Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy
Abstract Appropriate activation of dendritic cells (DC) is essential for successful active vaccination and induction of cell-mediated immunity. The scarcity of precursor cells, as well as long culture methods, have hampered wide-scale application of DC vaccines derived from $ CD34^{+} $ precursors,...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
van de Ven, Rieneke [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2011 |
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| Übergeordnetes Werk: |
Enthalten in: Cancer immunology immunotherapy - Berlin : Springer, 1976, 61(2011), 2 vom: 27. Aug., Seite 181-191 |
|---|---|
| Übergeordnetes Werk: |
volume:61 ; year:2011 ; number:2 ; day:27 ; month:08 ; pages:181-191 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00262-011-1039-x |
|---|
| Katalog-ID: |
SPR00323049X |
|---|
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| 100 | 1 | |a van de Ven, Rieneke |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy |
| 264 | 1 | |c 2011 | |
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| 500 | |a © Springer-Verlag 2011 | ||
| 520 | |a Abstract Appropriate activation of dendritic cells (DC) is essential for successful active vaccination and induction of cell-mediated immunity. The scarcity of precursor cells, as well as long culture methods, have hampered wide-scale application of DC vaccines derived from $ CD34^{+} $ precursors, despite their suggested superior efficacy over the more commonly applied monocyte-derived DC (MoDC). Here, employing the $ CD34^{+} $/$ CD14^{+} $ AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of $ CD34^{+} $ DC precursors into functional antigen-presenting cells (APC) in a three-day protocol. The drugs were found to act specifically on $ CD34^{+} $, and not on $ CD14^{+} $ DC precursors. Importantly, these observations were confirmed for primary $ CD34^{+} $ and $ CD14^{+} $ DC precursors from peripheral blood. Mitoxantrone-generated DC were fully differentiated within three days and after an additional 24 h of maturation, were as capable as standard 9-day differentiated and matured DC to migrate toward the lymph node-homing chemokines CCL19 and CCL21, to induce primary allogeneic T cell proliferation, and to prime functional MART1-specific $ CD8^{+} $ T lymphocytes. Our finding that anthraquinone-derivatives like mitoxantrone support rapid high-efficiency differentiation of DC precursors may have consequences for in vitro production of DC vaccines as well as for novel immunochemotherapy strategies. | ||
| 650 | 4 | |a CD34 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a precursors |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dendritic cell |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Differentiation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immunotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mitoxantrone |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cytostatic drugs |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Reurs, Anneke W. |4 aut | |
| 700 | 1 | |a Wijnands, Pepijn G. J. T. B. |4 aut | |
| 700 | 1 | |a van Wetering, Sandra |4 aut | |
| 700 | 1 | |a Kruisbeek, Ada M. |4 aut | |
| 700 | 1 | |a Hooijberg, Erik |4 aut | |
| 700 | 1 | |a Scheffer, George L. |4 aut | |
| 700 | 1 | |a Scheper, Rik J. |4 aut | |
| 700 | 1 | |a de Gruijl, Tanja D. |4 aut | |
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10.1007/s00262-011-1039-x doi (DE-627)SPR00323049X (SPR)s00262-011-1039-x-e DE-627 ger DE-627 rakwb eng van de Ven, Rieneke verfasserin aut Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2011 Abstract Appropriate activation of dendritic cells (DC) is essential for successful active vaccination and induction of cell-mediated immunity. The scarcity of precursor cells, as well as long culture methods, have hampered wide-scale application of DC vaccines derived from $ CD34^{+} $ precursors, despite their suggested superior efficacy over the more commonly applied monocyte-derived DC (MoDC). Here, employing the $ CD34^{+} $/$ CD14^{+} $ AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of $ CD34^{+} $ DC precursors into functional antigen-presenting cells (APC) in a three-day protocol. The drugs were found to act specifically on $ CD34^{+} $, and not on $ CD14^{+} $ DC precursors. Importantly, these observations were confirmed for primary $ CD34^{+} $ and $ CD14^{+} $ DC precursors from peripheral blood. Mitoxantrone-generated DC were fully differentiated within three days and after an additional 24 h of maturation, were as capable as standard 9-day differentiated and matured DC to migrate toward the lymph node-homing chemokines CCL19 and CCL21, to induce primary allogeneic T cell proliferation, and to prime functional MART1-specific $ CD8^{+} $ T lymphocytes. Our finding that anthraquinone-derivatives like mitoxantrone support rapid high-efficiency differentiation of DC precursors may have consequences for in vitro production of DC vaccines as well as for novel immunochemotherapy strategies. CD34 (dpeaa)DE-He213 precursors (dpeaa)DE-He213 Dendritic cell (dpeaa)DE-He213 Differentiation (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Mitoxantrone (dpeaa)DE-He213 Cytostatic drugs (dpeaa)DE-He213 Reurs, Anneke W. aut Wijnands, Pepijn G. J. T. B. aut van Wetering, Sandra aut Kruisbeek, Ada M. aut Hooijberg, Erik aut Scheffer, George L. aut Scheper, Rik J. aut de Gruijl, Tanja D. aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 61(2011), 2 vom: 27. Aug., Seite 181-191 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:61 year:2011 number:2 day:27 month:08 pages:181-191 https://dx.doi.org/10.1007/s00262-011-1039-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 61 2011 2 27 08 181-191 |
| spelling |
10.1007/s00262-011-1039-x doi (DE-627)SPR00323049X (SPR)s00262-011-1039-x-e DE-627 ger DE-627 rakwb eng van de Ven, Rieneke verfasserin aut Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2011 Abstract Appropriate activation of dendritic cells (DC) is essential for successful active vaccination and induction of cell-mediated immunity. The scarcity of precursor cells, as well as long culture methods, have hampered wide-scale application of DC vaccines derived from $ CD34^{+} $ precursors, despite their suggested superior efficacy over the more commonly applied monocyte-derived DC (MoDC). Here, employing the $ CD34^{+} $/$ CD14^{+} $ AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of $ CD34^{+} $ DC precursors into functional antigen-presenting cells (APC) in a three-day protocol. The drugs were found to act specifically on $ CD34^{+} $, and not on $ CD14^{+} $ DC precursors. Importantly, these observations were confirmed for primary $ CD34^{+} $ and $ CD14^{+} $ DC precursors from peripheral blood. Mitoxantrone-generated DC were fully differentiated within three days and after an additional 24 h of maturation, were as capable as standard 9-day differentiated and matured DC to migrate toward the lymph node-homing chemokines CCL19 and CCL21, to induce primary allogeneic T cell proliferation, and to prime functional MART1-specific $ CD8^{+} $ T lymphocytes. Our finding that anthraquinone-derivatives like mitoxantrone support rapid high-efficiency differentiation of DC precursors may have consequences for in vitro production of DC vaccines as well as for novel immunochemotherapy strategies. CD34 (dpeaa)DE-He213 precursors (dpeaa)DE-He213 Dendritic cell (dpeaa)DE-He213 Differentiation (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Mitoxantrone (dpeaa)DE-He213 Cytostatic drugs (dpeaa)DE-He213 Reurs, Anneke W. aut Wijnands, Pepijn G. J. T. B. aut van Wetering, Sandra aut Kruisbeek, Ada M. aut Hooijberg, Erik aut Scheffer, George L. aut Scheper, Rik J. aut de Gruijl, Tanja D. aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 61(2011), 2 vom: 27. Aug., Seite 181-191 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:61 year:2011 number:2 day:27 month:08 pages:181-191 https://dx.doi.org/10.1007/s00262-011-1039-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 61 2011 2 27 08 181-191 |
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10.1007/s00262-011-1039-x doi (DE-627)SPR00323049X (SPR)s00262-011-1039-x-e DE-627 ger DE-627 rakwb eng van de Ven, Rieneke verfasserin aut Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2011 Abstract Appropriate activation of dendritic cells (DC) is essential for successful active vaccination and induction of cell-mediated immunity. The scarcity of precursor cells, as well as long culture methods, have hampered wide-scale application of DC vaccines derived from $ CD34^{+} $ precursors, despite their suggested superior efficacy over the more commonly applied monocyte-derived DC (MoDC). Here, employing the $ CD34^{+} $/$ CD14^{+} $ AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of $ CD34^{+} $ DC precursors into functional antigen-presenting cells (APC) in a three-day protocol. The drugs were found to act specifically on $ CD34^{+} $, and not on $ CD14^{+} $ DC precursors. Importantly, these observations were confirmed for primary $ CD34^{+} $ and $ CD14^{+} $ DC precursors from peripheral blood. Mitoxantrone-generated DC were fully differentiated within three days and after an additional 24 h of maturation, were as capable as standard 9-day differentiated and matured DC to migrate toward the lymph node-homing chemokines CCL19 and CCL21, to induce primary allogeneic T cell proliferation, and to prime functional MART1-specific $ CD8^{+} $ T lymphocytes. Our finding that anthraquinone-derivatives like mitoxantrone support rapid high-efficiency differentiation of DC precursors may have consequences for in vitro production of DC vaccines as well as for novel immunochemotherapy strategies. CD34 (dpeaa)DE-He213 precursors (dpeaa)DE-He213 Dendritic cell (dpeaa)DE-He213 Differentiation (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Mitoxantrone (dpeaa)DE-He213 Cytostatic drugs (dpeaa)DE-He213 Reurs, Anneke W. aut Wijnands, Pepijn G. J. T. B. aut van Wetering, Sandra aut Kruisbeek, Ada M. aut Hooijberg, Erik aut Scheffer, George L. aut Scheper, Rik J. aut de Gruijl, Tanja D. aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 61(2011), 2 vom: 27. Aug., Seite 181-191 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:61 year:2011 number:2 day:27 month:08 pages:181-191 https://dx.doi.org/10.1007/s00262-011-1039-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 61 2011 2 27 08 181-191 |
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10.1007/s00262-011-1039-x doi (DE-627)SPR00323049X (SPR)s00262-011-1039-x-e DE-627 ger DE-627 rakwb eng van de Ven, Rieneke verfasserin aut Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2011 Abstract Appropriate activation of dendritic cells (DC) is essential for successful active vaccination and induction of cell-mediated immunity. The scarcity of precursor cells, as well as long culture methods, have hampered wide-scale application of DC vaccines derived from $ CD34^{+} $ precursors, despite their suggested superior efficacy over the more commonly applied monocyte-derived DC (MoDC). Here, employing the $ CD34^{+} $/$ CD14^{+} $ AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of $ CD34^{+} $ DC precursors into functional antigen-presenting cells (APC) in a three-day protocol. The drugs were found to act specifically on $ CD34^{+} $, and not on $ CD14^{+} $ DC precursors. Importantly, these observations were confirmed for primary $ CD34^{+} $ and $ CD14^{+} $ DC precursors from peripheral blood. Mitoxantrone-generated DC were fully differentiated within three days and after an additional 24 h of maturation, were as capable as standard 9-day differentiated and matured DC to migrate toward the lymph node-homing chemokines CCL19 and CCL21, to induce primary allogeneic T cell proliferation, and to prime functional MART1-specific $ CD8^{+} $ T lymphocytes. Our finding that anthraquinone-derivatives like mitoxantrone support rapid high-efficiency differentiation of DC precursors may have consequences for in vitro production of DC vaccines as well as for novel immunochemotherapy strategies. CD34 (dpeaa)DE-He213 precursors (dpeaa)DE-He213 Dendritic cell (dpeaa)DE-He213 Differentiation (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Mitoxantrone (dpeaa)DE-He213 Cytostatic drugs (dpeaa)DE-He213 Reurs, Anneke W. aut Wijnands, Pepijn G. J. T. B. aut van Wetering, Sandra aut Kruisbeek, Ada M. aut Hooijberg, Erik aut Scheffer, George L. aut Scheper, Rik J. aut de Gruijl, Tanja D. aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 61(2011), 2 vom: 27. Aug., Seite 181-191 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:61 year:2011 number:2 day:27 month:08 pages:181-191 https://dx.doi.org/10.1007/s00262-011-1039-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 61 2011 2 27 08 181-191 |
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10.1007/s00262-011-1039-x doi (DE-627)SPR00323049X (SPR)s00262-011-1039-x-e DE-627 ger DE-627 rakwb eng van de Ven, Rieneke verfasserin aut Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2011 Abstract Appropriate activation of dendritic cells (DC) is essential for successful active vaccination and induction of cell-mediated immunity. The scarcity of precursor cells, as well as long culture methods, have hampered wide-scale application of DC vaccines derived from $ CD34^{+} $ precursors, despite their suggested superior efficacy over the more commonly applied monocyte-derived DC (MoDC). Here, employing the $ CD34^{+} $/$ CD14^{+} $ AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of $ CD34^{+} $ DC precursors into functional antigen-presenting cells (APC) in a three-day protocol. The drugs were found to act specifically on $ CD34^{+} $, and not on $ CD14^{+} $ DC precursors. Importantly, these observations were confirmed for primary $ CD34^{+} $ and $ CD14^{+} $ DC precursors from peripheral blood. Mitoxantrone-generated DC were fully differentiated within three days and after an additional 24 h of maturation, were as capable as standard 9-day differentiated and matured DC to migrate toward the lymph node-homing chemokines CCL19 and CCL21, to induce primary allogeneic T cell proliferation, and to prime functional MART1-specific $ CD8^{+} $ T lymphocytes. Our finding that anthraquinone-derivatives like mitoxantrone support rapid high-efficiency differentiation of DC precursors may have consequences for in vitro production of DC vaccines as well as for novel immunochemotherapy strategies. CD34 (dpeaa)DE-He213 precursors (dpeaa)DE-He213 Dendritic cell (dpeaa)DE-He213 Differentiation (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Mitoxantrone (dpeaa)DE-He213 Cytostatic drugs (dpeaa)DE-He213 Reurs, Anneke W. aut Wijnands, Pepijn G. J. T. B. aut van Wetering, Sandra aut Kruisbeek, Ada M. aut Hooijberg, Erik aut Scheffer, George L. aut Scheper, Rik J. aut de Gruijl, Tanja D. aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 61(2011), 2 vom: 27. Aug., Seite 181-191 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:61 year:2011 number:2 day:27 month:08 pages:181-191 https://dx.doi.org/10.1007/s00262-011-1039-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 61 2011 2 27 08 181-191 |
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English |
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Enthalten in Cancer immunology immunotherapy 61(2011), 2 vom: 27. Aug., Seite 181-191 volume:61 year:2011 number:2 day:27 month:08 pages:181-191 |
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Enthalten in Cancer immunology immunotherapy 61(2011), 2 vom: 27. Aug., Seite 181-191 volume:61 year:2011 number:2 day:27 month:08 pages:181-191 |
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CD34 precursors Dendritic cell Differentiation Immunotherapy Mitoxantrone Cytostatic drugs |
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Cancer immunology immunotherapy |
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van de Ven, Rieneke @@aut@@ Reurs, Anneke W. @@aut@@ Wijnands, Pepijn G. J. T. B. @@aut@@ van Wetering, Sandra @@aut@@ Kruisbeek, Ada M. @@aut@@ Hooijberg, Erik @@aut@@ Scheffer, George L. @@aut@@ Scheper, Rik J. @@aut@@ de Gruijl, Tanja D. @@aut@@ |
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The scarcity of precursor cells, as well as long culture methods, have hampered wide-scale application of DC vaccines derived from $ CD34^{+} $ precursors, despite their suggested superior efficacy over the more commonly applied monocyte-derived DC (MoDC). Here, employing the $ CD34^{+} $/$ CD14^{+} $ AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of $ CD34^{+} $ DC precursors into functional antigen-presenting cells (APC) in a three-day protocol. The drugs were found to act specifically on $ CD34^{+} $, and not on $ CD14^{+} $ DC precursors. Importantly, these observations were confirmed for primary $ CD34^{+} $ and $ CD14^{+} $ DC precursors from peripheral blood. Mitoxantrone-generated DC were fully differentiated within three days and after an additional 24 h of maturation, were as capable as standard 9-day differentiated and matured DC to migrate toward the lymph node-homing chemokines CCL19 and CCL21, to induce primary allogeneic T cell proliferation, and to prime functional MART1-specific $ CD8^{+} $ T lymphocytes. 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van de Ven, Rieneke |
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van de Ven, Rieneke misc CD34 misc precursors misc Dendritic cell misc Differentiation misc Immunotherapy misc Mitoxantrone misc Cytostatic drugs Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy |
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Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy CD34 (dpeaa)DE-He213 precursors (dpeaa)DE-He213 Dendritic cell (dpeaa)DE-He213 Differentiation (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Mitoxantrone (dpeaa)DE-He213 Cytostatic drugs (dpeaa)DE-He213 |
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misc CD34 misc precursors misc Dendritic cell misc Differentiation misc Immunotherapy misc Mitoxantrone misc Cytostatic drugs |
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misc CD34 misc precursors misc Dendritic cell misc Differentiation misc Immunotherapy misc Mitoxantrone misc Cytostatic drugs |
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Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy |
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Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy |
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van de Ven, Rieneke |
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Cancer immunology immunotherapy |
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Cancer immunology immunotherapy |
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eng |
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2011 |
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van de Ven, Rieneke Reurs, Anneke W. Wijnands, Pepijn G. J. T. B. van Wetering, Sandra Kruisbeek, Ada M. Hooijberg, Erik Scheffer, George L. Scheper, Rik J. de Gruijl, Tanja D. |
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61 |
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Elektronische Aufsätze |
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van de Ven, Rieneke |
| doi_str_mv |
10.1007/s00262-011-1039-x |
| title_sort |
exposure of $ cd34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy |
| title_auth |
Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy |
| abstract |
Abstract Appropriate activation of dendritic cells (DC) is essential for successful active vaccination and induction of cell-mediated immunity. The scarcity of precursor cells, as well as long culture methods, have hampered wide-scale application of DC vaccines derived from $ CD34^{+} $ precursors, despite their suggested superior efficacy over the more commonly applied monocyte-derived DC (MoDC). Here, employing the $ CD34^{+} $/$ CD14^{+} $ AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of $ CD34^{+} $ DC precursors into functional antigen-presenting cells (APC) in a three-day protocol. The drugs were found to act specifically on $ CD34^{+} $, and not on $ CD14^{+} $ DC precursors. Importantly, these observations were confirmed for primary $ CD34^{+} $ and $ CD14^{+} $ DC precursors from peripheral blood. Mitoxantrone-generated DC were fully differentiated within three days and after an additional 24 h of maturation, were as capable as standard 9-day differentiated and matured DC to migrate toward the lymph node-homing chemokines CCL19 and CCL21, to induce primary allogeneic T cell proliferation, and to prime functional MART1-specific $ CD8^{+} $ T lymphocytes. Our finding that anthraquinone-derivatives like mitoxantrone support rapid high-efficiency differentiation of DC precursors may have consequences for in vitro production of DC vaccines as well as for novel immunochemotherapy strategies. © Springer-Verlag 2011 |
| abstractGer |
Abstract Appropriate activation of dendritic cells (DC) is essential for successful active vaccination and induction of cell-mediated immunity. The scarcity of precursor cells, as well as long culture methods, have hampered wide-scale application of DC vaccines derived from $ CD34^{+} $ precursors, despite their suggested superior efficacy over the more commonly applied monocyte-derived DC (MoDC). Here, employing the $ CD34^{+} $/$ CD14^{+} $ AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of $ CD34^{+} $ DC precursors into functional antigen-presenting cells (APC) in a three-day protocol. The drugs were found to act specifically on $ CD34^{+} $, and not on $ CD14^{+} $ DC precursors. Importantly, these observations were confirmed for primary $ CD34^{+} $ and $ CD14^{+} $ DC precursors from peripheral blood. Mitoxantrone-generated DC were fully differentiated within three days and after an additional 24 h of maturation, were as capable as standard 9-day differentiated and matured DC to migrate toward the lymph node-homing chemokines CCL19 and CCL21, to induce primary allogeneic T cell proliferation, and to prime functional MART1-specific $ CD8^{+} $ T lymphocytes. Our finding that anthraquinone-derivatives like mitoxantrone support rapid high-efficiency differentiation of DC precursors may have consequences for in vitro production of DC vaccines as well as for novel immunochemotherapy strategies. © Springer-Verlag 2011 |
| abstract_unstemmed |
Abstract Appropriate activation of dendritic cells (DC) is essential for successful active vaccination and induction of cell-mediated immunity. The scarcity of precursor cells, as well as long culture methods, have hampered wide-scale application of DC vaccines derived from $ CD34^{+} $ precursors, despite their suggested superior efficacy over the more commonly applied monocyte-derived DC (MoDC). Here, employing the $ CD34^{+} $/$ CD14^{+} $ AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of $ CD34^{+} $ DC precursors into functional antigen-presenting cells (APC) in a three-day protocol. The drugs were found to act specifically on $ CD34^{+} $, and not on $ CD14^{+} $ DC precursors. Importantly, these observations were confirmed for primary $ CD34^{+} $ and $ CD14^{+} $ DC precursors from peripheral blood. Mitoxantrone-generated DC were fully differentiated within three days and after an additional 24 h of maturation, were as capable as standard 9-day differentiated and matured DC to migrate toward the lymph node-homing chemokines CCL19 and CCL21, to induce primary allogeneic T cell proliferation, and to prime functional MART1-specific $ CD8^{+} $ T lymphocytes. Our finding that anthraquinone-derivatives like mitoxantrone support rapid high-efficiency differentiation of DC precursors may have consequences for in vitro production of DC vaccines as well as for novel immunochemotherapy strategies. © Springer-Verlag 2011 |
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| title_short |
Exposure of $ CD34^{+} $ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy |
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Reurs, Anneke W. Wijnands, Pepijn G. J. T. B. van Wetering, Sandra Kruisbeek, Ada M. Hooijberg, Erik Scheffer, George L. Scheper, Rik J. de Gruijl, Tanja D. |
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Reurs, Anneke W. Wijnands, Pepijn G. J. T. B. van Wetering, Sandra Kruisbeek, Ada M. Hooijberg, Erik Scheffer, George L. Scheper, Rik J. de Gruijl, Tanja D. |
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| score |
7.401532 |