COPD immunopathology
Abstract The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patient...
Ausführliche Beschreibung
Autor*in: |
Caramori, Gaetano [verfasserIn] |
---|
Format: |
E-Artikel |
---|---|
Sprache: |
Englisch |
Erschienen: |
2016 |
---|
Schlagwörter: |
Chronic Obstructive Pulmonary Disease |
---|
Anmerkung: |
© The Author(s) 2016 |
---|
Übergeordnetes Werk: |
Enthalten in: Springer Seminars in immunopathology - Berlin : Springer, 1978, 38(2016), 4 vom: 13. Mai, Seite 497-515 |
---|---|
Übergeordnetes Werk: |
volume:38 ; year:2016 ; number:4 ; day:13 ; month:05 ; pages:497-515 |
Links: |
---|
DOI / URN: |
10.1007/s00281-016-0561-5 |
---|
Katalog-ID: |
SPR003629554 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | SPR003629554 | ||
003 | DE-627 | ||
005 | 20230519153945.0 | ||
007 | cr uuu---uuuuu | ||
008 | 201001s2016 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s00281-016-0561-5 |2 doi | |
035 | |a (DE-627)SPR003629554 | ||
035 | |a (SPR)s00281-016-0561-5-e | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Caramori, Gaetano |e verfasserin |4 aut | |
245 | 1 | 0 | |a COPD immunopathology |
264 | 1 | |c 2016 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a © The Author(s) 2016 | ||
520 | |a Abstract The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function. | ||
650 | 4 | |a Chronic Obstructive Pulmonary Disease |7 (dpeaa)DE-He213 | |
650 | 4 | |a Chronic Obstructive Pulmonary Disease Patient |7 (dpeaa)DE-He213 | |
650 | 4 | |a Small Airway |7 (dpeaa)DE-He213 | |
650 | 4 | |a Lower Airway |7 (dpeaa)DE-He213 | |
650 | 4 | |a Severe Chronic Obstructive Pulmonary Disease |7 (dpeaa)DE-He213 | |
700 | 1 | |a Casolari, Paolo |4 aut | |
700 | 1 | |a Barczyk, Adam |4 aut | |
700 | 1 | |a Durham, Andrew L. |4 aut | |
700 | 1 | |a Di Stefano, Antonino |4 aut | |
700 | 1 | |a Adcock, Ian |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Springer Seminars in immunopathology |d Berlin : Springer, 1978 |g 38(2016), 4 vom: 13. Mai, Seite 497-515 |w (DE-627)271601337 |w (DE-600)1481154-6 |x 1432-2196 |7 nnns |
773 | 1 | 8 | |g volume:38 |g year:2016 |g number:4 |g day:13 |g month:05 |g pages:497-515 |
856 | 4 | 0 | |u https://dx.doi.org/10.1007/s00281-016-0561-5 |z kostenfrei |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_SPRINGER | ||
912 | |a SSG-OLC-PHA | ||
912 | |a GBV_ILN_20 | ||
912 | |a GBV_ILN_22 | ||
912 | |a GBV_ILN_23 | ||
912 | |a GBV_ILN_24 | ||
912 | |a GBV_ILN_31 | ||
912 | |a GBV_ILN_39 | ||
912 | |a GBV_ILN_40 | ||
912 | |a GBV_ILN_60 | ||
912 | |a GBV_ILN_62 | ||
912 | |a GBV_ILN_69 | ||
912 | |a GBV_ILN_70 | ||
912 | |a GBV_ILN_73 | ||
912 | |a GBV_ILN_74 | ||
912 | |a GBV_ILN_90 | ||
912 | |a GBV_ILN_95 | ||
912 | |a GBV_ILN_100 | ||
912 | |a GBV_ILN_105 | ||
912 | |a GBV_ILN_120 | ||
912 | |a GBV_ILN_152 | ||
912 | |a GBV_ILN_161 | ||
912 | |a GBV_ILN_171 | ||
912 | |a GBV_ILN_187 | ||
912 | |a GBV_ILN_224 | ||
912 | |a GBV_ILN_250 | ||
912 | |a GBV_ILN_267 | ||
912 | |a GBV_ILN_281 | ||
912 | |a GBV_ILN_285 | ||
912 | |a GBV_ILN_293 | ||
912 | |a GBV_ILN_370 | ||
912 | |a GBV_ILN_602 | ||
912 | |a GBV_ILN_702 | ||
912 | |a GBV_ILN_2010 | ||
951 | |a AR | ||
952 | |d 38 |j 2016 |e 4 |b 13 |c 05 |h 497-515 |
author_variant |
g c gc p c pc a b ab a l d al ald s a d sa sad i a ia |
---|---|
matchkey_str |
article:14322196:2016----::odmuoa |
hierarchy_sort_str |
2016 |
publishDate |
2016 |
allfields |
10.1007/s00281-016-0561-5 doi (DE-627)SPR003629554 (SPR)s00281-016-0561-5-e DE-627 ger DE-627 rakwb eng Caramori, Gaetano verfasserin aut COPD immunopathology 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2016 Abstract The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Chronic Obstructive Pulmonary Disease Patient (dpeaa)DE-He213 Small Airway (dpeaa)DE-He213 Lower Airway (dpeaa)DE-He213 Severe Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Casolari, Paolo aut Barczyk, Adam aut Durham, Andrew L. aut Di Stefano, Antonino aut Adcock, Ian aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 38(2016), 4 vom: 13. Mai, Seite 497-515 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:38 year:2016 number:4 day:13 month:05 pages:497-515 https://dx.doi.org/10.1007/s00281-016-0561-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2010 AR 38 2016 4 13 05 497-515 |
spelling |
10.1007/s00281-016-0561-5 doi (DE-627)SPR003629554 (SPR)s00281-016-0561-5-e DE-627 ger DE-627 rakwb eng Caramori, Gaetano verfasserin aut COPD immunopathology 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2016 Abstract The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Chronic Obstructive Pulmonary Disease Patient (dpeaa)DE-He213 Small Airway (dpeaa)DE-He213 Lower Airway (dpeaa)DE-He213 Severe Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Casolari, Paolo aut Barczyk, Adam aut Durham, Andrew L. aut Di Stefano, Antonino aut Adcock, Ian aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 38(2016), 4 vom: 13. Mai, Seite 497-515 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:38 year:2016 number:4 day:13 month:05 pages:497-515 https://dx.doi.org/10.1007/s00281-016-0561-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2010 AR 38 2016 4 13 05 497-515 |
allfields_unstemmed |
10.1007/s00281-016-0561-5 doi (DE-627)SPR003629554 (SPR)s00281-016-0561-5-e DE-627 ger DE-627 rakwb eng Caramori, Gaetano verfasserin aut COPD immunopathology 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2016 Abstract The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Chronic Obstructive Pulmonary Disease Patient (dpeaa)DE-He213 Small Airway (dpeaa)DE-He213 Lower Airway (dpeaa)DE-He213 Severe Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Casolari, Paolo aut Barczyk, Adam aut Durham, Andrew L. aut Di Stefano, Antonino aut Adcock, Ian aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 38(2016), 4 vom: 13. Mai, Seite 497-515 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:38 year:2016 number:4 day:13 month:05 pages:497-515 https://dx.doi.org/10.1007/s00281-016-0561-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2010 AR 38 2016 4 13 05 497-515 |
allfieldsGer |
10.1007/s00281-016-0561-5 doi (DE-627)SPR003629554 (SPR)s00281-016-0561-5-e DE-627 ger DE-627 rakwb eng Caramori, Gaetano verfasserin aut COPD immunopathology 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2016 Abstract The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Chronic Obstructive Pulmonary Disease Patient (dpeaa)DE-He213 Small Airway (dpeaa)DE-He213 Lower Airway (dpeaa)DE-He213 Severe Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Casolari, Paolo aut Barczyk, Adam aut Durham, Andrew L. aut Di Stefano, Antonino aut Adcock, Ian aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 38(2016), 4 vom: 13. Mai, Seite 497-515 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:38 year:2016 number:4 day:13 month:05 pages:497-515 https://dx.doi.org/10.1007/s00281-016-0561-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2010 AR 38 2016 4 13 05 497-515 |
allfieldsSound |
10.1007/s00281-016-0561-5 doi (DE-627)SPR003629554 (SPR)s00281-016-0561-5-e DE-627 ger DE-627 rakwb eng Caramori, Gaetano verfasserin aut COPD immunopathology 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2016 Abstract The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Chronic Obstructive Pulmonary Disease Patient (dpeaa)DE-He213 Small Airway (dpeaa)DE-He213 Lower Airway (dpeaa)DE-He213 Severe Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Casolari, Paolo aut Barczyk, Adam aut Durham, Andrew L. aut Di Stefano, Antonino aut Adcock, Ian aut Enthalten in Springer Seminars in immunopathology Berlin : Springer, 1978 38(2016), 4 vom: 13. Mai, Seite 497-515 (DE-627)271601337 (DE-600)1481154-6 1432-2196 nnns volume:38 year:2016 number:4 day:13 month:05 pages:497-515 https://dx.doi.org/10.1007/s00281-016-0561-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2010 AR 38 2016 4 13 05 497-515 |
language |
English |
source |
Enthalten in Springer Seminars in immunopathology 38(2016), 4 vom: 13. Mai, Seite 497-515 volume:38 year:2016 number:4 day:13 month:05 pages:497-515 |
sourceStr |
Enthalten in Springer Seminars in immunopathology 38(2016), 4 vom: 13. Mai, Seite 497-515 volume:38 year:2016 number:4 day:13 month:05 pages:497-515 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Patient Small Airway Lower Airway Severe Chronic Obstructive Pulmonary Disease |
isfreeaccess_bool |
true |
container_title |
Springer Seminars in immunopathology |
authorswithroles_txt_mv |
Caramori, Gaetano @@aut@@ Casolari, Paolo @@aut@@ Barczyk, Adam @@aut@@ Durham, Andrew L. @@aut@@ Di Stefano, Antonino @@aut@@ Adcock, Ian @@aut@@ |
publishDateDaySort_date |
2016-05-13T00:00:00Z |
hierarchy_top_id |
271601337 |
id |
SPR003629554 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR003629554</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519153945.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2016 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00281-016-0561-5</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR003629554</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00281-016-0561-5-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Caramori, Gaetano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">COPD immunopathology</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2016</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronic Obstructive Pulmonary Disease</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronic Obstructive Pulmonary Disease Patient</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Small Airway</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lower Airway</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Severe Chronic Obstructive Pulmonary Disease</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Casolari, Paolo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Barczyk, Adam</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Durham, Andrew L.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Di Stefano, Antonino</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Adcock, Ian</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Springer Seminars in immunopathology</subfield><subfield code="d">Berlin : Springer, 1978</subfield><subfield code="g">38(2016), 4 vom: 13. Mai, Seite 497-515</subfield><subfield code="w">(DE-627)271601337</subfield><subfield code="w">(DE-600)1481154-6</subfield><subfield code="x">1432-2196</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:38</subfield><subfield code="g">year:2016</subfield><subfield code="g">number:4</subfield><subfield code="g">day:13</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:497-515</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s00281-016-0561-5</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_90</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_100</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_120</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_187</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_250</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_267</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_281</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_702</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">38</subfield><subfield code="j">2016</subfield><subfield code="e">4</subfield><subfield code="b">13</subfield><subfield code="c">05</subfield><subfield code="h">497-515</subfield></datafield></record></collection>
|
author |
Caramori, Gaetano |
spellingShingle |
Caramori, Gaetano misc Chronic Obstructive Pulmonary Disease misc Chronic Obstructive Pulmonary Disease Patient misc Small Airway misc Lower Airway misc Severe Chronic Obstructive Pulmonary Disease COPD immunopathology |
authorStr |
Caramori, Gaetano |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)271601337 |
format |
electronic Article |
delete_txt_mv |
keep |
author_role |
aut aut aut aut aut aut |
collection |
springer |
remote_str |
true |
illustrated |
Not Illustrated |
issn |
1432-2196 |
topic_title |
COPD immunopathology Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Chronic Obstructive Pulmonary Disease Patient (dpeaa)DE-He213 Small Airway (dpeaa)DE-He213 Lower Airway (dpeaa)DE-He213 Severe Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 |
topic |
misc Chronic Obstructive Pulmonary Disease misc Chronic Obstructive Pulmonary Disease Patient misc Small Airway misc Lower Airway misc Severe Chronic Obstructive Pulmonary Disease |
topic_unstemmed |
misc Chronic Obstructive Pulmonary Disease misc Chronic Obstructive Pulmonary Disease Patient misc Small Airway misc Lower Airway misc Severe Chronic Obstructive Pulmonary Disease |
topic_browse |
misc Chronic Obstructive Pulmonary Disease misc Chronic Obstructive Pulmonary Disease Patient misc Small Airway misc Lower Airway misc Severe Chronic Obstructive Pulmonary Disease |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
cr |
hierarchy_parent_title |
Springer Seminars in immunopathology |
hierarchy_parent_id |
271601337 |
hierarchy_top_title |
Springer Seminars in immunopathology |
isfreeaccess_txt |
true |
familylinks_str_mv |
(DE-627)271601337 (DE-600)1481154-6 |
title |
COPD immunopathology |
ctrlnum |
(DE-627)SPR003629554 (SPR)s00281-016-0561-5-e |
title_full |
COPD immunopathology |
author_sort |
Caramori, Gaetano |
journal |
Springer Seminars in immunopathology |
journalStr |
Springer Seminars in immunopathology |
lang_code |
eng |
isOA_bool |
true |
recordtype |
marc |
publishDateSort |
2016 |
contenttype_str_mv |
txt |
container_start_page |
497 |
author_browse |
Caramori, Gaetano Casolari, Paolo Barczyk, Adam Durham, Andrew L. Di Stefano, Antonino Adcock, Ian |
container_volume |
38 |
format_se |
Elektronische Aufsätze |
author-letter |
Caramori, Gaetano |
doi_str_mv |
10.1007/s00281-016-0561-5 |
title_sort |
copd immunopathology |
title_auth |
COPD immunopathology |
abstract |
Abstract The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function. © The Author(s) 2016 |
abstractGer |
Abstract The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function. © The Author(s) 2016 |
abstract_unstemmed |
Abstract The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function. © The Author(s) 2016 |
collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2010 |
container_issue |
4 |
title_short |
COPD immunopathology |
url |
https://dx.doi.org/10.1007/s00281-016-0561-5 |
remote_bool |
true |
author2 |
Casolari, Paolo Barczyk, Adam Durham, Andrew L. Di Stefano, Antonino Adcock, Ian |
author2Str |
Casolari, Paolo Barczyk, Adam Durham, Andrew L. Di Stefano, Antonino Adcock, Ian |
ppnlink |
271601337 |
mediatype_str_mv |
c |
isOA_txt |
true |
hochschulschrift_bool |
false |
doi_str |
10.1007/s00281-016-0561-5 |
up_date |
2024-07-03T20:45:51.179Z |
_version_ |
1803592192423362560 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR003629554</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519153945.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2016 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00281-016-0561-5</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR003629554</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00281-016-0561-5-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Caramori, Gaetano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">COPD immunopathology</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2016</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronic Obstructive Pulmonary Disease</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronic Obstructive Pulmonary Disease Patient</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Small Airway</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lower Airway</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Severe Chronic Obstructive Pulmonary Disease</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Casolari, Paolo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Barczyk, Adam</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Durham, Andrew L.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Di Stefano, Antonino</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Adcock, Ian</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Springer Seminars in immunopathology</subfield><subfield code="d">Berlin : Springer, 1978</subfield><subfield code="g">38(2016), 4 vom: 13. Mai, Seite 497-515</subfield><subfield code="w">(DE-627)271601337</subfield><subfield code="w">(DE-600)1481154-6</subfield><subfield code="x">1432-2196</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:38</subfield><subfield code="g">year:2016</subfield><subfield code="g">number:4</subfield><subfield code="g">day:13</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:497-515</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s00281-016-0561-5</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_90</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_100</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_120</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_187</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_250</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_267</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_281</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_702</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">38</subfield><subfield code="j">2016</subfield><subfield code="e">4</subfield><subfield code="b">13</subfield><subfield code="c">05</subfield><subfield code="h">497-515</subfield></datafield></record></collection>
|
score |
7.401573 |