Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC
Abstract The recent identification of cytosolic pattern recognition receptors (PRRs) with leucine-rich repeats, which recognize pathogen-associated molecular patterns (PAMPs), has been garnering considerable attention. Activated PRRs form molecular complexes called inflammasomes, consisting of relat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Taniguchi, Shun’ichiro [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Anmerkung: |
© Springer-Verlag 2007 |
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| Übergeordnetes Werk: |
Enthalten in: Springer Seminars in immunopathology - Berlin : Springer, 1978, 29(2007), 3 vom: Sept., Seite 231-238 |
|---|---|
| Übergeordnetes Werk: |
volume:29 ; year:2007 ; number:3 ; month:09 ; pages:231-238 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00281-007-0082-3 |
|---|
| Katalog-ID: |
SPR003624714 |
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| 100 | 1 | |a Taniguchi, Shun’ichiro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC |
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| 520 | |a Abstract The recent identification of cytosolic pattern recognition receptors (PRRs) with leucine-rich repeats, which recognize pathogen-associated molecular patterns (PAMPs), has been garnering considerable attention. Activated PRRs form molecular complexes called inflammasomes, consisting of related proteins that include procaspase 1[interleukin (IL) 1β converting enzyme (ICE)]. Inflammasomes have been shown to facilitate molecular proximity, stimulate activation of procaspase 1, which consequently produces inflammatory cytokines IL-1β and IL-18 and ultimately lead to the initiation of innate immunity. An adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which recruits PRRs carrying the pyrin homologous domain (PYD) and procaspase 1 through PYD and CARD, respectively, is responsible for the formation of some inflammasomes and also activation of procaspase 1. In this review, our main attention will be directed to PYD region analysis of ASC to understand the interaction between PYD-carrying PRRs and ASC. Taking into consideration the other aspects of the ASC gene in the proapoptotic ability and down-regulation by methylation, the biological function of ASC will be discussed in relation to the epigenetic aspects of infection, inflammation, and cancer. | ||
| 650 | 4 | |a Pattern recognition receptors (PRRs) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Leucine-rich repeats (LRRs) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pathogen-associated molecular patterns (PAMPs) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a A PRR family of cytosolic NOD-like receptors (NLRs) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Apoptosis-associated speck-like protein containing a CARD (ASC) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pyrin homologous domain (PYD) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a NACHT-, LRR- and PYD-containing proteins (NALPs) |7 (dpeaa)DE-He213 | |
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| 650 | 4 | |a Inflammasome |7 (dpeaa)DE-He213 | |
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10.1007/s00281-007-0082-3 doi (DE-627)SPR003624714 (SPR)s00281-007-0082-3-e DE-627 ger DE-627 rakwb eng Taniguchi, Shun’ichiro verfasserin aut Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract The recent identification of cytosolic pattern recognition receptors (PRRs) with leucine-rich repeats, which recognize pathogen-associated molecular patterns (PAMPs), has been garnering considerable attention. Activated PRRs form molecular complexes called inflammasomes, consisting of related proteins that include procaspase 1[interleukin (IL) 1β converting enzyme (ICE)]. Inflammasomes have been shown to facilitate molecular proximity, stimulate activation of procaspase 1, which consequently produces inflammatory cytokines IL-1β and IL-18 and ultimately lead to the initiation of innate immunity. An adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which recruits PRRs carrying the pyrin homologous domain (PYD) and procaspase 1 through PYD and CARD, respectively, is responsible for the formation of some inflammasomes and also activation of procaspase 1. In this review, our main attention will be directed to PYD region analysis of ASC to understand the interaction between PYD-carrying PRRs and ASC. Taking into consideration the other aspects of the ASC gene in the proapoptotic ability and down-regulation by methylation, the biological function of ASC will be discussed in relation to the epigenetic aspects of infection, inflammation, and cancer. Pattern recognition receptors (PRRs) (dpeaa)DE-He213 Leucine-rich repeats (LRRs) (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 A PRR family of cytosolic NOD-like receptors (NLRs) (dpeaa)DE-He213 Apoptosis-associated speck-like protein containing a CARD (ASC) (dpeaa)DE-He213 Pyrin homologous domain (PYD) (dpeaa)DE-He213 NACHT-, LRR- and PYD-containing proteins (NALPs) (dpeaa)DE-He213 Caspase 1 (dpeaa)DE-He213 Inflammasome (dpeaa)DE-He213 IL-1β (dpeaa)DE-He213 IL-18 (dpeaa)DE-He213 IL-33 (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Sagara, Junji aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 29(2007), 3 vom: Sept., Seite 231-238 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:29 year:2007 number:3 month:09 pages:231-238 https://dx.doi.org/10.1007/s00281-007-0082-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2010 AR 29 2007 3 09 231-238 |
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10.1007/s00281-007-0082-3 doi (DE-627)SPR003624714 (SPR)s00281-007-0082-3-e DE-627 ger DE-627 rakwb eng Taniguchi, Shun’ichiro verfasserin aut Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract The recent identification of cytosolic pattern recognition receptors (PRRs) with leucine-rich repeats, which recognize pathogen-associated molecular patterns (PAMPs), has been garnering considerable attention. Activated PRRs form molecular complexes called inflammasomes, consisting of related proteins that include procaspase 1[interleukin (IL) 1β converting enzyme (ICE)]. Inflammasomes have been shown to facilitate molecular proximity, stimulate activation of procaspase 1, which consequently produces inflammatory cytokines IL-1β and IL-18 and ultimately lead to the initiation of innate immunity. An adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which recruits PRRs carrying the pyrin homologous domain (PYD) and procaspase 1 through PYD and CARD, respectively, is responsible for the formation of some inflammasomes and also activation of procaspase 1. In this review, our main attention will be directed to PYD region analysis of ASC to understand the interaction between PYD-carrying PRRs and ASC. Taking into consideration the other aspects of the ASC gene in the proapoptotic ability and down-regulation by methylation, the biological function of ASC will be discussed in relation to the epigenetic aspects of infection, inflammation, and cancer. Pattern recognition receptors (PRRs) (dpeaa)DE-He213 Leucine-rich repeats (LRRs) (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 A PRR family of cytosolic NOD-like receptors (NLRs) (dpeaa)DE-He213 Apoptosis-associated speck-like protein containing a CARD (ASC) (dpeaa)DE-He213 Pyrin homologous domain (PYD) (dpeaa)DE-He213 NACHT-, LRR- and PYD-containing proteins (NALPs) (dpeaa)DE-He213 Caspase 1 (dpeaa)DE-He213 Inflammasome (dpeaa)DE-He213 IL-1β (dpeaa)DE-He213 IL-18 (dpeaa)DE-He213 IL-33 (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Sagara, Junji aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 29(2007), 3 vom: Sept., Seite 231-238 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:29 year:2007 number:3 month:09 pages:231-238 https://dx.doi.org/10.1007/s00281-007-0082-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2010 AR 29 2007 3 09 231-238 |
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10.1007/s00281-007-0082-3 doi (DE-627)SPR003624714 (SPR)s00281-007-0082-3-e DE-627 ger DE-627 rakwb eng Taniguchi, Shun’ichiro verfasserin aut Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract The recent identification of cytosolic pattern recognition receptors (PRRs) with leucine-rich repeats, which recognize pathogen-associated molecular patterns (PAMPs), has been garnering considerable attention. Activated PRRs form molecular complexes called inflammasomes, consisting of related proteins that include procaspase 1[interleukin (IL) 1β converting enzyme (ICE)]. Inflammasomes have been shown to facilitate molecular proximity, stimulate activation of procaspase 1, which consequently produces inflammatory cytokines IL-1β and IL-18 and ultimately lead to the initiation of innate immunity. An adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which recruits PRRs carrying the pyrin homologous domain (PYD) and procaspase 1 through PYD and CARD, respectively, is responsible for the formation of some inflammasomes and also activation of procaspase 1. In this review, our main attention will be directed to PYD region analysis of ASC to understand the interaction between PYD-carrying PRRs and ASC. Taking into consideration the other aspects of the ASC gene in the proapoptotic ability and down-regulation by methylation, the biological function of ASC will be discussed in relation to the epigenetic aspects of infection, inflammation, and cancer. Pattern recognition receptors (PRRs) (dpeaa)DE-He213 Leucine-rich repeats (LRRs) (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 A PRR family of cytosolic NOD-like receptors (NLRs) (dpeaa)DE-He213 Apoptosis-associated speck-like protein containing a CARD (ASC) (dpeaa)DE-He213 Pyrin homologous domain (PYD) (dpeaa)DE-He213 NACHT-, LRR- and PYD-containing proteins (NALPs) (dpeaa)DE-He213 Caspase 1 (dpeaa)DE-He213 Inflammasome (dpeaa)DE-He213 IL-1β (dpeaa)DE-He213 IL-18 (dpeaa)DE-He213 IL-33 (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Sagara, Junji aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 29(2007), 3 vom: Sept., Seite 231-238 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:29 year:2007 number:3 month:09 pages:231-238 https://dx.doi.org/10.1007/s00281-007-0082-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2010 AR 29 2007 3 09 231-238 |
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10.1007/s00281-007-0082-3 doi (DE-627)SPR003624714 (SPR)s00281-007-0082-3-e DE-627 ger DE-627 rakwb eng Taniguchi, Shun’ichiro verfasserin aut Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract The recent identification of cytosolic pattern recognition receptors (PRRs) with leucine-rich repeats, which recognize pathogen-associated molecular patterns (PAMPs), has been garnering considerable attention. Activated PRRs form molecular complexes called inflammasomes, consisting of related proteins that include procaspase 1[interleukin (IL) 1β converting enzyme (ICE)]. Inflammasomes have been shown to facilitate molecular proximity, stimulate activation of procaspase 1, which consequently produces inflammatory cytokines IL-1β and IL-18 and ultimately lead to the initiation of innate immunity. An adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which recruits PRRs carrying the pyrin homologous domain (PYD) and procaspase 1 through PYD and CARD, respectively, is responsible for the formation of some inflammasomes and also activation of procaspase 1. In this review, our main attention will be directed to PYD region analysis of ASC to understand the interaction between PYD-carrying PRRs and ASC. Taking into consideration the other aspects of the ASC gene in the proapoptotic ability and down-regulation by methylation, the biological function of ASC will be discussed in relation to the epigenetic aspects of infection, inflammation, and cancer. Pattern recognition receptors (PRRs) (dpeaa)DE-He213 Leucine-rich repeats (LRRs) (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 A PRR family of cytosolic NOD-like receptors (NLRs) (dpeaa)DE-He213 Apoptosis-associated speck-like protein containing a CARD (ASC) (dpeaa)DE-He213 Pyrin homologous domain (PYD) (dpeaa)DE-He213 NACHT-, LRR- and PYD-containing proteins (NALPs) (dpeaa)DE-He213 Caspase 1 (dpeaa)DE-He213 Inflammasome (dpeaa)DE-He213 IL-1β (dpeaa)DE-He213 IL-18 (dpeaa)DE-He213 IL-33 (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Sagara, Junji aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 29(2007), 3 vom: Sept., Seite 231-238 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:29 year:2007 number:3 month:09 pages:231-238 https://dx.doi.org/10.1007/s00281-007-0082-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2010 AR 29 2007 3 09 231-238 |
| allfieldsSound |
10.1007/s00281-007-0082-3 doi (DE-627)SPR003624714 (SPR)s00281-007-0082-3-e DE-627 ger DE-627 rakwb eng Taniguchi, Shun’ichiro verfasserin aut Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract The recent identification of cytosolic pattern recognition receptors (PRRs) with leucine-rich repeats, which recognize pathogen-associated molecular patterns (PAMPs), has been garnering considerable attention. Activated PRRs form molecular complexes called inflammasomes, consisting of related proteins that include procaspase 1[interleukin (IL) 1β converting enzyme (ICE)]. Inflammasomes have been shown to facilitate molecular proximity, stimulate activation of procaspase 1, which consequently produces inflammatory cytokines IL-1β and IL-18 and ultimately lead to the initiation of innate immunity. An adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which recruits PRRs carrying the pyrin homologous domain (PYD) and procaspase 1 through PYD and CARD, respectively, is responsible for the formation of some inflammasomes and also activation of procaspase 1. In this review, our main attention will be directed to PYD region analysis of ASC to understand the interaction between PYD-carrying PRRs and ASC. Taking into consideration the other aspects of the ASC gene in the proapoptotic ability and down-regulation by methylation, the biological function of ASC will be discussed in relation to the epigenetic aspects of infection, inflammation, and cancer. Pattern recognition receptors (PRRs) (dpeaa)DE-He213 Leucine-rich repeats (LRRs) (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 A PRR family of cytosolic NOD-like receptors (NLRs) (dpeaa)DE-He213 Apoptosis-associated speck-like protein containing a CARD (ASC) (dpeaa)DE-He213 Pyrin homologous domain (PYD) (dpeaa)DE-He213 NACHT-, LRR- and PYD-containing proteins (NALPs) (dpeaa)DE-He213 Caspase 1 (dpeaa)DE-He213 Inflammasome (dpeaa)DE-He213 IL-1β (dpeaa)DE-He213 IL-18 (dpeaa)DE-He213 IL-33 (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Sagara, Junji aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 29(2007), 3 vom: Sept., Seite 231-238 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:29 year:2007 number:3 month:09 pages:231-238 https://dx.doi.org/10.1007/s00281-007-0082-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2010 AR 29 2007 3 09 231-238 |
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Pattern recognition receptors (PRRs) Leucine-rich repeats (LRRs) Pathogen-associated molecular patterns (PAMPs) A PRR family of cytosolic NOD-like receptors (NLRs) Apoptosis-associated speck-like protein containing a CARD (ASC) Pyrin homologous domain (PYD) NACHT-, LRR- and PYD-containing proteins (NALPs) Caspase 1 Inflammasome IL-1β IL-18 IL-33 Apoptosis |
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Taniguchi, Shun’ichiro @@aut@@ Sagara, Junji @@aut@@ |
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Taniguchi, Shun’ichiro |
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Taniguchi, Shun’ichiro misc Pattern recognition receptors (PRRs) misc Leucine-rich repeats (LRRs) misc Pathogen-associated molecular patterns (PAMPs) misc A PRR family of cytosolic NOD-like receptors (NLRs) misc Apoptosis-associated speck-like protein containing a CARD (ASC) misc Pyrin homologous domain (PYD) misc NACHT-, LRR- and PYD-containing proteins (NALPs) misc Caspase 1 misc Inflammasome misc IL-1β misc IL-18 misc IL-33 misc Apoptosis Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC |
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Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC Pattern recognition receptors (PRRs) (dpeaa)DE-He213 Leucine-rich repeats (LRRs) (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 A PRR family of cytosolic NOD-like receptors (NLRs) (dpeaa)DE-He213 Apoptosis-associated speck-like protein containing a CARD (ASC) (dpeaa)DE-He213 Pyrin homologous domain (PYD) (dpeaa)DE-He213 NACHT-, LRR- and PYD-containing proteins (NALPs) (dpeaa)DE-He213 Caspase 1 (dpeaa)DE-He213 Inflammasome (dpeaa)DE-He213 IL-1β (dpeaa)DE-He213 IL-18 (dpeaa)DE-He213 IL-33 (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 |
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misc Pattern recognition receptors (PRRs) misc Leucine-rich repeats (LRRs) misc Pathogen-associated molecular patterns (PAMPs) misc A PRR family of cytosolic NOD-like receptors (NLRs) misc Apoptosis-associated speck-like protein containing a CARD (ASC) misc Pyrin homologous domain (PYD) misc NACHT-, LRR- and PYD-containing proteins (NALPs) misc Caspase 1 misc Inflammasome misc IL-1β misc IL-18 misc IL-33 misc Apoptosis |
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misc Pattern recognition receptors (PRRs) misc Leucine-rich repeats (LRRs) misc Pathogen-associated molecular patterns (PAMPs) misc A PRR family of cytosolic NOD-like receptors (NLRs) misc Apoptosis-associated speck-like protein containing a CARD (ASC) misc Pyrin homologous domain (PYD) misc NACHT-, LRR- and PYD-containing proteins (NALPs) misc Caspase 1 misc Inflammasome misc IL-1β misc IL-18 misc IL-33 misc Apoptosis |
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regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, asc |
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Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC |
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Abstract The recent identification of cytosolic pattern recognition receptors (PRRs) with leucine-rich repeats, which recognize pathogen-associated molecular patterns (PAMPs), has been garnering considerable attention. Activated PRRs form molecular complexes called inflammasomes, consisting of related proteins that include procaspase 1[interleukin (IL) 1β converting enzyme (ICE)]. Inflammasomes have been shown to facilitate molecular proximity, stimulate activation of procaspase 1, which consequently produces inflammatory cytokines IL-1β and IL-18 and ultimately lead to the initiation of innate immunity. An adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which recruits PRRs carrying the pyrin homologous domain (PYD) and procaspase 1 through PYD and CARD, respectively, is responsible for the formation of some inflammasomes and also activation of procaspase 1. In this review, our main attention will be directed to PYD region analysis of ASC to understand the interaction between PYD-carrying PRRs and ASC. Taking into consideration the other aspects of the ASC gene in the proapoptotic ability and down-regulation by methylation, the biological function of ASC will be discussed in relation to the epigenetic aspects of infection, inflammation, and cancer. © Springer-Verlag 2007 |
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Abstract The recent identification of cytosolic pattern recognition receptors (PRRs) with leucine-rich repeats, which recognize pathogen-associated molecular patterns (PAMPs), has been garnering considerable attention. Activated PRRs form molecular complexes called inflammasomes, consisting of related proteins that include procaspase 1[interleukin (IL) 1β converting enzyme (ICE)]. Inflammasomes have been shown to facilitate molecular proximity, stimulate activation of procaspase 1, which consequently produces inflammatory cytokines IL-1β and IL-18 and ultimately lead to the initiation of innate immunity. An adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which recruits PRRs carrying the pyrin homologous domain (PYD) and procaspase 1 through PYD and CARD, respectively, is responsible for the formation of some inflammasomes and also activation of procaspase 1. In this review, our main attention will be directed to PYD region analysis of ASC to understand the interaction between PYD-carrying PRRs and ASC. Taking into consideration the other aspects of the ASC gene in the proapoptotic ability and down-regulation by methylation, the biological function of ASC will be discussed in relation to the epigenetic aspects of infection, inflammation, and cancer. © Springer-Verlag 2007 |
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Abstract The recent identification of cytosolic pattern recognition receptors (PRRs) with leucine-rich repeats, which recognize pathogen-associated molecular patterns (PAMPs), has been garnering considerable attention. Activated PRRs form molecular complexes called inflammasomes, consisting of related proteins that include procaspase 1[interleukin (IL) 1β converting enzyme (ICE)]. Inflammasomes have been shown to facilitate molecular proximity, stimulate activation of procaspase 1, which consequently produces inflammatory cytokines IL-1β and IL-18 and ultimately lead to the initiation of innate immunity. An adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which recruits PRRs carrying the pyrin homologous domain (PYD) and procaspase 1 through PYD and CARD, respectively, is responsible for the formation of some inflammasomes and also activation of procaspase 1. In this review, our main attention will be directed to PYD region analysis of ASC to understand the interaction between PYD-carrying PRRs and ASC. Taking into consideration the other aspects of the ASC gene in the proapoptotic ability and down-regulation by methylation, the biological function of ASC will be discussed in relation to the epigenetic aspects of infection, inflammation, and cancer. © Springer-Verlag 2007 |
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code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">IL-33</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Apoptosis</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sagara, Junji</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Springer Seminars in immunopathology</subfield><subfield code="d">Berlin : Springer, 1978</subfield><subfield code="g">29(2007), 3 vom: Sept., Seite 231-238</subfield><subfield code="w">(DE-627)271601337</subfield><subfield code="w">(DE-600)1481154-6</subfield><subfield code="x">1432-2196</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:29</subfield><subfield code="g">year:2007</subfield><subfield code="g">number:3</subfield><subfield code="g">month:09</subfield><subfield code="g">pages:231-238</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s00281-007-0082-3</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_90</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_100</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_120</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_187</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_250</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_267</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_281</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_702</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_711</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">29</subfield><subfield code="j">2007</subfield><subfield code="e">3</subfield><subfield code="c">09</subfield><subfield code="h">231-238</subfield></datafield></record></collection>
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