Perfusion CT: Can it predict the development of pancreatic necrosis in early stage of severe acute pancreatitis?
Purpose Pancreatic necrosis is an important determinant of patient outcome in severe acute pancreatitis (SAP). This prospective study was conducted to evaluate if perfusion CT (PCT) can predict the development of necrosis at an early stage in SAP. Methods PCT was performed within 72 h of abdominal p...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yadav, Ajay Kumar [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science+Business Media New York 2014 |
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| Übergeordnetes Werk: |
Enthalten in: Abdominal radiology - [Boston, MA] : Springer US, 2016, 40(2014), 3 vom: 31. Aug., Seite 488-499 |
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| Übergeordnetes Werk: |
volume:40 ; year:2014 ; number:3 ; day:31 ; month:08 ; pages:488-499 |
| Links: |
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| DOI / URN: |
10.1007/s00261-014-0226-6 |
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SPR003193942 |
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| 520 | |a Purpose Pancreatic necrosis is an important determinant of patient outcome in severe acute pancreatitis (SAP). This prospective study was conducted to evaluate if perfusion CT (PCT) can predict the development of necrosis at an early stage in SAP. Methods PCT was performed within 72 h of abdominal pain in 57 consecutive admitted patients of acute pancreatitis, out of which four patients were excluded. Thirty-two patients were classified as SAP and 21 as mild acute pancreatitis (MAP) on the basis of APACHE II or SIRS criteria or presence of organ failure. All patients underwent a follow-up CECT at 3 weeks to look for pancreatic necrosis. Results Out of 32 patients of SAP, 14 patients showed perfusion defects. The mean blood flow (BF) in these areas was 11.47 ± 5.56 mL/100 mL/min and median blood volume (BV) was 3.92 mL/100 mL (0.5–8.49 mL/100 mL). All these patients developed necrosis on follow-up scan. Two patients who did not show perfusion defects also developed necrosis. Remaining 37 patients (16 SAP and 21 MAP) did not show perfusion defect and did not develop necrosis on follow-up. All regions showing BF less than ≤23.45 mL/100 mL/min and BV ≤8.49 mL/100 mL developed pancreatic necrosis. The values of perfusion parameters may vary with the scanner, mathematical model and protocol used. The sensitivity and specificity of PCT for predicting pancreatic necrosis were 87.5% and 100%, respectively. The cut off values of BF and BV for predicting the development of pancreatic necrosis were 27.29 mL/100 mL/min and 8.96 mL/100 mL, respectively, based on ROC curve. Summary PCT is a reliable tool for early prediction of pancreatic necrosis, which may open new avenues to prevent this ominous complication. | ||
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| 700 | 1 | |a Garg, Pramod Kumar |4 aut | |
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10.1007/s00261-014-0226-6 doi (DE-627)SPR003193942 (SPR)s00261-014-0226-6-e DE-627 ger DE-627 rakwb eng Yadav, Ajay Kumar verfasserin aut Perfusion CT: Can it predict the development of pancreatic necrosis in early stage of severe acute pancreatitis? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media New York 2014 Purpose Pancreatic necrosis is an important determinant of patient outcome in severe acute pancreatitis (SAP). This prospective study was conducted to evaluate if perfusion CT (PCT) can predict the development of necrosis at an early stage in SAP. Methods PCT was performed within 72 h of abdominal pain in 57 consecutive admitted patients of acute pancreatitis, out of which four patients were excluded. Thirty-two patients were classified as SAP and 21 as mild acute pancreatitis (MAP) on the basis of APACHE II or SIRS criteria or presence of organ failure. All patients underwent a follow-up CECT at 3 weeks to look for pancreatic necrosis. Results Out of 32 patients of SAP, 14 patients showed perfusion defects. The mean blood flow (BF) in these areas was 11.47 ± 5.56 mL/100 mL/min and median blood volume (BV) was 3.92 mL/100 mL (0.5–8.49 mL/100 mL). All these patients developed necrosis on follow-up scan. Two patients who did not show perfusion defects also developed necrosis. Remaining 37 patients (16 SAP and 21 MAP) did not show perfusion defect and did not develop necrosis on follow-up. All regions showing BF less than ≤23.45 mL/100 mL/min and BV ≤8.49 mL/100 mL developed pancreatic necrosis. The values of perfusion parameters may vary with the scanner, mathematical model and protocol used. The sensitivity and specificity of PCT for predicting pancreatic necrosis were 87.5% and 100%, respectively. The cut off values of BF and BV for predicting the development of pancreatic necrosis were 27.29 mL/100 mL/min and 8.96 mL/100 mL, respectively, based on ROC curve. Summary PCT is a reliable tool for early prediction of pancreatic necrosis, which may open new avenues to prevent this ominous complication. Pancreas (dpeaa)DE-He213 Perfusion CT (dpeaa)DE-He213 Severe acute pancreatitis (dpeaa)DE-He213 Sharma, Raju aut Kandasamy, Devasenathipathy aut Bhalla, Ashu Seith aut Gamanagatti, Shivanand aut Srivastava, Deep N. aut Upadhyay, Ashish Datt aut Garg, Pramod Kumar aut Enthalten in Abdominal radiology [Boston, MA] : Springer US, 2016 40(2014), 3 vom: 31. Aug., Seite 488-499 (DE-627)847023133 (DE-600)2845742-0 2366-0058 nnns volume:40 year:2014 number:3 day:31 month:08 pages:488-499 https://dx.doi.org/10.1007/s00261-014-0226-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_150 GBV_ILN_2113 AR 40 2014 3 31 08 488-499 |
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10.1007/s00261-014-0226-6 doi (DE-627)SPR003193942 (SPR)s00261-014-0226-6-e DE-627 ger DE-627 rakwb eng Yadav, Ajay Kumar verfasserin aut Perfusion CT: Can it predict the development of pancreatic necrosis in early stage of severe acute pancreatitis? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media New York 2014 Purpose Pancreatic necrosis is an important determinant of patient outcome in severe acute pancreatitis (SAP). This prospective study was conducted to evaluate if perfusion CT (PCT) can predict the development of necrosis at an early stage in SAP. Methods PCT was performed within 72 h of abdominal pain in 57 consecutive admitted patients of acute pancreatitis, out of which four patients were excluded. Thirty-two patients were classified as SAP and 21 as mild acute pancreatitis (MAP) on the basis of APACHE II or SIRS criteria or presence of organ failure. All patients underwent a follow-up CECT at 3 weeks to look for pancreatic necrosis. Results Out of 32 patients of SAP, 14 patients showed perfusion defects. The mean blood flow (BF) in these areas was 11.47 ± 5.56 mL/100 mL/min and median blood volume (BV) was 3.92 mL/100 mL (0.5–8.49 mL/100 mL). All these patients developed necrosis on follow-up scan. Two patients who did not show perfusion defects also developed necrosis. Remaining 37 patients (16 SAP and 21 MAP) did not show perfusion defect and did not develop necrosis on follow-up. All regions showing BF less than ≤23.45 mL/100 mL/min and BV ≤8.49 mL/100 mL developed pancreatic necrosis. The values of perfusion parameters may vary with the scanner, mathematical model and protocol used. The sensitivity and specificity of PCT for predicting pancreatic necrosis were 87.5% and 100%, respectively. The cut off values of BF and BV for predicting the development of pancreatic necrosis were 27.29 mL/100 mL/min and 8.96 mL/100 mL, respectively, based on ROC curve. Summary PCT is a reliable tool for early prediction of pancreatic necrosis, which may open new avenues to prevent this ominous complication. Pancreas (dpeaa)DE-He213 Perfusion CT (dpeaa)DE-He213 Severe acute pancreatitis (dpeaa)DE-He213 Sharma, Raju aut Kandasamy, Devasenathipathy aut Bhalla, Ashu Seith aut Gamanagatti, Shivanand aut Srivastava, Deep N. aut Upadhyay, Ashish Datt aut Garg, Pramod Kumar aut Enthalten in Abdominal radiology [Boston, MA] : Springer US, 2016 40(2014), 3 vom: 31. Aug., Seite 488-499 (DE-627)847023133 (DE-600)2845742-0 2366-0058 nnns volume:40 year:2014 number:3 day:31 month:08 pages:488-499 https://dx.doi.org/10.1007/s00261-014-0226-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_150 GBV_ILN_2113 AR 40 2014 3 31 08 488-499 |
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10.1007/s00261-014-0226-6 doi (DE-627)SPR003193942 (SPR)s00261-014-0226-6-e DE-627 ger DE-627 rakwb eng Yadav, Ajay Kumar verfasserin aut Perfusion CT: Can it predict the development of pancreatic necrosis in early stage of severe acute pancreatitis? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media New York 2014 Purpose Pancreatic necrosis is an important determinant of patient outcome in severe acute pancreatitis (SAP). This prospective study was conducted to evaluate if perfusion CT (PCT) can predict the development of necrosis at an early stage in SAP. Methods PCT was performed within 72 h of abdominal pain in 57 consecutive admitted patients of acute pancreatitis, out of which four patients were excluded. Thirty-two patients were classified as SAP and 21 as mild acute pancreatitis (MAP) on the basis of APACHE II or SIRS criteria or presence of organ failure. All patients underwent a follow-up CECT at 3 weeks to look for pancreatic necrosis. Results Out of 32 patients of SAP, 14 patients showed perfusion defects. The mean blood flow (BF) in these areas was 11.47 ± 5.56 mL/100 mL/min and median blood volume (BV) was 3.92 mL/100 mL (0.5–8.49 mL/100 mL). All these patients developed necrosis on follow-up scan. Two patients who did not show perfusion defects also developed necrosis. Remaining 37 patients (16 SAP and 21 MAP) did not show perfusion defect and did not develop necrosis on follow-up. All regions showing BF less than ≤23.45 mL/100 mL/min and BV ≤8.49 mL/100 mL developed pancreatic necrosis. The values of perfusion parameters may vary with the scanner, mathematical model and protocol used. The sensitivity and specificity of PCT for predicting pancreatic necrosis were 87.5% and 100%, respectively. The cut off values of BF and BV for predicting the development of pancreatic necrosis were 27.29 mL/100 mL/min and 8.96 mL/100 mL, respectively, based on ROC curve. Summary PCT is a reliable tool for early prediction of pancreatic necrosis, which may open new avenues to prevent this ominous complication. Pancreas (dpeaa)DE-He213 Perfusion CT (dpeaa)DE-He213 Severe acute pancreatitis (dpeaa)DE-He213 Sharma, Raju aut Kandasamy, Devasenathipathy aut Bhalla, Ashu Seith aut Gamanagatti, Shivanand aut Srivastava, Deep N. aut Upadhyay, Ashish Datt aut Garg, Pramod Kumar aut Enthalten in Abdominal radiology [Boston, MA] : Springer US, 2016 40(2014), 3 vom: 31. Aug., Seite 488-499 (DE-627)847023133 (DE-600)2845742-0 2366-0058 nnns volume:40 year:2014 number:3 day:31 month:08 pages:488-499 https://dx.doi.org/10.1007/s00261-014-0226-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_150 GBV_ILN_2113 AR 40 2014 3 31 08 488-499 |
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10.1007/s00261-014-0226-6 doi (DE-627)SPR003193942 (SPR)s00261-014-0226-6-e DE-627 ger DE-627 rakwb eng Yadav, Ajay Kumar verfasserin aut Perfusion CT: Can it predict the development of pancreatic necrosis in early stage of severe acute pancreatitis? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media New York 2014 Purpose Pancreatic necrosis is an important determinant of patient outcome in severe acute pancreatitis (SAP). This prospective study was conducted to evaluate if perfusion CT (PCT) can predict the development of necrosis at an early stage in SAP. Methods PCT was performed within 72 h of abdominal pain in 57 consecutive admitted patients of acute pancreatitis, out of which four patients were excluded. Thirty-two patients were classified as SAP and 21 as mild acute pancreatitis (MAP) on the basis of APACHE II or SIRS criteria or presence of organ failure. All patients underwent a follow-up CECT at 3 weeks to look for pancreatic necrosis. Results Out of 32 patients of SAP, 14 patients showed perfusion defects. The mean blood flow (BF) in these areas was 11.47 ± 5.56 mL/100 mL/min and median blood volume (BV) was 3.92 mL/100 mL (0.5–8.49 mL/100 mL). All these patients developed necrosis on follow-up scan. Two patients who did not show perfusion defects also developed necrosis. Remaining 37 patients (16 SAP and 21 MAP) did not show perfusion defect and did not develop necrosis on follow-up. All regions showing BF less than ≤23.45 mL/100 mL/min and BV ≤8.49 mL/100 mL developed pancreatic necrosis. The values of perfusion parameters may vary with the scanner, mathematical model and protocol used. The sensitivity and specificity of PCT for predicting pancreatic necrosis were 87.5% and 100%, respectively. The cut off values of BF and BV for predicting the development of pancreatic necrosis were 27.29 mL/100 mL/min and 8.96 mL/100 mL, respectively, based on ROC curve. Summary PCT is a reliable tool for early prediction of pancreatic necrosis, which may open new avenues to prevent this ominous complication. Pancreas (dpeaa)DE-He213 Perfusion CT (dpeaa)DE-He213 Severe acute pancreatitis (dpeaa)DE-He213 Sharma, Raju aut Kandasamy, Devasenathipathy aut Bhalla, Ashu Seith aut Gamanagatti, Shivanand aut Srivastava, Deep N. aut Upadhyay, Ashish Datt aut Garg, Pramod Kumar aut Enthalten in Abdominal radiology [Boston, MA] : Springer US, 2016 40(2014), 3 vom: 31. Aug., Seite 488-499 (DE-627)847023133 (DE-600)2845742-0 2366-0058 nnns volume:40 year:2014 number:3 day:31 month:08 pages:488-499 https://dx.doi.org/10.1007/s00261-014-0226-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_150 GBV_ILN_2113 AR 40 2014 3 31 08 488-499 |
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10.1007/s00261-014-0226-6 doi (DE-627)SPR003193942 (SPR)s00261-014-0226-6-e DE-627 ger DE-627 rakwb eng Yadav, Ajay Kumar verfasserin aut Perfusion CT: Can it predict the development of pancreatic necrosis in early stage of severe acute pancreatitis? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media New York 2014 Purpose Pancreatic necrosis is an important determinant of patient outcome in severe acute pancreatitis (SAP). This prospective study was conducted to evaluate if perfusion CT (PCT) can predict the development of necrosis at an early stage in SAP. Methods PCT was performed within 72 h of abdominal pain in 57 consecutive admitted patients of acute pancreatitis, out of which four patients were excluded. Thirty-two patients were classified as SAP and 21 as mild acute pancreatitis (MAP) on the basis of APACHE II or SIRS criteria or presence of organ failure. All patients underwent a follow-up CECT at 3 weeks to look for pancreatic necrosis. Results Out of 32 patients of SAP, 14 patients showed perfusion defects. The mean blood flow (BF) in these areas was 11.47 ± 5.56 mL/100 mL/min and median blood volume (BV) was 3.92 mL/100 mL (0.5–8.49 mL/100 mL). All these patients developed necrosis on follow-up scan. Two patients who did not show perfusion defects also developed necrosis. Remaining 37 patients (16 SAP and 21 MAP) did not show perfusion defect and did not develop necrosis on follow-up. All regions showing BF less than ≤23.45 mL/100 mL/min and BV ≤8.49 mL/100 mL developed pancreatic necrosis. The values of perfusion parameters may vary with the scanner, mathematical model and protocol used. The sensitivity and specificity of PCT for predicting pancreatic necrosis were 87.5% and 100%, respectively. The cut off values of BF and BV for predicting the development of pancreatic necrosis were 27.29 mL/100 mL/min and 8.96 mL/100 mL, respectively, based on ROC curve. Summary PCT is a reliable tool for early prediction of pancreatic necrosis, which may open new avenues to prevent this ominous complication. Pancreas (dpeaa)DE-He213 Perfusion CT (dpeaa)DE-He213 Severe acute pancreatitis (dpeaa)DE-He213 Sharma, Raju aut Kandasamy, Devasenathipathy aut Bhalla, Ashu Seith aut Gamanagatti, Shivanand aut Srivastava, Deep N. aut Upadhyay, Ashish Datt aut Garg, Pramod Kumar aut Enthalten in Abdominal radiology [Boston, MA] : Springer US, 2016 40(2014), 3 vom: 31. Aug., Seite 488-499 (DE-627)847023133 (DE-600)2845742-0 2366-0058 nnns volume:40 year:2014 number:3 day:31 month:08 pages:488-499 https://dx.doi.org/10.1007/s00261-014-0226-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_150 GBV_ILN_2113 AR 40 2014 3 31 08 488-499 |
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Perfusion CT: Can it predict the development of pancreatic necrosis in early stage of severe acute pancreatitis? Pancreas (dpeaa)DE-He213 Perfusion CT (dpeaa)DE-He213 Severe acute pancreatitis (dpeaa)DE-He213 |
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Yadav, Ajay Kumar Sharma, Raju Kandasamy, Devasenathipathy Bhalla, Ashu Seith Gamanagatti, Shivanand Srivastava, Deep N. Upadhyay, Ashish Datt Garg, Pramod Kumar |
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perfusion ct: can it predict the development of pancreatic necrosis in early stage of severe acute pancreatitis? |
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Perfusion CT: Can it predict the development of pancreatic necrosis in early stage of severe acute pancreatitis? |
| abstract |
Purpose Pancreatic necrosis is an important determinant of patient outcome in severe acute pancreatitis (SAP). This prospective study was conducted to evaluate if perfusion CT (PCT) can predict the development of necrosis at an early stage in SAP. Methods PCT was performed within 72 h of abdominal pain in 57 consecutive admitted patients of acute pancreatitis, out of which four patients were excluded. Thirty-two patients were classified as SAP and 21 as mild acute pancreatitis (MAP) on the basis of APACHE II or SIRS criteria or presence of organ failure. All patients underwent a follow-up CECT at 3 weeks to look for pancreatic necrosis. Results Out of 32 patients of SAP, 14 patients showed perfusion defects. The mean blood flow (BF) in these areas was 11.47 ± 5.56 mL/100 mL/min and median blood volume (BV) was 3.92 mL/100 mL (0.5–8.49 mL/100 mL). All these patients developed necrosis on follow-up scan. Two patients who did not show perfusion defects also developed necrosis. Remaining 37 patients (16 SAP and 21 MAP) did not show perfusion defect and did not develop necrosis on follow-up. All regions showing BF less than ≤23.45 mL/100 mL/min and BV ≤8.49 mL/100 mL developed pancreatic necrosis. The values of perfusion parameters may vary with the scanner, mathematical model and protocol used. The sensitivity and specificity of PCT for predicting pancreatic necrosis were 87.5% and 100%, respectively. The cut off values of BF and BV for predicting the development of pancreatic necrosis were 27.29 mL/100 mL/min and 8.96 mL/100 mL, respectively, based on ROC curve. Summary PCT is a reliable tool for early prediction of pancreatic necrosis, which may open new avenues to prevent this ominous complication. © Springer Science+Business Media New York 2014 |
| abstractGer |
Purpose Pancreatic necrosis is an important determinant of patient outcome in severe acute pancreatitis (SAP). This prospective study was conducted to evaluate if perfusion CT (PCT) can predict the development of necrosis at an early stage in SAP. Methods PCT was performed within 72 h of abdominal pain in 57 consecutive admitted patients of acute pancreatitis, out of which four patients were excluded. Thirty-two patients were classified as SAP and 21 as mild acute pancreatitis (MAP) on the basis of APACHE II or SIRS criteria or presence of organ failure. All patients underwent a follow-up CECT at 3 weeks to look for pancreatic necrosis. Results Out of 32 patients of SAP, 14 patients showed perfusion defects. The mean blood flow (BF) in these areas was 11.47 ± 5.56 mL/100 mL/min and median blood volume (BV) was 3.92 mL/100 mL (0.5–8.49 mL/100 mL). All these patients developed necrosis on follow-up scan. Two patients who did not show perfusion defects also developed necrosis. Remaining 37 patients (16 SAP and 21 MAP) did not show perfusion defect and did not develop necrosis on follow-up. All regions showing BF less than ≤23.45 mL/100 mL/min and BV ≤8.49 mL/100 mL developed pancreatic necrosis. The values of perfusion parameters may vary with the scanner, mathematical model and protocol used. The sensitivity and specificity of PCT for predicting pancreatic necrosis were 87.5% and 100%, respectively. The cut off values of BF and BV for predicting the development of pancreatic necrosis were 27.29 mL/100 mL/min and 8.96 mL/100 mL, respectively, based on ROC curve. Summary PCT is a reliable tool for early prediction of pancreatic necrosis, which may open new avenues to prevent this ominous complication. © Springer Science+Business Media New York 2014 |
| abstract_unstemmed |
Purpose Pancreatic necrosis is an important determinant of patient outcome in severe acute pancreatitis (SAP). This prospective study was conducted to evaluate if perfusion CT (PCT) can predict the development of necrosis at an early stage in SAP. Methods PCT was performed within 72 h of abdominal pain in 57 consecutive admitted patients of acute pancreatitis, out of which four patients were excluded. Thirty-two patients were classified as SAP and 21 as mild acute pancreatitis (MAP) on the basis of APACHE II or SIRS criteria or presence of organ failure. All patients underwent a follow-up CECT at 3 weeks to look for pancreatic necrosis. Results Out of 32 patients of SAP, 14 patients showed perfusion defects. The mean blood flow (BF) in these areas was 11.47 ± 5.56 mL/100 mL/min and median blood volume (BV) was 3.92 mL/100 mL (0.5–8.49 mL/100 mL). All these patients developed necrosis on follow-up scan. Two patients who did not show perfusion defects also developed necrosis. Remaining 37 patients (16 SAP and 21 MAP) did not show perfusion defect and did not develop necrosis on follow-up. All regions showing BF less than ≤23.45 mL/100 mL/min and BV ≤8.49 mL/100 mL developed pancreatic necrosis. The values of perfusion parameters may vary with the scanner, mathematical model and protocol used. The sensitivity and specificity of PCT for predicting pancreatic necrosis were 87.5% and 100%, respectively. The cut off values of BF and BV for predicting the development of pancreatic necrosis were 27.29 mL/100 mL/min and 8.96 mL/100 mL, respectively, based on ROC curve. Summary PCT is a reliable tool for early prediction of pancreatic necrosis, which may open new avenues to prevent this ominous complication. © Springer Science+Business Media New York 2014 |
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