$ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients
Abstract The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL sub...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Napolitano, Maria [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2009 |
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| Übergeordnetes Werk: |
Enthalten in: Cancer immunology immunotherapy - Berlin : Springer, 1976, 59(2009), 4 vom: 25. Sept., Seite 511-517 |
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| Übergeordnetes Werk: |
volume:59 ; year:2009 ; number:4 ; day:25 ; month:09 ; pages:511-517 |
| Links: |
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| DOI / URN: |
10.1007/s00262-009-0766-8 |
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| Katalog-ID: |
SPR003226964 |
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| 100 | 1 | |a Napolitano, Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients |
| 264 | 1 | |c 2009 | |
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| 520 | |a Abstract The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I–III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the $ χ^{2} $ test. The Kaplan–Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ higher than 25% of PBL showed a longer DFS. Conversely, $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ <25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes <25% of PBL, and 94% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ >25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers. | ||
| 650 | 4 | |a CXCR4 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Melanoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Prognosis |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ottaiano, Alessandro |4 aut | |
| 700 | 1 | |a Mauro, Francesca |4 aut | |
| 700 | 1 | |a Ieranò, Caterina |4 aut | |
| 700 | 1 | |a Satriano, Rocco |4 aut | |
| 700 | 1 | |a Pacelli, Roberto |4 aut | |
| 700 | 1 | |a Franco, Renato |4 aut | |
| 700 | 1 | |a De Angelis, Valentina |4 aut | |
| 700 | 1 | |a Castello, Giuseppe |4 aut | |
| 700 | 1 | |a Scala, Stefania |4 aut | |
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2009 |
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2009 |
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10.1007/s00262-009-0766-8 doi (DE-627)SPR003226964 (SPR)s00262-009-0766-8-e DE-627 ger DE-627 rakwb eng Napolitano, Maria verfasserin aut $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Abstract The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I–III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the $ χ^{2} $ test. The Kaplan–Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ higher than 25% of PBL showed a longer DFS. Conversely, $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ <25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes <25% of PBL, and 94% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ >25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers. CXCR4 (dpeaa)DE-He213 Melanoma (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Ottaiano, Alessandro aut Mauro, Francesca aut Ieranò, Caterina aut Satriano, Rocco aut Pacelli, Roberto aut Franco, Renato aut De Angelis, Valentina aut Castello, Giuseppe aut Scala, Stefania aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 59(2009), 4 vom: 25. Sept., Seite 511-517 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:59 year:2009 number:4 day:25 month:09 pages:511-517 https://dx.doi.org/10.1007/s00262-009-0766-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 59 2009 4 25 09 511-517 |
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10.1007/s00262-009-0766-8 doi (DE-627)SPR003226964 (SPR)s00262-009-0766-8-e DE-627 ger DE-627 rakwb eng Napolitano, Maria verfasserin aut $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Abstract The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I–III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the $ χ^{2} $ test. The Kaplan–Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ higher than 25% of PBL showed a longer DFS. Conversely, $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ <25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes <25% of PBL, and 94% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ >25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers. CXCR4 (dpeaa)DE-He213 Melanoma (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Ottaiano, Alessandro aut Mauro, Francesca aut Ieranò, Caterina aut Satriano, Rocco aut Pacelli, Roberto aut Franco, Renato aut De Angelis, Valentina aut Castello, Giuseppe aut Scala, Stefania aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 59(2009), 4 vom: 25. Sept., Seite 511-517 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:59 year:2009 number:4 day:25 month:09 pages:511-517 https://dx.doi.org/10.1007/s00262-009-0766-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 59 2009 4 25 09 511-517 |
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10.1007/s00262-009-0766-8 doi (DE-627)SPR003226964 (SPR)s00262-009-0766-8-e DE-627 ger DE-627 rakwb eng Napolitano, Maria verfasserin aut $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Abstract The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I–III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the $ χ^{2} $ test. The Kaplan–Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ higher than 25% of PBL showed a longer DFS. Conversely, $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ <25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes <25% of PBL, and 94% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ >25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers. CXCR4 (dpeaa)DE-He213 Melanoma (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Ottaiano, Alessandro aut Mauro, Francesca aut Ieranò, Caterina aut Satriano, Rocco aut Pacelli, Roberto aut Franco, Renato aut De Angelis, Valentina aut Castello, Giuseppe aut Scala, Stefania aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 59(2009), 4 vom: 25. Sept., Seite 511-517 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:59 year:2009 number:4 day:25 month:09 pages:511-517 https://dx.doi.org/10.1007/s00262-009-0766-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 59 2009 4 25 09 511-517 |
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10.1007/s00262-009-0766-8 doi (DE-627)SPR003226964 (SPR)s00262-009-0766-8-e DE-627 ger DE-627 rakwb eng Napolitano, Maria verfasserin aut $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Abstract The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I–III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the $ χ^{2} $ test. The Kaplan–Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ higher than 25% of PBL showed a longer DFS. Conversely, $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ <25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes <25% of PBL, and 94% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ >25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers. CXCR4 (dpeaa)DE-He213 Melanoma (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Ottaiano, Alessandro aut Mauro, Francesca aut Ieranò, Caterina aut Satriano, Rocco aut Pacelli, Roberto aut Franco, Renato aut De Angelis, Valentina aut Castello, Giuseppe aut Scala, Stefania aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 59(2009), 4 vom: 25. Sept., Seite 511-517 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:59 year:2009 number:4 day:25 month:09 pages:511-517 https://dx.doi.org/10.1007/s00262-009-0766-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 59 2009 4 25 09 511-517 |
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10.1007/s00262-009-0766-8 doi (DE-627)SPR003226964 (SPR)s00262-009-0766-8-e DE-627 ger DE-627 rakwb eng Napolitano, Maria verfasserin aut $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Abstract The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I–III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the $ χ^{2} $ test. The Kaplan–Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ higher than 25% of PBL showed a longer DFS. Conversely, $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ <25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes <25% of PBL, and 94% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ >25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers. CXCR4 (dpeaa)DE-He213 Melanoma (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Ottaiano, Alessandro aut Mauro, Francesca aut Ieranò, Caterina aut Satriano, Rocco aut Pacelli, Roberto aut Franco, Renato aut De Angelis, Valentina aut Castello, Giuseppe aut Scala, Stefania aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 59(2009), 4 vom: 25. Sept., Seite 511-517 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:59 year:2009 number:4 day:25 month:09 pages:511-517 https://dx.doi.org/10.1007/s00262-009-0766-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 59 2009 4 25 09 511-517 |
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English |
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Enthalten in Cancer immunology immunotherapy 59(2009), 4 vom: 25. Sept., Seite 511-517 volume:59 year:2009 number:4 day:25 month:09 pages:511-517 |
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Enthalten in Cancer immunology immunotherapy 59(2009), 4 vom: 25. Sept., Seite 511-517 volume:59 year:2009 number:4 day:25 month:09 pages:511-517 |
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CXCR4 Melanoma Prognosis |
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Cancer immunology immunotherapy |
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Napolitano, Maria @@aut@@ Ottaiano, Alessandro @@aut@@ Mauro, Francesca @@aut@@ Ieranò, Caterina @@aut@@ Satriano, Rocco @@aut@@ Pacelli, Roberto @@aut@@ Franco, Renato @@aut@@ De Angelis, Valentina @@aut@@ Castello, Giuseppe @@aut@@ Scala, Stefania @@aut@@ |
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2009-09-25T00:00:00Z |
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To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I–III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the $ χ^{2} $ test. The Kaplan–Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ higher than 25% of PBL showed a longer DFS. Conversely, $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ <25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes <25% of PBL, and 94% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ >25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes. 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Napolitano, Maria |
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Napolitano, Maria misc CXCR4 misc Melanoma misc Prognosis $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients |
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$ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients CXCR4 (dpeaa)DE-He213 Melanoma (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 |
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$ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients |
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$ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients |
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Napolitano, Maria Ottaiano, Alessandro Mauro, Francesca Ieranò, Caterina Satriano, Rocco Pacelli, Roberto Franco, Renato De Angelis, Valentina Castello, Giuseppe Scala, Stefania |
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Napolitano, Maria |
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| title_sort |
$ cd4^{+} %$ cd45ra^{+} %$ cxcr4^{+} $ lymphocytes are inversely associated with progression in stages i–iii melanoma patients |
| title_auth |
$ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients |
| abstract |
Abstract The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I–III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the $ χ^{2} $ test. The Kaplan–Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ higher than 25% of PBL showed a longer DFS. Conversely, $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ <25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes <25% of PBL, and 94% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ >25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers. © Springer-Verlag 2009 |
| abstractGer |
Abstract The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I–III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the $ χ^{2} $ test. The Kaplan–Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ higher than 25% of PBL showed a longer DFS. Conversely, $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ <25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes <25% of PBL, and 94% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ >25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers. © Springer-Verlag 2009 |
| abstract_unstemmed |
Abstract The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I–III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the $ χ^{2} $ test. The Kaplan–Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ higher than 25% of PBL showed a longer DFS. Conversely, $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ <25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes <25% of PBL, and 94% for patients with $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ >25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset $ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers. © Springer-Verlag 2009 |
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$ CD4^{+} %$ CD45RA^{+} %$ CXCR4^{+} $ lymphocytes are inversely associated with progression in stages I–III melanoma patients |
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| score |
7.397929 |