Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery
Background In gastric cancer, the recurrence rate is high even after curative surgery. A relevant issue is the identification of independent prognostic factors to select high-risk patients; such features can be used as predictive factors for tailored therapies. In this study we have investigated the...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Galizia, Gennaro [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Schlagwörter: |
Epidermal Growth Factor Receptor |
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| Anmerkung: |
© Société Internationale de Chirurgie 2007 |
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| Übergeordnetes Werk: |
Enthalten in: World Journal of Surgery - Springer-Verlag, 1996, 31(2007), 7 vom: 22. Mai, Seite 1458-1468 |
|---|---|
| Übergeordnetes Werk: |
volume:31 ; year:2007 ; number:7 ; day:22 ; month:05 ; pages:1458-1468 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00268-007-9016-4 |
|---|
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SPR003413608 |
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| 520 | |a Background In gastric cancer, the recurrence rate is high even after curative surgery. A relevant issue is the identification of independent prognostic factors to select high-risk patients; such features can be used as predictive factors for tailored therapies. In this study we have investigated the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for predicting cancer behavior and clinical outcome in gastric cancer patients undergoing potentially curative surgery. Methods Epidermal growth factor receptor determination using a commercially available immunohistochemistry (IHC) kit was performed in tissues from 82 gastric cancer patients receiving primary surgical treatment and in 25 normal gastric mucosa specimens from noncancer patients. The EGFR positivity was correlated with disease recurrence and survival in univariate and multivariate analyses. Results Forty-four percent (36 cases) of gastric cancers were EGFR positive. In 66 curatively treated patients, EGFR expression correlated with disease recurrence and poorer survival in both univariate and multivariate analyses. In a multivariate model for predicting recurrence and survival, advanced tumor extension ($ T_{3} $ or $ T_{4} $), nodal metastases, and EGFR expression were the only independent covariates. In particular, EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system. Conclusions These findings suggest that EGFR expression may be useful in identifying high-risk gastric cancer patients undergoing potentially curative surgery. Multimodal treatments should be considered in the adjuvant treatment of these patients. | ||
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10.1007/s00268-007-9016-4 doi (DE-627)SPR003413608 (SPR)s00268-007-9016-4-e DE-627 ger DE-627 rakwb eng Galizia, Gennaro verfasserin aut Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2007 Background In gastric cancer, the recurrence rate is high even after curative surgery. A relevant issue is the identification of independent prognostic factors to select high-risk patients; such features can be used as predictive factors for tailored therapies. In this study we have investigated the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for predicting cancer behavior and clinical outcome in gastric cancer patients undergoing potentially curative surgery. Methods Epidermal growth factor receptor determination using a commercially available immunohistochemistry (IHC) kit was performed in tissues from 82 gastric cancer patients receiving primary surgical treatment and in 25 normal gastric mucosa specimens from noncancer patients. The EGFR positivity was correlated with disease recurrence and survival in univariate and multivariate analyses. Results Forty-four percent (36 cases) of gastric cancers were EGFR positive. In 66 curatively treated patients, EGFR expression correlated with disease recurrence and poorer survival in both univariate and multivariate analyses. In a multivariate model for predicting recurrence and survival, advanced tumor extension ($ T_{3} $ or $ T_{4} $), nodal metastases, and EGFR expression were the only independent covariates. In particular, EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system. Conclusions These findings suggest that EGFR expression may be useful in identifying high-risk gastric cancer patients undergoing potentially curative surgery. Multimodal treatments should be considered in the adjuvant treatment of these patients. Gastric Cancer (dpeaa)DE-He213 Epidermal Growth Factor Receptor (dpeaa)DE-He213 Gastric Cancer Patient (dpeaa)DE-He213 Epidermal Growth Factor Receptor Expression (dpeaa)DE-He213 Epidermal Growth Factor Receptor Protein Expression (dpeaa)DE-He213 Lieto, Eva aut Orditura, Michele aut Castellano, Paolo aut Mura, Anna La aut Imperatore, Vincenzo aut Pinto, Margherita aut Zamboli, Anna aut De Vita, Ferdinando aut Ferraraccio, Francesca aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 31(2007), 7 vom: 22. Mai, Seite 1458-1468 (DE-627)SPR003391159 nnns volume:31 year:2007 number:7 day:22 month:05 pages:1458-1468 https://dx.doi.org/10.1007/s00268-007-9016-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 31 2007 7 22 05 1458-1468 |
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10.1007/s00268-007-9016-4 doi (DE-627)SPR003413608 (SPR)s00268-007-9016-4-e DE-627 ger DE-627 rakwb eng Galizia, Gennaro verfasserin aut Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2007 Background In gastric cancer, the recurrence rate is high even after curative surgery. A relevant issue is the identification of independent prognostic factors to select high-risk patients; such features can be used as predictive factors for tailored therapies. In this study we have investigated the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for predicting cancer behavior and clinical outcome in gastric cancer patients undergoing potentially curative surgery. Methods Epidermal growth factor receptor determination using a commercially available immunohistochemistry (IHC) kit was performed in tissues from 82 gastric cancer patients receiving primary surgical treatment and in 25 normal gastric mucosa specimens from noncancer patients. The EGFR positivity was correlated with disease recurrence and survival in univariate and multivariate analyses. Results Forty-four percent (36 cases) of gastric cancers were EGFR positive. In 66 curatively treated patients, EGFR expression correlated with disease recurrence and poorer survival in both univariate and multivariate analyses. In a multivariate model for predicting recurrence and survival, advanced tumor extension ($ T_{3} $ or $ T_{4} $), nodal metastases, and EGFR expression were the only independent covariates. In particular, EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system. Conclusions These findings suggest that EGFR expression may be useful in identifying high-risk gastric cancer patients undergoing potentially curative surgery. Multimodal treatments should be considered in the adjuvant treatment of these patients. Gastric Cancer (dpeaa)DE-He213 Epidermal Growth Factor Receptor (dpeaa)DE-He213 Gastric Cancer Patient (dpeaa)DE-He213 Epidermal Growth Factor Receptor Expression (dpeaa)DE-He213 Epidermal Growth Factor Receptor Protein Expression (dpeaa)DE-He213 Lieto, Eva aut Orditura, Michele aut Castellano, Paolo aut Mura, Anna La aut Imperatore, Vincenzo aut Pinto, Margherita aut Zamboli, Anna aut De Vita, Ferdinando aut Ferraraccio, Francesca aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 31(2007), 7 vom: 22. Mai, Seite 1458-1468 (DE-627)SPR003391159 nnns volume:31 year:2007 number:7 day:22 month:05 pages:1458-1468 https://dx.doi.org/10.1007/s00268-007-9016-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 31 2007 7 22 05 1458-1468 |
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10.1007/s00268-007-9016-4 doi (DE-627)SPR003413608 (SPR)s00268-007-9016-4-e DE-627 ger DE-627 rakwb eng Galizia, Gennaro verfasserin aut Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2007 Background In gastric cancer, the recurrence rate is high even after curative surgery. A relevant issue is the identification of independent prognostic factors to select high-risk patients; such features can be used as predictive factors for tailored therapies. In this study we have investigated the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for predicting cancer behavior and clinical outcome in gastric cancer patients undergoing potentially curative surgery. Methods Epidermal growth factor receptor determination using a commercially available immunohistochemistry (IHC) kit was performed in tissues from 82 gastric cancer patients receiving primary surgical treatment and in 25 normal gastric mucosa specimens from noncancer patients. The EGFR positivity was correlated with disease recurrence and survival in univariate and multivariate analyses. Results Forty-four percent (36 cases) of gastric cancers were EGFR positive. In 66 curatively treated patients, EGFR expression correlated with disease recurrence and poorer survival in both univariate and multivariate analyses. In a multivariate model for predicting recurrence and survival, advanced tumor extension ($ T_{3} $ or $ T_{4} $), nodal metastases, and EGFR expression were the only independent covariates. In particular, EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system. Conclusions These findings suggest that EGFR expression may be useful in identifying high-risk gastric cancer patients undergoing potentially curative surgery. Multimodal treatments should be considered in the adjuvant treatment of these patients. Gastric Cancer (dpeaa)DE-He213 Epidermal Growth Factor Receptor (dpeaa)DE-He213 Gastric Cancer Patient (dpeaa)DE-He213 Epidermal Growth Factor Receptor Expression (dpeaa)DE-He213 Epidermal Growth Factor Receptor Protein Expression (dpeaa)DE-He213 Lieto, Eva aut Orditura, Michele aut Castellano, Paolo aut Mura, Anna La aut Imperatore, Vincenzo aut Pinto, Margherita aut Zamboli, Anna aut De Vita, Ferdinando aut Ferraraccio, Francesca aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 31(2007), 7 vom: 22. Mai, Seite 1458-1468 (DE-627)SPR003391159 nnns volume:31 year:2007 number:7 day:22 month:05 pages:1458-1468 https://dx.doi.org/10.1007/s00268-007-9016-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 31 2007 7 22 05 1458-1468 |
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10.1007/s00268-007-9016-4 doi (DE-627)SPR003413608 (SPR)s00268-007-9016-4-e DE-627 ger DE-627 rakwb eng Galizia, Gennaro verfasserin aut Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2007 Background In gastric cancer, the recurrence rate is high even after curative surgery. A relevant issue is the identification of independent prognostic factors to select high-risk patients; such features can be used as predictive factors for tailored therapies. In this study we have investigated the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for predicting cancer behavior and clinical outcome in gastric cancer patients undergoing potentially curative surgery. Methods Epidermal growth factor receptor determination using a commercially available immunohistochemistry (IHC) kit was performed in tissues from 82 gastric cancer patients receiving primary surgical treatment and in 25 normal gastric mucosa specimens from noncancer patients. The EGFR positivity was correlated with disease recurrence and survival in univariate and multivariate analyses. Results Forty-four percent (36 cases) of gastric cancers were EGFR positive. In 66 curatively treated patients, EGFR expression correlated with disease recurrence and poorer survival in both univariate and multivariate analyses. In a multivariate model for predicting recurrence and survival, advanced tumor extension ($ T_{3} $ or $ T_{4} $), nodal metastases, and EGFR expression were the only independent covariates. In particular, EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system. Conclusions These findings suggest that EGFR expression may be useful in identifying high-risk gastric cancer patients undergoing potentially curative surgery. Multimodal treatments should be considered in the adjuvant treatment of these patients. Gastric Cancer (dpeaa)DE-He213 Epidermal Growth Factor Receptor (dpeaa)DE-He213 Gastric Cancer Patient (dpeaa)DE-He213 Epidermal Growth Factor Receptor Expression (dpeaa)DE-He213 Epidermal Growth Factor Receptor Protein Expression (dpeaa)DE-He213 Lieto, Eva aut Orditura, Michele aut Castellano, Paolo aut Mura, Anna La aut Imperatore, Vincenzo aut Pinto, Margherita aut Zamboli, Anna aut De Vita, Ferdinando aut Ferraraccio, Francesca aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 31(2007), 7 vom: 22. Mai, Seite 1458-1468 (DE-627)SPR003391159 nnns volume:31 year:2007 number:7 day:22 month:05 pages:1458-1468 https://dx.doi.org/10.1007/s00268-007-9016-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 31 2007 7 22 05 1458-1468 |
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10.1007/s00268-007-9016-4 doi (DE-627)SPR003413608 (SPR)s00268-007-9016-4-e DE-627 ger DE-627 rakwb eng Galizia, Gennaro verfasserin aut Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2007 Background In gastric cancer, the recurrence rate is high even after curative surgery. A relevant issue is the identification of independent prognostic factors to select high-risk patients; such features can be used as predictive factors for tailored therapies. In this study we have investigated the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for predicting cancer behavior and clinical outcome in gastric cancer patients undergoing potentially curative surgery. Methods Epidermal growth factor receptor determination using a commercially available immunohistochemistry (IHC) kit was performed in tissues from 82 gastric cancer patients receiving primary surgical treatment and in 25 normal gastric mucosa specimens from noncancer patients. The EGFR positivity was correlated with disease recurrence and survival in univariate and multivariate analyses. Results Forty-four percent (36 cases) of gastric cancers were EGFR positive. In 66 curatively treated patients, EGFR expression correlated with disease recurrence and poorer survival in both univariate and multivariate analyses. In a multivariate model for predicting recurrence and survival, advanced tumor extension ($ T_{3} $ or $ T_{4} $), nodal metastases, and EGFR expression were the only independent covariates. In particular, EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system. Conclusions These findings suggest that EGFR expression may be useful in identifying high-risk gastric cancer patients undergoing potentially curative surgery. Multimodal treatments should be considered in the adjuvant treatment of these patients. Gastric Cancer (dpeaa)DE-He213 Epidermal Growth Factor Receptor (dpeaa)DE-He213 Gastric Cancer Patient (dpeaa)DE-He213 Epidermal Growth Factor Receptor Expression (dpeaa)DE-He213 Epidermal Growth Factor Receptor Protein Expression (dpeaa)DE-He213 Lieto, Eva aut Orditura, Michele aut Castellano, Paolo aut Mura, Anna La aut Imperatore, Vincenzo aut Pinto, Margherita aut Zamboli, Anna aut De Vita, Ferdinando aut Ferraraccio, Francesca aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 31(2007), 7 vom: 22. Mai, Seite 1458-1468 (DE-627)SPR003391159 nnns volume:31 year:2007 number:7 day:22 month:05 pages:1458-1468 https://dx.doi.org/10.1007/s00268-007-9016-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 31 2007 7 22 05 1458-1468 |
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Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery Gastric Cancer (dpeaa)DE-He213 Epidermal Growth Factor Receptor (dpeaa)DE-He213 Gastric Cancer Patient (dpeaa)DE-He213 Epidermal Growth Factor Receptor Expression (dpeaa)DE-He213 Epidermal Growth Factor Receptor Protein Expression (dpeaa)DE-He213 |
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Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery |
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Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery |
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Galizia, Gennaro |
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World Journal of Surgery |
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Galizia, Gennaro Lieto, Eva Orditura, Michele Castellano, Paolo Mura, Anna La Imperatore, Vincenzo Pinto, Margherita Zamboli, Anna De Vita, Ferdinando Ferraraccio, Francesca |
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epidermal growth factor receptor (egfr) expression is associated with a worse prognosis in gastric cancer patients undergoing curative surgery |
| title_auth |
Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery |
| abstract |
Background In gastric cancer, the recurrence rate is high even after curative surgery. A relevant issue is the identification of independent prognostic factors to select high-risk patients; such features can be used as predictive factors for tailored therapies. In this study we have investigated the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for predicting cancer behavior and clinical outcome in gastric cancer patients undergoing potentially curative surgery. Methods Epidermal growth factor receptor determination using a commercially available immunohistochemistry (IHC) kit was performed in tissues from 82 gastric cancer patients receiving primary surgical treatment and in 25 normal gastric mucosa specimens from noncancer patients. The EGFR positivity was correlated with disease recurrence and survival in univariate and multivariate analyses. Results Forty-four percent (36 cases) of gastric cancers were EGFR positive. In 66 curatively treated patients, EGFR expression correlated with disease recurrence and poorer survival in both univariate and multivariate analyses. In a multivariate model for predicting recurrence and survival, advanced tumor extension ($ T_{3} $ or $ T_{4} $), nodal metastases, and EGFR expression were the only independent covariates. In particular, EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system. Conclusions These findings suggest that EGFR expression may be useful in identifying high-risk gastric cancer patients undergoing potentially curative surgery. Multimodal treatments should be considered in the adjuvant treatment of these patients. © Société Internationale de Chirurgie 2007 |
| abstractGer |
Background In gastric cancer, the recurrence rate is high even after curative surgery. A relevant issue is the identification of independent prognostic factors to select high-risk patients; such features can be used as predictive factors for tailored therapies. In this study we have investigated the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for predicting cancer behavior and clinical outcome in gastric cancer patients undergoing potentially curative surgery. Methods Epidermal growth factor receptor determination using a commercially available immunohistochemistry (IHC) kit was performed in tissues from 82 gastric cancer patients receiving primary surgical treatment and in 25 normal gastric mucosa specimens from noncancer patients. The EGFR positivity was correlated with disease recurrence and survival in univariate and multivariate analyses. Results Forty-four percent (36 cases) of gastric cancers were EGFR positive. In 66 curatively treated patients, EGFR expression correlated with disease recurrence and poorer survival in both univariate and multivariate analyses. In a multivariate model for predicting recurrence and survival, advanced tumor extension ($ T_{3} $ or $ T_{4} $), nodal metastases, and EGFR expression were the only independent covariates. In particular, EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system. Conclusions These findings suggest that EGFR expression may be useful in identifying high-risk gastric cancer patients undergoing potentially curative surgery. Multimodal treatments should be considered in the adjuvant treatment of these patients. © Société Internationale de Chirurgie 2007 |
| abstract_unstemmed |
Background In gastric cancer, the recurrence rate is high even after curative surgery. A relevant issue is the identification of independent prognostic factors to select high-risk patients; such features can be used as predictive factors for tailored therapies. In this study we have investigated the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for predicting cancer behavior and clinical outcome in gastric cancer patients undergoing potentially curative surgery. Methods Epidermal growth factor receptor determination using a commercially available immunohistochemistry (IHC) kit was performed in tissues from 82 gastric cancer patients receiving primary surgical treatment and in 25 normal gastric mucosa specimens from noncancer patients. The EGFR positivity was correlated with disease recurrence and survival in univariate and multivariate analyses. Results Forty-four percent (36 cases) of gastric cancers were EGFR positive. In 66 curatively treated patients, EGFR expression correlated with disease recurrence and poorer survival in both univariate and multivariate analyses. In a multivariate model for predicting recurrence and survival, advanced tumor extension ($ T_{3} $ or $ T_{4} $), nodal metastases, and EGFR expression were the only independent covariates. In particular, EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system. Conclusions These findings suggest that EGFR expression may be useful in identifying high-risk gastric cancer patients undergoing potentially curative surgery. Multimodal treatments should be considered in the adjuvant treatment of these patients. © Société Internationale de Chirurgie 2007 |
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Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery |
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Lieto, Eva Orditura, Michele Castellano, Paolo Mura, Anna La Imperatore, Vincenzo Pinto, Margherita Zamboli, Anna De Vita, Ferdinando Ferraraccio, Francesca |
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