Survival after Lung Metastasectomy in Colorectal Cancer Patients with Previously Resected Liver Metastases
Background Resection of hepatic metastases is indicated in selected stage IV colorectal cancer (CRC) patients. A minority will eventually develop pulmonary metastases and may undergo lung surgery with curative intent. The aims of the present study were to assess clinical outcome and identify paramet...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gonzalez, Michel [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Anmerkung: |
© Société Internationale de Chirurgie 2011 |
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| Übergeordnetes Werk: |
Enthalten in: World Journal of Surgery - Springer-Verlag, 1996, 36(2011), 2 vom: 14. Dez., Seite 386-391 |
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| Übergeordnetes Werk: |
volume:36 ; year:2011 ; number:2 ; day:14 ; month:12 ; pages:386-391 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00268-011-1381-3 |
|---|
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SPR00343673X |
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| 520 | |a Background Resection of hepatic metastases is indicated in selected stage IV colorectal cancer (CRC) patients. A minority will eventually develop pulmonary metastases and may undergo lung surgery with curative intent. The aims of the present study were to assess clinical outcome and identify parameters predicting survival after pulmonary metastasectomy in patients who underwent prior resection of hepatic CRC metastases. Methods We performed a retrospective analysis of 27 consecutive patients (median age 62 years; range: 33–75 years) who underwent resection of pulmonary metastases after previous hepatic metastasectomy from CRC in two institutions from 1996 to 2009. All patients underwent complete resection (R0) for both colorectal and hepatic metastases. Results Median follow-up was 32 months (range: 3–69 months) after resection of lung metastases and 65 months (range: 19–146 months) after resection of primary CRC. Three- and 5-year overall survival rates after lung surgery were 56 and 39%, respectively, and median survival was 46 months (95% CI 35–57). Median disease-free survival after pulmonary metastasectomy was 13 months (95% CI 5–21). At the time of last follow-up, seven patients (26%) had no evidence of recurrent disease and 6 of these 7 patients presented initially with a single lung metastasis. Conclusions Resection of lung metastases from CRC patients may result in prolonged survival, even after previous hepatic metastasectomy. Yet, prolonged disease-free survival remains the exception, and seems to occur only in patients with a single lung lesion. | ||
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10.1007/s00268-011-1381-3 doi (DE-627)SPR00343673X (SPR)s00268-011-1381-3-e DE-627 ger DE-627 rakwb eng Gonzalez, Michel verfasserin aut Survival after Lung Metastasectomy in Colorectal Cancer Patients with Previously Resected Liver Metastases 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2011 Background Resection of hepatic metastases is indicated in selected stage IV colorectal cancer (CRC) patients. A minority will eventually develop pulmonary metastases and may undergo lung surgery with curative intent. The aims of the present study were to assess clinical outcome and identify parameters predicting survival after pulmonary metastasectomy in patients who underwent prior resection of hepatic CRC metastases. Methods We performed a retrospective analysis of 27 consecutive patients (median age 62 years; range: 33–75 years) who underwent resection of pulmonary metastases after previous hepatic metastasectomy from CRC in two institutions from 1996 to 2009. All patients underwent complete resection (R0) for both colorectal and hepatic metastases. Results Median follow-up was 32 months (range: 3–69 months) after resection of lung metastases and 65 months (range: 19–146 months) after resection of primary CRC. Three- and 5-year overall survival rates after lung surgery were 56 and 39%, respectively, and median survival was 46 months (95% CI 35–57). Median disease-free survival after pulmonary metastasectomy was 13 months (95% CI 5–21). At the time of last follow-up, seven patients (26%) had no evidence of recurrent disease and 6 of these 7 patients presented initially with a single lung metastasis. Conclusions Resection of lung metastases from CRC patients may result in prolonged survival, even after previous hepatic metastasectomy. Yet, prolonged disease-free survival remains the exception, and seems to occur only in patients with a single lung lesion. Liver Metastasis (dpeaa)DE-He213 Oxaliplatin (dpeaa)DE-He213 Lung Metastasis (dpeaa)DE-He213 Pulmonary Metastasis (dpeaa)DE-He213 Primary Tumor Resection (dpeaa)DE-He213 Robert, John Henri aut Halkic, Nermin aut Mentha, Gilles aut Roth, Arnaud aut Perneger, Thomas aut Ris, Hans Beat aut Gervaz, Pascal aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 36(2011), 2 vom: 14. Dez., Seite 386-391 (DE-627)SPR003391159 nnns volume:36 year:2011 number:2 day:14 month:12 pages:386-391 https://dx.doi.org/10.1007/s00268-011-1381-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 36 2011 2 14 12 386-391 |
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10.1007/s00268-011-1381-3 doi (DE-627)SPR00343673X (SPR)s00268-011-1381-3-e DE-627 ger DE-627 rakwb eng Gonzalez, Michel verfasserin aut Survival after Lung Metastasectomy in Colorectal Cancer Patients with Previously Resected Liver Metastases 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2011 Background Resection of hepatic metastases is indicated in selected stage IV colorectal cancer (CRC) patients. A minority will eventually develop pulmonary metastases and may undergo lung surgery with curative intent. The aims of the present study were to assess clinical outcome and identify parameters predicting survival after pulmonary metastasectomy in patients who underwent prior resection of hepatic CRC metastases. Methods We performed a retrospective analysis of 27 consecutive patients (median age 62 years; range: 33–75 years) who underwent resection of pulmonary metastases after previous hepatic metastasectomy from CRC in two institutions from 1996 to 2009. All patients underwent complete resection (R0) for both colorectal and hepatic metastases. Results Median follow-up was 32 months (range: 3–69 months) after resection of lung metastases and 65 months (range: 19–146 months) after resection of primary CRC. Three- and 5-year overall survival rates after lung surgery were 56 and 39%, respectively, and median survival was 46 months (95% CI 35–57). Median disease-free survival after pulmonary metastasectomy was 13 months (95% CI 5–21). At the time of last follow-up, seven patients (26%) had no evidence of recurrent disease and 6 of these 7 patients presented initially with a single lung metastasis. Conclusions Resection of lung metastases from CRC patients may result in prolonged survival, even after previous hepatic metastasectomy. Yet, prolonged disease-free survival remains the exception, and seems to occur only in patients with a single lung lesion. Liver Metastasis (dpeaa)DE-He213 Oxaliplatin (dpeaa)DE-He213 Lung Metastasis (dpeaa)DE-He213 Pulmonary Metastasis (dpeaa)DE-He213 Primary Tumor Resection (dpeaa)DE-He213 Robert, John Henri aut Halkic, Nermin aut Mentha, Gilles aut Roth, Arnaud aut Perneger, Thomas aut Ris, Hans Beat aut Gervaz, Pascal aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 36(2011), 2 vom: 14. Dez., Seite 386-391 (DE-627)SPR003391159 nnns volume:36 year:2011 number:2 day:14 month:12 pages:386-391 https://dx.doi.org/10.1007/s00268-011-1381-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 36 2011 2 14 12 386-391 |
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10.1007/s00268-011-1381-3 doi (DE-627)SPR00343673X (SPR)s00268-011-1381-3-e DE-627 ger DE-627 rakwb eng Gonzalez, Michel verfasserin aut Survival after Lung Metastasectomy in Colorectal Cancer Patients with Previously Resected Liver Metastases 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2011 Background Resection of hepatic metastases is indicated in selected stage IV colorectal cancer (CRC) patients. A minority will eventually develop pulmonary metastases and may undergo lung surgery with curative intent. The aims of the present study were to assess clinical outcome and identify parameters predicting survival after pulmonary metastasectomy in patients who underwent prior resection of hepatic CRC metastases. Methods We performed a retrospective analysis of 27 consecutive patients (median age 62 years; range: 33–75 years) who underwent resection of pulmonary metastases after previous hepatic metastasectomy from CRC in two institutions from 1996 to 2009. All patients underwent complete resection (R0) for both colorectal and hepatic metastases. Results Median follow-up was 32 months (range: 3–69 months) after resection of lung metastases and 65 months (range: 19–146 months) after resection of primary CRC. Three- and 5-year overall survival rates after lung surgery were 56 and 39%, respectively, and median survival was 46 months (95% CI 35–57). Median disease-free survival after pulmonary metastasectomy was 13 months (95% CI 5–21). At the time of last follow-up, seven patients (26%) had no evidence of recurrent disease and 6 of these 7 patients presented initially with a single lung metastasis. Conclusions Resection of lung metastases from CRC patients may result in prolonged survival, even after previous hepatic metastasectomy. Yet, prolonged disease-free survival remains the exception, and seems to occur only in patients with a single lung lesion. Liver Metastasis (dpeaa)DE-He213 Oxaliplatin (dpeaa)DE-He213 Lung Metastasis (dpeaa)DE-He213 Pulmonary Metastasis (dpeaa)DE-He213 Primary Tumor Resection (dpeaa)DE-He213 Robert, John Henri aut Halkic, Nermin aut Mentha, Gilles aut Roth, Arnaud aut Perneger, Thomas aut Ris, Hans Beat aut Gervaz, Pascal aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 36(2011), 2 vom: 14. Dez., Seite 386-391 (DE-627)SPR003391159 nnns volume:36 year:2011 number:2 day:14 month:12 pages:386-391 https://dx.doi.org/10.1007/s00268-011-1381-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 36 2011 2 14 12 386-391 |
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10.1007/s00268-011-1381-3 doi (DE-627)SPR00343673X (SPR)s00268-011-1381-3-e DE-627 ger DE-627 rakwb eng Gonzalez, Michel verfasserin aut Survival after Lung Metastasectomy in Colorectal Cancer Patients with Previously Resected Liver Metastases 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2011 Background Resection of hepatic metastases is indicated in selected stage IV colorectal cancer (CRC) patients. A minority will eventually develop pulmonary metastases and may undergo lung surgery with curative intent. The aims of the present study were to assess clinical outcome and identify parameters predicting survival after pulmonary metastasectomy in patients who underwent prior resection of hepatic CRC metastases. Methods We performed a retrospective analysis of 27 consecutive patients (median age 62 years; range: 33–75 years) who underwent resection of pulmonary metastases after previous hepatic metastasectomy from CRC in two institutions from 1996 to 2009. All patients underwent complete resection (R0) for both colorectal and hepatic metastases. Results Median follow-up was 32 months (range: 3–69 months) after resection of lung metastases and 65 months (range: 19–146 months) after resection of primary CRC. Three- and 5-year overall survival rates after lung surgery were 56 and 39%, respectively, and median survival was 46 months (95% CI 35–57). Median disease-free survival after pulmonary metastasectomy was 13 months (95% CI 5–21). At the time of last follow-up, seven patients (26%) had no evidence of recurrent disease and 6 of these 7 patients presented initially with a single lung metastasis. Conclusions Resection of lung metastases from CRC patients may result in prolonged survival, even after previous hepatic metastasectomy. Yet, prolonged disease-free survival remains the exception, and seems to occur only in patients with a single lung lesion. Liver Metastasis (dpeaa)DE-He213 Oxaliplatin (dpeaa)DE-He213 Lung Metastasis (dpeaa)DE-He213 Pulmonary Metastasis (dpeaa)DE-He213 Primary Tumor Resection (dpeaa)DE-He213 Robert, John Henri aut Halkic, Nermin aut Mentha, Gilles aut Roth, Arnaud aut Perneger, Thomas aut Ris, Hans Beat aut Gervaz, Pascal aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 36(2011), 2 vom: 14. Dez., Seite 386-391 (DE-627)SPR003391159 nnns volume:36 year:2011 number:2 day:14 month:12 pages:386-391 https://dx.doi.org/10.1007/s00268-011-1381-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 36 2011 2 14 12 386-391 |
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10.1007/s00268-011-1381-3 doi (DE-627)SPR00343673X (SPR)s00268-011-1381-3-e DE-627 ger DE-627 rakwb eng Gonzalez, Michel verfasserin aut Survival after Lung Metastasectomy in Colorectal Cancer Patients with Previously Resected Liver Metastases 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2011 Background Resection of hepatic metastases is indicated in selected stage IV colorectal cancer (CRC) patients. A minority will eventually develop pulmonary metastases and may undergo lung surgery with curative intent. The aims of the present study were to assess clinical outcome and identify parameters predicting survival after pulmonary metastasectomy in patients who underwent prior resection of hepatic CRC metastases. Methods We performed a retrospective analysis of 27 consecutive patients (median age 62 years; range: 33–75 years) who underwent resection of pulmonary metastases after previous hepatic metastasectomy from CRC in two institutions from 1996 to 2009. All patients underwent complete resection (R0) for both colorectal and hepatic metastases. Results Median follow-up was 32 months (range: 3–69 months) after resection of lung metastases and 65 months (range: 19–146 months) after resection of primary CRC. Three- and 5-year overall survival rates after lung surgery were 56 and 39%, respectively, and median survival was 46 months (95% CI 35–57). Median disease-free survival after pulmonary metastasectomy was 13 months (95% CI 5–21). At the time of last follow-up, seven patients (26%) had no evidence of recurrent disease and 6 of these 7 patients presented initially with a single lung metastasis. Conclusions Resection of lung metastases from CRC patients may result in prolonged survival, even after previous hepatic metastasectomy. Yet, prolonged disease-free survival remains the exception, and seems to occur only in patients with a single lung lesion. Liver Metastasis (dpeaa)DE-He213 Oxaliplatin (dpeaa)DE-He213 Lung Metastasis (dpeaa)DE-He213 Pulmonary Metastasis (dpeaa)DE-He213 Primary Tumor Resection (dpeaa)DE-He213 Robert, John Henri aut Halkic, Nermin aut Mentha, Gilles aut Roth, Arnaud aut Perneger, Thomas aut Ris, Hans Beat aut Gervaz, Pascal aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 36(2011), 2 vom: 14. Dez., Seite 386-391 (DE-627)SPR003391159 nnns volume:36 year:2011 number:2 day:14 month:12 pages:386-391 https://dx.doi.org/10.1007/s00268-011-1381-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 36 2011 2 14 12 386-391 |
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Survival after Lung Metastasectomy in Colorectal Cancer Patients with Previously Resected Liver Metastases |
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Survival after Lung Metastasectomy in Colorectal Cancer Patients with Previously Resected Liver Metastases |
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Gonzalez, Michel |
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World Journal of Surgery |
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2011 |
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Gonzalez, Michel Robert, John Henri Halkic, Nermin Mentha, Gilles Roth, Arnaud Perneger, Thomas Ris, Hans Beat Gervaz, Pascal |
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36 |
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Elektronische Aufsätze |
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Gonzalez, Michel |
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10.1007/s00268-011-1381-3 |
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survival after lung metastasectomy in colorectal cancer patients with previously resected liver metastases |
| title_auth |
Survival after Lung Metastasectomy in Colorectal Cancer Patients with Previously Resected Liver Metastases |
| abstract |
Background Resection of hepatic metastases is indicated in selected stage IV colorectal cancer (CRC) patients. A minority will eventually develop pulmonary metastases and may undergo lung surgery with curative intent. The aims of the present study were to assess clinical outcome and identify parameters predicting survival after pulmonary metastasectomy in patients who underwent prior resection of hepatic CRC metastases. Methods We performed a retrospective analysis of 27 consecutive patients (median age 62 years; range: 33–75 years) who underwent resection of pulmonary metastases after previous hepatic metastasectomy from CRC in two institutions from 1996 to 2009. All patients underwent complete resection (R0) for both colorectal and hepatic metastases. Results Median follow-up was 32 months (range: 3–69 months) after resection of lung metastases and 65 months (range: 19–146 months) after resection of primary CRC. Three- and 5-year overall survival rates after lung surgery were 56 and 39%, respectively, and median survival was 46 months (95% CI 35–57). Median disease-free survival after pulmonary metastasectomy was 13 months (95% CI 5–21). At the time of last follow-up, seven patients (26%) had no evidence of recurrent disease and 6 of these 7 patients presented initially with a single lung metastasis. Conclusions Resection of lung metastases from CRC patients may result in prolonged survival, even after previous hepatic metastasectomy. Yet, prolonged disease-free survival remains the exception, and seems to occur only in patients with a single lung lesion. © Société Internationale de Chirurgie 2011 |
| abstractGer |
Background Resection of hepatic metastases is indicated in selected stage IV colorectal cancer (CRC) patients. A minority will eventually develop pulmonary metastases and may undergo lung surgery with curative intent. The aims of the present study were to assess clinical outcome and identify parameters predicting survival after pulmonary metastasectomy in patients who underwent prior resection of hepatic CRC metastases. Methods We performed a retrospective analysis of 27 consecutive patients (median age 62 years; range: 33–75 years) who underwent resection of pulmonary metastases after previous hepatic metastasectomy from CRC in two institutions from 1996 to 2009. All patients underwent complete resection (R0) for both colorectal and hepatic metastases. Results Median follow-up was 32 months (range: 3–69 months) after resection of lung metastases and 65 months (range: 19–146 months) after resection of primary CRC. Three- and 5-year overall survival rates after lung surgery were 56 and 39%, respectively, and median survival was 46 months (95% CI 35–57). Median disease-free survival after pulmonary metastasectomy was 13 months (95% CI 5–21). At the time of last follow-up, seven patients (26%) had no evidence of recurrent disease and 6 of these 7 patients presented initially with a single lung metastasis. Conclusions Resection of lung metastases from CRC patients may result in prolonged survival, even after previous hepatic metastasectomy. Yet, prolonged disease-free survival remains the exception, and seems to occur only in patients with a single lung lesion. © Société Internationale de Chirurgie 2011 |
| abstract_unstemmed |
Background Resection of hepatic metastases is indicated in selected stage IV colorectal cancer (CRC) patients. A minority will eventually develop pulmonary metastases and may undergo lung surgery with curative intent. The aims of the present study were to assess clinical outcome and identify parameters predicting survival after pulmonary metastasectomy in patients who underwent prior resection of hepatic CRC metastases. Methods We performed a retrospective analysis of 27 consecutive patients (median age 62 years; range: 33–75 years) who underwent resection of pulmonary metastases after previous hepatic metastasectomy from CRC in two institutions from 1996 to 2009. All patients underwent complete resection (R0) for both colorectal and hepatic metastases. Results Median follow-up was 32 months (range: 3–69 months) after resection of lung metastases and 65 months (range: 19–146 months) after resection of primary CRC. Three- and 5-year overall survival rates after lung surgery were 56 and 39%, respectively, and median survival was 46 months (95% CI 35–57). Median disease-free survival after pulmonary metastasectomy was 13 months (95% CI 5–21). At the time of last follow-up, seven patients (26%) had no evidence of recurrent disease and 6 of these 7 patients presented initially with a single lung metastasis. Conclusions Resection of lung metastases from CRC patients may result in prolonged survival, even after previous hepatic metastasectomy. Yet, prolonged disease-free survival remains the exception, and seems to occur only in patients with a single lung lesion. © Société Internationale de Chirurgie 2011 |
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Survival after Lung Metastasectomy in Colorectal Cancer Patients with Previously Resected Liver Metastases |
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Robert, John Henri Halkic, Nermin Mentha, Gilles Roth, Arnaud Perneger, Thomas Ris, Hans Beat Gervaz, Pascal |
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