A phase I study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients
Background This phase I study was conducted to evaluate the feasibility and to determine the recommended doses of the combination therapy of S-1 and irinotecan (CPT-11) in patients with advanced non-small cell lung cancer (NSCLC) as second-line treatment. Methods Patients with NSCLC who were previou...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yoda, Satoshi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2010 |
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| Übergeordnetes Werk: |
Enthalten in: Cancer chemotherapy and pharmacology - Berlin : Springer, 1978, 67(2010), 3 vom: 09. Dez., Seite 717-722 |
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| Übergeordnetes Werk: |
volume:67 ; year:2010 ; number:3 ; day:09 ; month:12 ; pages:717-722 |
| Links: |
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| DOI / URN: |
10.1007/s00280-010-1539-y |
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| Katalog-ID: |
SPR003597342 |
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| 100 | 1 | |a Yoda, Satoshi |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A phase I study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients |
| 264 | 1 | |c 2010 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a © Springer-Verlag 2010 | ||
| 520 | |a Background This phase I study was conducted to evaluate the feasibility and to determine the recommended doses of the combination therapy of S-1 and irinotecan (CPT-11) in patients with advanced non-small cell lung cancer (NSCLC) as second-line treatment. Methods Patients with NSCLC who were previously treated with one chemotherapy regimen and had a performance status of 0 or 1 were eligible. CPT-11 was administered at 60 mg/$ m^{2} $ (level 1), 80 mg/$ m^{2} $ (level 2) on days 1 and 8, and oral S-1 was administered at 80 mg/day for body surface area (BSA) less than 1.25 $ m^{2} $, 100 mg/day for BSA 1.25–1.5 $ m^{2} $, and 120 mg/day for BSA more than 1.5 $ m^{2} $ on days 1–14 every 3 weeks. The dose-limiting toxicity (DLT) was defined as grade 4 leukocytopenia or neutropenia, grade ≥3 neutropenia with fever over 38°C, grade ≥3 thrombocytopenia, or grade ≥3 major nonhematological toxicities. Results Nine patients were enrolled in the study. None of 3 patients enrolled in level 1 had any DLT. Of 6 patients in level 2, 2 patients had grade 3 diarrhea and one had grade 3 interstitial pneumonia. Level 1 was declared as the recommended dose. Conclusion The feasibility of the combination therapy of S-1 and CPT-11 was shown in the second-line setting for the treatment of advanced NSCLC. The recommended dose of CPT-11 was 60 mg/$ m^{2} $ combined with standard dose of S-1 for phase II trials of pretreated advanced NSCLC patients. | ||
| 650 | 4 | |a S-1 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Irinotecan |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Non-small cell lung cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Second line |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Phase I trial |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Soejima, Kenzo |4 aut | |
| 700 | 1 | |a Yasuda, Hiroyuki |4 aut | |
| 700 | 1 | |a Naoki, Katsuhiko |4 aut | |
| 700 | 1 | |a Kawada, Ichiro |4 aut | |
| 700 | 1 | |a Watanabe, Hideo |4 aut | |
| 700 | 1 | |a Nakachi, Ichiro |4 aut | |
| 700 | 1 | |a Satomi, Ryosuke |4 aut | |
| 700 | 1 | |a Nakayama, Sohei |4 aut | |
| 700 | 1 | |a Ikemura, Sinnosuke |4 aut | |
| 700 | 1 | |a Terai, Hideki |4 aut | |
| 700 | 1 | |a Sato, Takashi |4 aut | |
| 700 | 1 | |a Morosawa, Maiko |4 aut | |
| 700 | 1 | |a Asano, Koichiro |4 aut | |
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10.1007/s00280-010-1539-y doi (DE-627)SPR003597342 (SPR)s00280-010-1539-y-e DE-627 ger DE-627 rakwb eng Yoda, Satoshi verfasserin aut A phase I study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Background This phase I study was conducted to evaluate the feasibility and to determine the recommended doses of the combination therapy of S-1 and irinotecan (CPT-11) in patients with advanced non-small cell lung cancer (NSCLC) as second-line treatment. Methods Patients with NSCLC who were previously treated with one chemotherapy regimen and had a performance status of 0 or 1 were eligible. CPT-11 was administered at 60 mg/$ m^{2} $ (level 1), 80 mg/$ m^{2} $ (level 2) on days 1 and 8, and oral S-1 was administered at 80 mg/day for body surface area (BSA) less than 1.25 $ m^{2} $, 100 mg/day for BSA 1.25–1.5 $ m^{2} $, and 120 mg/day for BSA more than 1.5 $ m^{2} $ on days 1–14 every 3 weeks. The dose-limiting toxicity (DLT) was defined as grade 4 leukocytopenia or neutropenia, grade ≥3 neutropenia with fever over 38°C, grade ≥3 thrombocytopenia, or grade ≥3 major nonhematological toxicities. Results Nine patients were enrolled in the study. None of 3 patients enrolled in level 1 had any DLT. Of 6 patients in level 2, 2 patients had grade 3 diarrhea and one had grade 3 interstitial pneumonia. Level 1 was declared as the recommended dose. Conclusion The feasibility of the combination therapy of S-1 and CPT-11 was shown in the second-line setting for the treatment of advanced NSCLC. The recommended dose of CPT-11 was 60 mg/$ m^{2} $ combined with standard dose of S-1 for phase II trials of pretreated advanced NSCLC patients. S-1 (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Non-small cell lung cancer (dpeaa)DE-He213 Second line (dpeaa)DE-He213 Phase I trial (dpeaa)DE-He213 Soejima, Kenzo aut Yasuda, Hiroyuki aut Naoki, Katsuhiko aut Kawada, Ichiro aut Watanabe, Hideo aut Nakachi, Ichiro aut Satomi, Ryosuke aut Nakayama, Sohei aut Ikemura, Sinnosuke aut Terai, Hideki aut Sato, Takashi aut Morosawa, Maiko aut Asano, Koichiro aut Enthalten in Cancer chemotherapy and pharmacology Berlin : Springer, 1978 67(2010), 3 vom: 09. Dez., Seite 717-722 (DE-627)253390435 (DE-600)1458488-8 1432-0843 nnns volume:67 year:2010 number:3 day:09 month:12 pages:717-722 https://dx.doi.org/10.1007/s00280-010-1539-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 67 2010 3 09 12 717-722 |
| spelling |
10.1007/s00280-010-1539-y doi (DE-627)SPR003597342 (SPR)s00280-010-1539-y-e DE-627 ger DE-627 rakwb eng Yoda, Satoshi verfasserin aut A phase I study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Background This phase I study was conducted to evaluate the feasibility and to determine the recommended doses of the combination therapy of S-1 and irinotecan (CPT-11) in patients with advanced non-small cell lung cancer (NSCLC) as second-line treatment. Methods Patients with NSCLC who were previously treated with one chemotherapy regimen and had a performance status of 0 or 1 were eligible. CPT-11 was administered at 60 mg/$ m^{2} $ (level 1), 80 mg/$ m^{2} $ (level 2) on days 1 and 8, and oral S-1 was administered at 80 mg/day for body surface area (BSA) less than 1.25 $ m^{2} $, 100 mg/day for BSA 1.25–1.5 $ m^{2} $, and 120 mg/day for BSA more than 1.5 $ m^{2} $ on days 1–14 every 3 weeks. The dose-limiting toxicity (DLT) was defined as grade 4 leukocytopenia or neutropenia, grade ≥3 neutropenia with fever over 38°C, grade ≥3 thrombocytopenia, or grade ≥3 major nonhematological toxicities. Results Nine patients were enrolled in the study. None of 3 patients enrolled in level 1 had any DLT. Of 6 patients in level 2, 2 patients had grade 3 diarrhea and one had grade 3 interstitial pneumonia. Level 1 was declared as the recommended dose. Conclusion The feasibility of the combination therapy of S-1 and CPT-11 was shown in the second-line setting for the treatment of advanced NSCLC. The recommended dose of CPT-11 was 60 mg/$ m^{2} $ combined with standard dose of S-1 for phase II trials of pretreated advanced NSCLC patients. S-1 (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Non-small cell lung cancer (dpeaa)DE-He213 Second line (dpeaa)DE-He213 Phase I trial (dpeaa)DE-He213 Soejima, Kenzo aut Yasuda, Hiroyuki aut Naoki, Katsuhiko aut Kawada, Ichiro aut Watanabe, Hideo aut Nakachi, Ichiro aut Satomi, Ryosuke aut Nakayama, Sohei aut Ikemura, Sinnosuke aut Terai, Hideki aut Sato, Takashi aut Morosawa, Maiko aut Asano, Koichiro aut Enthalten in Cancer chemotherapy and pharmacology Berlin : Springer, 1978 67(2010), 3 vom: 09. Dez., Seite 717-722 (DE-627)253390435 (DE-600)1458488-8 1432-0843 nnns volume:67 year:2010 number:3 day:09 month:12 pages:717-722 https://dx.doi.org/10.1007/s00280-010-1539-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 67 2010 3 09 12 717-722 |
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10.1007/s00280-010-1539-y doi (DE-627)SPR003597342 (SPR)s00280-010-1539-y-e DE-627 ger DE-627 rakwb eng Yoda, Satoshi verfasserin aut A phase I study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Background This phase I study was conducted to evaluate the feasibility and to determine the recommended doses of the combination therapy of S-1 and irinotecan (CPT-11) in patients with advanced non-small cell lung cancer (NSCLC) as second-line treatment. Methods Patients with NSCLC who were previously treated with one chemotherapy regimen and had a performance status of 0 or 1 were eligible. CPT-11 was administered at 60 mg/$ m^{2} $ (level 1), 80 mg/$ m^{2} $ (level 2) on days 1 and 8, and oral S-1 was administered at 80 mg/day for body surface area (BSA) less than 1.25 $ m^{2} $, 100 mg/day for BSA 1.25–1.5 $ m^{2} $, and 120 mg/day for BSA more than 1.5 $ m^{2} $ on days 1–14 every 3 weeks. The dose-limiting toxicity (DLT) was defined as grade 4 leukocytopenia or neutropenia, grade ≥3 neutropenia with fever over 38°C, grade ≥3 thrombocytopenia, or grade ≥3 major nonhematological toxicities. Results Nine patients were enrolled in the study. None of 3 patients enrolled in level 1 had any DLT. Of 6 patients in level 2, 2 patients had grade 3 diarrhea and one had grade 3 interstitial pneumonia. Level 1 was declared as the recommended dose. Conclusion The feasibility of the combination therapy of S-1 and CPT-11 was shown in the second-line setting for the treatment of advanced NSCLC. The recommended dose of CPT-11 was 60 mg/$ m^{2} $ combined with standard dose of S-1 for phase II trials of pretreated advanced NSCLC patients. S-1 (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Non-small cell lung cancer (dpeaa)DE-He213 Second line (dpeaa)DE-He213 Phase I trial (dpeaa)DE-He213 Soejima, Kenzo aut Yasuda, Hiroyuki aut Naoki, Katsuhiko aut Kawada, Ichiro aut Watanabe, Hideo aut Nakachi, Ichiro aut Satomi, Ryosuke aut Nakayama, Sohei aut Ikemura, Sinnosuke aut Terai, Hideki aut Sato, Takashi aut Morosawa, Maiko aut Asano, Koichiro aut Enthalten in Cancer chemotherapy and pharmacology Berlin : Springer, 1978 67(2010), 3 vom: 09. Dez., Seite 717-722 (DE-627)253390435 (DE-600)1458488-8 1432-0843 nnns volume:67 year:2010 number:3 day:09 month:12 pages:717-722 https://dx.doi.org/10.1007/s00280-010-1539-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 67 2010 3 09 12 717-722 |
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10.1007/s00280-010-1539-y doi (DE-627)SPR003597342 (SPR)s00280-010-1539-y-e DE-627 ger DE-627 rakwb eng Yoda, Satoshi verfasserin aut A phase I study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Background This phase I study was conducted to evaluate the feasibility and to determine the recommended doses of the combination therapy of S-1 and irinotecan (CPT-11) in patients with advanced non-small cell lung cancer (NSCLC) as second-line treatment. Methods Patients with NSCLC who were previously treated with one chemotherapy regimen and had a performance status of 0 or 1 were eligible. CPT-11 was administered at 60 mg/$ m^{2} $ (level 1), 80 mg/$ m^{2} $ (level 2) on days 1 and 8, and oral S-1 was administered at 80 mg/day for body surface area (BSA) less than 1.25 $ m^{2} $, 100 mg/day for BSA 1.25–1.5 $ m^{2} $, and 120 mg/day for BSA more than 1.5 $ m^{2} $ on days 1–14 every 3 weeks. The dose-limiting toxicity (DLT) was defined as grade 4 leukocytopenia or neutropenia, grade ≥3 neutropenia with fever over 38°C, grade ≥3 thrombocytopenia, or grade ≥3 major nonhematological toxicities. Results Nine patients were enrolled in the study. None of 3 patients enrolled in level 1 had any DLT. Of 6 patients in level 2, 2 patients had grade 3 diarrhea and one had grade 3 interstitial pneumonia. Level 1 was declared as the recommended dose. Conclusion The feasibility of the combination therapy of S-1 and CPT-11 was shown in the second-line setting for the treatment of advanced NSCLC. The recommended dose of CPT-11 was 60 mg/$ m^{2} $ combined with standard dose of S-1 for phase II trials of pretreated advanced NSCLC patients. S-1 (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Non-small cell lung cancer (dpeaa)DE-He213 Second line (dpeaa)DE-He213 Phase I trial (dpeaa)DE-He213 Soejima, Kenzo aut Yasuda, Hiroyuki aut Naoki, Katsuhiko aut Kawada, Ichiro aut Watanabe, Hideo aut Nakachi, Ichiro aut Satomi, Ryosuke aut Nakayama, Sohei aut Ikemura, Sinnosuke aut Terai, Hideki aut Sato, Takashi aut Morosawa, Maiko aut Asano, Koichiro aut Enthalten in Cancer chemotherapy and pharmacology Berlin : Springer, 1978 67(2010), 3 vom: 09. Dez., Seite 717-722 (DE-627)253390435 (DE-600)1458488-8 1432-0843 nnns volume:67 year:2010 number:3 day:09 month:12 pages:717-722 https://dx.doi.org/10.1007/s00280-010-1539-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 67 2010 3 09 12 717-722 |
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10.1007/s00280-010-1539-y doi (DE-627)SPR003597342 (SPR)s00280-010-1539-y-e DE-627 ger DE-627 rakwb eng Yoda, Satoshi verfasserin aut A phase I study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2010 Background This phase I study was conducted to evaluate the feasibility and to determine the recommended doses of the combination therapy of S-1 and irinotecan (CPT-11) in patients with advanced non-small cell lung cancer (NSCLC) as second-line treatment. Methods Patients with NSCLC who were previously treated with one chemotherapy regimen and had a performance status of 0 or 1 were eligible. CPT-11 was administered at 60 mg/$ m^{2} $ (level 1), 80 mg/$ m^{2} $ (level 2) on days 1 and 8, and oral S-1 was administered at 80 mg/day for body surface area (BSA) less than 1.25 $ m^{2} $, 100 mg/day for BSA 1.25–1.5 $ m^{2} $, and 120 mg/day for BSA more than 1.5 $ m^{2} $ on days 1–14 every 3 weeks. The dose-limiting toxicity (DLT) was defined as grade 4 leukocytopenia or neutropenia, grade ≥3 neutropenia with fever over 38°C, grade ≥3 thrombocytopenia, or grade ≥3 major nonhematological toxicities. Results Nine patients were enrolled in the study. None of 3 patients enrolled in level 1 had any DLT. Of 6 patients in level 2, 2 patients had grade 3 diarrhea and one had grade 3 interstitial pneumonia. Level 1 was declared as the recommended dose. Conclusion The feasibility of the combination therapy of S-1 and CPT-11 was shown in the second-line setting for the treatment of advanced NSCLC. The recommended dose of CPT-11 was 60 mg/$ m^{2} $ combined with standard dose of S-1 for phase II trials of pretreated advanced NSCLC patients. S-1 (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Non-small cell lung cancer (dpeaa)DE-He213 Second line (dpeaa)DE-He213 Phase I trial (dpeaa)DE-He213 Soejima, Kenzo aut Yasuda, Hiroyuki aut Naoki, Katsuhiko aut Kawada, Ichiro aut Watanabe, Hideo aut Nakachi, Ichiro aut Satomi, Ryosuke aut Nakayama, Sohei aut Ikemura, Sinnosuke aut Terai, Hideki aut Sato, Takashi aut Morosawa, Maiko aut Asano, Koichiro aut Enthalten in Cancer chemotherapy and pharmacology Berlin : Springer, 1978 67(2010), 3 vom: 09. Dez., Seite 717-722 (DE-627)253390435 (DE-600)1458488-8 1432-0843 nnns volume:67 year:2010 number:3 day:09 month:12 pages:717-722 https://dx.doi.org/10.1007/s00280-010-1539-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 67 2010 3 09 12 717-722 |
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Enthalten in Cancer chemotherapy and pharmacology 67(2010), 3 vom: 09. Dez., Seite 717-722 volume:67 year:2010 number:3 day:09 month:12 pages:717-722 |
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Enthalten in Cancer chemotherapy and pharmacology 67(2010), 3 vom: 09. Dez., Seite 717-722 volume:67 year:2010 number:3 day:09 month:12 pages:717-722 |
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S-1 Irinotecan Non-small cell lung cancer Second line Phase I trial |
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Cancer chemotherapy and pharmacology |
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Yoda, Satoshi @@aut@@ Soejima, Kenzo @@aut@@ Yasuda, Hiroyuki @@aut@@ Naoki, Katsuhiko @@aut@@ Kawada, Ichiro @@aut@@ Watanabe, Hideo @@aut@@ Nakachi, Ichiro @@aut@@ Satomi, Ryosuke @@aut@@ Nakayama, Sohei @@aut@@ Ikemura, Sinnosuke @@aut@@ Terai, Hideki @@aut@@ Sato, Takashi @@aut@@ Morosawa, Maiko @@aut@@ Asano, Koichiro @@aut@@ |
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Methods Patients with NSCLC who were previously treated with one chemotherapy regimen and had a performance status of 0 or 1 were eligible. CPT-11 was administered at 60 mg/$ m^{2} $ (level 1), 80 mg/$ m^{2} $ (level 2) on days 1 and 8, and oral S-1 was administered at 80 mg/day for body surface area (BSA) less than 1.25 $ m^{2} $, 100 mg/day for BSA 1.25–1.5 $ m^{2} $, and 120 mg/day for BSA more than 1.5 $ m^{2} $ on days 1–14 every 3 weeks. The dose-limiting toxicity (DLT) was defined as grade 4 leukocytopenia or neutropenia, grade ≥3 neutropenia with fever over 38°C, grade ≥3 thrombocytopenia, or grade ≥3 major nonhematological toxicities. Results Nine patients were enrolled in the study. None of 3 patients enrolled in level 1 had any DLT. Of 6 patients in level 2, 2 patients had grade 3 diarrhea and one had grade 3 interstitial pneumonia. Level 1 was declared as the recommended dose. Conclusion The feasibility of the combination therapy of S-1 and CPT-11 was shown in the second-line setting for the treatment of advanced NSCLC. 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Yoda, Satoshi |
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A phase I study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients S-1 (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Non-small cell lung cancer (dpeaa)DE-He213 Second line (dpeaa)DE-He213 Phase I trial (dpeaa)DE-He213 |
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A phase I study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients |
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Yoda, Satoshi |
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Cancer chemotherapy and pharmacology |
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Yoda, Satoshi Soejima, Kenzo Yasuda, Hiroyuki Naoki, Katsuhiko Kawada, Ichiro Watanabe, Hideo Nakachi, Ichiro Satomi, Ryosuke Nakayama, Sohei Ikemura, Sinnosuke Terai, Hideki Sato, Takashi Morosawa, Maiko Asano, Koichiro |
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Elektronische Aufsätze |
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Yoda, Satoshi |
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10.1007/s00280-010-1539-y |
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phase i study of s-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients |
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A phase I study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients |
| abstract |
Background This phase I study was conducted to evaluate the feasibility and to determine the recommended doses of the combination therapy of S-1 and irinotecan (CPT-11) in patients with advanced non-small cell lung cancer (NSCLC) as second-line treatment. Methods Patients with NSCLC who were previously treated with one chemotherapy regimen and had a performance status of 0 or 1 were eligible. CPT-11 was administered at 60 mg/$ m^{2} $ (level 1), 80 mg/$ m^{2} $ (level 2) on days 1 and 8, and oral S-1 was administered at 80 mg/day for body surface area (BSA) less than 1.25 $ m^{2} $, 100 mg/day for BSA 1.25–1.5 $ m^{2} $, and 120 mg/day for BSA more than 1.5 $ m^{2} $ on days 1–14 every 3 weeks. The dose-limiting toxicity (DLT) was defined as grade 4 leukocytopenia or neutropenia, grade ≥3 neutropenia with fever over 38°C, grade ≥3 thrombocytopenia, or grade ≥3 major nonhematological toxicities. Results Nine patients were enrolled in the study. None of 3 patients enrolled in level 1 had any DLT. Of 6 patients in level 2, 2 patients had grade 3 diarrhea and one had grade 3 interstitial pneumonia. Level 1 was declared as the recommended dose. Conclusion The feasibility of the combination therapy of S-1 and CPT-11 was shown in the second-line setting for the treatment of advanced NSCLC. The recommended dose of CPT-11 was 60 mg/$ m^{2} $ combined with standard dose of S-1 for phase II trials of pretreated advanced NSCLC patients. © Springer-Verlag 2010 |
| abstractGer |
Background This phase I study was conducted to evaluate the feasibility and to determine the recommended doses of the combination therapy of S-1 and irinotecan (CPT-11) in patients with advanced non-small cell lung cancer (NSCLC) as second-line treatment. Methods Patients with NSCLC who were previously treated with one chemotherapy regimen and had a performance status of 0 or 1 were eligible. CPT-11 was administered at 60 mg/$ m^{2} $ (level 1), 80 mg/$ m^{2} $ (level 2) on days 1 and 8, and oral S-1 was administered at 80 mg/day for body surface area (BSA) less than 1.25 $ m^{2} $, 100 mg/day for BSA 1.25–1.5 $ m^{2} $, and 120 mg/day for BSA more than 1.5 $ m^{2} $ on days 1–14 every 3 weeks. The dose-limiting toxicity (DLT) was defined as grade 4 leukocytopenia or neutropenia, grade ≥3 neutropenia with fever over 38°C, grade ≥3 thrombocytopenia, or grade ≥3 major nonhematological toxicities. Results Nine patients were enrolled in the study. None of 3 patients enrolled in level 1 had any DLT. Of 6 patients in level 2, 2 patients had grade 3 diarrhea and one had grade 3 interstitial pneumonia. Level 1 was declared as the recommended dose. Conclusion The feasibility of the combination therapy of S-1 and CPT-11 was shown in the second-line setting for the treatment of advanced NSCLC. The recommended dose of CPT-11 was 60 mg/$ m^{2} $ combined with standard dose of S-1 for phase II trials of pretreated advanced NSCLC patients. © Springer-Verlag 2010 |
| abstract_unstemmed |
Background This phase I study was conducted to evaluate the feasibility and to determine the recommended doses of the combination therapy of S-1 and irinotecan (CPT-11) in patients with advanced non-small cell lung cancer (NSCLC) as second-line treatment. Methods Patients with NSCLC who were previously treated with one chemotherapy regimen and had a performance status of 0 or 1 were eligible. CPT-11 was administered at 60 mg/$ m^{2} $ (level 1), 80 mg/$ m^{2} $ (level 2) on days 1 and 8, and oral S-1 was administered at 80 mg/day for body surface area (BSA) less than 1.25 $ m^{2} $, 100 mg/day for BSA 1.25–1.5 $ m^{2} $, and 120 mg/day for BSA more than 1.5 $ m^{2} $ on days 1–14 every 3 weeks. The dose-limiting toxicity (DLT) was defined as grade 4 leukocytopenia or neutropenia, grade ≥3 neutropenia with fever over 38°C, grade ≥3 thrombocytopenia, or grade ≥3 major nonhematological toxicities. Results Nine patients were enrolled in the study. None of 3 patients enrolled in level 1 had any DLT. Of 6 patients in level 2, 2 patients had grade 3 diarrhea and one had grade 3 interstitial pneumonia. Level 1 was declared as the recommended dose. Conclusion The feasibility of the combination therapy of S-1 and CPT-11 was shown in the second-line setting for the treatment of advanced NSCLC. The recommended dose of CPT-11 was 60 mg/$ m^{2} $ combined with standard dose of S-1 for phase II trials of pretreated advanced NSCLC patients. © Springer-Verlag 2010 |
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A phase I study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients |
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Soejima, Kenzo Yasuda, Hiroyuki Naoki, Katsuhiko Kawada, Ichiro Watanabe, Hideo Nakachi, Ichiro Satomi, Ryosuke Nakayama, Sohei Ikemura, Sinnosuke Terai, Hideki Sato, Takashi Morosawa, Maiko Asano, Koichiro |
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| score |
7.401164 |