Estimating the Need for Neck Lymphadenectomy in Submucosal Esophageal Cancer Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging: Clinical Validation Study
Background In cases of thoracic esophageal cancer, multidirectional lymphatic flow from the tumor means that lymph node metastasis can occur in an area extending from the neck to the abdomen. To validate a method for limiting the performance of three-field lymphadenectomy only to patients who need i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Motoyama, Satoru [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Anmerkung: |
© Société Internationale de Chirurgie 2011 |
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| Übergeordnetes Werk: |
Enthalten in: World Journal of Surgery - Springer-Verlag, 1996, 36(2011), 1 vom: 21. Okt., Seite 83-89 |
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| Übergeordnetes Werk: |
volume:36 ; year:2011 ; number:1 ; day:21 ; month:10 ; pages:83-89 |
| Links: |
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| DOI / URN: |
10.1007/s00268-011-1322-1 |
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SPR003435040 |
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| 520 | |a Background In cases of thoracic esophageal cancer, multidirectional lymphatic flow from the tumor means that lymph node metastasis can occur in an area extending from the neck to the abdomen. To validate a method for limiting the performance of three-field lymphadenectomy only to patients who need it, we carried out a prospective study in which superparamagnetic iron oxide (SPIO)-enhanced lymphatic mapping was used to determine whether to perform neck lymph node dissection in patients with submucosal thoracic esophageal cancer. Methods A total of 22 patients with clinically submucosal thoracic squamous cell esophageal cancer, without neck lymph node metastasis, were enrolled. SPIO was endoscopically injected into the peritumoral submucosal layer, after which its appearance in lymph nodes in the neck was evaluated using magnetic resonance imaging (MRI). Neck lymph nodes were then dissected based on the SPIO-enhanced MRI lymphatic mapping. Results Influx of SPIO into lymph nodes was detected in 21 patients (95% detection rate). SPIO flowed to the neck in 8 (36%) patients. Influx of SPIO into neck lymph nodes was unilateral in five patients and bilateral in three patients, and the lymph nodes were dissected accordingly. A cancer-involved node was identified in two of those patients. In 14 patients, we did not dissect neck nodes. Patients were followed up for 6 to 47 months. The neck lymph node recurrence rate was zero, and the overall recurrence rate was 5%. Conclusions SPIO-enhanced lymphatic mapping may be useful for estimating the need for three-field lymphadenectomy with neck dissection. | ||
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| 650 | 4 | |a Esophageal Cancer |7 (dpeaa)DE-He213 | |
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10.1007/s00268-011-1322-1 doi (DE-627)SPR003435040 (SPR)s00268-011-1322-1-e DE-627 ger DE-627 rakwb eng Motoyama, Satoru verfasserin aut Estimating the Need for Neck Lymphadenectomy in Submucosal Esophageal Cancer Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging: Clinical Validation Study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2011 Background In cases of thoracic esophageal cancer, multidirectional lymphatic flow from the tumor means that lymph node metastasis can occur in an area extending from the neck to the abdomen. To validate a method for limiting the performance of three-field lymphadenectomy only to patients who need it, we carried out a prospective study in which superparamagnetic iron oxide (SPIO)-enhanced lymphatic mapping was used to determine whether to perform neck lymph node dissection in patients with submucosal thoracic esophageal cancer. Methods A total of 22 patients with clinically submucosal thoracic squamous cell esophageal cancer, without neck lymph node metastasis, were enrolled. SPIO was endoscopically injected into the peritumoral submucosal layer, after which its appearance in lymph nodes in the neck was evaluated using magnetic resonance imaging (MRI). Neck lymph nodes were then dissected based on the SPIO-enhanced MRI lymphatic mapping. Results Influx of SPIO into lymph nodes was detected in 21 patients (95% detection rate). SPIO flowed to the neck in 8 (36%) patients. Influx of SPIO into neck lymph nodes was unilateral in five patients and bilateral in three patients, and the lymph nodes were dissected accordingly. A cancer-involved node was identified in two of those patients. In 14 patients, we did not dissect neck nodes. Patients were followed up for 6 to 47 months. The neck lymph node recurrence rate was zero, and the overall recurrence rate was 5%. Conclusions SPIO-enhanced lymphatic mapping may be useful for estimating the need for three-field lymphadenectomy with neck dissection. Sentinel Lymph Node (dpeaa)DE-He213 Esophageal Cancer (dpeaa)DE-He213 Neck Lymph Node (dpeaa)DE-He213 Lymphatic Mapping (dpeaa)DE-He213 Lymphatic Flow (dpeaa)DE-He213 Ishiyama, Koichi aut Maruyama, Kiyotomi aut Narita, Komei aut Minamiya, Yoshihiro aut Ogawa, Jun-ichi aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 36(2011), 1 vom: 21. Okt., Seite 83-89 (DE-627)SPR003391159 nnns volume:36 year:2011 number:1 day:21 month:10 pages:83-89 https://dx.doi.org/10.1007/s00268-011-1322-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 36 2011 1 21 10 83-89 |
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10.1007/s00268-011-1322-1 doi (DE-627)SPR003435040 (SPR)s00268-011-1322-1-e DE-627 ger DE-627 rakwb eng Motoyama, Satoru verfasserin aut Estimating the Need for Neck Lymphadenectomy in Submucosal Esophageal Cancer Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging: Clinical Validation Study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2011 Background In cases of thoracic esophageal cancer, multidirectional lymphatic flow from the tumor means that lymph node metastasis can occur in an area extending from the neck to the abdomen. To validate a method for limiting the performance of three-field lymphadenectomy only to patients who need it, we carried out a prospective study in which superparamagnetic iron oxide (SPIO)-enhanced lymphatic mapping was used to determine whether to perform neck lymph node dissection in patients with submucosal thoracic esophageal cancer. Methods A total of 22 patients with clinically submucosal thoracic squamous cell esophageal cancer, without neck lymph node metastasis, were enrolled. SPIO was endoscopically injected into the peritumoral submucosal layer, after which its appearance in lymph nodes in the neck was evaluated using magnetic resonance imaging (MRI). Neck lymph nodes were then dissected based on the SPIO-enhanced MRI lymphatic mapping. Results Influx of SPIO into lymph nodes was detected in 21 patients (95% detection rate). SPIO flowed to the neck in 8 (36%) patients. Influx of SPIO into neck lymph nodes was unilateral in five patients and bilateral in three patients, and the lymph nodes were dissected accordingly. A cancer-involved node was identified in two of those patients. In 14 patients, we did not dissect neck nodes. Patients were followed up for 6 to 47 months. The neck lymph node recurrence rate was zero, and the overall recurrence rate was 5%. Conclusions SPIO-enhanced lymphatic mapping may be useful for estimating the need for three-field lymphadenectomy with neck dissection. Sentinel Lymph Node (dpeaa)DE-He213 Esophageal Cancer (dpeaa)DE-He213 Neck Lymph Node (dpeaa)DE-He213 Lymphatic Mapping (dpeaa)DE-He213 Lymphatic Flow (dpeaa)DE-He213 Ishiyama, Koichi aut Maruyama, Kiyotomi aut Narita, Komei aut Minamiya, Yoshihiro aut Ogawa, Jun-ichi aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 36(2011), 1 vom: 21. Okt., Seite 83-89 (DE-627)SPR003391159 nnns volume:36 year:2011 number:1 day:21 month:10 pages:83-89 https://dx.doi.org/10.1007/s00268-011-1322-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 36 2011 1 21 10 83-89 |
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10.1007/s00268-011-1322-1 doi (DE-627)SPR003435040 (SPR)s00268-011-1322-1-e DE-627 ger DE-627 rakwb eng Motoyama, Satoru verfasserin aut Estimating the Need for Neck Lymphadenectomy in Submucosal Esophageal Cancer Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging: Clinical Validation Study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2011 Background In cases of thoracic esophageal cancer, multidirectional lymphatic flow from the tumor means that lymph node metastasis can occur in an area extending from the neck to the abdomen. To validate a method for limiting the performance of three-field lymphadenectomy only to patients who need it, we carried out a prospective study in which superparamagnetic iron oxide (SPIO)-enhanced lymphatic mapping was used to determine whether to perform neck lymph node dissection in patients with submucosal thoracic esophageal cancer. Methods A total of 22 patients with clinically submucosal thoracic squamous cell esophageal cancer, without neck lymph node metastasis, were enrolled. SPIO was endoscopically injected into the peritumoral submucosal layer, after which its appearance in lymph nodes in the neck was evaluated using magnetic resonance imaging (MRI). Neck lymph nodes were then dissected based on the SPIO-enhanced MRI lymphatic mapping. Results Influx of SPIO into lymph nodes was detected in 21 patients (95% detection rate). SPIO flowed to the neck in 8 (36%) patients. Influx of SPIO into neck lymph nodes was unilateral in five patients and bilateral in three patients, and the lymph nodes were dissected accordingly. A cancer-involved node was identified in two of those patients. In 14 patients, we did not dissect neck nodes. Patients were followed up for 6 to 47 months. The neck lymph node recurrence rate was zero, and the overall recurrence rate was 5%. Conclusions SPIO-enhanced lymphatic mapping may be useful for estimating the need for three-field lymphadenectomy with neck dissection. Sentinel Lymph Node (dpeaa)DE-He213 Esophageal Cancer (dpeaa)DE-He213 Neck Lymph Node (dpeaa)DE-He213 Lymphatic Mapping (dpeaa)DE-He213 Lymphatic Flow (dpeaa)DE-He213 Ishiyama, Koichi aut Maruyama, Kiyotomi aut Narita, Komei aut Minamiya, Yoshihiro aut Ogawa, Jun-ichi aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 36(2011), 1 vom: 21. Okt., Seite 83-89 (DE-627)SPR003391159 nnns volume:36 year:2011 number:1 day:21 month:10 pages:83-89 https://dx.doi.org/10.1007/s00268-011-1322-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 36 2011 1 21 10 83-89 |
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10.1007/s00268-011-1322-1 doi (DE-627)SPR003435040 (SPR)s00268-011-1322-1-e DE-627 ger DE-627 rakwb eng Motoyama, Satoru verfasserin aut Estimating the Need for Neck Lymphadenectomy in Submucosal Esophageal Cancer Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging: Clinical Validation Study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2011 Background In cases of thoracic esophageal cancer, multidirectional lymphatic flow from the tumor means that lymph node metastasis can occur in an area extending from the neck to the abdomen. To validate a method for limiting the performance of three-field lymphadenectomy only to patients who need it, we carried out a prospective study in which superparamagnetic iron oxide (SPIO)-enhanced lymphatic mapping was used to determine whether to perform neck lymph node dissection in patients with submucosal thoracic esophageal cancer. Methods A total of 22 patients with clinically submucosal thoracic squamous cell esophageal cancer, without neck lymph node metastasis, were enrolled. SPIO was endoscopically injected into the peritumoral submucosal layer, after which its appearance in lymph nodes in the neck was evaluated using magnetic resonance imaging (MRI). Neck lymph nodes were then dissected based on the SPIO-enhanced MRI lymphatic mapping. Results Influx of SPIO into lymph nodes was detected in 21 patients (95% detection rate). SPIO flowed to the neck in 8 (36%) patients. Influx of SPIO into neck lymph nodes was unilateral in five patients and bilateral in three patients, and the lymph nodes were dissected accordingly. A cancer-involved node was identified in two of those patients. In 14 patients, we did not dissect neck nodes. Patients were followed up for 6 to 47 months. The neck lymph node recurrence rate was zero, and the overall recurrence rate was 5%. Conclusions SPIO-enhanced lymphatic mapping may be useful for estimating the need for three-field lymphadenectomy with neck dissection. Sentinel Lymph Node (dpeaa)DE-He213 Esophageal Cancer (dpeaa)DE-He213 Neck Lymph Node (dpeaa)DE-He213 Lymphatic Mapping (dpeaa)DE-He213 Lymphatic Flow (dpeaa)DE-He213 Ishiyama, Koichi aut Maruyama, Kiyotomi aut Narita, Komei aut Minamiya, Yoshihiro aut Ogawa, Jun-ichi aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 36(2011), 1 vom: 21. Okt., Seite 83-89 (DE-627)SPR003391159 nnns volume:36 year:2011 number:1 day:21 month:10 pages:83-89 https://dx.doi.org/10.1007/s00268-011-1322-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 36 2011 1 21 10 83-89 |
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10.1007/s00268-011-1322-1 doi (DE-627)SPR003435040 (SPR)s00268-011-1322-1-e DE-627 ger DE-627 rakwb eng Motoyama, Satoru verfasserin aut Estimating the Need for Neck Lymphadenectomy in Submucosal Esophageal Cancer Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging: Clinical Validation Study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2011 Background In cases of thoracic esophageal cancer, multidirectional lymphatic flow from the tumor means that lymph node metastasis can occur in an area extending from the neck to the abdomen. To validate a method for limiting the performance of three-field lymphadenectomy only to patients who need it, we carried out a prospective study in which superparamagnetic iron oxide (SPIO)-enhanced lymphatic mapping was used to determine whether to perform neck lymph node dissection in patients with submucosal thoracic esophageal cancer. Methods A total of 22 patients with clinically submucosal thoracic squamous cell esophageal cancer, without neck lymph node metastasis, were enrolled. SPIO was endoscopically injected into the peritumoral submucosal layer, after which its appearance in lymph nodes in the neck was evaluated using magnetic resonance imaging (MRI). Neck lymph nodes were then dissected based on the SPIO-enhanced MRI lymphatic mapping. Results Influx of SPIO into lymph nodes was detected in 21 patients (95% detection rate). SPIO flowed to the neck in 8 (36%) patients. Influx of SPIO into neck lymph nodes was unilateral in five patients and bilateral in three patients, and the lymph nodes were dissected accordingly. A cancer-involved node was identified in two of those patients. In 14 patients, we did not dissect neck nodes. Patients were followed up for 6 to 47 months. The neck lymph node recurrence rate was zero, and the overall recurrence rate was 5%. Conclusions SPIO-enhanced lymphatic mapping may be useful for estimating the need for three-field lymphadenectomy with neck dissection. Sentinel Lymph Node (dpeaa)DE-He213 Esophageal Cancer (dpeaa)DE-He213 Neck Lymph Node (dpeaa)DE-He213 Lymphatic Mapping (dpeaa)DE-He213 Lymphatic Flow (dpeaa)DE-He213 Ishiyama, Koichi aut Maruyama, Kiyotomi aut Narita, Komei aut Minamiya, Yoshihiro aut Ogawa, Jun-ichi aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 36(2011), 1 vom: 21. Okt., Seite 83-89 (DE-627)SPR003391159 nnns volume:36 year:2011 number:1 day:21 month:10 pages:83-89 https://dx.doi.org/10.1007/s00268-011-1322-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 36 2011 1 21 10 83-89 |
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Motoyama, Satoru |
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Motoyama, Satoru misc Sentinel Lymph Node misc Esophageal Cancer misc Neck Lymph Node misc Lymphatic Mapping misc Lymphatic Flow Estimating the Need for Neck Lymphadenectomy in Submucosal Esophageal Cancer Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging: Clinical Validation Study |
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Estimating the Need for Neck Lymphadenectomy in Submucosal Esophageal Cancer Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging: Clinical Validation Study Sentinel Lymph Node (dpeaa)DE-He213 Esophageal Cancer (dpeaa)DE-He213 Neck Lymph Node (dpeaa)DE-He213 Lymphatic Mapping (dpeaa)DE-He213 Lymphatic Flow (dpeaa)DE-He213 |
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Estimating the Need for Neck Lymphadenectomy in Submucosal Esophageal Cancer Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging: Clinical Validation Study |
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| title_full |
Estimating the Need for Neck Lymphadenectomy in Submucosal Esophageal Cancer Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging: Clinical Validation Study |
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Motoyama, Satoru |
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World Journal of Surgery |
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World Journal of Surgery |
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eng |
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2011 |
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83 |
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Motoyama, Satoru Ishiyama, Koichi Maruyama, Kiyotomi Narita, Komei Minamiya, Yoshihiro Ogawa, Jun-ichi |
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36 |
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Elektronische Aufsätze |
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Motoyama, Satoru |
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10.1007/s00268-011-1322-1 |
| title_sort |
estimating the need for neck lymphadenectomy in submucosal esophageal cancer using superparamagnetic iron oxide-enhanced magnetic resonance imaging: clinical validation study |
| title_auth |
Estimating the Need for Neck Lymphadenectomy in Submucosal Esophageal Cancer Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging: Clinical Validation Study |
| abstract |
Background In cases of thoracic esophageal cancer, multidirectional lymphatic flow from the tumor means that lymph node metastasis can occur in an area extending from the neck to the abdomen. To validate a method for limiting the performance of three-field lymphadenectomy only to patients who need it, we carried out a prospective study in which superparamagnetic iron oxide (SPIO)-enhanced lymphatic mapping was used to determine whether to perform neck lymph node dissection in patients with submucosal thoracic esophageal cancer. Methods A total of 22 patients with clinically submucosal thoracic squamous cell esophageal cancer, without neck lymph node metastasis, were enrolled. SPIO was endoscopically injected into the peritumoral submucosal layer, after which its appearance in lymph nodes in the neck was evaluated using magnetic resonance imaging (MRI). Neck lymph nodes were then dissected based on the SPIO-enhanced MRI lymphatic mapping. Results Influx of SPIO into lymph nodes was detected in 21 patients (95% detection rate). SPIO flowed to the neck in 8 (36%) patients. Influx of SPIO into neck lymph nodes was unilateral in five patients and bilateral in three patients, and the lymph nodes were dissected accordingly. A cancer-involved node was identified in two of those patients. In 14 patients, we did not dissect neck nodes. Patients were followed up for 6 to 47 months. The neck lymph node recurrence rate was zero, and the overall recurrence rate was 5%. Conclusions SPIO-enhanced lymphatic mapping may be useful for estimating the need for three-field lymphadenectomy with neck dissection. © Société Internationale de Chirurgie 2011 |
| abstractGer |
Background In cases of thoracic esophageal cancer, multidirectional lymphatic flow from the tumor means that lymph node metastasis can occur in an area extending from the neck to the abdomen. To validate a method for limiting the performance of three-field lymphadenectomy only to patients who need it, we carried out a prospective study in which superparamagnetic iron oxide (SPIO)-enhanced lymphatic mapping was used to determine whether to perform neck lymph node dissection in patients with submucosal thoracic esophageal cancer. Methods A total of 22 patients with clinically submucosal thoracic squamous cell esophageal cancer, without neck lymph node metastasis, were enrolled. SPIO was endoscopically injected into the peritumoral submucosal layer, after which its appearance in lymph nodes in the neck was evaluated using magnetic resonance imaging (MRI). Neck lymph nodes were then dissected based on the SPIO-enhanced MRI lymphatic mapping. Results Influx of SPIO into lymph nodes was detected in 21 patients (95% detection rate). SPIO flowed to the neck in 8 (36%) patients. Influx of SPIO into neck lymph nodes was unilateral in five patients and bilateral in three patients, and the lymph nodes were dissected accordingly. A cancer-involved node was identified in two of those patients. In 14 patients, we did not dissect neck nodes. Patients were followed up for 6 to 47 months. The neck lymph node recurrence rate was zero, and the overall recurrence rate was 5%. Conclusions SPIO-enhanced lymphatic mapping may be useful for estimating the need for three-field lymphadenectomy with neck dissection. © Société Internationale de Chirurgie 2011 |
| abstract_unstemmed |
Background In cases of thoracic esophageal cancer, multidirectional lymphatic flow from the tumor means that lymph node metastasis can occur in an area extending from the neck to the abdomen. To validate a method for limiting the performance of three-field lymphadenectomy only to patients who need it, we carried out a prospective study in which superparamagnetic iron oxide (SPIO)-enhanced lymphatic mapping was used to determine whether to perform neck lymph node dissection in patients with submucosal thoracic esophageal cancer. Methods A total of 22 patients with clinically submucosal thoracic squamous cell esophageal cancer, without neck lymph node metastasis, were enrolled. SPIO was endoscopically injected into the peritumoral submucosal layer, after which its appearance in lymph nodes in the neck was evaluated using magnetic resonance imaging (MRI). Neck lymph nodes were then dissected based on the SPIO-enhanced MRI lymphatic mapping. Results Influx of SPIO into lymph nodes was detected in 21 patients (95% detection rate). SPIO flowed to the neck in 8 (36%) patients. Influx of SPIO into neck lymph nodes was unilateral in five patients and bilateral in three patients, and the lymph nodes were dissected accordingly. A cancer-involved node was identified in two of those patients. In 14 patients, we did not dissect neck nodes. Patients were followed up for 6 to 47 months. The neck lymph node recurrence rate was zero, and the overall recurrence rate was 5%. Conclusions SPIO-enhanced lymphatic mapping may be useful for estimating the need for three-field lymphadenectomy with neck dissection. © Société Internationale de Chirurgie 2011 |
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Estimating the Need for Neck Lymphadenectomy in Submucosal Esophageal Cancer Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging: Clinical Validation Study |
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Ishiyama, Koichi Maruyama, Kiyotomi Narita, Komei Minamiya, Yoshihiro Ogawa, Jun-ichi |
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Ishiyama, Koichi Maruyama, Kiyotomi Narita, Komei Minamiya, Yoshihiro Ogawa, Jun-ichi |
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2024-07-03T19:28:34.760Z |
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