Connexins participate in the initiation and progression of atherosclerosis

Abstract Connexins are members of a large family of transmembrane proteins that form hemichannels or gap junctions. These channels allow the exchange of ions and small metabolites between the cytosol and extracellular space or between neighboring cells. Connexins are important in vascular physiology...
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Gespeichert in:

Autor*in:	Morel, Sandrine [verfasserIn] Burnier, Laurent Kwak, Brenda R.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Connexins Hemichannels Gap junctions Atherosclerosis Restenosis

Anmerkung:	© Springer-Verlag 2009

Übergeordnetes Werk:	Enthalten in: Springer Seminars in immunopathology - Berlin : Springer, 1978, 31(2009), 1 vom: 30. Apr., Seite 49-61
Übergeordnetes Werk:	volume:31 ; year:2009 ; number:1 ; day:30 ; month:04 ; pages:49-61

Links:	Volltext

DOI / URN:	10.1007/s00281-009-0147-6

Katalog-ID:	SPR003625354

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allfields	10.1007/s00281-009-0147-6 doi (DE-627)SPR003625354 (SPR)s00281-009-0147-6-e DE-627 ger DE-627 rakwb eng Morel, Sandrine verfasserin aut Connexins participate in the initiation and progression of atherosclerosis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Abstract Connexins are members of a large family of transmembrane proteins that form hemichannels or gap junctions. These channels allow the exchange of ions and small metabolites between the cytosol and extracellular space or between neighboring cells. Connexins are important in vascular physiology; they support radial and longitudinal cell-to-cell communication in the vascular wall. Four connexins are expressed in the vascular wall: Cx37, Cx40, Cx43, and Cx45. Their expression is not uniform in all blood vessels and varies with vascular territory and species. Significant changes in the expression pattern of vascular connexins have been described during the development of atherosclerosis, a progressive inflammatory disease. In this review, we provide an overview of (1) the tools used to study the involvement of connexins in atherosclerosis, (2) the participation of connexins in atherogenesis, (3) the increasing interest of a polymorphism in the human connexin37 gene as marker of cardiovascular disease, and (4) the possible therapeutic implications of connexins. Connexins (dpeaa)DE-He213 Hemichannels (dpeaa)DE-He213 Gap junctions (dpeaa)DE-He213 Atherosclerosis (dpeaa)DE-He213 Restenosis (dpeaa)DE-He213 Burnier, Laurent aut Kwak, Brenda R. aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 31(2009), 1 vom: 30. Apr., Seite 49-61 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:31 year:2009 number:1 day:30 month:04 pages:49-61 https://dx.doi.org/10.1007/s00281-009-0147-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2010 AR 31 2009 1 30 04 49-61
spelling	10.1007/s00281-009-0147-6 doi (DE-627)SPR003625354 (SPR)s00281-009-0147-6-e DE-627 ger DE-627 rakwb eng Morel, Sandrine verfasserin aut Connexins participate in the initiation and progression of atherosclerosis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Abstract Connexins are members of a large family of transmembrane proteins that form hemichannels or gap junctions. These channels allow the exchange of ions and small metabolites between the cytosol and extracellular space or between neighboring cells. Connexins are important in vascular physiology; they support radial and longitudinal cell-to-cell communication in the vascular wall. Four connexins are expressed in the vascular wall: Cx37, Cx40, Cx43, and Cx45. Their expression is not uniform in all blood vessels and varies with vascular territory and species. Significant changes in the expression pattern of vascular connexins have been described during the development of atherosclerosis, a progressive inflammatory disease. In this review, we provide an overview of (1) the tools used to study the involvement of connexins in atherosclerosis, (2) the participation of connexins in atherogenesis, (3) the increasing interest of a polymorphism in the human connexin37 gene as marker of cardiovascular disease, and (4) the possible therapeutic implications of connexins. Connexins (dpeaa)DE-He213 Hemichannels (dpeaa)DE-He213 Gap junctions (dpeaa)DE-He213 Atherosclerosis (dpeaa)DE-He213 Restenosis (dpeaa)DE-He213 Burnier, Laurent aut Kwak, Brenda R. aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 31(2009), 1 vom: 30. Apr., Seite 49-61 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:31 year:2009 number:1 day:30 month:04 pages:49-61 https://dx.doi.org/10.1007/s00281-009-0147-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2010 AR 31 2009 1 30 04 49-61
allfields_unstemmed	10.1007/s00281-009-0147-6 doi (DE-627)SPR003625354 (SPR)s00281-009-0147-6-e DE-627 ger DE-627 rakwb eng Morel, Sandrine verfasserin aut Connexins participate in the initiation and progression of atherosclerosis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2009 Abstract Connexins are members of a large family of transmembrane proteins that form hemichannels or gap junctions. These channels allow the exchange of ions and small metabolites between the cytosol and extracellular space or between neighboring cells. Connexins are important in vascular physiology; they support radial and longitudinal cell-to-cell communication in the vascular wall. Four connexins are expressed in the vascular wall: Cx37, Cx40, Cx43, and Cx45. Their expression is not uniform in all blood vessels and varies with vascular territory and species. Significant changes in the expression pattern of vascular connexins have been described during the development of atherosclerosis, a progressive inflammatory disease. In this review, we provide an overview of (1) the tools used to study the involvement of connexins in atherosclerosis, (2) the participation of connexins in atherogenesis, (3) the increasing interest of a polymorphism in the human connexin37 gene as marker of cardiovascular disease, and (4) the possible therapeutic implications of connexins. Connexins (dpeaa)DE-He213 Hemichannels (dpeaa)DE-He213 Gap junctions (dpeaa)DE-He213 Atherosclerosis (dpeaa)DE-He213 Restenosis (dpeaa)DE-He213 Burnier, Laurent aut Kwak, Brenda R. aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 31(2009), 1 vom: 30. Apr., Seite 49-61 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:31 year:2009 number:1 day:30 month:04 pages:49-61 https://dx.doi.org/10.1007/s00281-009-0147-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2010 AR 31 2009 1 30 04 49-61
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source	Enthalten in Springer Seminars in immunopathology 31(2009), 1 vom: 30. Apr., Seite 49-61 volume:31 year:2009 number:1 day:30 month:04 pages:49-61
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author	Morel, Sandrine
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topic_title	Connexins participate in the initiation and progression of atherosclerosis Connexins (dpeaa)DE-He213 Hemichannels (dpeaa)DE-He213 Gap junctions (dpeaa)DE-He213 Atherosclerosis (dpeaa)DE-He213 Restenosis (dpeaa)DE-He213
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title_sort	connexins participate in the initiation and progression of atherosclerosis
title_auth	Connexins participate in the initiation and progression of atherosclerosis
abstract	Abstract Connexins are members of a large family of transmembrane proteins that form hemichannels or gap junctions. These channels allow the exchange of ions and small metabolites between the cytosol and extracellular space or between neighboring cells. Connexins are important in vascular physiology; they support radial and longitudinal cell-to-cell communication in the vascular wall. Four connexins are expressed in the vascular wall: Cx37, Cx40, Cx43, and Cx45. Their expression is not uniform in all blood vessels and varies with vascular territory and species. Significant changes in the expression pattern of vascular connexins have been described during the development of atherosclerosis, a progressive inflammatory disease. In this review, we provide an overview of (1) the tools used to study the involvement of connexins in atherosclerosis, (2) the participation of connexins in atherogenesis, (3) the increasing interest of a polymorphism in the human connexin37 gene as marker of cardiovascular disease, and (4) the possible therapeutic implications of connexins. © Springer-Verlag 2009
abstractGer	Abstract Connexins are members of a large family of transmembrane proteins that form hemichannels or gap junctions. These channels allow the exchange of ions and small metabolites between the cytosol and extracellular space or between neighboring cells. Connexins are important in vascular physiology; they support radial and longitudinal cell-to-cell communication in the vascular wall. Four connexins are expressed in the vascular wall: Cx37, Cx40, Cx43, and Cx45. Their expression is not uniform in all blood vessels and varies with vascular territory and species. Significant changes in the expression pattern of vascular connexins have been described during the development of atherosclerosis, a progressive inflammatory disease. In this review, we provide an overview of (1) the tools used to study the involvement of connexins in atherosclerosis, (2) the participation of connexins in atherogenesis, (3) the increasing interest of a polymorphism in the human connexin37 gene as marker of cardiovascular disease, and (4) the possible therapeutic implications of connexins. © Springer-Verlag 2009
abstract_unstemmed	Abstract Connexins are members of a large family of transmembrane proteins that form hemichannels or gap junctions. These channels allow the exchange of ions and small metabolites between the cytosol and extracellular space or between neighboring cells. Connexins are important in vascular physiology; they support radial and longitudinal cell-to-cell communication in the vascular wall. Four connexins are expressed in the vascular wall: Cx37, Cx40, Cx43, and Cx45. Their expression is not uniform in all blood vessels and varies with vascular territory and species. Significant changes in the expression pattern of vascular connexins have been described during the development of atherosclerosis, a progressive inflammatory disease. In this review, we provide an overview of (1) the tools used to study the involvement of connexins in atherosclerosis, (2) the participation of connexins in atherogenesis, (3) the increasing interest of a polymorphism in the human connexin37 gene as marker of cardiovascular disease, and (4) the possible therapeutic implications of connexins. © Springer-Verlag 2009
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title_short	Connexins participate in the initiation and progression of atherosclerosis
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