Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice
Background Platelets have been proven to promote liver regeneration after hepatectomy. Kupffer cells produce inflammatory cytokines and also promote liver regeneration. In the present study, we examined whether platelets promote liver regeneration after hepatectomy under conditions of Kupffer cell d...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Murata, Soichiro [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2008 |
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| Schlagwörter: |
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| Anmerkung: |
© Société Internationale de Chirurgie 2008 |
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| Übergeordnetes Werk: |
Enthalten in: World Journal of Surgery - Springer-Verlag, 1996, 32(2008), 6 vom: 01. März, Seite 1088-1096 |
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| Übergeordnetes Werk: |
volume:32 ; year:2008 ; number:6 ; day:01 ; month:03 ; pages:1088-1096 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00268-008-9493-0 |
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SPR003417867 |
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| 520 | |a Background Platelets have been proven to promote liver regeneration after hepatectomy. Kupffer cells produce inflammatory cytokines and also promote liver regeneration. In the present study, we examined whether platelets promote liver regeneration after hepatectomy under conditions of Kupffer cell depletion. Methods Seventy percent hepatectomy was carried out in mice, which were subsequently divided into four groups: (1) a normal group without any treatment, (2) a Kupffer cell depleted (KD) group, (3) a thrombocytotic group, and (4) a combined thrombocytotic and Kupffer cell depleted (TKD) group. Growth kinetics in the liver regeneration, growth factors, inflammatory cytokines, and signal transduction relating to hepatocyte proliferation were analyzed. Results In the KD group, liver regeneration was significantly delayed compared to the normal group 48 h after hepatectomy. On the other hand, liver regeneration of the TKD group increased significantly compared to KD group, to a level that was the same as that recorded in the normal group. In the thrombocytotic group, liver regeneration increased significantly compared to the normal group. Tumor necrosis factor alpha (TNF-α) expression was lower in the KD and TKD groups than in the normal group after hepatectomy, but, in the TKD group, hepatocyte growth factor and Akt phosphorylation were higher than in the normal and KD groups. Conclusions After hepatectomy, liver regeneration in the Kupffer cell depleted group was delayed because of lower TNF-α expression. Platelets promote liver regeneration even under condition of Kupffer cell depletion by stimulating hepatocyte growth factor and insulin-like growth factor-1 expression, and they activate Akt. | ||
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| 700 | 1 | |a Hisakura, Katsuji |4 aut | |
| 700 | 1 | |a Nakano, Yoritaka |4 aut | |
| 700 | 1 | |a Hashimoto, Ikuka |4 aut | |
| 700 | 1 | |a Ohkohchi, Nobuhiro |4 aut | |
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10.1007/s00268-008-9493-0 doi (DE-627)SPR003417867 (SPR)s00268-008-9493-0-e DE-627 ger DE-627 rakwb eng Murata, Soichiro verfasserin aut Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Background Platelets have been proven to promote liver regeneration after hepatectomy. Kupffer cells produce inflammatory cytokines and also promote liver regeneration. In the present study, we examined whether platelets promote liver regeneration after hepatectomy under conditions of Kupffer cell depletion. Methods Seventy percent hepatectomy was carried out in mice, which were subsequently divided into four groups: (1) a normal group without any treatment, (2) a Kupffer cell depleted (KD) group, (3) a thrombocytotic group, and (4) a combined thrombocytotic and Kupffer cell depleted (TKD) group. Growth kinetics in the liver regeneration, growth factors, inflammatory cytokines, and signal transduction relating to hepatocyte proliferation were analyzed. Results In the KD group, liver regeneration was significantly delayed compared to the normal group 48 h after hepatectomy. On the other hand, liver regeneration of the TKD group increased significantly compared to KD group, to a level that was the same as that recorded in the normal group. In the thrombocytotic group, liver regeneration increased significantly compared to the normal group. Tumor necrosis factor alpha (TNF-α) expression was lower in the KD and TKD groups than in the normal group after hepatectomy, but, in the TKD group, hepatocyte growth factor and Akt phosphorylation were higher than in the normal and KD groups. Conclusions After hepatectomy, liver regeneration in the Kupffer cell depleted group was delayed because of lower TNF-α expression. Platelets promote liver regeneration even under condition of Kupffer cell depletion by stimulating hepatocyte growth factor and insulin-like growth factor-1 expression, and they activate Akt. Hepatocyte Growth Factor (dpeaa)DE-He213 Normal Group (dpeaa)DE-He213 Proliferate Cell Nuclear Antigen (dpeaa)DE-He213 Kupffer Cell (dpeaa)DE-He213 Liver Regeneration (dpeaa)DE-He213 Matsuo, Ryota aut Ikeda, Osamu aut Myronovych, Andriy aut Watanabe, Motonobu aut Hisakura, Katsuji aut Nakano, Yoritaka aut Hashimoto, Ikuka aut Ohkohchi, Nobuhiro aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 6 vom: 01. März, Seite 1088-1096 (DE-627)SPR003391159 nnns volume:32 year:2008 number:6 day:01 month:03 pages:1088-1096 https://dx.doi.org/10.1007/s00268-008-9493-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 6 01 03 1088-1096 |
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10.1007/s00268-008-9493-0 doi (DE-627)SPR003417867 (SPR)s00268-008-9493-0-e DE-627 ger DE-627 rakwb eng Murata, Soichiro verfasserin aut Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Background Platelets have been proven to promote liver regeneration after hepatectomy. Kupffer cells produce inflammatory cytokines and also promote liver regeneration. In the present study, we examined whether platelets promote liver regeneration after hepatectomy under conditions of Kupffer cell depletion. Methods Seventy percent hepatectomy was carried out in mice, which were subsequently divided into four groups: (1) a normal group without any treatment, (2) a Kupffer cell depleted (KD) group, (3) a thrombocytotic group, and (4) a combined thrombocytotic and Kupffer cell depleted (TKD) group. Growth kinetics in the liver regeneration, growth factors, inflammatory cytokines, and signal transduction relating to hepatocyte proliferation were analyzed. Results In the KD group, liver regeneration was significantly delayed compared to the normal group 48 h after hepatectomy. On the other hand, liver regeneration of the TKD group increased significantly compared to KD group, to a level that was the same as that recorded in the normal group. In the thrombocytotic group, liver regeneration increased significantly compared to the normal group. Tumor necrosis factor alpha (TNF-α) expression was lower in the KD and TKD groups than in the normal group after hepatectomy, but, in the TKD group, hepatocyte growth factor and Akt phosphorylation were higher than in the normal and KD groups. Conclusions After hepatectomy, liver regeneration in the Kupffer cell depleted group was delayed because of lower TNF-α expression. Platelets promote liver regeneration even under condition of Kupffer cell depletion by stimulating hepatocyte growth factor and insulin-like growth factor-1 expression, and they activate Akt. Hepatocyte Growth Factor (dpeaa)DE-He213 Normal Group (dpeaa)DE-He213 Proliferate Cell Nuclear Antigen (dpeaa)DE-He213 Kupffer Cell (dpeaa)DE-He213 Liver Regeneration (dpeaa)DE-He213 Matsuo, Ryota aut Ikeda, Osamu aut Myronovych, Andriy aut Watanabe, Motonobu aut Hisakura, Katsuji aut Nakano, Yoritaka aut Hashimoto, Ikuka aut Ohkohchi, Nobuhiro aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 6 vom: 01. März, Seite 1088-1096 (DE-627)SPR003391159 nnns volume:32 year:2008 number:6 day:01 month:03 pages:1088-1096 https://dx.doi.org/10.1007/s00268-008-9493-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 6 01 03 1088-1096 |
| allfields_unstemmed |
10.1007/s00268-008-9493-0 doi (DE-627)SPR003417867 (SPR)s00268-008-9493-0-e DE-627 ger DE-627 rakwb eng Murata, Soichiro verfasserin aut Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Background Platelets have been proven to promote liver regeneration after hepatectomy. Kupffer cells produce inflammatory cytokines and also promote liver regeneration. In the present study, we examined whether platelets promote liver regeneration after hepatectomy under conditions of Kupffer cell depletion. Methods Seventy percent hepatectomy was carried out in mice, which were subsequently divided into four groups: (1) a normal group without any treatment, (2) a Kupffer cell depleted (KD) group, (3) a thrombocytotic group, and (4) a combined thrombocytotic and Kupffer cell depleted (TKD) group. Growth kinetics in the liver regeneration, growth factors, inflammatory cytokines, and signal transduction relating to hepatocyte proliferation were analyzed. Results In the KD group, liver regeneration was significantly delayed compared to the normal group 48 h after hepatectomy. On the other hand, liver regeneration of the TKD group increased significantly compared to KD group, to a level that was the same as that recorded in the normal group. In the thrombocytotic group, liver regeneration increased significantly compared to the normal group. Tumor necrosis factor alpha (TNF-α) expression was lower in the KD and TKD groups than in the normal group after hepatectomy, but, in the TKD group, hepatocyte growth factor and Akt phosphorylation were higher than in the normal and KD groups. Conclusions After hepatectomy, liver regeneration in the Kupffer cell depleted group was delayed because of lower TNF-α expression. Platelets promote liver regeneration even under condition of Kupffer cell depletion by stimulating hepatocyte growth factor and insulin-like growth factor-1 expression, and they activate Akt. Hepatocyte Growth Factor (dpeaa)DE-He213 Normal Group (dpeaa)DE-He213 Proliferate Cell Nuclear Antigen (dpeaa)DE-He213 Kupffer Cell (dpeaa)DE-He213 Liver Regeneration (dpeaa)DE-He213 Matsuo, Ryota aut Ikeda, Osamu aut Myronovych, Andriy aut Watanabe, Motonobu aut Hisakura, Katsuji aut Nakano, Yoritaka aut Hashimoto, Ikuka aut Ohkohchi, Nobuhiro aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 6 vom: 01. März, Seite 1088-1096 (DE-627)SPR003391159 nnns volume:32 year:2008 number:6 day:01 month:03 pages:1088-1096 https://dx.doi.org/10.1007/s00268-008-9493-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 6 01 03 1088-1096 |
| allfieldsGer |
10.1007/s00268-008-9493-0 doi (DE-627)SPR003417867 (SPR)s00268-008-9493-0-e DE-627 ger DE-627 rakwb eng Murata, Soichiro verfasserin aut Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Background Platelets have been proven to promote liver regeneration after hepatectomy. Kupffer cells produce inflammatory cytokines and also promote liver regeneration. In the present study, we examined whether platelets promote liver regeneration after hepatectomy under conditions of Kupffer cell depletion. Methods Seventy percent hepatectomy was carried out in mice, which were subsequently divided into four groups: (1) a normal group without any treatment, (2) a Kupffer cell depleted (KD) group, (3) a thrombocytotic group, and (4) a combined thrombocytotic and Kupffer cell depleted (TKD) group. Growth kinetics in the liver regeneration, growth factors, inflammatory cytokines, and signal transduction relating to hepatocyte proliferation were analyzed. Results In the KD group, liver regeneration was significantly delayed compared to the normal group 48 h after hepatectomy. On the other hand, liver regeneration of the TKD group increased significantly compared to KD group, to a level that was the same as that recorded in the normal group. In the thrombocytotic group, liver regeneration increased significantly compared to the normal group. Tumor necrosis factor alpha (TNF-α) expression was lower in the KD and TKD groups than in the normal group after hepatectomy, but, in the TKD group, hepatocyte growth factor and Akt phosphorylation were higher than in the normal and KD groups. Conclusions After hepatectomy, liver regeneration in the Kupffer cell depleted group was delayed because of lower TNF-α expression. Platelets promote liver regeneration even under condition of Kupffer cell depletion by stimulating hepatocyte growth factor and insulin-like growth factor-1 expression, and they activate Akt. Hepatocyte Growth Factor (dpeaa)DE-He213 Normal Group (dpeaa)DE-He213 Proliferate Cell Nuclear Antigen (dpeaa)DE-He213 Kupffer Cell (dpeaa)DE-He213 Liver Regeneration (dpeaa)DE-He213 Matsuo, Ryota aut Ikeda, Osamu aut Myronovych, Andriy aut Watanabe, Motonobu aut Hisakura, Katsuji aut Nakano, Yoritaka aut Hashimoto, Ikuka aut Ohkohchi, Nobuhiro aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 6 vom: 01. März, Seite 1088-1096 (DE-627)SPR003391159 nnns volume:32 year:2008 number:6 day:01 month:03 pages:1088-1096 https://dx.doi.org/10.1007/s00268-008-9493-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 6 01 03 1088-1096 |
| allfieldsSound |
10.1007/s00268-008-9493-0 doi (DE-627)SPR003417867 (SPR)s00268-008-9493-0-e DE-627 ger DE-627 rakwb eng Murata, Soichiro verfasserin aut Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Background Platelets have been proven to promote liver regeneration after hepatectomy. Kupffer cells produce inflammatory cytokines and also promote liver regeneration. In the present study, we examined whether platelets promote liver regeneration after hepatectomy under conditions of Kupffer cell depletion. Methods Seventy percent hepatectomy was carried out in mice, which were subsequently divided into four groups: (1) a normal group without any treatment, (2) a Kupffer cell depleted (KD) group, (3) a thrombocytotic group, and (4) a combined thrombocytotic and Kupffer cell depleted (TKD) group. Growth kinetics in the liver regeneration, growth factors, inflammatory cytokines, and signal transduction relating to hepatocyte proliferation were analyzed. Results In the KD group, liver regeneration was significantly delayed compared to the normal group 48 h after hepatectomy. On the other hand, liver regeneration of the TKD group increased significantly compared to KD group, to a level that was the same as that recorded in the normal group. In the thrombocytotic group, liver regeneration increased significantly compared to the normal group. Tumor necrosis factor alpha (TNF-α) expression was lower in the KD and TKD groups than in the normal group after hepatectomy, but, in the TKD group, hepatocyte growth factor and Akt phosphorylation were higher than in the normal and KD groups. Conclusions After hepatectomy, liver regeneration in the Kupffer cell depleted group was delayed because of lower TNF-α expression. Platelets promote liver regeneration even under condition of Kupffer cell depletion by stimulating hepatocyte growth factor and insulin-like growth factor-1 expression, and they activate Akt. Hepatocyte Growth Factor (dpeaa)DE-He213 Normal Group (dpeaa)DE-He213 Proliferate Cell Nuclear Antigen (dpeaa)DE-He213 Kupffer Cell (dpeaa)DE-He213 Liver Regeneration (dpeaa)DE-He213 Matsuo, Ryota aut Ikeda, Osamu aut Myronovych, Andriy aut Watanabe, Motonobu aut Hisakura, Katsuji aut Nakano, Yoritaka aut Hashimoto, Ikuka aut Ohkohchi, Nobuhiro aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 6 vom: 01. März, Seite 1088-1096 (DE-627)SPR003391159 nnns volume:32 year:2008 number:6 day:01 month:03 pages:1088-1096 https://dx.doi.org/10.1007/s00268-008-9493-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 6 01 03 1088-1096 |
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Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice Hepatocyte Growth Factor (dpeaa)DE-He213 Normal Group (dpeaa)DE-He213 Proliferate Cell Nuclear Antigen (dpeaa)DE-He213 Kupffer Cell (dpeaa)DE-He213 Liver Regeneration (dpeaa)DE-He213 |
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Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice |
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Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice |
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Murata, Soichiro |
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2008 |
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Murata, Soichiro Matsuo, Ryota Ikeda, Osamu Myronovych, Andriy Watanabe, Motonobu Hisakura, Katsuji Nakano, Yoritaka Hashimoto, Ikuka Ohkohchi, Nobuhiro |
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platelets promote liver regeneration under conditions of kupffer cell depletion after hepatectomy in mice |
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Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice |
| abstract |
Background Platelets have been proven to promote liver regeneration after hepatectomy. Kupffer cells produce inflammatory cytokines and also promote liver regeneration. In the present study, we examined whether platelets promote liver regeneration after hepatectomy under conditions of Kupffer cell depletion. Methods Seventy percent hepatectomy was carried out in mice, which were subsequently divided into four groups: (1) a normal group without any treatment, (2) a Kupffer cell depleted (KD) group, (3) a thrombocytotic group, and (4) a combined thrombocytotic and Kupffer cell depleted (TKD) group. Growth kinetics in the liver regeneration, growth factors, inflammatory cytokines, and signal transduction relating to hepatocyte proliferation were analyzed. Results In the KD group, liver regeneration was significantly delayed compared to the normal group 48 h after hepatectomy. On the other hand, liver regeneration of the TKD group increased significantly compared to KD group, to a level that was the same as that recorded in the normal group. In the thrombocytotic group, liver regeneration increased significantly compared to the normal group. Tumor necrosis factor alpha (TNF-α) expression was lower in the KD and TKD groups than in the normal group after hepatectomy, but, in the TKD group, hepatocyte growth factor and Akt phosphorylation were higher than in the normal and KD groups. Conclusions After hepatectomy, liver regeneration in the Kupffer cell depleted group was delayed because of lower TNF-α expression. Platelets promote liver regeneration even under condition of Kupffer cell depletion by stimulating hepatocyte growth factor and insulin-like growth factor-1 expression, and they activate Akt. © Société Internationale de Chirurgie 2008 |
| abstractGer |
Background Platelets have been proven to promote liver regeneration after hepatectomy. Kupffer cells produce inflammatory cytokines and also promote liver regeneration. In the present study, we examined whether platelets promote liver regeneration after hepatectomy under conditions of Kupffer cell depletion. Methods Seventy percent hepatectomy was carried out in mice, which were subsequently divided into four groups: (1) a normal group without any treatment, (2) a Kupffer cell depleted (KD) group, (3) a thrombocytotic group, and (4) a combined thrombocytotic and Kupffer cell depleted (TKD) group. Growth kinetics in the liver regeneration, growth factors, inflammatory cytokines, and signal transduction relating to hepatocyte proliferation were analyzed. Results In the KD group, liver regeneration was significantly delayed compared to the normal group 48 h after hepatectomy. On the other hand, liver regeneration of the TKD group increased significantly compared to KD group, to a level that was the same as that recorded in the normal group. In the thrombocytotic group, liver regeneration increased significantly compared to the normal group. Tumor necrosis factor alpha (TNF-α) expression was lower in the KD and TKD groups than in the normal group after hepatectomy, but, in the TKD group, hepatocyte growth factor and Akt phosphorylation were higher than in the normal and KD groups. Conclusions After hepatectomy, liver regeneration in the Kupffer cell depleted group was delayed because of lower TNF-α expression. Platelets promote liver regeneration even under condition of Kupffer cell depletion by stimulating hepatocyte growth factor and insulin-like growth factor-1 expression, and they activate Akt. © Société Internationale de Chirurgie 2008 |
| abstract_unstemmed |
Background Platelets have been proven to promote liver regeneration after hepatectomy. Kupffer cells produce inflammatory cytokines and also promote liver regeneration. In the present study, we examined whether platelets promote liver regeneration after hepatectomy under conditions of Kupffer cell depletion. Methods Seventy percent hepatectomy was carried out in mice, which were subsequently divided into four groups: (1) a normal group without any treatment, (2) a Kupffer cell depleted (KD) group, (3) a thrombocytotic group, and (4) a combined thrombocytotic and Kupffer cell depleted (TKD) group. Growth kinetics in the liver regeneration, growth factors, inflammatory cytokines, and signal transduction relating to hepatocyte proliferation were analyzed. Results In the KD group, liver regeneration was significantly delayed compared to the normal group 48 h after hepatectomy. On the other hand, liver regeneration of the TKD group increased significantly compared to KD group, to a level that was the same as that recorded in the normal group. In the thrombocytotic group, liver regeneration increased significantly compared to the normal group. Tumor necrosis factor alpha (TNF-α) expression was lower in the KD and TKD groups than in the normal group after hepatectomy, but, in the TKD group, hepatocyte growth factor and Akt phosphorylation were higher than in the normal and KD groups. Conclusions After hepatectomy, liver regeneration in the Kupffer cell depleted group was delayed because of lower TNF-α expression. Platelets promote liver regeneration even under condition of Kupffer cell depletion by stimulating hepatocyte growth factor and insulin-like growth factor-1 expression, and they activate Akt. © Société Internationale de Chirurgie 2008 |
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Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice |
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Matsuo, Ryota Ikeda, Osamu Myronovych, Andriy Watanabe, Motonobu Hisakura, Katsuji Nakano, Yoritaka Hashimoto, Ikuka Ohkohchi, Nobuhiro |
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