Bone Mineral Density Before and After Surgical Cure of Cushing’s Syndrome Due to Adrenocortical Adenoma: Prospective Study
Abstract Osteoporosis is a major complication of Cushing’s syndrome. The aim of the present study was to assess the chronologic effect of surgical cure on bone mineral density (BMD) in patients with Cushing’s syndrome due to adrenal adenoma. BMD was examined in 28 patients before laparoscopic adrena...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kawamata, Akiko [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2008 |
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| Schlagwörter: |
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| Anmerkung: |
© Société Internationale de Chirurgie 2008 |
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| Übergeordnetes Werk: |
Enthalten in: World Journal of Surgery - Springer-Verlag, 1996, 32(2008), 5 vom: 23. Jan., Seite 890-896 |
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| Übergeordnetes Werk: |
volume:32 ; year:2008 ; number:5 ; day:23 ; month:01 ; pages:890-896 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00268-007-9394-7 |
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| Katalog-ID: |
SPR003417247 |
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| 520 | |a Abstract Osteoporosis is a major complication of Cushing’s syndrome. The aim of the present study was to assess the chronologic effect of surgical cure on bone mineral density (BMD) in patients with Cushing’s syndrome due to adrenal adenoma. BMD was examined in 28 patients before laparoscopic adrenalectomy; 17 patients with reduced BMD were then included in the longitudinal evaluation. BMD was determined using dual energy X-ray absorptiometry (DXA) before and at 3, 6, 12, 18, and 24 months after adrenalectomy. The prevalence of osteoporosis was 64% (95% confidence interval 44–81%). Preoperative BMD of the lumbar spine in the lateral projection was significantly lower than that of the femoral neck (mean ± SD score: −3.53 ± 0.75 vs. −1.54 ± 0.22, p = 0.003). A significant increase in BMD was observed at 3 months after surgery in the lumbar spine (p = 0.0004). Improvement at both sites was maintained at 24 months after surgery. The postoperative percentage change in BMD of the lumbar spine was significantly higher than that of the femoral neck (mean ± SD 36.7% ± 26.5% vs. 11.2% ± 12.1%, p = 0.01). The change in the seven premenopausal patients was significantly higher than that in the three postmenopausal patients (p = 0.0006). Surgical cure of hypercortisolism provides significant improvement in BMD in patients with Cushing’s syndrome due to adrenal adenoma. The improvement is particularly apparent in the lumbar spine measured in the lateral projection. Premenopausal women are more likely to benefit from surgery in terms of secondary osteoporosis. | ||
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10.1007/s00268-007-9394-7 doi (DE-627)SPR003417247 (SPR)s00268-007-9394-7-e DE-627 ger DE-627 rakwb eng Kawamata, Akiko verfasserin aut Bone Mineral Density Before and After Surgical Cure of Cushing’s Syndrome Due to Adrenocortical Adenoma: Prospective Study 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Abstract Osteoporosis is a major complication of Cushing’s syndrome. The aim of the present study was to assess the chronologic effect of surgical cure on bone mineral density (BMD) in patients with Cushing’s syndrome due to adrenal adenoma. BMD was examined in 28 patients before laparoscopic adrenalectomy; 17 patients with reduced BMD were then included in the longitudinal evaluation. BMD was determined using dual energy X-ray absorptiometry (DXA) before and at 3, 6, 12, 18, and 24 months after adrenalectomy. The prevalence of osteoporosis was 64% (95% confidence interval 44–81%). Preoperative BMD of the lumbar spine in the lateral projection was significantly lower than that of the femoral neck (mean ± SD score: −3.53 ± 0.75 vs. −1.54 ± 0.22, p = 0.003). A significant increase in BMD was observed at 3 months after surgery in the lumbar spine (p = 0.0004). Improvement at both sites was maintained at 24 months after surgery. The postoperative percentage change in BMD of the lumbar spine was significantly higher than that of the femoral neck (mean ± SD 36.7% ± 26.5% vs. 11.2% ± 12.1%, p = 0.01). The change in the seven premenopausal patients was significantly higher than that in the three postmenopausal patients (p = 0.0006). Surgical cure of hypercortisolism provides significant improvement in BMD in patients with Cushing’s syndrome due to adrenal adenoma. The improvement is particularly apparent in the lumbar spine measured in the lateral projection. Premenopausal women are more likely to benefit from surgery in terms of secondary osteoporosis. Bone Mineral Density (dpeaa)DE-He213 Lumbar Spine (dpeaa)DE-He213 Femoral Neck (dpeaa)DE-He213 Laparoscopic Adrenalectomy (dpeaa)DE-He213 Lateral Projection (dpeaa)DE-He213 Iihara, Masatoshi aut Okamoto, Takahiro aut Obara, Takao aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 5 vom: 23. Jan., Seite 890-896 (DE-627)SPR003391159 nnns volume:32 year:2008 number:5 day:23 month:01 pages:890-896 https://dx.doi.org/10.1007/s00268-007-9394-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 5 23 01 890-896 |
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10.1007/s00268-007-9394-7 doi (DE-627)SPR003417247 (SPR)s00268-007-9394-7-e DE-627 ger DE-627 rakwb eng Kawamata, Akiko verfasserin aut Bone Mineral Density Before and After Surgical Cure of Cushing’s Syndrome Due to Adrenocortical Adenoma: Prospective Study 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Abstract Osteoporosis is a major complication of Cushing’s syndrome. The aim of the present study was to assess the chronologic effect of surgical cure on bone mineral density (BMD) in patients with Cushing’s syndrome due to adrenal adenoma. BMD was examined in 28 patients before laparoscopic adrenalectomy; 17 patients with reduced BMD were then included in the longitudinal evaluation. BMD was determined using dual energy X-ray absorptiometry (DXA) before and at 3, 6, 12, 18, and 24 months after adrenalectomy. The prevalence of osteoporosis was 64% (95% confidence interval 44–81%). Preoperative BMD of the lumbar spine in the lateral projection was significantly lower than that of the femoral neck (mean ± SD score: −3.53 ± 0.75 vs. −1.54 ± 0.22, p = 0.003). A significant increase in BMD was observed at 3 months after surgery in the lumbar spine (p = 0.0004). Improvement at both sites was maintained at 24 months after surgery. The postoperative percentage change in BMD of the lumbar spine was significantly higher than that of the femoral neck (mean ± SD 36.7% ± 26.5% vs. 11.2% ± 12.1%, p = 0.01). The change in the seven premenopausal patients was significantly higher than that in the three postmenopausal patients (p = 0.0006). Surgical cure of hypercortisolism provides significant improvement in BMD in patients with Cushing’s syndrome due to adrenal adenoma. The improvement is particularly apparent in the lumbar spine measured in the lateral projection. Premenopausal women are more likely to benefit from surgery in terms of secondary osteoporosis. Bone Mineral Density (dpeaa)DE-He213 Lumbar Spine (dpeaa)DE-He213 Femoral Neck (dpeaa)DE-He213 Laparoscopic Adrenalectomy (dpeaa)DE-He213 Lateral Projection (dpeaa)DE-He213 Iihara, Masatoshi aut Okamoto, Takahiro aut Obara, Takao aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 5 vom: 23. Jan., Seite 890-896 (DE-627)SPR003391159 nnns volume:32 year:2008 number:5 day:23 month:01 pages:890-896 https://dx.doi.org/10.1007/s00268-007-9394-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 5 23 01 890-896 |
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10.1007/s00268-007-9394-7 doi (DE-627)SPR003417247 (SPR)s00268-007-9394-7-e DE-627 ger DE-627 rakwb eng Kawamata, Akiko verfasserin aut Bone Mineral Density Before and After Surgical Cure of Cushing’s Syndrome Due to Adrenocortical Adenoma: Prospective Study 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Abstract Osteoporosis is a major complication of Cushing’s syndrome. The aim of the present study was to assess the chronologic effect of surgical cure on bone mineral density (BMD) in patients with Cushing’s syndrome due to adrenal adenoma. BMD was examined in 28 patients before laparoscopic adrenalectomy; 17 patients with reduced BMD were then included in the longitudinal evaluation. BMD was determined using dual energy X-ray absorptiometry (DXA) before and at 3, 6, 12, 18, and 24 months after adrenalectomy. The prevalence of osteoporosis was 64% (95% confidence interval 44–81%). Preoperative BMD of the lumbar spine in the lateral projection was significantly lower than that of the femoral neck (mean ± SD score: −3.53 ± 0.75 vs. −1.54 ± 0.22, p = 0.003). A significant increase in BMD was observed at 3 months after surgery in the lumbar spine (p = 0.0004). Improvement at both sites was maintained at 24 months after surgery. The postoperative percentage change in BMD of the lumbar spine was significantly higher than that of the femoral neck (mean ± SD 36.7% ± 26.5% vs. 11.2% ± 12.1%, p = 0.01). The change in the seven premenopausal patients was significantly higher than that in the three postmenopausal patients (p = 0.0006). Surgical cure of hypercortisolism provides significant improvement in BMD in patients with Cushing’s syndrome due to adrenal adenoma. The improvement is particularly apparent in the lumbar spine measured in the lateral projection. Premenopausal women are more likely to benefit from surgery in terms of secondary osteoporosis. Bone Mineral Density (dpeaa)DE-He213 Lumbar Spine (dpeaa)DE-He213 Femoral Neck (dpeaa)DE-He213 Laparoscopic Adrenalectomy (dpeaa)DE-He213 Lateral Projection (dpeaa)DE-He213 Iihara, Masatoshi aut Okamoto, Takahiro aut Obara, Takao aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 5 vom: 23. Jan., Seite 890-896 (DE-627)SPR003391159 nnns volume:32 year:2008 number:5 day:23 month:01 pages:890-896 https://dx.doi.org/10.1007/s00268-007-9394-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 5 23 01 890-896 |
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10.1007/s00268-007-9394-7 doi (DE-627)SPR003417247 (SPR)s00268-007-9394-7-e DE-627 ger DE-627 rakwb eng Kawamata, Akiko verfasserin aut Bone Mineral Density Before and After Surgical Cure of Cushing’s Syndrome Due to Adrenocortical Adenoma: Prospective Study 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Abstract Osteoporosis is a major complication of Cushing’s syndrome. The aim of the present study was to assess the chronologic effect of surgical cure on bone mineral density (BMD) in patients with Cushing’s syndrome due to adrenal adenoma. BMD was examined in 28 patients before laparoscopic adrenalectomy; 17 patients with reduced BMD were then included in the longitudinal evaluation. BMD was determined using dual energy X-ray absorptiometry (DXA) before and at 3, 6, 12, 18, and 24 months after adrenalectomy. The prevalence of osteoporosis was 64% (95% confidence interval 44–81%). Preoperative BMD of the lumbar spine in the lateral projection was significantly lower than that of the femoral neck (mean ± SD score: −3.53 ± 0.75 vs. −1.54 ± 0.22, p = 0.003). A significant increase in BMD was observed at 3 months after surgery in the lumbar spine (p = 0.0004). Improvement at both sites was maintained at 24 months after surgery. The postoperative percentage change in BMD of the lumbar spine was significantly higher than that of the femoral neck (mean ± SD 36.7% ± 26.5% vs. 11.2% ± 12.1%, p = 0.01). The change in the seven premenopausal patients was significantly higher than that in the three postmenopausal patients (p = 0.0006). Surgical cure of hypercortisolism provides significant improvement in BMD in patients with Cushing’s syndrome due to adrenal adenoma. The improvement is particularly apparent in the lumbar spine measured in the lateral projection. Premenopausal women are more likely to benefit from surgery in terms of secondary osteoporosis. Bone Mineral Density (dpeaa)DE-He213 Lumbar Spine (dpeaa)DE-He213 Femoral Neck (dpeaa)DE-He213 Laparoscopic Adrenalectomy (dpeaa)DE-He213 Lateral Projection (dpeaa)DE-He213 Iihara, Masatoshi aut Okamoto, Takahiro aut Obara, Takao aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 5 vom: 23. Jan., Seite 890-896 (DE-627)SPR003391159 nnns volume:32 year:2008 number:5 day:23 month:01 pages:890-896 https://dx.doi.org/10.1007/s00268-007-9394-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 5 23 01 890-896 |
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Bone Mineral Density Before and After Surgical Cure of Cushing’s Syndrome Due to Adrenocortical Adenoma: Prospective Study |
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| title_full |
Bone Mineral Density Before and After Surgical Cure of Cushing’s Syndrome Due to Adrenocortical Adenoma: Prospective Study |
| author_sort |
Kawamata, Akiko |
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World Journal of Surgery |
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World Journal of Surgery |
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eng |
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2008 |
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890 |
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Kawamata, Akiko Iihara, Masatoshi Okamoto, Takahiro Obara, Takao |
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32 |
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Elektronische Aufsätze |
| author-letter |
Kawamata, Akiko |
| doi_str_mv |
10.1007/s00268-007-9394-7 |
| title_sort |
bone mineral density before and after surgical cure of cushing’s syndrome due to adrenocortical adenoma: prospective study |
| title_auth |
Bone Mineral Density Before and After Surgical Cure of Cushing’s Syndrome Due to Adrenocortical Adenoma: Prospective Study |
| abstract |
Abstract Osteoporosis is a major complication of Cushing’s syndrome. The aim of the present study was to assess the chronologic effect of surgical cure on bone mineral density (BMD) in patients with Cushing’s syndrome due to adrenal adenoma. BMD was examined in 28 patients before laparoscopic adrenalectomy; 17 patients with reduced BMD were then included in the longitudinal evaluation. BMD was determined using dual energy X-ray absorptiometry (DXA) before and at 3, 6, 12, 18, and 24 months after adrenalectomy. The prevalence of osteoporosis was 64% (95% confidence interval 44–81%). Preoperative BMD of the lumbar spine in the lateral projection was significantly lower than that of the femoral neck (mean ± SD score: −3.53 ± 0.75 vs. −1.54 ± 0.22, p = 0.003). A significant increase in BMD was observed at 3 months after surgery in the lumbar spine (p = 0.0004). Improvement at both sites was maintained at 24 months after surgery. The postoperative percentage change in BMD of the lumbar spine was significantly higher than that of the femoral neck (mean ± SD 36.7% ± 26.5% vs. 11.2% ± 12.1%, p = 0.01). The change in the seven premenopausal patients was significantly higher than that in the three postmenopausal patients (p = 0.0006). Surgical cure of hypercortisolism provides significant improvement in BMD in patients with Cushing’s syndrome due to adrenal adenoma. The improvement is particularly apparent in the lumbar spine measured in the lateral projection. Premenopausal women are more likely to benefit from surgery in terms of secondary osteoporosis. © Société Internationale de Chirurgie 2008 |
| abstractGer |
Abstract Osteoporosis is a major complication of Cushing’s syndrome. The aim of the present study was to assess the chronologic effect of surgical cure on bone mineral density (BMD) in patients with Cushing’s syndrome due to adrenal adenoma. BMD was examined in 28 patients before laparoscopic adrenalectomy; 17 patients with reduced BMD were then included in the longitudinal evaluation. BMD was determined using dual energy X-ray absorptiometry (DXA) before and at 3, 6, 12, 18, and 24 months after adrenalectomy. The prevalence of osteoporosis was 64% (95% confidence interval 44–81%). Preoperative BMD of the lumbar spine in the lateral projection was significantly lower than that of the femoral neck (mean ± SD score: −3.53 ± 0.75 vs. −1.54 ± 0.22, p = 0.003). A significant increase in BMD was observed at 3 months after surgery in the lumbar spine (p = 0.0004). Improvement at both sites was maintained at 24 months after surgery. The postoperative percentage change in BMD of the lumbar spine was significantly higher than that of the femoral neck (mean ± SD 36.7% ± 26.5% vs. 11.2% ± 12.1%, p = 0.01). The change in the seven premenopausal patients was significantly higher than that in the three postmenopausal patients (p = 0.0006). Surgical cure of hypercortisolism provides significant improvement in BMD in patients with Cushing’s syndrome due to adrenal adenoma. The improvement is particularly apparent in the lumbar spine measured in the lateral projection. Premenopausal women are more likely to benefit from surgery in terms of secondary osteoporosis. © Société Internationale de Chirurgie 2008 |
| abstract_unstemmed |
Abstract Osteoporosis is a major complication of Cushing’s syndrome. The aim of the present study was to assess the chronologic effect of surgical cure on bone mineral density (BMD) in patients with Cushing’s syndrome due to adrenal adenoma. BMD was examined in 28 patients before laparoscopic adrenalectomy; 17 patients with reduced BMD were then included in the longitudinal evaluation. BMD was determined using dual energy X-ray absorptiometry (DXA) before and at 3, 6, 12, 18, and 24 months after adrenalectomy. The prevalence of osteoporosis was 64% (95% confidence interval 44–81%). Preoperative BMD of the lumbar spine in the lateral projection was significantly lower than that of the femoral neck (mean ± SD score: −3.53 ± 0.75 vs. −1.54 ± 0.22, p = 0.003). A significant increase in BMD was observed at 3 months after surgery in the lumbar spine (p = 0.0004). Improvement at both sites was maintained at 24 months after surgery. The postoperative percentage change in BMD of the lumbar spine was significantly higher than that of the femoral neck (mean ± SD 36.7% ± 26.5% vs. 11.2% ± 12.1%, p = 0.01). The change in the seven premenopausal patients was significantly higher than that in the three postmenopausal patients (p = 0.0006). Surgical cure of hypercortisolism provides significant improvement in BMD in patients with Cushing’s syndrome due to adrenal adenoma. The improvement is particularly apparent in the lumbar spine measured in the lateral projection. Premenopausal women are more likely to benefit from surgery in terms of secondary osteoporosis. © Société Internationale de Chirurgie 2008 |
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| title_short |
Bone Mineral Density Before and After Surgical Cure of Cushing’s Syndrome Due to Adrenocortical Adenoma: Prospective Study |
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https://dx.doi.org/10.1007/s00268-007-9394-7 |
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Iihara, Masatoshi Okamoto, Takahiro Obara, Takao |
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| up_date |
2024-07-03T19:23:42.093Z |
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