Effect of Interstitial Laser Hyperthermia in a Murine Model of Colorectal Liver Metastases: Scanning Electron Microscopic Study
Abstract Interstitial laser hyperthermia (ILH) is an in situ ablative technique used to treat colorectal liver metastases. The relatively high recurrence of tumor after treatment by ILH may be related to incomplete destruction. Little is known about the effectiveness of ILH for destroying tumor micr...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Muralidharan, Vijayaragavan [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2003 |
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| Schlagwörter: |
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| Anmerkung: |
© Société Internationale de Chirurgie 2003 |
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| Übergeordnetes Werk: |
Enthalten in: World Journal of Surgery - Springer-Verlag, 1996, 28(2003), 1 vom: 05. Dez., Seite 33-37 |
|---|---|
| Übergeordnetes Werk: |
volume:28 ; year:2003 ; number:1 ; day:05 ; month:12 ; pages:33-37 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00268-003-6973-0 |
|---|
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SPR003399656 |
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| 520 | |a Abstract Interstitial laser hyperthermia (ILH) is an in situ ablative technique used to treat colorectal liver metastases. The relatively high recurrence of tumor after treatment by ILH may be related to incomplete destruction. Little is known about the effectiveness of ILH for destroying tumor microvasculature. The aim of this study was to define the changes to the microvascular architecture of tumors after treatment with ILH, specifically focusing on the completeness of tumor vasculature destruction. An intrasplenic induction model of liver metastases in 4- to 6-week-old male inbred CBA mice was used. Laser hyperthermia was applied to liver and tumor tissue using a bare optical quartz fiber from a Medilas Fibertom 4100 Nd:YAG surgical laser generator. The animals underwent microvascular corrosion casting of the livers immediately after application of ILH. Microvascular casts were then prepared and studied by scanning electron microscopy. ILH produced complete, uniform destruction of the tumor microvasculature with compete hemostasis. Blood flow in vessels larger than 100 μm diameter had a relatively protective effect, although ILH was able to overcome this barrier effectively by increasing the energy applied. ILH produces complete destruction of tumor microvasculature with hemostasis. The protective effect of blood flow in larger vessels can be overcome by the appropriate use of higher energy levels. | ||
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10.1007/s00268-003-6973-0 doi (DE-627)SPR003399656 (SPR)s00268-003-6973-0-e DE-627 ger DE-627 rakwb eng Muralidharan, Vijayaragavan verfasserin aut Effect of Interstitial Laser Hyperthermia in a Murine Model of Colorectal Liver Metastases: Scanning Electron Microscopic Study 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2003 Abstract Interstitial laser hyperthermia (ILH) is an in situ ablative technique used to treat colorectal liver metastases. The relatively high recurrence of tumor after treatment by ILH may be related to incomplete destruction. Little is known about the effectiveness of ILH for destroying tumor microvasculature. The aim of this study was to define the changes to the microvascular architecture of tumors after treatment with ILH, specifically focusing on the completeness of tumor vasculature destruction. An intrasplenic induction model of liver metastases in 4- to 6-week-old male inbred CBA mice was used. Laser hyperthermia was applied to liver and tumor tissue using a bare optical quartz fiber from a Medilas Fibertom 4100 Nd:YAG surgical laser generator. The animals underwent microvascular corrosion casting of the livers immediately after application of ILH. Microvascular casts were then prepared and studied by scanning electron microscopy. ILH produced complete, uniform destruction of the tumor microvasculature with compete hemostasis. Blood flow in vessels larger than 100 μm diameter had a relatively protective effect, although ILH was able to overcome this barrier effectively by increasing the energy applied. ILH produces complete destruction of tumor microvasculature with hemostasis. The protective effect of blood flow in larger vessels can be overcome by the appropriate use of higher energy levels. Liver Metastasis (dpeaa)DE-He213 Colorectal Liver Metastasis (dpeaa)DE-He213 Tumor Vasculature (dpeaa)DE-He213 Liver Sinusoid (dpeaa)DE-He213 Tumor Microvasculature (dpeaa)DE-He213 Nikfarjam, Mehrdad aut Malcontenti-Wilson, Caterina aut Christophi, Christopher aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 28(2003), 1 vom: 05. Dez., Seite 33-37 (DE-627)SPR003391159 nnns volume:28 year:2003 number:1 day:05 month:12 pages:33-37 https://dx.doi.org/10.1007/s00268-003-6973-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 28 2003 1 05 12 33-37 |
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10.1007/s00268-003-6973-0 doi (DE-627)SPR003399656 (SPR)s00268-003-6973-0-e DE-627 ger DE-627 rakwb eng Muralidharan, Vijayaragavan verfasserin aut Effect of Interstitial Laser Hyperthermia in a Murine Model of Colorectal Liver Metastases: Scanning Electron Microscopic Study 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2003 Abstract Interstitial laser hyperthermia (ILH) is an in situ ablative technique used to treat colorectal liver metastases. The relatively high recurrence of tumor after treatment by ILH may be related to incomplete destruction. Little is known about the effectiveness of ILH for destroying tumor microvasculature. The aim of this study was to define the changes to the microvascular architecture of tumors after treatment with ILH, specifically focusing on the completeness of tumor vasculature destruction. An intrasplenic induction model of liver metastases in 4- to 6-week-old male inbred CBA mice was used. Laser hyperthermia was applied to liver and tumor tissue using a bare optical quartz fiber from a Medilas Fibertom 4100 Nd:YAG surgical laser generator. The animals underwent microvascular corrosion casting of the livers immediately after application of ILH. Microvascular casts were then prepared and studied by scanning electron microscopy. ILH produced complete, uniform destruction of the tumor microvasculature with compete hemostasis. Blood flow in vessels larger than 100 μm diameter had a relatively protective effect, although ILH was able to overcome this barrier effectively by increasing the energy applied. ILH produces complete destruction of tumor microvasculature with hemostasis. The protective effect of blood flow in larger vessels can be overcome by the appropriate use of higher energy levels. Liver Metastasis (dpeaa)DE-He213 Colorectal Liver Metastasis (dpeaa)DE-He213 Tumor Vasculature (dpeaa)DE-He213 Liver Sinusoid (dpeaa)DE-He213 Tumor Microvasculature (dpeaa)DE-He213 Nikfarjam, Mehrdad aut Malcontenti-Wilson, Caterina aut Christophi, Christopher aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 28(2003), 1 vom: 05. Dez., Seite 33-37 (DE-627)SPR003391159 nnns volume:28 year:2003 number:1 day:05 month:12 pages:33-37 https://dx.doi.org/10.1007/s00268-003-6973-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 28 2003 1 05 12 33-37 |
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10.1007/s00268-003-6973-0 doi (DE-627)SPR003399656 (SPR)s00268-003-6973-0-e DE-627 ger DE-627 rakwb eng Muralidharan, Vijayaragavan verfasserin aut Effect of Interstitial Laser Hyperthermia in a Murine Model of Colorectal Liver Metastases: Scanning Electron Microscopic Study 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2003 Abstract Interstitial laser hyperthermia (ILH) is an in situ ablative technique used to treat colorectal liver metastases. The relatively high recurrence of tumor after treatment by ILH may be related to incomplete destruction. Little is known about the effectiveness of ILH for destroying tumor microvasculature. The aim of this study was to define the changes to the microvascular architecture of tumors after treatment with ILH, specifically focusing on the completeness of tumor vasculature destruction. An intrasplenic induction model of liver metastases in 4- to 6-week-old male inbred CBA mice was used. Laser hyperthermia was applied to liver and tumor tissue using a bare optical quartz fiber from a Medilas Fibertom 4100 Nd:YAG surgical laser generator. The animals underwent microvascular corrosion casting of the livers immediately after application of ILH. Microvascular casts were then prepared and studied by scanning electron microscopy. ILH produced complete, uniform destruction of the tumor microvasculature with compete hemostasis. Blood flow in vessels larger than 100 μm diameter had a relatively protective effect, although ILH was able to overcome this barrier effectively by increasing the energy applied. ILH produces complete destruction of tumor microvasculature with hemostasis. The protective effect of blood flow in larger vessels can be overcome by the appropriate use of higher energy levels. Liver Metastasis (dpeaa)DE-He213 Colorectal Liver Metastasis (dpeaa)DE-He213 Tumor Vasculature (dpeaa)DE-He213 Liver Sinusoid (dpeaa)DE-He213 Tumor Microvasculature (dpeaa)DE-He213 Nikfarjam, Mehrdad aut Malcontenti-Wilson, Caterina aut Christophi, Christopher aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 28(2003), 1 vom: 05. Dez., Seite 33-37 (DE-627)SPR003391159 nnns volume:28 year:2003 number:1 day:05 month:12 pages:33-37 https://dx.doi.org/10.1007/s00268-003-6973-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 28 2003 1 05 12 33-37 |
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10.1007/s00268-003-6973-0 doi (DE-627)SPR003399656 (SPR)s00268-003-6973-0-e DE-627 ger DE-627 rakwb eng Muralidharan, Vijayaragavan verfasserin aut Effect of Interstitial Laser Hyperthermia in a Murine Model of Colorectal Liver Metastases: Scanning Electron Microscopic Study 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2003 Abstract Interstitial laser hyperthermia (ILH) is an in situ ablative technique used to treat colorectal liver metastases. The relatively high recurrence of tumor after treatment by ILH may be related to incomplete destruction. Little is known about the effectiveness of ILH for destroying tumor microvasculature. The aim of this study was to define the changes to the microvascular architecture of tumors after treatment with ILH, specifically focusing on the completeness of tumor vasculature destruction. An intrasplenic induction model of liver metastases in 4- to 6-week-old male inbred CBA mice was used. Laser hyperthermia was applied to liver and tumor tissue using a bare optical quartz fiber from a Medilas Fibertom 4100 Nd:YAG surgical laser generator. The animals underwent microvascular corrosion casting of the livers immediately after application of ILH. Microvascular casts were then prepared and studied by scanning electron microscopy. ILH produced complete, uniform destruction of the tumor microvasculature with compete hemostasis. Blood flow in vessels larger than 100 μm diameter had a relatively protective effect, although ILH was able to overcome this barrier effectively by increasing the energy applied. ILH produces complete destruction of tumor microvasculature with hemostasis. The protective effect of blood flow in larger vessels can be overcome by the appropriate use of higher energy levels. Liver Metastasis (dpeaa)DE-He213 Colorectal Liver Metastasis (dpeaa)DE-He213 Tumor Vasculature (dpeaa)DE-He213 Liver Sinusoid (dpeaa)DE-He213 Tumor Microvasculature (dpeaa)DE-He213 Nikfarjam, Mehrdad aut Malcontenti-Wilson, Caterina aut Christophi, Christopher aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 28(2003), 1 vom: 05. Dez., Seite 33-37 (DE-627)SPR003391159 nnns volume:28 year:2003 number:1 day:05 month:12 pages:33-37 https://dx.doi.org/10.1007/s00268-003-6973-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 28 2003 1 05 12 33-37 |
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10.1007/s00268-003-6973-0 doi (DE-627)SPR003399656 (SPR)s00268-003-6973-0-e DE-627 ger DE-627 rakwb eng Muralidharan, Vijayaragavan verfasserin aut Effect of Interstitial Laser Hyperthermia in a Murine Model of Colorectal Liver Metastases: Scanning Electron Microscopic Study 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2003 Abstract Interstitial laser hyperthermia (ILH) is an in situ ablative technique used to treat colorectal liver metastases. The relatively high recurrence of tumor after treatment by ILH may be related to incomplete destruction. Little is known about the effectiveness of ILH for destroying tumor microvasculature. The aim of this study was to define the changes to the microvascular architecture of tumors after treatment with ILH, specifically focusing on the completeness of tumor vasculature destruction. An intrasplenic induction model of liver metastases in 4- to 6-week-old male inbred CBA mice was used. Laser hyperthermia was applied to liver and tumor tissue using a bare optical quartz fiber from a Medilas Fibertom 4100 Nd:YAG surgical laser generator. The animals underwent microvascular corrosion casting of the livers immediately after application of ILH. Microvascular casts were then prepared and studied by scanning electron microscopy. ILH produced complete, uniform destruction of the tumor microvasculature with compete hemostasis. Blood flow in vessels larger than 100 μm diameter had a relatively protective effect, although ILH was able to overcome this barrier effectively by increasing the energy applied. ILH produces complete destruction of tumor microvasculature with hemostasis. The protective effect of blood flow in larger vessels can be overcome by the appropriate use of higher energy levels. Liver Metastasis (dpeaa)DE-He213 Colorectal Liver Metastasis (dpeaa)DE-He213 Tumor Vasculature (dpeaa)DE-He213 Liver Sinusoid (dpeaa)DE-He213 Tumor Microvasculature (dpeaa)DE-He213 Nikfarjam, Mehrdad aut Malcontenti-Wilson, Caterina aut Christophi, Christopher aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 28(2003), 1 vom: 05. Dez., Seite 33-37 (DE-627)SPR003391159 nnns volume:28 year:2003 number:1 day:05 month:12 pages:33-37 https://dx.doi.org/10.1007/s00268-003-6973-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 28 2003 1 05 12 33-37 |
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Effect of Interstitial Laser Hyperthermia in a Murine Model of Colorectal Liver Metastases: Scanning Electron Microscopic Study Liver Metastasis (dpeaa)DE-He213 Colorectal Liver Metastasis (dpeaa)DE-He213 Tumor Vasculature (dpeaa)DE-He213 Liver Sinusoid (dpeaa)DE-He213 Tumor Microvasculature (dpeaa)DE-He213 |
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effect of interstitial laser hyperthermia in a murine model of colorectal liver metastases: scanning electron microscopic study |
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Effect of Interstitial Laser Hyperthermia in a Murine Model of Colorectal Liver Metastases: Scanning Electron Microscopic Study |
| abstract |
Abstract Interstitial laser hyperthermia (ILH) is an in situ ablative technique used to treat colorectal liver metastases. The relatively high recurrence of tumor after treatment by ILH may be related to incomplete destruction. Little is known about the effectiveness of ILH for destroying tumor microvasculature. The aim of this study was to define the changes to the microvascular architecture of tumors after treatment with ILH, specifically focusing on the completeness of tumor vasculature destruction. An intrasplenic induction model of liver metastases in 4- to 6-week-old male inbred CBA mice was used. Laser hyperthermia was applied to liver and tumor tissue using a bare optical quartz fiber from a Medilas Fibertom 4100 Nd:YAG surgical laser generator. The animals underwent microvascular corrosion casting of the livers immediately after application of ILH. Microvascular casts were then prepared and studied by scanning electron microscopy. ILH produced complete, uniform destruction of the tumor microvasculature with compete hemostasis. Blood flow in vessels larger than 100 μm diameter had a relatively protective effect, although ILH was able to overcome this barrier effectively by increasing the energy applied. ILH produces complete destruction of tumor microvasculature with hemostasis. The protective effect of blood flow in larger vessels can be overcome by the appropriate use of higher energy levels. © Société Internationale de Chirurgie 2003 |
| abstractGer |
Abstract Interstitial laser hyperthermia (ILH) is an in situ ablative technique used to treat colorectal liver metastases. The relatively high recurrence of tumor after treatment by ILH may be related to incomplete destruction. Little is known about the effectiveness of ILH for destroying tumor microvasculature. The aim of this study was to define the changes to the microvascular architecture of tumors after treatment with ILH, specifically focusing on the completeness of tumor vasculature destruction. An intrasplenic induction model of liver metastases in 4- to 6-week-old male inbred CBA mice was used. Laser hyperthermia was applied to liver and tumor tissue using a bare optical quartz fiber from a Medilas Fibertom 4100 Nd:YAG surgical laser generator. The animals underwent microvascular corrosion casting of the livers immediately after application of ILH. Microvascular casts were then prepared and studied by scanning electron microscopy. ILH produced complete, uniform destruction of the tumor microvasculature with compete hemostasis. Blood flow in vessels larger than 100 μm diameter had a relatively protective effect, although ILH was able to overcome this barrier effectively by increasing the energy applied. ILH produces complete destruction of tumor microvasculature with hemostasis. The protective effect of blood flow in larger vessels can be overcome by the appropriate use of higher energy levels. © Société Internationale de Chirurgie 2003 |
| abstract_unstemmed |
Abstract Interstitial laser hyperthermia (ILH) is an in situ ablative technique used to treat colorectal liver metastases. The relatively high recurrence of tumor after treatment by ILH may be related to incomplete destruction. Little is known about the effectiveness of ILH for destroying tumor microvasculature. The aim of this study was to define the changes to the microvascular architecture of tumors after treatment with ILH, specifically focusing on the completeness of tumor vasculature destruction. An intrasplenic induction model of liver metastases in 4- to 6-week-old male inbred CBA mice was used. Laser hyperthermia was applied to liver and tumor tissue using a bare optical quartz fiber from a Medilas Fibertom 4100 Nd:YAG surgical laser generator. The animals underwent microvascular corrosion casting of the livers immediately after application of ILH. Microvascular casts were then prepared and studied by scanning electron microscopy. ILH produced complete, uniform destruction of the tumor microvasculature with compete hemostasis. Blood flow in vessels larger than 100 μm diameter had a relatively protective effect, although ILH was able to overcome this barrier effectively by increasing the energy applied. ILH produces complete destruction of tumor microvasculature with hemostasis. The protective effect of blood flow in larger vessels can be overcome by the appropriate use of higher energy levels. © Société Internationale de Chirurgie 2003 |
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| title_short |
Effect of Interstitial Laser Hyperthermia in a Murine Model of Colorectal Liver Metastases: Scanning Electron Microscopic Study |
| url |
https://dx.doi.org/10.1007/s00268-003-6973-0 |
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Nikfarjam, Mehrdad Malcontenti-Wilson, Caterina Christophi, Christopher |
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| doi_str |
10.1007/s00268-003-6973-0 |
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2024-07-03T19:19:04.074Z |
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