Survival in Resected Stage II Colorectal Cancer Is Dependent on Tumor Depth, Vascular Invasion, Postoperative CEA Level, and The Number of Examined Lymph Nodes
Background The aim of the present study was to determine which aspects of tumor histology influence postoperative early relapse and overall survival rates after radical resection of stage II colorectal cancer (CRC). Methods Data were collected for 425 patients with stage II CRC who began treatment a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tsai, Hsiang-Lin [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Anmerkung: |
© Société Internationale de Chirurgie 2015 |
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| Übergeordnetes Werk: |
Enthalten in: World Journal of Surgery - Springer-Verlag, 1996, 40(2015), 4 vom: 11. Nov., Seite 1002-1009 |
|---|---|
| Übergeordnetes Werk: |
volume:40 ; year:2015 ; number:4 ; day:11 ; month:11 ; pages:1002-1009 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00268-015-3331-y |
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SPR003456676 |
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| 520 | |a Background The aim of the present study was to determine which aspects of tumor histology influence postoperative early relapse and overall survival rates after radical resection of stage II colorectal cancer (CRC). Methods Data were collected for 425 patients with stage II CRC who began treatment at a single institution between January 2006 and October 2013. All the enrolled patients were followed up on until death or until December 2014. Clinically significant factors affecting postoperative early relapse and overall survival rates were analyzed. Results Using a multivariate analysis, tumor invasion depth (P = 0.008), vascular invasion (P = 0.029), postoperative carcinoembryonic antigen (CEA) level (P = 0.001), and retrieval of less than 12 lymph nodes (P = 0.002) were found to be independent predictors for postoperative early relapse. A combination of tumor invasion depth, vascular invasion, postoperative CEA level, and number of lymph nodes retrieved showed that the greater the number of predictors involved, the higher the likelihood of postoperative early relapse and the poorer the overall survival. Conclusions This study revealed that T4 invasion, vascular invasion, postoperative CEA level, and the number of examined lymph nodes may significantly affect the prognosis of stage II CRC patients after radical resection. The risks of postoperative early relapse and worse clinical outcome increase in proportion to the values of these four parameters. | ||
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10.1007/s00268-015-3331-y doi (DE-627)SPR003456676 (SPR)s00268-015-3331-y-e DE-627 ger DE-627 rakwb eng Tsai, Hsiang-Lin verfasserin aut Survival in Resected Stage II Colorectal Cancer Is Dependent on Tumor Depth, Vascular Invasion, Postoperative CEA Level, and The Number of Examined Lymph Nodes 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2015 Background The aim of the present study was to determine which aspects of tumor histology influence postoperative early relapse and overall survival rates after radical resection of stage II colorectal cancer (CRC). Methods Data were collected for 425 patients with stage II CRC who began treatment at a single institution between January 2006 and October 2013. All the enrolled patients were followed up on until death or until December 2014. Clinically significant factors affecting postoperative early relapse and overall survival rates were analyzed. Results Using a multivariate analysis, tumor invasion depth (P = 0.008), vascular invasion (P = 0.029), postoperative carcinoembryonic antigen (CEA) level (P = 0.001), and retrieval of less than 12 lymph nodes (P = 0.002) were found to be independent predictors for postoperative early relapse. A combination of tumor invasion depth, vascular invasion, postoperative CEA level, and number of lymph nodes retrieved showed that the greater the number of predictors involved, the higher the likelihood of postoperative early relapse and the poorer the overall survival. Conclusions This study revealed that T4 invasion, vascular invasion, postoperative CEA level, and the number of examined lymph nodes may significantly affect the prognosis of stage II CRC patients after radical resection. The risks of postoperative early relapse and worse clinical outcome increase in proportion to the values of these four parameters. Vascular Invasion (dpeaa)DE-He213 Perineural Invasion (dpeaa)DE-He213 Early Relapse (dpeaa)DE-He213 Examine Lymph Node (dpeaa)DE-He213 Tumor Invasion Depth (dpeaa)DE-He213 Huang, Ching-Wen aut Chen, Chao-Wen aut Yeh, Yung-Sung aut Ma, Cheng-Jen aut Wang, Jaw-Yuan aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 40(2015), 4 vom: 11. Nov., Seite 1002-1009 (DE-627)SPR003391159 nnns volume:40 year:2015 number:4 day:11 month:11 pages:1002-1009 https://dx.doi.org/10.1007/s00268-015-3331-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 40 2015 4 11 11 1002-1009 |
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10.1007/s00268-015-3331-y doi (DE-627)SPR003456676 (SPR)s00268-015-3331-y-e DE-627 ger DE-627 rakwb eng Tsai, Hsiang-Lin verfasserin aut Survival in Resected Stage II Colorectal Cancer Is Dependent on Tumor Depth, Vascular Invasion, Postoperative CEA Level, and The Number of Examined Lymph Nodes 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2015 Background The aim of the present study was to determine which aspects of tumor histology influence postoperative early relapse and overall survival rates after radical resection of stage II colorectal cancer (CRC). Methods Data were collected for 425 patients with stage II CRC who began treatment at a single institution between January 2006 and October 2013. All the enrolled patients were followed up on until death or until December 2014. Clinically significant factors affecting postoperative early relapse and overall survival rates were analyzed. Results Using a multivariate analysis, tumor invasion depth (P = 0.008), vascular invasion (P = 0.029), postoperative carcinoembryonic antigen (CEA) level (P = 0.001), and retrieval of less than 12 lymph nodes (P = 0.002) were found to be independent predictors for postoperative early relapse. A combination of tumor invasion depth, vascular invasion, postoperative CEA level, and number of lymph nodes retrieved showed that the greater the number of predictors involved, the higher the likelihood of postoperative early relapse and the poorer the overall survival. Conclusions This study revealed that T4 invasion, vascular invasion, postoperative CEA level, and the number of examined lymph nodes may significantly affect the prognosis of stage II CRC patients after radical resection. The risks of postoperative early relapse and worse clinical outcome increase in proportion to the values of these four parameters. Vascular Invasion (dpeaa)DE-He213 Perineural Invasion (dpeaa)DE-He213 Early Relapse (dpeaa)DE-He213 Examine Lymph Node (dpeaa)DE-He213 Tumor Invasion Depth (dpeaa)DE-He213 Huang, Ching-Wen aut Chen, Chao-Wen aut Yeh, Yung-Sung aut Ma, Cheng-Jen aut Wang, Jaw-Yuan aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 40(2015), 4 vom: 11. Nov., Seite 1002-1009 (DE-627)SPR003391159 nnns volume:40 year:2015 number:4 day:11 month:11 pages:1002-1009 https://dx.doi.org/10.1007/s00268-015-3331-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 40 2015 4 11 11 1002-1009 |
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10.1007/s00268-015-3331-y doi (DE-627)SPR003456676 (SPR)s00268-015-3331-y-e DE-627 ger DE-627 rakwb eng Tsai, Hsiang-Lin verfasserin aut Survival in Resected Stage II Colorectal Cancer Is Dependent on Tumor Depth, Vascular Invasion, Postoperative CEA Level, and The Number of Examined Lymph Nodes 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2015 Background The aim of the present study was to determine which aspects of tumor histology influence postoperative early relapse and overall survival rates after radical resection of stage II colorectal cancer (CRC). Methods Data were collected for 425 patients with stage II CRC who began treatment at a single institution between January 2006 and October 2013. All the enrolled patients were followed up on until death or until December 2014. Clinically significant factors affecting postoperative early relapse and overall survival rates were analyzed. Results Using a multivariate analysis, tumor invasion depth (P = 0.008), vascular invasion (P = 0.029), postoperative carcinoembryonic antigen (CEA) level (P = 0.001), and retrieval of less than 12 lymph nodes (P = 0.002) were found to be independent predictors for postoperative early relapse. A combination of tumor invasion depth, vascular invasion, postoperative CEA level, and number of lymph nodes retrieved showed that the greater the number of predictors involved, the higher the likelihood of postoperative early relapse and the poorer the overall survival. Conclusions This study revealed that T4 invasion, vascular invasion, postoperative CEA level, and the number of examined lymph nodes may significantly affect the prognosis of stage II CRC patients after radical resection. The risks of postoperative early relapse and worse clinical outcome increase in proportion to the values of these four parameters. Vascular Invasion (dpeaa)DE-He213 Perineural Invasion (dpeaa)DE-He213 Early Relapse (dpeaa)DE-He213 Examine Lymph Node (dpeaa)DE-He213 Tumor Invasion Depth (dpeaa)DE-He213 Huang, Ching-Wen aut Chen, Chao-Wen aut Yeh, Yung-Sung aut Ma, Cheng-Jen aut Wang, Jaw-Yuan aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 40(2015), 4 vom: 11. Nov., Seite 1002-1009 (DE-627)SPR003391159 nnns volume:40 year:2015 number:4 day:11 month:11 pages:1002-1009 https://dx.doi.org/10.1007/s00268-015-3331-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 40 2015 4 11 11 1002-1009 |
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10.1007/s00268-015-3331-y doi (DE-627)SPR003456676 (SPR)s00268-015-3331-y-e DE-627 ger DE-627 rakwb eng Tsai, Hsiang-Lin verfasserin aut Survival in Resected Stage II Colorectal Cancer Is Dependent on Tumor Depth, Vascular Invasion, Postoperative CEA Level, and The Number of Examined Lymph Nodes 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2015 Background The aim of the present study was to determine which aspects of tumor histology influence postoperative early relapse and overall survival rates after radical resection of stage II colorectal cancer (CRC). Methods Data were collected for 425 patients with stage II CRC who began treatment at a single institution between January 2006 and October 2013. All the enrolled patients were followed up on until death or until December 2014. Clinically significant factors affecting postoperative early relapse and overall survival rates were analyzed. Results Using a multivariate analysis, tumor invasion depth (P = 0.008), vascular invasion (P = 0.029), postoperative carcinoembryonic antigen (CEA) level (P = 0.001), and retrieval of less than 12 lymph nodes (P = 0.002) were found to be independent predictors for postoperative early relapse. A combination of tumor invasion depth, vascular invasion, postoperative CEA level, and number of lymph nodes retrieved showed that the greater the number of predictors involved, the higher the likelihood of postoperative early relapse and the poorer the overall survival. Conclusions This study revealed that T4 invasion, vascular invasion, postoperative CEA level, and the number of examined lymph nodes may significantly affect the prognosis of stage II CRC patients after radical resection. The risks of postoperative early relapse and worse clinical outcome increase in proportion to the values of these four parameters. Vascular Invasion (dpeaa)DE-He213 Perineural Invasion (dpeaa)DE-He213 Early Relapse (dpeaa)DE-He213 Examine Lymph Node (dpeaa)DE-He213 Tumor Invasion Depth (dpeaa)DE-He213 Huang, Ching-Wen aut Chen, Chao-Wen aut Yeh, Yung-Sung aut Ma, Cheng-Jen aut Wang, Jaw-Yuan aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 40(2015), 4 vom: 11. Nov., Seite 1002-1009 (DE-627)SPR003391159 nnns volume:40 year:2015 number:4 day:11 month:11 pages:1002-1009 https://dx.doi.org/10.1007/s00268-015-3331-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 40 2015 4 11 11 1002-1009 |
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10.1007/s00268-015-3331-y doi (DE-627)SPR003456676 (SPR)s00268-015-3331-y-e DE-627 ger DE-627 rakwb eng Tsai, Hsiang-Lin verfasserin aut Survival in Resected Stage II Colorectal Cancer Is Dependent on Tumor Depth, Vascular Invasion, Postoperative CEA Level, and The Number of Examined Lymph Nodes 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Société Internationale de Chirurgie 2015 Background The aim of the present study was to determine which aspects of tumor histology influence postoperative early relapse and overall survival rates after radical resection of stage II colorectal cancer (CRC). Methods Data were collected for 425 patients with stage II CRC who began treatment at a single institution between January 2006 and October 2013. All the enrolled patients were followed up on until death or until December 2014. Clinically significant factors affecting postoperative early relapse and overall survival rates were analyzed. Results Using a multivariate analysis, tumor invasion depth (P = 0.008), vascular invasion (P = 0.029), postoperative carcinoembryonic antigen (CEA) level (P = 0.001), and retrieval of less than 12 lymph nodes (P = 0.002) were found to be independent predictors for postoperative early relapse. A combination of tumor invasion depth, vascular invasion, postoperative CEA level, and number of lymph nodes retrieved showed that the greater the number of predictors involved, the higher the likelihood of postoperative early relapse and the poorer the overall survival. Conclusions This study revealed that T4 invasion, vascular invasion, postoperative CEA level, and the number of examined lymph nodes may significantly affect the prognosis of stage II CRC patients after radical resection. The risks of postoperative early relapse and worse clinical outcome increase in proportion to the values of these four parameters. Vascular Invasion (dpeaa)DE-He213 Perineural Invasion (dpeaa)DE-He213 Early Relapse (dpeaa)DE-He213 Examine Lymph Node (dpeaa)DE-He213 Tumor Invasion Depth (dpeaa)DE-He213 Huang, Ching-Wen aut Chen, Chao-Wen aut Yeh, Yung-Sung aut Ma, Cheng-Jen aut Wang, Jaw-Yuan aut Enthalten in World Journal of Surgery Springer-Verlag, 1996 40(2015), 4 vom: 11. Nov., Seite 1002-1009 (DE-627)SPR003391159 nnns volume:40 year:2015 number:4 day:11 month:11 pages:1002-1009 https://dx.doi.org/10.1007/s00268-015-3331-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 40 2015 4 11 11 1002-1009 |
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Tsai, Hsiang-Lin Huang, Ching-Wen Chen, Chao-Wen Yeh, Yung-Sung Ma, Cheng-Jen Wang, Jaw-Yuan |
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Tsai, Hsiang-Lin |
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10.1007/s00268-015-3331-y |
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survival in resected stage ii colorectal cancer is dependent on tumor depth, vascular invasion, postoperative cea level, and the number of examined lymph nodes |
| title_auth |
Survival in Resected Stage II Colorectal Cancer Is Dependent on Tumor Depth, Vascular Invasion, Postoperative CEA Level, and The Number of Examined Lymph Nodes |
| abstract |
Background The aim of the present study was to determine which aspects of tumor histology influence postoperative early relapse and overall survival rates after radical resection of stage II colorectal cancer (CRC). Methods Data were collected for 425 patients with stage II CRC who began treatment at a single institution between January 2006 and October 2013. All the enrolled patients were followed up on until death or until December 2014. Clinically significant factors affecting postoperative early relapse and overall survival rates were analyzed. Results Using a multivariate analysis, tumor invasion depth (P = 0.008), vascular invasion (P = 0.029), postoperative carcinoembryonic antigen (CEA) level (P = 0.001), and retrieval of less than 12 lymph nodes (P = 0.002) were found to be independent predictors for postoperative early relapse. A combination of tumor invasion depth, vascular invasion, postoperative CEA level, and number of lymph nodes retrieved showed that the greater the number of predictors involved, the higher the likelihood of postoperative early relapse and the poorer the overall survival. Conclusions This study revealed that T4 invasion, vascular invasion, postoperative CEA level, and the number of examined lymph nodes may significantly affect the prognosis of stage II CRC patients after radical resection. The risks of postoperative early relapse and worse clinical outcome increase in proportion to the values of these four parameters. © Société Internationale de Chirurgie 2015 |
| abstractGer |
Background The aim of the present study was to determine which aspects of tumor histology influence postoperative early relapse and overall survival rates after radical resection of stage II colorectal cancer (CRC). Methods Data were collected for 425 patients with stage II CRC who began treatment at a single institution between January 2006 and October 2013. All the enrolled patients were followed up on until death or until December 2014. Clinically significant factors affecting postoperative early relapse and overall survival rates were analyzed. Results Using a multivariate analysis, tumor invasion depth (P = 0.008), vascular invasion (P = 0.029), postoperative carcinoembryonic antigen (CEA) level (P = 0.001), and retrieval of less than 12 lymph nodes (P = 0.002) were found to be independent predictors for postoperative early relapse. A combination of tumor invasion depth, vascular invasion, postoperative CEA level, and number of lymph nodes retrieved showed that the greater the number of predictors involved, the higher the likelihood of postoperative early relapse and the poorer the overall survival. Conclusions This study revealed that T4 invasion, vascular invasion, postoperative CEA level, and the number of examined lymph nodes may significantly affect the prognosis of stage II CRC patients after radical resection. The risks of postoperative early relapse and worse clinical outcome increase in proportion to the values of these four parameters. © Société Internationale de Chirurgie 2015 |
| abstract_unstemmed |
Background The aim of the present study was to determine which aspects of tumor histology influence postoperative early relapse and overall survival rates after radical resection of stage II colorectal cancer (CRC). Methods Data were collected for 425 patients with stage II CRC who began treatment at a single institution between January 2006 and October 2013. All the enrolled patients were followed up on until death or until December 2014. Clinically significant factors affecting postoperative early relapse and overall survival rates were analyzed. Results Using a multivariate analysis, tumor invasion depth (P = 0.008), vascular invasion (P = 0.029), postoperative carcinoembryonic antigen (CEA) level (P = 0.001), and retrieval of less than 12 lymph nodes (P = 0.002) were found to be independent predictors for postoperative early relapse. A combination of tumor invasion depth, vascular invasion, postoperative CEA level, and number of lymph nodes retrieved showed that the greater the number of predictors involved, the higher the likelihood of postoperative early relapse and the poorer the overall survival. Conclusions This study revealed that T4 invasion, vascular invasion, postoperative CEA level, and the number of examined lymph nodes may significantly affect the prognosis of stage II CRC patients after radical resection. The risks of postoperative early relapse and worse clinical outcome increase in proportion to the values of these four parameters. © Société Internationale de Chirurgie 2015 |
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Survival in Resected Stage II Colorectal Cancer Is Dependent on Tumor Depth, Vascular Invasion, Postoperative CEA Level, and The Number of Examined Lymph Nodes |
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