Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma
Abstract In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy. We conducted a prospective...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kim, Shin [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2005 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2005 |
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| Übergeordnetes Werk: |
Enthalten in: Annals of hematology - Berlin : Springer, 1955, 84(2005), 11 vom: 24. Aug., Seite 742-747 |
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| Übergeordnetes Werk: |
volume:84 ; year:2005 ; number:11 ; day:24 ; month:08 ; pages:742-747 |
| Links: |
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| DOI / URN: |
10.1007/s00277-005-1103-8 |
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| Katalog-ID: |
SPR003732835 |
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| 245 | 1 | 0 | |a Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma |
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| 520 | |a Abstract In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy. We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 μg kg once a day) or split dose (5 μg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy was cyclophosphamide 4 g/$ m^{2} $ for MM and ESHAP with or without Rituximab for NHL. The median number of harvested CD34+ cells was 19.4×$ 10^{6} $/kg and 15.8×$ 10^{6} $/kg in the single- and split-dose groups, respectively (p=0.47). Targeted collection of 5×$ 10^{6} $ CD34+ cells/kg was achieved in 18/20 patients in the single-dose group and in all 20 patients of the split-dose group (p=0.24), with the median number of sessions 1 and 2 in the single- and split-dose groups, respectively (p=0.13). We could not observe statistically significant differences between a single-dose and split-dose lenograstim following chemotherapy in enhancing the mobilization of PBPCs in MM or NHL patients. | ||
| 650 | 4 | |a Mobilization |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a G-CSF |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Autologous stem cell transplantation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Non-Hodgkin’s lymphoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Multiple myeloma |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kim, Hyo-Jung |4 aut | |
| 700 | 1 | |a Park, Jung Sun |4 aut | |
| 700 | 1 | |a Lee, Jungsin |4 aut | |
| 700 | 1 | |a Chi, Hyun-Sook |4 aut | |
| 700 | 1 | |a Park, Chan Jeong |4 aut | |
| 700 | 1 | |a Huh, Jooryung |4 aut | |
| 700 | 1 | |a Suh, Cheolwon |4 aut | |
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10.1007/s00277-005-1103-8 doi (DE-627)SPR003732835 (SPR)s00277-005-1103-8-e DE-627 ger DE-627 rakwb eng Kim, Shin verfasserin aut Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Abstract In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy. We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 μg kg once a day) or split dose (5 μg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy was cyclophosphamide 4 g/$ m^{2} $ for MM and ESHAP with or without Rituximab for NHL. The median number of harvested CD34+ cells was 19.4×$ 10^{6} $/kg and 15.8×$ 10^{6} $/kg in the single- and split-dose groups, respectively (p=0.47). Targeted collection of 5×$ 10^{6} $ CD34+ cells/kg was achieved in 18/20 patients in the single-dose group and in all 20 patients of the split-dose group (p=0.24), with the median number of sessions 1 and 2 in the single- and split-dose groups, respectively (p=0.13). We could not observe statistically significant differences between a single-dose and split-dose lenograstim following chemotherapy in enhancing the mobilization of PBPCs in MM or NHL patients. Mobilization (dpeaa)DE-He213 G-CSF (dpeaa)DE-He213 Autologous stem cell transplantation (dpeaa)DE-He213 Non-Hodgkin’s lymphoma (dpeaa)DE-He213 Multiple myeloma (dpeaa)DE-He213 Kim, Hyo-Jung aut Park, Jung Sun aut Lee, Jungsin aut Chi, Hyun-Sook aut Park, Chan Jeong aut Huh, Jooryung aut Suh, Cheolwon aut Enthalten in Annals of hematology Berlin : Springer, 1955 84(2005), 11 vom: 24. Aug., Seite 742-747 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:84 year:2005 number:11 day:24 month:08 pages:742-747 https://dx.doi.org/10.1007/s00277-005-1103-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 84 2005 11 24 08 742-747 |
| spelling |
10.1007/s00277-005-1103-8 doi (DE-627)SPR003732835 (SPR)s00277-005-1103-8-e DE-627 ger DE-627 rakwb eng Kim, Shin verfasserin aut Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Abstract In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy. We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 μg kg once a day) or split dose (5 μg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy was cyclophosphamide 4 g/$ m^{2} $ for MM and ESHAP with or without Rituximab for NHL. The median number of harvested CD34+ cells was 19.4×$ 10^{6} $/kg and 15.8×$ 10^{6} $/kg in the single- and split-dose groups, respectively (p=0.47). Targeted collection of 5×$ 10^{6} $ CD34+ cells/kg was achieved in 18/20 patients in the single-dose group and in all 20 patients of the split-dose group (p=0.24), with the median number of sessions 1 and 2 in the single- and split-dose groups, respectively (p=0.13). We could not observe statistically significant differences between a single-dose and split-dose lenograstim following chemotherapy in enhancing the mobilization of PBPCs in MM or NHL patients. Mobilization (dpeaa)DE-He213 G-CSF (dpeaa)DE-He213 Autologous stem cell transplantation (dpeaa)DE-He213 Non-Hodgkin’s lymphoma (dpeaa)DE-He213 Multiple myeloma (dpeaa)DE-He213 Kim, Hyo-Jung aut Park, Jung Sun aut Lee, Jungsin aut Chi, Hyun-Sook aut Park, Chan Jeong aut Huh, Jooryung aut Suh, Cheolwon aut Enthalten in Annals of hematology Berlin : Springer, 1955 84(2005), 11 vom: 24. Aug., Seite 742-747 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:84 year:2005 number:11 day:24 month:08 pages:742-747 https://dx.doi.org/10.1007/s00277-005-1103-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 84 2005 11 24 08 742-747 |
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10.1007/s00277-005-1103-8 doi (DE-627)SPR003732835 (SPR)s00277-005-1103-8-e DE-627 ger DE-627 rakwb eng Kim, Shin verfasserin aut Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Abstract In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy. We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 μg kg once a day) or split dose (5 μg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy was cyclophosphamide 4 g/$ m^{2} $ for MM and ESHAP with or without Rituximab for NHL. The median number of harvested CD34+ cells was 19.4×$ 10^{6} $/kg and 15.8×$ 10^{6} $/kg in the single- and split-dose groups, respectively (p=0.47). Targeted collection of 5×$ 10^{6} $ CD34+ cells/kg was achieved in 18/20 patients in the single-dose group and in all 20 patients of the split-dose group (p=0.24), with the median number of sessions 1 and 2 in the single- and split-dose groups, respectively (p=0.13). We could not observe statistically significant differences between a single-dose and split-dose lenograstim following chemotherapy in enhancing the mobilization of PBPCs in MM or NHL patients. Mobilization (dpeaa)DE-He213 G-CSF (dpeaa)DE-He213 Autologous stem cell transplantation (dpeaa)DE-He213 Non-Hodgkin’s lymphoma (dpeaa)DE-He213 Multiple myeloma (dpeaa)DE-He213 Kim, Hyo-Jung aut Park, Jung Sun aut Lee, Jungsin aut Chi, Hyun-Sook aut Park, Chan Jeong aut Huh, Jooryung aut Suh, Cheolwon aut Enthalten in Annals of hematology Berlin : Springer, 1955 84(2005), 11 vom: 24. Aug., Seite 742-747 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:84 year:2005 number:11 day:24 month:08 pages:742-747 https://dx.doi.org/10.1007/s00277-005-1103-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 84 2005 11 24 08 742-747 |
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10.1007/s00277-005-1103-8 doi (DE-627)SPR003732835 (SPR)s00277-005-1103-8-e DE-627 ger DE-627 rakwb eng Kim, Shin verfasserin aut Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Abstract In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy. We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 μg kg once a day) or split dose (5 μg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy was cyclophosphamide 4 g/$ m^{2} $ for MM and ESHAP with or without Rituximab for NHL. The median number of harvested CD34+ cells was 19.4×$ 10^{6} $/kg and 15.8×$ 10^{6} $/kg in the single- and split-dose groups, respectively (p=0.47). Targeted collection of 5×$ 10^{6} $ CD34+ cells/kg was achieved in 18/20 patients in the single-dose group and in all 20 patients of the split-dose group (p=0.24), with the median number of sessions 1 and 2 in the single- and split-dose groups, respectively (p=0.13). We could not observe statistically significant differences between a single-dose and split-dose lenograstim following chemotherapy in enhancing the mobilization of PBPCs in MM or NHL patients. Mobilization (dpeaa)DE-He213 G-CSF (dpeaa)DE-He213 Autologous stem cell transplantation (dpeaa)DE-He213 Non-Hodgkin’s lymphoma (dpeaa)DE-He213 Multiple myeloma (dpeaa)DE-He213 Kim, Hyo-Jung aut Park, Jung Sun aut Lee, Jungsin aut Chi, Hyun-Sook aut Park, Chan Jeong aut Huh, Jooryung aut Suh, Cheolwon aut Enthalten in Annals of hematology Berlin : Springer, 1955 84(2005), 11 vom: 24. Aug., Seite 742-747 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:84 year:2005 number:11 day:24 month:08 pages:742-747 https://dx.doi.org/10.1007/s00277-005-1103-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 84 2005 11 24 08 742-747 |
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10.1007/s00277-005-1103-8 doi (DE-627)SPR003732835 (SPR)s00277-005-1103-8-e DE-627 ger DE-627 rakwb eng Kim, Shin verfasserin aut Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2005 Abstract In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy. We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 μg kg once a day) or split dose (5 μg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy was cyclophosphamide 4 g/$ m^{2} $ for MM and ESHAP with or without Rituximab for NHL. The median number of harvested CD34+ cells was 19.4×$ 10^{6} $/kg and 15.8×$ 10^{6} $/kg in the single- and split-dose groups, respectively (p=0.47). Targeted collection of 5×$ 10^{6} $ CD34+ cells/kg was achieved in 18/20 patients in the single-dose group and in all 20 patients of the split-dose group (p=0.24), with the median number of sessions 1 and 2 in the single- and split-dose groups, respectively (p=0.13). We could not observe statistically significant differences between a single-dose and split-dose lenograstim following chemotherapy in enhancing the mobilization of PBPCs in MM or NHL patients. Mobilization (dpeaa)DE-He213 G-CSF (dpeaa)DE-He213 Autologous stem cell transplantation (dpeaa)DE-He213 Non-Hodgkin’s lymphoma (dpeaa)DE-He213 Multiple myeloma (dpeaa)DE-He213 Kim, Hyo-Jung aut Park, Jung Sun aut Lee, Jungsin aut Chi, Hyun-Sook aut Park, Chan Jeong aut Huh, Jooryung aut Suh, Cheolwon aut Enthalten in Annals of hematology Berlin : Springer, 1955 84(2005), 11 vom: 24. Aug., Seite 742-747 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:84 year:2005 number:11 day:24 month:08 pages:742-747 https://dx.doi.org/10.1007/s00277-005-1103-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 84 2005 11 24 08 742-747 |
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Enthalten in Annals of hematology 84(2005), 11 vom: 24. Aug., Seite 742-747 volume:84 year:2005 number:11 day:24 month:08 pages:742-747 |
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Mobilization G-CSF Autologous stem cell transplantation Non-Hodgkin’s lymphoma Multiple myeloma |
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Kim, Shin @@aut@@ Kim, Hyo-Jung @@aut@@ Park, Jung Sun @@aut@@ Lee, Jungsin @@aut@@ Chi, Hyun-Sook @@aut@@ Park, Chan Jeong @@aut@@ Huh, Jooryung @@aut@@ Suh, Cheolwon @@aut@@ |
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2005-08-24T00:00:00Z |
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We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 μg kg once a day) or split dose (5 μg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy was cyclophosphamide 4 g/$ m^{2} $ for MM and ESHAP with or without Rituximab for NHL. The median number of harvested CD34+ cells was 19.4×$ 10^{6} $/kg and 15.8×$ 10^{6} $/kg in the single- and split-dose groups, respectively (p=0.47). Targeted collection of 5×$ 10^{6} $ CD34+ cells/kg was achieved in 18/20 patients in the single-dose group and in all 20 patients of the split-dose group (p=0.24), with the median number of sessions 1 and 2 in the single- and split-dose groups, respectively (p=0.13). 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Kim, Shin |
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Kim, Shin misc Mobilization misc G-CSF misc Autologous stem cell transplantation misc Non-Hodgkin’s lymphoma misc Multiple myeloma Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma |
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Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma Mobilization (dpeaa)DE-He213 G-CSF (dpeaa)DE-He213 Autologous stem cell transplantation (dpeaa)DE-He213 Non-Hodgkin’s lymphoma (dpeaa)DE-He213 Multiple myeloma (dpeaa)DE-He213 |
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Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma |
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Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma |
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Kim, Shin Kim, Hyo-Jung Park, Jung Sun Lee, Jungsin Chi, Hyun-Sook Park, Chan Jeong Huh, Jooryung Suh, Cheolwon |
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prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-hodgkin’s lymphoma |
| title_auth |
Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma |
| abstract |
Abstract In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy. We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 μg kg once a day) or split dose (5 μg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy was cyclophosphamide 4 g/$ m^{2} $ for MM and ESHAP with or without Rituximab for NHL. The median number of harvested CD34+ cells was 19.4×$ 10^{6} $/kg and 15.8×$ 10^{6} $/kg in the single- and split-dose groups, respectively (p=0.47). Targeted collection of 5×$ 10^{6} $ CD34+ cells/kg was achieved in 18/20 patients in the single-dose group and in all 20 patients of the split-dose group (p=0.24), with the median number of sessions 1 and 2 in the single- and split-dose groups, respectively (p=0.13). We could not observe statistically significant differences between a single-dose and split-dose lenograstim following chemotherapy in enhancing the mobilization of PBPCs in MM or NHL patients. © Springer-Verlag 2005 |
| abstractGer |
Abstract In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy. We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 μg kg once a day) or split dose (5 μg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy was cyclophosphamide 4 g/$ m^{2} $ for MM and ESHAP with or without Rituximab for NHL. The median number of harvested CD34+ cells was 19.4×$ 10^{6} $/kg and 15.8×$ 10^{6} $/kg in the single- and split-dose groups, respectively (p=0.47). Targeted collection of 5×$ 10^{6} $ CD34+ cells/kg was achieved in 18/20 patients in the single-dose group and in all 20 patients of the split-dose group (p=0.24), with the median number of sessions 1 and 2 in the single- and split-dose groups, respectively (p=0.13). We could not observe statistically significant differences between a single-dose and split-dose lenograstim following chemotherapy in enhancing the mobilization of PBPCs in MM or NHL patients. © Springer-Verlag 2005 |
| abstract_unstemmed |
Abstract In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy. We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 μg kg once a day) or split dose (5 μg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy was cyclophosphamide 4 g/$ m^{2} $ for MM and ESHAP with or without Rituximab for NHL. The median number of harvested CD34+ cells was 19.4×$ 10^{6} $/kg and 15.8×$ 10^{6} $/kg in the single- and split-dose groups, respectively (p=0.47). Targeted collection of 5×$ 10^{6} $ CD34+ cells/kg was achieved in 18/20 patients in the single-dose group and in all 20 patients of the split-dose group (p=0.24), with the median number of sessions 1 and 2 in the single- and split-dose groups, respectively (p=0.13). We could not observe statistically significant differences between a single-dose and split-dose lenograstim following chemotherapy in enhancing the mobilization of PBPCs in MM or NHL patients. © Springer-Verlag 2005 |
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| title_short |
Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma |
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https://dx.doi.org/10.1007/s00277-005-1103-8 |
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Kim, Hyo-Jung Park, Jung Sun Lee, Jungsin Chi, Hyun-Sook Park, Chan Jeong Huh, Jooryung Suh, Cheolwon |
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2024-07-03T21:19:17.502Z |
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| score |
7.400629 |