Platelets Promote Liver Regeneration in Early Period after Hepatectomy in Mice
Background Platelets contain several growth factors, including platelet-derived growth factor and hepatocyte growth factor. Materials and methods We examined the effects of platelet increment on liver regeneration after 70% hepatectomy. Hepatectomies were carried out in male BALB/c mice, and subsequ...
Ausführliche Beschreibung
Autor*in: |
Murata, Soichiro [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2007 |
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Anmerkung: |
© Société Internationale de Chirurgie 2007 |
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Übergeordnetes Werk: |
Enthalten in: World Journal of Surgery - Springer-Verlag, 1996, 31(2007), 4 vom: 05. März, Seite 808-816 |
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Übergeordnetes Werk: |
volume:31 ; year:2007 ; number:4 ; day:05 ; month:03 ; pages:808-816 |
Links: |
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DOI / URN: |
10.1007/s00268-006-0772-3 |
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Katalog-ID: |
SPR003412679 |
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520 | |a Background Platelets contain several growth factors, including platelet-derived growth factor and hepatocyte growth factor. Materials and methods We examined the effects of platelet increment on liver regeneration after 70% hepatectomy. Hepatectomies were carried out in male BALB/c mice, and subsequently divided into three groups: (i) untreated mice, (ii) thrombocytotic mice induced with thrombopoietin, and (iii) thrombocytopenic mice induced with anti-platelet antibody. Growth kinetics in the liver were analyzed as a function of the liver/body weight ratio, the mitotic index, the proliferating cell nuclear antigen labeling index and Ki-67 labeling index. Activation of signal transduction pathways relating to cell proliferation were examined, including the STAT3, Akt, and ERK1/2 pathways. Platelet accumulation in the residual liver was quantified by immunohistochemistry and transmission electron microscopy. Results In thrombocytotic and thrombocytopenic mice, liver/body weight ratios and Ki-67 labeling indices were significantly increased and significantly decreased, respectively, compared with untreated mice 48 hours post-hepatectomy. The Akt pathway was strongly activated, and platelet accumulation was significantly increased in thrombocytotic group 5 minutes post-hepatectomy compared with normal and thrombocytopenic groups. After hepatectomy platelets accumulated in the sinusoids of liver and promoted hepatocyte proliferation in early period after hepatectomy. Conclusion By increasing or decreasing the platelet, marked changes in liver regeneration can occur, due to differences in cellular signaling and mitosis. | ||
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10.1007/s00268-006-0772-3 doi (DE-627)SPR003412679 (SPR)s00268-006-0772-3-e DE-627 ger DE-627 rakwb eng Murata, Soichiro verfasserin aut Platelets Promote Liver Regeneration in Early Period after Hepatectomy in Mice 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2007 Background Platelets contain several growth factors, including platelet-derived growth factor and hepatocyte growth factor. Materials and methods We examined the effects of platelet increment on liver regeneration after 70% hepatectomy. Hepatectomies were carried out in male BALB/c mice, and subsequently divided into three groups: (i) untreated mice, (ii) thrombocytotic mice induced with thrombopoietin, and (iii) thrombocytopenic mice induced with anti-platelet antibody. Growth kinetics in the liver were analyzed as a function of the liver/body weight ratio, the mitotic index, the proliferating cell nuclear antigen labeling index and Ki-67 labeling index. Activation of signal transduction pathways relating to cell proliferation were examined, including the STAT3, Akt, and ERK1/2 pathways. Platelet accumulation in the residual liver was quantified by immunohistochemistry and transmission electron microscopy. Results In thrombocytotic and thrombocytopenic mice, liver/body weight ratios and Ki-67 labeling indices were significantly increased and significantly decreased, respectively, compared with untreated mice 48 hours post-hepatectomy. The Akt pathway was strongly activated, and platelet accumulation was significantly increased in thrombocytotic group 5 minutes post-hepatectomy compared with normal and thrombocytopenic groups. After hepatectomy platelets accumulated in the sinusoids of liver and promoted hepatocyte proliferation in early period after hepatectomy. Conclusion By increasing or decreasing the platelet, marked changes in liver regeneration can occur, due to differences in cellular signaling and mitosis. Hepatocyte Growth Factor (dpeaa)DE-He213 Proliferate Cell Nuclear Antigen (dpeaa)DE-He213 Liver Regeneration (dpeaa)DE-He213 Sinusoidal Endothelial Cell (dpeaa)DE-He213 Hepatocyte Proliferation (dpeaa)DE-He213 Ohkohchi, Nobuhiro aut Matsuo, Ryota aut Ikeda, Osamu aut Myronovych, Andriy aut Hoshi, Reiko aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 31(2007), 4 vom: 05. März, Seite 808-816 (DE-627)SPR003391159 nnns volume:31 year:2007 number:4 day:05 month:03 pages:808-816 https://dx.doi.org/10.1007/s00268-006-0772-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 31 2007 4 05 03 808-816 |
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10.1007/s00268-006-0772-3 doi (DE-627)SPR003412679 (SPR)s00268-006-0772-3-e DE-627 ger DE-627 rakwb eng Murata, Soichiro verfasserin aut Platelets Promote Liver Regeneration in Early Period after Hepatectomy in Mice 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2007 Background Platelets contain several growth factors, including platelet-derived growth factor and hepatocyte growth factor. Materials and methods We examined the effects of platelet increment on liver regeneration after 70% hepatectomy. Hepatectomies were carried out in male BALB/c mice, and subsequently divided into three groups: (i) untreated mice, (ii) thrombocytotic mice induced with thrombopoietin, and (iii) thrombocytopenic mice induced with anti-platelet antibody. Growth kinetics in the liver were analyzed as a function of the liver/body weight ratio, the mitotic index, the proliferating cell nuclear antigen labeling index and Ki-67 labeling index. Activation of signal transduction pathways relating to cell proliferation were examined, including the STAT3, Akt, and ERK1/2 pathways. Platelet accumulation in the residual liver was quantified by immunohistochemistry and transmission electron microscopy. Results In thrombocytotic and thrombocytopenic mice, liver/body weight ratios and Ki-67 labeling indices were significantly increased and significantly decreased, respectively, compared with untreated mice 48 hours post-hepatectomy. The Akt pathway was strongly activated, and platelet accumulation was significantly increased in thrombocytotic group 5 minutes post-hepatectomy compared with normal and thrombocytopenic groups. After hepatectomy platelets accumulated in the sinusoids of liver and promoted hepatocyte proliferation in early period after hepatectomy. Conclusion By increasing or decreasing the platelet, marked changes in liver regeneration can occur, due to differences in cellular signaling and mitosis. Hepatocyte Growth Factor (dpeaa)DE-He213 Proliferate Cell Nuclear Antigen (dpeaa)DE-He213 Liver Regeneration (dpeaa)DE-He213 Sinusoidal Endothelial Cell (dpeaa)DE-He213 Hepatocyte Proliferation (dpeaa)DE-He213 Ohkohchi, Nobuhiro aut Matsuo, Ryota aut Ikeda, Osamu aut Myronovych, Andriy aut Hoshi, Reiko aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 31(2007), 4 vom: 05. März, Seite 808-816 (DE-627)SPR003391159 nnns volume:31 year:2007 number:4 day:05 month:03 pages:808-816 https://dx.doi.org/10.1007/s00268-006-0772-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 31 2007 4 05 03 808-816 |
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10.1007/s00268-006-0772-3 doi (DE-627)SPR003412679 (SPR)s00268-006-0772-3-e DE-627 ger DE-627 rakwb eng Murata, Soichiro verfasserin aut Platelets Promote Liver Regeneration in Early Period after Hepatectomy in Mice 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2007 Background Platelets contain several growth factors, including platelet-derived growth factor and hepatocyte growth factor. Materials and methods We examined the effects of platelet increment on liver regeneration after 70% hepatectomy. Hepatectomies were carried out in male BALB/c mice, and subsequently divided into three groups: (i) untreated mice, (ii) thrombocytotic mice induced with thrombopoietin, and (iii) thrombocytopenic mice induced with anti-platelet antibody. Growth kinetics in the liver were analyzed as a function of the liver/body weight ratio, the mitotic index, the proliferating cell nuclear antigen labeling index and Ki-67 labeling index. Activation of signal transduction pathways relating to cell proliferation were examined, including the STAT3, Akt, and ERK1/2 pathways. Platelet accumulation in the residual liver was quantified by immunohistochemistry and transmission electron microscopy. Results In thrombocytotic and thrombocytopenic mice, liver/body weight ratios and Ki-67 labeling indices were significantly increased and significantly decreased, respectively, compared with untreated mice 48 hours post-hepatectomy. The Akt pathway was strongly activated, and platelet accumulation was significantly increased in thrombocytotic group 5 minutes post-hepatectomy compared with normal and thrombocytopenic groups. After hepatectomy platelets accumulated in the sinusoids of liver and promoted hepatocyte proliferation in early period after hepatectomy. Conclusion By increasing or decreasing the platelet, marked changes in liver regeneration can occur, due to differences in cellular signaling and mitosis. Hepatocyte Growth Factor (dpeaa)DE-He213 Proliferate Cell Nuclear Antigen (dpeaa)DE-He213 Liver Regeneration (dpeaa)DE-He213 Sinusoidal Endothelial Cell (dpeaa)DE-He213 Hepatocyte Proliferation (dpeaa)DE-He213 Ohkohchi, Nobuhiro aut Matsuo, Ryota aut Ikeda, Osamu aut Myronovych, Andriy aut Hoshi, Reiko aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 31(2007), 4 vom: 05. März, Seite 808-816 (DE-627)SPR003391159 nnns volume:31 year:2007 number:4 day:05 month:03 pages:808-816 https://dx.doi.org/10.1007/s00268-006-0772-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 31 2007 4 05 03 808-816 |
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10.1007/s00268-006-0772-3 doi (DE-627)SPR003412679 (SPR)s00268-006-0772-3-e DE-627 ger DE-627 rakwb eng Murata, Soichiro verfasserin aut Platelets Promote Liver Regeneration in Early Period after Hepatectomy in Mice 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2007 Background Platelets contain several growth factors, including platelet-derived growth factor and hepatocyte growth factor. Materials and methods We examined the effects of platelet increment on liver regeneration after 70% hepatectomy. Hepatectomies were carried out in male BALB/c mice, and subsequently divided into three groups: (i) untreated mice, (ii) thrombocytotic mice induced with thrombopoietin, and (iii) thrombocytopenic mice induced with anti-platelet antibody. Growth kinetics in the liver were analyzed as a function of the liver/body weight ratio, the mitotic index, the proliferating cell nuclear antigen labeling index and Ki-67 labeling index. Activation of signal transduction pathways relating to cell proliferation were examined, including the STAT3, Akt, and ERK1/2 pathways. Platelet accumulation in the residual liver was quantified by immunohistochemistry and transmission electron microscopy. Results In thrombocytotic and thrombocytopenic mice, liver/body weight ratios and Ki-67 labeling indices were significantly increased and significantly decreased, respectively, compared with untreated mice 48 hours post-hepatectomy. The Akt pathway was strongly activated, and platelet accumulation was significantly increased in thrombocytotic group 5 minutes post-hepatectomy compared with normal and thrombocytopenic groups. After hepatectomy platelets accumulated in the sinusoids of liver and promoted hepatocyte proliferation in early period after hepatectomy. Conclusion By increasing or decreasing the platelet, marked changes in liver regeneration can occur, due to differences in cellular signaling and mitosis. Hepatocyte Growth Factor (dpeaa)DE-He213 Proliferate Cell Nuclear Antigen (dpeaa)DE-He213 Liver Regeneration (dpeaa)DE-He213 Sinusoidal Endothelial Cell (dpeaa)DE-He213 Hepatocyte Proliferation (dpeaa)DE-He213 Ohkohchi, Nobuhiro aut Matsuo, Ryota aut Ikeda, Osamu aut Myronovych, Andriy aut Hoshi, Reiko aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 31(2007), 4 vom: 05. März, Seite 808-816 (DE-627)SPR003391159 nnns volume:31 year:2007 number:4 day:05 month:03 pages:808-816 https://dx.doi.org/10.1007/s00268-006-0772-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 31 2007 4 05 03 808-816 |
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10.1007/s00268-006-0772-3 doi (DE-627)SPR003412679 (SPR)s00268-006-0772-3-e DE-627 ger DE-627 rakwb eng Murata, Soichiro verfasserin aut Platelets Promote Liver Regeneration in Early Period after Hepatectomy in Mice 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2007 Background Platelets contain several growth factors, including platelet-derived growth factor and hepatocyte growth factor. Materials and methods We examined the effects of platelet increment on liver regeneration after 70% hepatectomy. Hepatectomies were carried out in male BALB/c mice, and subsequently divided into three groups: (i) untreated mice, (ii) thrombocytotic mice induced with thrombopoietin, and (iii) thrombocytopenic mice induced with anti-platelet antibody. Growth kinetics in the liver were analyzed as a function of the liver/body weight ratio, the mitotic index, the proliferating cell nuclear antigen labeling index and Ki-67 labeling index. Activation of signal transduction pathways relating to cell proliferation were examined, including the STAT3, Akt, and ERK1/2 pathways. Platelet accumulation in the residual liver was quantified by immunohistochemistry and transmission electron microscopy. Results In thrombocytotic and thrombocytopenic mice, liver/body weight ratios and Ki-67 labeling indices were significantly increased and significantly decreased, respectively, compared with untreated mice 48 hours post-hepatectomy. The Akt pathway was strongly activated, and platelet accumulation was significantly increased in thrombocytotic group 5 minutes post-hepatectomy compared with normal and thrombocytopenic groups. After hepatectomy platelets accumulated in the sinusoids of liver and promoted hepatocyte proliferation in early period after hepatectomy. Conclusion By increasing or decreasing the platelet, marked changes in liver regeneration can occur, due to differences in cellular signaling and mitosis. Hepatocyte Growth Factor (dpeaa)DE-He213 Proliferate Cell Nuclear Antigen (dpeaa)DE-He213 Liver Regeneration (dpeaa)DE-He213 Sinusoidal Endothelial Cell (dpeaa)DE-He213 Hepatocyte Proliferation (dpeaa)DE-He213 Ohkohchi, Nobuhiro aut Matsuo, Ryota aut Ikeda, Osamu aut Myronovych, Andriy aut Hoshi, Reiko aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 31(2007), 4 vom: 05. März, Seite 808-816 (DE-627)SPR003391159 nnns volume:31 year:2007 number:4 day:05 month:03 pages:808-816 https://dx.doi.org/10.1007/s00268-006-0772-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 31 2007 4 05 03 808-816 |
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Materials and methods We examined the effects of platelet increment on liver regeneration after 70% hepatectomy. Hepatectomies were carried out in male BALB/c mice, and subsequently divided into three groups: (i) untreated mice, (ii) thrombocytotic mice induced with thrombopoietin, and (iii) thrombocytopenic mice induced with anti-platelet antibody. Growth kinetics in the liver were analyzed as a function of the liver/body weight ratio, the mitotic index, the proliferating cell nuclear antigen labeling index and Ki-67 labeling index. Activation of signal transduction pathways relating to cell proliferation were examined, including the STAT3, Akt, and ERK1/2 pathways. Platelet accumulation in the residual liver was quantified by immunohistochemistry and transmission electron microscopy. Results In thrombocytotic and thrombocytopenic mice, liver/body weight ratios and Ki-67 labeling indices were significantly increased and significantly decreased, respectively, compared with untreated mice 48 hours post-hepatectomy. The Akt pathway was strongly activated, and platelet accumulation was significantly increased in thrombocytotic group 5 minutes post-hepatectomy compared with normal and thrombocytopenic groups. After hepatectomy platelets accumulated in the sinusoids of liver and promoted hepatocyte proliferation in early period after hepatectomy. 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Murata, Soichiro |
doi_str_mv |
10.1007/s00268-006-0772-3 |
title_sort |
platelets promote liver regeneration in early period after hepatectomy in mice |
title_auth |
Platelets Promote Liver Regeneration in Early Period after Hepatectomy in Mice |
abstract |
Background Platelets contain several growth factors, including platelet-derived growth factor and hepatocyte growth factor. Materials and methods We examined the effects of platelet increment on liver regeneration after 70% hepatectomy. Hepatectomies were carried out in male BALB/c mice, and subsequently divided into three groups: (i) untreated mice, (ii) thrombocytotic mice induced with thrombopoietin, and (iii) thrombocytopenic mice induced with anti-platelet antibody. Growth kinetics in the liver were analyzed as a function of the liver/body weight ratio, the mitotic index, the proliferating cell nuclear antigen labeling index and Ki-67 labeling index. Activation of signal transduction pathways relating to cell proliferation were examined, including the STAT3, Akt, and ERK1/2 pathways. Platelet accumulation in the residual liver was quantified by immunohistochemistry and transmission electron microscopy. Results In thrombocytotic and thrombocytopenic mice, liver/body weight ratios and Ki-67 labeling indices were significantly increased and significantly decreased, respectively, compared with untreated mice 48 hours post-hepatectomy. The Akt pathway was strongly activated, and platelet accumulation was significantly increased in thrombocytotic group 5 minutes post-hepatectomy compared with normal and thrombocytopenic groups. After hepatectomy platelets accumulated in the sinusoids of liver and promoted hepatocyte proliferation in early period after hepatectomy. Conclusion By increasing or decreasing the platelet, marked changes in liver regeneration can occur, due to differences in cellular signaling and mitosis. © Société Internationale de Chirurgie 2007 |
abstractGer |
Background Platelets contain several growth factors, including platelet-derived growth factor and hepatocyte growth factor. Materials and methods We examined the effects of platelet increment on liver regeneration after 70% hepatectomy. Hepatectomies were carried out in male BALB/c mice, and subsequently divided into three groups: (i) untreated mice, (ii) thrombocytotic mice induced with thrombopoietin, and (iii) thrombocytopenic mice induced with anti-platelet antibody. Growth kinetics in the liver were analyzed as a function of the liver/body weight ratio, the mitotic index, the proliferating cell nuclear antigen labeling index and Ki-67 labeling index. Activation of signal transduction pathways relating to cell proliferation were examined, including the STAT3, Akt, and ERK1/2 pathways. Platelet accumulation in the residual liver was quantified by immunohistochemistry and transmission electron microscopy. Results In thrombocytotic and thrombocytopenic mice, liver/body weight ratios and Ki-67 labeling indices were significantly increased and significantly decreased, respectively, compared with untreated mice 48 hours post-hepatectomy. The Akt pathway was strongly activated, and platelet accumulation was significantly increased in thrombocytotic group 5 minutes post-hepatectomy compared with normal and thrombocytopenic groups. After hepatectomy platelets accumulated in the sinusoids of liver and promoted hepatocyte proliferation in early period after hepatectomy. Conclusion By increasing or decreasing the platelet, marked changes in liver regeneration can occur, due to differences in cellular signaling and mitosis. © Société Internationale de Chirurgie 2007 |
abstract_unstemmed |
Background Platelets contain several growth factors, including platelet-derived growth factor and hepatocyte growth factor. Materials and methods We examined the effects of platelet increment on liver regeneration after 70% hepatectomy. Hepatectomies were carried out in male BALB/c mice, and subsequently divided into three groups: (i) untreated mice, (ii) thrombocytotic mice induced with thrombopoietin, and (iii) thrombocytopenic mice induced with anti-platelet antibody. Growth kinetics in the liver were analyzed as a function of the liver/body weight ratio, the mitotic index, the proliferating cell nuclear antigen labeling index and Ki-67 labeling index. Activation of signal transduction pathways relating to cell proliferation were examined, including the STAT3, Akt, and ERK1/2 pathways. Platelet accumulation in the residual liver was quantified by immunohistochemistry and transmission electron microscopy. Results In thrombocytotic and thrombocytopenic mice, liver/body weight ratios and Ki-67 labeling indices were significantly increased and significantly decreased, respectively, compared with untreated mice 48 hours post-hepatectomy. The Akt pathway was strongly activated, and platelet accumulation was significantly increased in thrombocytotic group 5 minutes post-hepatectomy compared with normal and thrombocytopenic groups. After hepatectomy platelets accumulated in the sinusoids of liver and promoted hepatocyte proliferation in early period after hepatectomy. Conclusion By increasing or decreasing the platelet, marked changes in liver regeneration can occur, due to differences in cellular signaling and mitosis. © Société Internationale de Chirurgie 2007 |
collection_details |
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title_short |
Platelets Promote Liver Regeneration in Early Period after Hepatectomy in Mice |
url |
https://dx.doi.org/10.1007/s00268-006-0772-3 |
remote_bool |
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author2 |
Ohkohchi, Nobuhiro Matsuo, Ryota Ikeda, Osamu Myronovych, Andriy Hoshi, Reiko |
author2Str |
Ohkohchi, Nobuhiro Matsuo, Ryota Ikeda, Osamu Myronovych, Andriy Hoshi, Reiko |
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up_date |
2024-07-03T19:22:29.496Z |
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