Success of Surgery for Primary Aldosteronism Judged by Residual Autonomous Aldosterone Production
Abstract Since February 1996 we have prospectively assessed residual adrenal autonomy by the fludrocortisone suppression test (FST) in 23 patients 3 months after unilateral adrenalectomy for Conn syndrome and in 45 patients after a longer interval. In regard to blood pressure, 36 (53%) patients were...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Rutherford, John C. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1998 |
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| Schlagwörter: |
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| Anmerkung: |
© by the Société Internationale de Chirugie 1998 |
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| Übergeordnetes Werk: |
Enthalten in: World Journal of Surgery - Springer-Verlag, 1996, 22(1998), 12 vom: Dez., Seite 1243-1245 |
|---|---|
| Übergeordnetes Werk: |
volume:22 ; year:1998 ; number:12 ; month:12 ; pages:1243-1245 |
| Links: |
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| DOI / URN: |
10.1007/s002689900552 |
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SPR003391396 |
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| 520 | |a Abstract Since February 1996 we have prospectively assessed residual adrenal autonomy by the fludrocortisone suppression test (FST) in 23 patients 3 months after unilateral adrenalectomy for Conn syndrome and in 45 patients after a longer interval. In regard to blood pressure, 36 (53%) patients were cured of hypertension and the remaining 32 (47%) patients had improved hypertension control at the time of their latest postoperative clinical assessment. In regard to the outcome of surgery, patients who achieved normal suppressibility of aldosterone were regarded as cured, and those who had greater suppressibility after surgery were considered improved. Time since surgery for the whole group averaged 26 months. By these biochemical criteria, 42 patients (62%) were cured by surgery, and the rest improved; 16 (76%) of 21 women were cured, and 26 (55%) of 47 men. The women (mean ± SD age 47 ± 11 years) were significantly ( p < 0.05) younger than the men (52 ± 9 years). Preoperative aldosterone levels before and after FST were similar in the cured and improved groups and fell significantly (p < 0.01) in both groups following surgery. After surgical reduction of autonomous aldosterone production, mean plasma renin activity levels increased sixfold in the cured group and threefold in the improved group. Surgical mortality in this group of 68 patients with Conn syndrome was zero. | ||
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| 650 | 4 | |a Unilateral Adrenalectomy |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Taylor, Wendy L. |4 aut | |
| 700 | 1 | |a Stowasser, Michael |4 aut | |
| 700 | 1 | |a Gordon, Richard D. |4 aut | |
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10.1007/s002689900552 doi (DE-627)SPR003391396 (SPR)s002689900552-e DE-627 ger DE-627 rakwb eng Rutherford, John C. verfasserin aut Success of Surgery for Primary Aldosteronism Judged by Residual Autonomous Aldosterone Production 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © by the Société Internationale de Chirugie 1998 Abstract Since February 1996 we have prospectively assessed residual adrenal autonomy by the fludrocortisone suppression test (FST) in 23 patients 3 months after unilateral adrenalectomy for Conn syndrome and in 45 patients after a longer interval. In regard to blood pressure, 36 (53%) patients were cured of hypertension and the remaining 32 (47%) patients had improved hypertension control at the time of their latest postoperative clinical assessment. In regard to the outcome of surgery, patients who achieved normal suppressibility of aldosterone were regarded as cured, and those who had greater suppressibility after surgery were considered improved. Time since surgery for the whole group averaged 26 months. By these biochemical criteria, 42 patients (62%) were cured by surgery, and the rest improved; 16 (76%) of 21 women were cured, and 26 (55%) of 47 men. The women (mean ± SD age 47 ± 11 years) were significantly ( p < 0.05) younger than the men (52 ± 9 years). Preoperative aldosterone levels before and after FST were similar in the cured and improved groups and fell significantly (p < 0.01) in both groups following surgery. After surgical reduction of autonomous aldosterone production, mean plasma renin activity levels increased sixfold in the cured group and threefold in the improved group. Surgical mortality in this group of 68 patients with Conn syndrome was zero. Aldosterone (dpeaa)DE-He213 Primary Aldosteronism (dpeaa)DE-He213 Laparoscopic Adrenalectomy (dpeaa)DE-He213 Adrenal Venous Sampling (dpeaa)DE-He213 Unilateral Adrenalectomy (dpeaa)DE-He213 Taylor, Wendy L. aut Stowasser, Michael aut Gordon, Richard D. aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 22(1998), 12 vom: Dez., Seite 1243-1245 (DE-627)SPR003391159 nnns volume:22 year:1998 number:12 month:12 pages:1243-1245 https://dx.doi.org/10.1007/s002689900552 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 22 1998 12 12 1243-1245 |
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10.1007/s002689900552 doi (DE-627)SPR003391396 (SPR)s002689900552-e DE-627 ger DE-627 rakwb eng Rutherford, John C. verfasserin aut Success of Surgery for Primary Aldosteronism Judged by Residual Autonomous Aldosterone Production 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © by the Société Internationale de Chirugie 1998 Abstract Since February 1996 we have prospectively assessed residual adrenal autonomy by the fludrocortisone suppression test (FST) in 23 patients 3 months after unilateral adrenalectomy for Conn syndrome and in 45 patients after a longer interval. In regard to blood pressure, 36 (53%) patients were cured of hypertension and the remaining 32 (47%) patients had improved hypertension control at the time of their latest postoperative clinical assessment. In regard to the outcome of surgery, patients who achieved normal suppressibility of aldosterone were regarded as cured, and those who had greater suppressibility after surgery were considered improved. Time since surgery for the whole group averaged 26 months. By these biochemical criteria, 42 patients (62%) were cured by surgery, and the rest improved; 16 (76%) of 21 women were cured, and 26 (55%) of 47 men. The women (mean ± SD age 47 ± 11 years) were significantly ( p < 0.05) younger than the men (52 ± 9 years). Preoperative aldosterone levels before and after FST were similar in the cured and improved groups and fell significantly (p < 0.01) in both groups following surgery. After surgical reduction of autonomous aldosterone production, mean plasma renin activity levels increased sixfold in the cured group and threefold in the improved group. Surgical mortality in this group of 68 patients with Conn syndrome was zero. Aldosterone (dpeaa)DE-He213 Primary Aldosteronism (dpeaa)DE-He213 Laparoscopic Adrenalectomy (dpeaa)DE-He213 Adrenal Venous Sampling (dpeaa)DE-He213 Unilateral Adrenalectomy (dpeaa)DE-He213 Taylor, Wendy L. aut Stowasser, Michael aut Gordon, Richard D. aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 22(1998), 12 vom: Dez., Seite 1243-1245 (DE-627)SPR003391159 nnns volume:22 year:1998 number:12 month:12 pages:1243-1245 https://dx.doi.org/10.1007/s002689900552 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 22 1998 12 12 1243-1245 |
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10.1007/s002689900552 doi (DE-627)SPR003391396 (SPR)s002689900552-e DE-627 ger DE-627 rakwb eng Rutherford, John C. verfasserin aut Success of Surgery for Primary Aldosteronism Judged by Residual Autonomous Aldosterone Production 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © by the Société Internationale de Chirugie 1998 Abstract Since February 1996 we have prospectively assessed residual adrenal autonomy by the fludrocortisone suppression test (FST) in 23 patients 3 months after unilateral adrenalectomy for Conn syndrome and in 45 patients after a longer interval. In regard to blood pressure, 36 (53%) patients were cured of hypertension and the remaining 32 (47%) patients had improved hypertension control at the time of their latest postoperative clinical assessment. In regard to the outcome of surgery, patients who achieved normal suppressibility of aldosterone were regarded as cured, and those who had greater suppressibility after surgery were considered improved. Time since surgery for the whole group averaged 26 months. By these biochemical criteria, 42 patients (62%) were cured by surgery, and the rest improved; 16 (76%) of 21 women were cured, and 26 (55%) of 47 men. The women (mean ± SD age 47 ± 11 years) were significantly ( p < 0.05) younger than the men (52 ± 9 years). Preoperative aldosterone levels before and after FST were similar in the cured and improved groups and fell significantly (p < 0.01) in both groups following surgery. After surgical reduction of autonomous aldosterone production, mean plasma renin activity levels increased sixfold in the cured group and threefold in the improved group. Surgical mortality in this group of 68 patients with Conn syndrome was zero. Aldosterone (dpeaa)DE-He213 Primary Aldosteronism (dpeaa)DE-He213 Laparoscopic Adrenalectomy (dpeaa)DE-He213 Adrenal Venous Sampling (dpeaa)DE-He213 Unilateral Adrenalectomy (dpeaa)DE-He213 Taylor, Wendy L. aut Stowasser, Michael aut Gordon, Richard D. aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 22(1998), 12 vom: Dez., Seite 1243-1245 (DE-627)SPR003391159 nnns volume:22 year:1998 number:12 month:12 pages:1243-1245 https://dx.doi.org/10.1007/s002689900552 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 22 1998 12 12 1243-1245 |
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10.1007/s002689900552 doi (DE-627)SPR003391396 (SPR)s002689900552-e DE-627 ger DE-627 rakwb eng Rutherford, John C. verfasserin aut Success of Surgery for Primary Aldosteronism Judged by Residual Autonomous Aldosterone Production 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © by the Société Internationale de Chirugie 1998 Abstract Since February 1996 we have prospectively assessed residual adrenal autonomy by the fludrocortisone suppression test (FST) in 23 patients 3 months after unilateral adrenalectomy for Conn syndrome and in 45 patients after a longer interval. In regard to blood pressure, 36 (53%) patients were cured of hypertension and the remaining 32 (47%) patients had improved hypertension control at the time of their latest postoperative clinical assessment. In regard to the outcome of surgery, patients who achieved normal suppressibility of aldosterone were regarded as cured, and those who had greater suppressibility after surgery were considered improved. Time since surgery for the whole group averaged 26 months. By these biochemical criteria, 42 patients (62%) were cured by surgery, and the rest improved; 16 (76%) of 21 women were cured, and 26 (55%) of 47 men. The women (mean ± SD age 47 ± 11 years) were significantly ( p < 0.05) younger than the men (52 ± 9 years). Preoperative aldosterone levels before and after FST were similar in the cured and improved groups and fell significantly (p < 0.01) in both groups following surgery. After surgical reduction of autonomous aldosterone production, mean plasma renin activity levels increased sixfold in the cured group and threefold in the improved group. Surgical mortality in this group of 68 patients with Conn syndrome was zero. Aldosterone (dpeaa)DE-He213 Primary Aldosteronism (dpeaa)DE-He213 Laparoscopic Adrenalectomy (dpeaa)DE-He213 Adrenal Venous Sampling (dpeaa)DE-He213 Unilateral Adrenalectomy (dpeaa)DE-He213 Taylor, Wendy L. aut Stowasser, Michael aut Gordon, Richard D. aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 22(1998), 12 vom: Dez., Seite 1243-1245 (DE-627)SPR003391159 nnns volume:22 year:1998 number:12 month:12 pages:1243-1245 https://dx.doi.org/10.1007/s002689900552 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 22 1998 12 12 1243-1245 |
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10.1007/s002689900552 doi (DE-627)SPR003391396 (SPR)s002689900552-e DE-627 ger DE-627 rakwb eng Rutherford, John C. verfasserin aut Success of Surgery for Primary Aldosteronism Judged by Residual Autonomous Aldosterone Production 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © by the Société Internationale de Chirugie 1998 Abstract Since February 1996 we have prospectively assessed residual adrenal autonomy by the fludrocortisone suppression test (FST) in 23 patients 3 months after unilateral adrenalectomy for Conn syndrome and in 45 patients after a longer interval. In regard to blood pressure, 36 (53%) patients were cured of hypertension and the remaining 32 (47%) patients had improved hypertension control at the time of their latest postoperative clinical assessment. In regard to the outcome of surgery, patients who achieved normal suppressibility of aldosterone were regarded as cured, and those who had greater suppressibility after surgery were considered improved. Time since surgery for the whole group averaged 26 months. By these biochemical criteria, 42 patients (62%) were cured by surgery, and the rest improved; 16 (76%) of 21 women were cured, and 26 (55%) of 47 men. The women (mean ± SD age 47 ± 11 years) were significantly ( p < 0.05) younger than the men (52 ± 9 years). Preoperative aldosterone levels before and after FST were similar in the cured and improved groups and fell significantly (p < 0.01) in both groups following surgery. After surgical reduction of autonomous aldosterone production, mean plasma renin activity levels increased sixfold in the cured group and threefold in the improved group. Surgical mortality in this group of 68 patients with Conn syndrome was zero. Aldosterone (dpeaa)DE-He213 Primary Aldosteronism (dpeaa)DE-He213 Laparoscopic Adrenalectomy (dpeaa)DE-He213 Adrenal Venous Sampling (dpeaa)DE-He213 Unilateral Adrenalectomy (dpeaa)DE-He213 Taylor, Wendy L. aut Stowasser, Michael aut Gordon, Richard D. aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 22(1998), 12 vom: Dez., Seite 1243-1245 (DE-627)SPR003391159 nnns volume:22 year:1998 number:12 month:12 pages:1243-1245 https://dx.doi.org/10.1007/s002689900552 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 22 1998 12 12 1243-1245 |
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Rutherford, John C. misc Aldosterone misc Primary Aldosteronism misc Laparoscopic Adrenalectomy misc Adrenal Venous Sampling misc Unilateral Adrenalectomy Success of Surgery for Primary Aldosteronism Judged by Residual Autonomous Aldosterone Production |
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success of surgery for primary aldosteronism judged by residual autonomous aldosterone production |
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Success of Surgery for Primary Aldosteronism Judged by Residual Autonomous Aldosterone Production |
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Abstract Since February 1996 we have prospectively assessed residual adrenal autonomy by the fludrocortisone suppression test (FST) in 23 patients 3 months after unilateral adrenalectomy for Conn syndrome and in 45 patients after a longer interval. In regard to blood pressure, 36 (53%) patients were cured of hypertension and the remaining 32 (47%) patients had improved hypertension control at the time of their latest postoperative clinical assessment. In regard to the outcome of surgery, patients who achieved normal suppressibility of aldosterone were regarded as cured, and those who had greater suppressibility after surgery were considered improved. Time since surgery for the whole group averaged 26 months. By these biochemical criteria, 42 patients (62%) were cured by surgery, and the rest improved; 16 (76%) of 21 women were cured, and 26 (55%) of 47 men. The women (mean ± SD age 47 ± 11 years) were significantly ( p < 0.05) younger than the men (52 ± 9 years). Preoperative aldosterone levels before and after FST were similar in the cured and improved groups and fell significantly (p < 0.01) in both groups following surgery. After surgical reduction of autonomous aldosterone production, mean plasma renin activity levels increased sixfold in the cured group and threefold in the improved group. Surgical mortality in this group of 68 patients with Conn syndrome was zero. © by the Société Internationale de Chirugie 1998 |
| abstractGer |
Abstract Since February 1996 we have prospectively assessed residual adrenal autonomy by the fludrocortisone suppression test (FST) in 23 patients 3 months after unilateral adrenalectomy for Conn syndrome and in 45 patients after a longer interval. In regard to blood pressure, 36 (53%) patients were cured of hypertension and the remaining 32 (47%) patients had improved hypertension control at the time of their latest postoperative clinical assessment. In regard to the outcome of surgery, patients who achieved normal suppressibility of aldosterone were regarded as cured, and those who had greater suppressibility after surgery were considered improved. Time since surgery for the whole group averaged 26 months. By these biochemical criteria, 42 patients (62%) were cured by surgery, and the rest improved; 16 (76%) of 21 women were cured, and 26 (55%) of 47 men. The women (mean ± SD age 47 ± 11 years) were significantly ( p < 0.05) younger than the men (52 ± 9 years). Preoperative aldosterone levels before and after FST were similar in the cured and improved groups and fell significantly (p < 0.01) in both groups following surgery. After surgical reduction of autonomous aldosterone production, mean plasma renin activity levels increased sixfold in the cured group and threefold in the improved group. Surgical mortality in this group of 68 patients with Conn syndrome was zero. © by the Société Internationale de Chirugie 1998 |
| abstract_unstemmed |
Abstract Since February 1996 we have prospectively assessed residual adrenal autonomy by the fludrocortisone suppression test (FST) in 23 patients 3 months after unilateral adrenalectomy for Conn syndrome and in 45 patients after a longer interval. In regard to blood pressure, 36 (53%) patients were cured of hypertension and the remaining 32 (47%) patients had improved hypertension control at the time of their latest postoperative clinical assessment. In regard to the outcome of surgery, patients who achieved normal suppressibility of aldosterone were regarded as cured, and those who had greater suppressibility after surgery were considered improved. Time since surgery for the whole group averaged 26 months. By these biochemical criteria, 42 patients (62%) were cured by surgery, and the rest improved; 16 (76%) of 21 women were cured, and 26 (55%) of 47 men. The women (mean ± SD age 47 ± 11 years) were significantly ( p < 0.05) younger than the men (52 ± 9 years). Preoperative aldosterone levels before and after FST were similar in the cured and improved groups and fell significantly (p < 0.01) in both groups following surgery. After surgical reduction of autonomous aldosterone production, mean plasma renin activity levels increased sixfold in the cured group and threefold in the improved group. Surgical mortality in this group of 68 patients with Conn syndrome was zero. © by the Société Internationale de Chirugie 1998 |
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Success of Surgery for Primary Aldosteronism Judged by Residual Autonomous Aldosterone Production |
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Taylor, Wendy L. Stowasser, Michael Gordon, Richard D. |
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