Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation
Background The real efficacy of radiofrequency ablation (RFA) in destroying hepatocellular carcinoma is not completely known, nor is the ability of computed tomography (CT) to precisely assess response. Our aims were to analyze pathological response, tumor size influence, and CT response evaluation....
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Rodríguez-Sanjuán, Juan C. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2008 |
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| Schlagwörter: |
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| Anmerkung: |
© Société Internationale de Chirurgie 2008 |
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| Übergeordnetes Werk: |
Enthalten in: World Journal of Surgery - Springer-Verlag, 1996, 32(2008), 7 vom: 29. März, Seite 1489-1494 |
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| Übergeordnetes Werk: |
volume:32 ; year:2008 ; number:7 ; day:29 ; month:03 ; pages:1489-1494 |
| Links: |
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| DOI / URN: |
10.1007/s00268-008-9559-z |
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SPR003418642 |
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| 100 | 1 | |a Rodríguez-Sanjuán, Juan C. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation |
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| 520 | |a Background The real efficacy of radiofrequency ablation (RFA) in destroying hepatocellular carcinoma is not completely known, nor is the ability of computed tomography (CT) to precisely assess response. Our aims were to analyze pathological response, tumor size influence, and CT response evaluation. Materials and methods This was a retrospective study of 30 hepatocellular carcinoma nodules treated by RFA before liver transplant (LT) in 28 patients. Pathological study of the whole removed liver was then performed and the tumor response was classified as complete, incomplete, or absent. The biggest nodule diameter was estimated by CT or ultrasound. The procedure was carried out percutaneously in all but 3 patients, and in those 3 it was done surgically. Results The pathological response was complete in 14 nodules (46.7%) and incomplete in 16 (53.3%). The differences in mean preoperative diameter between cases with complete and incomplete response were not significant (p = 0.3). We found that small tumors were not always completely destroyed, whereas bigger tumors could be successfully deleted. There was no clear association between any location and better or poorer response. The detection of RFA incomplete response by means of CT scan had 50% sensitivity and 100% specificity. Conclusions In our experience, RFA can achieve some degree of tumor destruction in every treated case of hepatocellular carcinoma, the complete response rate being slightly lower than half. We have not found any association of response with tumor size or interval RFA-transplant. Second, CT had not enough sensitivity to assess RFA response of hepatocellular carcinoma. | ||
| 650 | 4 | |a Hepatocellular Carcinoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Liver Transplantation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pathological Response |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Complete Pathological Response |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Incomplete Response |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a González, Francisco |4 aut | |
| 700 | 1 | |a Juanco, Carlos |4 aut | |
| 700 | 1 | |a Herrera, Luis A. |4 aut | |
| 700 | 1 | |a López-Bautista, Mercedes |4 aut | |
| 700 | 1 | |a González-Noriega, Mónica |4 aut | |
| 700 | 1 | |a García-Somacarrera, Elena |4 aut | |
| 700 | 1 | |a Figols, Javier |4 aut | |
| 700 | 1 | |a Gómez-Fleitas, Manuel |4 aut | |
| 700 | 1 | |a Silván, Martín |4 aut | |
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10.1007/s00268-008-9559-z doi (DE-627)SPR003418642 (SPR)s00268-008-9559-z-e DE-627 ger DE-627 rakwb eng Rodríguez-Sanjuán, Juan C. verfasserin aut Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Background The real efficacy of radiofrequency ablation (RFA) in destroying hepatocellular carcinoma is not completely known, nor is the ability of computed tomography (CT) to precisely assess response. Our aims were to analyze pathological response, tumor size influence, and CT response evaluation. Materials and methods This was a retrospective study of 30 hepatocellular carcinoma nodules treated by RFA before liver transplant (LT) in 28 patients. Pathological study of the whole removed liver was then performed and the tumor response was classified as complete, incomplete, or absent. The biggest nodule diameter was estimated by CT or ultrasound. The procedure was carried out percutaneously in all but 3 patients, and in those 3 it was done surgically. Results The pathological response was complete in 14 nodules (46.7%) and incomplete in 16 (53.3%). The differences in mean preoperative diameter between cases with complete and incomplete response were not significant (p = 0.3). We found that small tumors were not always completely destroyed, whereas bigger tumors could be successfully deleted. There was no clear association between any location and better or poorer response. The detection of RFA incomplete response by means of CT scan had 50% sensitivity and 100% specificity. Conclusions In our experience, RFA can achieve some degree of tumor destruction in every treated case of hepatocellular carcinoma, the complete response rate being slightly lower than half. We have not found any association of response with tumor size or interval RFA-transplant. Second, CT had not enough sensitivity to assess RFA response of hepatocellular carcinoma. Hepatocellular Carcinoma (dpeaa)DE-He213 Liver Transplantation (dpeaa)DE-He213 Pathological Response (dpeaa)DE-He213 Complete Pathological Response (dpeaa)DE-He213 Incomplete Response (dpeaa)DE-He213 González, Francisco aut Juanco, Carlos aut Herrera, Luis A. aut López-Bautista, Mercedes aut González-Noriega, Mónica aut García-Somacarrera, Elena aut Figols, Javier aut Gómez-Fleitas, Manuel aut Silván, Martín aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 7 vom: 29. März, Seite 1489-1494 (DE-627)SPR003391159 nnns volume:32 year:2008 number:7 day:29 month:03 pages:1489-1494 https://dx.doi.org/10.1007/s00268-008-9559-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 7 29 03 1489-1494 |
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10.1007/s00268-008-9559-z doi (DE-627)SPR003418642 (SPR)s00268-008-9559-z-e DE-627 ger DE-627 rakwb eng Rodríguez-Sanjuán, Juan C. verfasserin aut Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Background The real efficacy of radiofrequency ablation (RFA) in destroying hepatocellular carcinoma is not completely known, nor is the ability of computed tomography (CT) to precisely assess response. Our aims were to analyze pathological response, tumor size influence, and CT response evaluation. Materials and methods This was a retrospective study of 30 hepatocellular carcinoma nodules treated by RFA before liver transplant (LT) in 28 patients. Pathological study of the whole removed liver was then performed and the tumor response was classified as complete, incomplete, or absent. The biggest nodule diameter was estimated by CT or ultrasound. The procedure was carried out percutaneously in all but 3 patients, and in those 3 it was done surgically. Results The pathological response was complete in 14 nodules (46.7%) and incomplete in 16 (53.3%). The differences in mean preoperative diameter between cases with complete and incomplete response were not significant (p = 0.3). We found that small tumors were not always completely destroyed, whereas bigger tumors could be successfully deleted. There was no clear association between any location and better or poorer response. The detection of RFA incomplete response by means of CT scan had 50% sensitivity and 100% specificity. Conclusions In our experience, RFA can achieve some degree of tumor destruction in every treated case of hepatocellular carcinoma, the complete response rate being slightly lower than half. We have not found any association of response with tumor size or interval RFA-transplant. Second, CT had not enough sensitivity to assess RFA response of hepatocellular carcinoma. Hepatocellular Carcinoma (dpeaa)DE-He213 Liver Transplantation (dpeaa)DE-He213 Pathological Response (dpeaa)DE-He213 Complete Pathological Response (dpeaa)DE-He213 Incomplete Response (dpeaa)DE-He213 González, Francisco aut Juanco, Carlos aut Herrera, Luis A. aut López-Bautista, Mercedes aut González-Noriega, Mónica aut García-Somacarrera, Elena aut Figols, Javier aut Gómez-Fleitas, Manuel aut Silván, Martín aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 7 vom: 29. März, Seite 1489-1494 (DE-627)SPR003391159 nnns volume:32 year:2008 number:7 day:29 month:03 pages:1489-1494 https://dx.doi.org/10.1007/s00268-008-9559-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 7 29 03 1489-1494 |
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10.1007/s00268-008-9559-z doi (DE-627)SPR003418642 (SPR)s00268-008-9559-z-e DE-627 ger DE-627 rakwb eng Rodríguez-Sanjuán, Juan C. verfasserin aut Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Background The real efficacy of radiofrequency ablation (RFA) in destroying hepatocellular carcinoma is not completely known, nor is the ability of computed tomography (CT) to precisely assess response. Our aims were to analyze pathological response, tumor size influence, and CT response evaluation. Materials and methods This was a retrospective study of 30 hepatocellular carcinoma nodules treated by RFA before liver transplant (LT) in 28 patients. Pathological study of the whole removed liver was then performed and the tumor response was classified as complete, incomplete, or absent. The biggest nodule diameter was estimated by CT or ultrasound. The procedure was carried out percutaneously in all but 3 patients, and in those 3 it was done surgically. Results The pathological response was complete in 14 nodules (46.7%) and incomplete in 16 (53.3%). The differences in mean preoperative diameter between cases with complete and incomplete response were not significant (p = 0.3). We found that small tumors were not always completely destroyed, whereas bigger tumors could be successfully deleted. There was no clear association between any location and better or poorer response. The detection of RFA incomplete response by means of CT scan had 50% sensitivity and 100% specificity. Conclusions In our experience, RFA can achieve some degree of tumor destruction in every treated case of hepatocellular carcinoma, the complete response rate being slightly lower than half. We have not found any association of response with tumor size or interval RFA-transplant. Second, CT had not enough sensitivity to assess RFA response of hepatocellular carcinoma. Hepatocellular Carcinoma (dpeaa)DE-He213 Liver Transplantation (dpeaa)DE-He213 Pathological Response (dpeaa)DE-He213 Complete Pathological Response (dpeaa)DE-He213 Incomplete Response (dpeaa)DE-He213 González, Francisco aut Juanco, Carlos aut Herrera, Luis A. aut López-Bautista, Mercedes aut González-Noriega, Mónica aut García-Somacarrera, Elena aut Figols, Javier aut Gómez-Fleitas, Manuel aut Silván, Martín aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 7 vom: 29. März, Seite 1489-1494 (DE-627)SPR003391159 nnns volume:32 year:2008 number:7 day:29 month:03 pages:1489-1494 https://dx.doi.org/10.1007/s00268-008-9559-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 7 29 03 1489-1494 |
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10.1007/s00268-008-9559-z doi (DE-627)SPR003418642 (SPR)s00268-008-9559-z-e DE-627 ger DE-627 rakwb eng Rodríguez-Sanjuán, Juan C. verfasserin aut Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Background The real efficacy of radiofrequency ablation (RFA) in destroying hepatocellular carcinoma is not completely known, nor is the ability of computed tomography (CT) to precisely assess response. Our aims were to analyze pathological response, tumor size influence, and CT response evaluation. Materials and methods This was a retrospective study of 30 hepatocellular carcinoma nodules treated by RFA before liver transplant (LT) in 28 patients. Pathological study of the whole removed liver was then performed and the tumor response was classified as complete, incomplete, or absent. The biggest nodule diameter was estimated by CT or ultrasound. The procedure was carried out percutaneously in all but 3 patients, and in those 3 it was done surgically. Results The pathological response was complete in 14 nodules (46.7%) and incomplete in 16 (53.3%). The differences in mean preoperative diameter between cases with complete and incomplete response were not significant (p = 0.3). We found that small tumors were not always completely destroyed, whereas bigger tumors could be successfully deleted. There was no clear association between any location and better or poorer response. The detection of RFA incomplete response by means of CT scan had 50% sensitivity and 100% specificity. Conclusions In our experience, RFA can achieve some degree of tumor destruction in every treated case of hepatocellular carcinoma, the complete response rate being slightly lower than half. We have not found any association of response with tumor size or interval RFA-transplant. Second, CT had not enough sensitivity to assess RFA response of hepatocellular carcinoma. Hepatocellular Carcinoma (dpeaa)DE-He213 Liver Transplantation (dpeaa)DE-He213 Pathological Response (dpeaa)DE-He213 Complete Pathological Response (dpeaa)DE-He213 Incomplete Response (dpeaa)DE-He213 González, Francisco aut Juanco, Carlos aut Herrera, Luis A. aut López-Bautista, Mercedes aut González-Noriega, Mónica aut García-Somacarrera, Elena aut Figols, Javier aut Gómez-Fleitas, Manuel aut Silván, Martín aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 7 vom: 29. März, Seite 1489-1494 (DE-627)SPR003391159 nnns volume:32 year:2008 number:7 day:29 month:03 pages:1489-1494 https://dx.doi.org/10.1007/s00268-008-9559-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 7 29 03 1489-1494 |
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10.1007/s00268-008-9559-z doi (DE-627)SPR003418642 (SPR)s00268-008-9559-z-e DE-627 ger DE-627 rakwb eng Rodríguez-Sanjuán, Juan C. verfasserin aut Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2008 Background The real efficacy of radiofrequency ablation (RFA) in destroying hepatocellular carcinoma is not completely known, nor is the ability of computed tomography (CT) to precisely assess response. Our aims were to analyze pathological response, tumor size influence, and CT response evaluation. Materials and methods This was a retrospective study of 30 hepatocellular carcinoma nodules treated by RFA before liver transplant (LT) in 28 patients. Pathological study of the whole removed liver was then performed and the tumor response was classified as complete, incomplete, or absent. The biggest nodule diameter was estimated by CT or ultrasound. The procedure was carried out percutaneously in all but 3 patients, and in those 3 it was done surgically. Results The pathological response was complete in 14 nodules (46.7%) and incomplete in 16 (53.3%). The differences in mean preoperative diameter between cases with complete and incomplete response were not significant (p = 0.3). We found that small tumors were not always completely destroyed, whereas bigger tumors could be successfully deleted. There was no clear association between any location and better or poorer response. The detection of RFA incomplete response by means of CT scan had 50% sensitivity and 100% specificity. Conclusions In our experience, RFA can achieve some degree of tumor destruction in every treated case of hepatocellular carcinoma, the complete response rate being slightly lower than half. We have not found any association of response with tumor size or interval RFA-transplant. Second, CT had not enough sensitivity to assess RFA response of hepatocellular carcinoma. Hepatocellular Carcinoma (dpeaa)DE-He213 Liver Transplantation (dpeaa)DE-He213 Pathological Response (dpeaa)DE-He213 Complete Pathological Response (dpeaa)DE-He213 Incomplete Response (dpeaa)DE-He213 González, Francisco aut Juanco, Carlos aut Herrera, Luis A. aut López-Bautista, Mercedes aut González-Noriega, Mónica aut García-Somacarrera, Elena aut Figols, Javier aut Gómez-Fleitas, Manuel aut Silván, Martín aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 32(2008), 7 vom: 29. März, Seite 1489-1494 (DE-627)SPR003391159 nnns volume:32 year:2008 number:7 day:29 month:03 pages:1489-1494 https://dx.doi.org/10.1007/s00268-008-9559-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 32 2008 7 29 03 1489-1494 |
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| author |
Rodríguez-Sanjuán, Juan C. |
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Rodríguez-Sanjuán, Juan C. misc Hepatocellular Carcinoma misc Liver Transplantation misc Pathological Response misc Complete Pathological Response misc Incomplete Response Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation |
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Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation Hepatocellular Carcinoma (dpeaa)DE-He213 Liver Transplantation (dpeaa)DE-He213 Pathological Response (dpeaa)DE-He213 Complete Pathological Response (dpeaa)DE-He213 Incomplete Response (dpeaa)DE-He213 |
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Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation |
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Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation |
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Rodríguez-Sanjuán, Juan C. |
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World Journal of Surgery |
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2008 |
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Rodríguez-Sanjuán, Juan C. González, Francisco Juanco, Carlos Herrera, Luis A. López-Bautista, Mercedes González-Noriega, Mónica García-Somacarrera, Elena Figols, Javier Gómez-Fleitas, Manuel Silván, Martín |
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radiological and pathological assessment of hepatocellular carcinoma response to radiofrequency. a study on removed liver after transplantation |
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Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation |
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Background The real efficacy of radiofrequency ablation (RFA) in destroying hepatocellular carcinoma is not completely known, nor is the ability of computed tomography (CT) to precisely assess response. Our aims were to analyze pathological response, tumor size influence, and CT response evaluation. Materials and methods This was a retrospective study of 30 hepatocellular carcinoma nodules treated by RFA before liver transplant (LT) in 28 patients. Pathological study of the whole removed liver was then performed and the tumor response was classified as complete, incomplete, or absent. The biggest nodule diameter was estimated by CT or ultrasound. The procedure was carried out percutaneously in all but 3 patients, and in those 3 it was done surgically. Results The pathological response was complete in 14 nodules (46.7%) and incomplete in 16 (53.3%). The differences in mean preoperative diameter between cases with complete and incomplete response were not significant (p = 0.3). We found that small tumors were not always completely destroyed, whereas bigger tumors could be successfully deleted. There was no clear association between any location and better or poorer response. The detection of RFA incomplete response by means of CT scan had 50% sensitivity and 100% specificity. Conclusions In our experience, RFA can achieve some degree of tumor destruction in every treated case of hepatocellular carcinoma, the complete response rate being slightly lower than half. We have not found any association of response with tumor size or interval RFA-transplant. Second, CT had not enough sensitivity to assess RFA response of hepatocellular carcinoma. © Société Internationale de Chirurgie 2008 |
| abstractGer |
Background The real efficacy of radiofrequency ablation (RFA) in destroying hepatocellular carcinoma is not completely known, nor is the ability of computed tomography (CT) to precisely assess response. Our aims were to analyze pathological response, tumor size influence, and CT response evaluation. Materials and methods This was a retrospective study of 30 hepatocellular carcinoma nodules treated by RFA before liver transplant (LT) in 28 patients. Pathological study of the whole removed liver was then performed and the tumor response was classified as complete, incomplete, or absent. The biggest nodule diameter was estimated by CT or ultrasound. The procedure was carried out percutaneously in all but 3 patients, and in those 3 it was done surgically. Results The pathological response was complete in 14 nodules (46.7%) and incomplete in 16 (53.3%). The differences in mean preoperative diameter between cases with complete and incomplete response were not significant (p = 0.3). We found that small tumors were not always completely destroyed, whereas bigger tumors could be successfully deleted. There was no clear association between any location and better or poorer response. The detection of RFA incomplete response by means of CT scan had 50% sensitivity and 100% specificity. Conclusions In our experience, RFA can achieve some degree of tumor destruction in every treated case of hepatocellular carcinoma, the complete response rate being slightly lower than half. We have not found any association of response with tumor size or interval RFA-transplant. Second, CT had not enough sensitivity to assess RFA response of hepatocellular carcinoma. © Société Internationale de Chirurgie 2008 |
| abstract_unstemmed |
Background The real efficacy of radiofrequency ablation (RFA) in destroying hepatocellular carcinoma is not completely known, nor is the ability of computed tomography (CT) to precisely assess response. Our aims were to analyze pathological response, tumor size influence, and CT response evaluation. Materials and methods This was a retrospective study of 30 hepatocellular carcinoma nodules treated by RFA before liver transplant (LT) in 28 patients. Pathological study of the whole removed liver was then performed and the tumor response was classified as complete, incomplete, or absent. The biggest nodule diameter was estimated by CT or ultrasound. The procedure was carried out percutaneously in all but 3 patients, and in those 3 it was done surgically. Results The pathological response was complete in 14 nodules (46.7%) and incomplete in 16 (53.3%). The differences in mean preoperative diameter between cases with complete and incomplete response were not significant (p = 0.3). We found that small tumors were not always completely destroyed, whereas bigger tumors could be successfully deleted. There was no clear association between any location and better or poorer response. The detection of RFA incomplete response by means of CT scan had 50% sensitivity and 100% specificity. Conclusions In our experience, RFA can achieve some degree of tumor destruction in every treated case of hepatocellular carcinoma, the complete response rate being slightly lower than half. We have not found any association of response with tumor size or interval RFA-transplant. Second, CT had not enough sensitivity to assess RFA response of hepatocellular carcinoma. © Société Internationale de Chirurgie 2008 |
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Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation |
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González, Francisco Juanco, Carlos Herrera, Luis A. López-Bautista, Mercedes González-Noriega, Mónica García-Somacarrera, Elena Figols, Javier Gómez-Fleitas, Manuel Silván, Martín |
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González, Francisco Juanco, Carlos Herrera, Luis A. López-Bautista, Mercedes González-Noriega, Mónica García-Somacarrera, Elena Figols, Javier Gómez-Fleitas, Manuel Silván, Martín |
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