities of identified nodules on vascular dynamic phases (30–35 s after injection–arterial phase; 180–190 s after injection late phase) and on HB phases. Correlation between nodules MR patterns and histological classification was analyzed by means of dedicated statistical software. Results No differences were appreciable among ERs of HGDN and HCCs on HB phase (P > 0.001). Lesions’ enhancement on vascular dynamic and on HB phases significantly correlated to histological classification of nodules (P < 0.0001). Nodular hyperintensity on arterial phase and hypointensity on late phase were highly predictive for HCC (PPV 100%), with a moderate sensitivity (72.5%). Nodular hypointensity on HB phase was detected on 39/40 HCCs (sensitivity 97.5%) and in 21/30 HGDNs, whereas no LGDN showed it. Conclusions Hyperenhancement on arterial phase and hypointensity on late phase are the most specific clues for the diagnosis of HCC. 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Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers HCC (dpeaa)DE-He213 Magnetic resonance (dpeaa)DE-He213 Gd-EOB-DTPA (dpeaa)DE-He213 High grade dysplastic nodule (dpeaa)DE-He213 Cirrhosis (dpeaa)DE-He213 |
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Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers |
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contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers |
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Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers |
| abstract |
Purpose To analyze Gd-EOB-DTPA-enhanced magnetic resonance (MR) findings of nodules (low-grade dysplastic nodules—LGDNs; high-grade dysplastic nodules—HGDN, and hepatocellular carcinoma—HCC), histologically identified on cirrhotic, explanted livers. Methods IRB approval was obtained for this study. Thirty-four patients underwent Gd-EOB-DTPA-enhanced MR examinations (1.5T system), that included 20-min delayed hepatobiliary (HB) phase imaging, before undergoing orthotopic liver transplantation (OLT; mean time MR-OLT: 2.7 months). A total of 102 hepatic nodules were identified and analyzed at histopathological examination, and classified as LGDN, HGDN, and HCC. Two radiologists by consensus performed a quantitative (enhancement ratios, ERs) and a qualitative analyses of signal intensities of identified nodules on vascular dynamic phases (30–35 s after injection–arterial phase; 180–190 s after injection late phase) and on HB phases. Correlation between nodules MR patterns and histological classification was analyzed by means of dedicated statistical software. Results No differences were appreciable among ERs of HGDN and HCCs on HB phase (P > 0.001). Lesions’ enhancement on vascular dynamic and on HB phases significantly correlated to histological classification of nodules (P < 0.0001). Nodular hyperintensity on arterial phase and hypointensity on late phase were highly predictive for HCC (PPV 100%), with a moderate sensitivity (72.5%). Nodular hypointensity on HB phase was detected on 39/40 HCCs (sensitivity 97.5%) and in 21/30 HGDNs, whereas no LGDN showed it. Conclusions Hyperenhancement on arterial phase and hypointensity on late phase are the most specific clues for the diagnosis of HCC. Hypointensity on HB phase shows a PPV of 100% in suggesting nodular premalignancy/malignancy, independently from nodular dynamic vascular enhancement. © Springer Science+Business Media, LLC 2012 |
| abstractGer |
Purpose To analyze Gd-EOB-DTPA-enhanced magnetic resonance (MR) findings of nodules (low-grade dysplastic nodules—LGDNs; high-grade dysplastic nodules—HGDN, and hepatocellular carcinoma—HCC), histologically identified on cirrhotic, explanted livers. Methods IRB approval was obtained for this study. Thirty-four patients underwent Gd-EOB-DTPA-enhanced MR examinations (1.5T system), that included 20-min delayed hepatobiliary (HB) phase imaging, before undergoing orthotopic liver transplantation (OLT; mean time MR-OLT: 2.7 months). A total of 102 hepatic nodules were identified and analyzed at histopathological examination, and classified as LGDN, HGDN, and HCC. Two radiologists by consensus performed a quantitative (enhancement ratios, ERs) and a qualitative analyses of signal intensities of identified nodules on vascular dynamic phases (30–35 s after injection–arterial phase; 180–190 s after injection late phase) and on HB phases. Correlation between nodules MR patterns and histological classification was analyzed by means of dedicated statistical software. Results No differences were appreciable among ERs of HGDN and HCCs on HB phase (P > 0.001). Lesions’ enhancement on vascular dynamic and on HB phases significantly correlated to histological classification of nodules (P < 0.0001). Nodular hyperintensity on arterial phase and hypointensity on late phase were highly predictive for HCC (PPV 100%), with a moderate sensitivity (72.5%). Nodular hypointensity on HB phase was detected on 39/40 HCCs (sensitivity 97.5%) and in 21/30 HGDNs, whereas no LGDN showed it. Conclusions Hyperenhancement on arterial phase and hypointensity on late phase are the most specific clues for the diagnosis of HCC. Hypointensity on HB phase shows a PPV of 100% in suggesting nodular premalignancy/malignancy, independently from nodular dynamic vascular enhancement. © Springer Science+Business Media, LLC 2012 |
| abstract_unstemmed |
Purpose To analyze Gd-EOB-DTPA-enhanced magnetic resonance (MR) findings of nodules (low-grade dysplastic nodules—LGDNs; high-grade dysplastic nodules—HGDN, and hepatocellular carcinoma—HCC), histologically identified on cirrhotic, explanted livers. Methods IRB approval was obtained for this study. Thirty-four patients underwent Gd-EOB-DTPA-enhanced MR examinations (1.5T system), that included 20-min delayed hepatobiliary (HB) phase imaging, before undergoing orthotopic liver transplantation (OLT; mean time MR-OLT: 2.7 months). A total of 102 hepatic nodules were identified and analyzed at histopathological examination, and classified as LGDN, HGDN, and HCC. Two radiologists by consensus performed a quantitative (enhancement ratios, ERs) and a qualitative analyses of signal intensities of identified nodules on vascular dynamic phases (30–35 s after injection–arterial phase; 180–190 s after injection late phase) and on HB phases. Correlation between nodules MR patterns and histological classification was analyzed by means of dedicated statistical software. Results No differences were appreciable among ERs of HGDN and HCCs on HB phase (P > 0.001). Lesions’ enhancement on vascular dynamic and on HB phases significantly correlated to histological classification of nodules (P < 0.0001). Nodular hyperintensity on arterial phase and hypointensity on late phase were highly predictive for HCC (PPV 100%), with a moderate sensitivity (72.5%). Nodular hypointensity on HB phase was detected on 39/40 HCCs (sensitivity 97.5%) and in 21/30 HGDNs, whereas no LGDN showed it. Conclusions Hyperenhancement on arterial phase and hypointensity on late phase are the most specific clues for the diagnosis of HCC. Hypointensity on HB phase shows a PPV of 100% in suggesting nodular premalignancy/malignancy, independently from nodular dynamic vascular enhancement. © Springer Science+Business Media, LLC 2012 |
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